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Items: 29

1.

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.

Jerby-Arnon L, Shah P, Cuoco MS, Rodman C, Su MJ, Melms JC, Leeson R, Kanodia A, Mei S, Lin JR, Wang S, Rabasha B, Liu D, Zhang G, Margolais C, Ashenberg O, Ott PA, Buchbinder EI, Haq R, Hodi FS, Boland GM, Sullivan RJ, Frederick DT, Miao B, Moll T, Flaherty KT, Herlyn M, Jenkins RW, Thummalapalli R, Kowalczyk MS, Cañadas I, Schilling B, Cartwright ANR, Luoma AM, Malu S, Hwu P, Bernatchez C, Forget MA, Barbie DA, Shalek AK, Tirosh I, Sorger PK, Wucherpfennig K, Van Allen EM, Schadendorf D, Johnson BE, Rotem A, Rozenblatt-Rosen O, Garraway LA, Yoon CH, Izar B, Regev A.

Cell. 2018 Nov 1;175(4):984-997.e24. doi: 10.1016/j.cell.2018.09.006.

PMID:
30388455
2.

Alpha-fetoprotein (AFP) as tumor marker in a patient with urothelial cancer with exceptional response to anti-PD-1 therapy and an escape lesion mimic.

Melms JC, Thummalapalli R, Shaw K, Ye H, Tsai L, Bhatt RS, Izar B.

J Immunother Cancer. 2018 Sep 12;6(1):89. doi: 10.1186/s40425-018-0394-y.

3.

Clinical outcomes of patients with resected, early-stage ALK-positive lung cancer.

Chaft JE, Dagogo-Jack I, Santini FC, Eng J, Yeap BY, Izar B, Chin E, Jones DR, Kris MG, Shaw AT, Gainor JF.

Lung Cancer. 2018 Aug;122:67-71. doi: 10.1016/j.lungcan.2018.05.020. Epub 2018 May 22.

PMID:
30032847
4.

Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes.

Lin JR, Izar B, Wang S, Yapp C, Mei S, Shah PM, Santagata S, Sorger PK.

Elife. 2018 Jul 11;7. pii: e31657. doi: 10.7554/eLife.31657.

5.

Implementation of cell-free tumor DNA sequencing from the cerebrospinal fluid to guide treatment in a patient with primary leptomeningeal melanoma: A case report.

Melms JC, Ho KW, Thummalapalli R, Tyler J, Brinker TJ, Singh V, Sengupta S, Mier J, Izar B.

Mol Clin Oncol. 2018 Jul;9(1):58-61. doi: 10.3892/mco.2018.1621. Epub 2018 May 9.

6.

Listeria monocytogenes Induces a Virulence-Dependent microRNA Signature That Regulates the Immune Response in Galleria mellonella.

Mannala GK, Izar B, Rupp O, Schultze T, Goesmann A, Chakraborty T, Hain T.

Front Microbiol. 2017 Dec 12;8:2463. doi: 10.3389/fmicb.2017.02463. eCollection 2017.

7.

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Jenkins RW, Aref AR, Lizotte PH, Ivanova E, Stinson S, Zhou CW, Bowden M, Deng J, Liu H, Miao D, He MX, Walker W, Zhang G, Tian T, Cheng C, Wei Z, Palakurthi S, Bittinger M, Vitzthum H, Kim JW, Merlino A, Quinn M, Venkataramani C, Kaplan JA, Portell A, Gokhale PC, Phillips B, Smart A, Rotem A, Jones RE, Keogh L, Anguiano M, Stapleton L, Jia Z, Barzily-Rokni M, Cañadas I, Thai TC, Hammond MR, Vlahos R, Wang ES, Zhang H, Li S, Hanna GJ, Huang W, Hoang MP, Piris A, Eliane JP, Stemmer-Rachamimov AO, Cameron L, Su MJ, Shah P, Izar B, Thakuria M, LeBoeuf NR, Rabinowits G, Gunda V, Parangi S, Cleary JM, Miller BC, Kitajima S, Thummalapalli R, Miao B, Barbie TU, Sivathanu V, Wong J, Richards WG, Bueno R, Yoon CH, Miret J, Herlyn M, Garraway LA, Van Allen EM, Freeman GJ, Kirschmeier PT, Lorch JH, Ott PA, Hodi FS, Flaherty KT, Kamm RD, Boland GM, Wong KK, Dornan D, Paweletz CP, Barbie DA.

Cancer Discov. 2018 Feb;8(2):196-215. doi: 10.1158/2159-8290.CD-17-0833. Epub 2017 Nov 3.

8.

Photoaging Mobile Apps as a Novel Opportunity for Melanoma Prevention: Pilot Study.

Brinker TJ, Schadendorf D, Klode J, Cosgarea I, Rösch A, Jansen P, Stoffels I, Izar B.

JMIR Mhealth Uhealth. 2017 Jul 26;5(7):e101. doi: 10.2196/mhealth.8231.

9.

A first-in-human phase I, multicenter, open-label, dose-escalation study of the oral RAF/VEGFR-2 inhibitor (RAF265) in locally advanced or metastatic melanoma independent from BRAF mutation status.

Izar B, Sharfman W, Hodi FS, Lawrence D, Flaherty KT, Amaravadi R, Kim KB, Puzanov I, Sosman J, Dummer R, Goldinger SM, Lam L, Kakar S, Tang Z, Krieter O, McDermott DF, Atkins MB.

Cancer Med. 2017 Aug;6(8):1904-1914. doi: 10.1002/cam4.1140. Epub 2017 Jul 18.

10.

IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment.

Nirschl CJ, Suárez-Fariñas M, Izar B, Prakadan S, Dannenfelser R, Tirosh I, Liu Y, Zhu Q, Devi KSP, Carroll SL, Chau D, Rezaee M, Kim TG, Huang R, Fuentes-Duculan J, Song-Zhao GX, Gulati N, Lowes MA, King SL, Quintana FJ, Lee YS, Krueger JG, Sarin KY, Yoon CH, Garraway L, Regev A, Shalek AK, Troyanskaya O, Anandasabapathy N.

Cell. 2017 Jun 29;170(1):127-141.e15. doi: 10.1016/j.cell.2017.06.016.

11.

A Medical Student-Delivered Smoking Prevention Program, Education Against Tobacco, for Secondary Schools in Germany: Randomized Controlled Trial.

Brinker TJ, Owczarek AD, Seeger W, Groneberg DA, Brieske CM, Jansen P, Klode J, Stoffels I, Schadendorf D, Izar B, Fries FN, Hofmann FJ.

J Med Internet Res. 2017 Jun 6;19(6):e199. doi: 10.2196/jmir.7906.

12.

Clinical Trial Design and Endpoints for Stage IV Melanoma in the Modern Era.

Izar B, Regan MM, McDermott DF.

Cancer J. 2017 Jan/Feb;23(1):63-67. doi: 10.1097/PPO.0000000000000243. Review.

PMID:
28114257
13.

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.

Fallahi-Sichani M, Becker V, Izar B, Baker GJ, Lin JR, Boswell SA, Shah P, Rotem A, Garraway LA, Sorger PK.

Mol Syst Biol. 2017 Jan 9;13(1):905. doi: 10.15252/msb.20166796.

14.

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma.

Tirosh I, Venteicher AS, Hebert C, Escalante LE, Patel AP, Yizhak K, Fisher JM, Rodman C, Mount C, Filbin MG, Neftel C, Desai N, Nyman J, Izar B, Luo CC, Francis JM, Patel AA, Onozato ML, Riggi N, Livak KJ, Gennert D, Satija R, Nahed BV, Curry WT, Martuza RL, Mylvaganam R, Iafrate AJ, Frosch MP, Golub TR, Rivera MN, Getz G, Rozenblatt-Rosen O, Cahill DP, Monje M, Bernstein BE, Louis DN, Regev A, Suvà ML.

Nature. 2016 Nov 10;539(7628):309-313. doi: 10.1038/nature20123. Epub 2016 Nov 2.

15.

GILA, a Replacement for the Soft-Agar Assay that Permits High-Throughput Drug and Genetic Screens for Cellular Transformation.

Izar B, Rotem A.

Curr Protoc Mol Biol. 2016 Oct 10;116:28.8.1-28.8.12. doi: 10.1002/cpmb.26.

PMID:
27723082
16.

Gene expression profiling at birth characterizing the preterm infant with early onset infection.

Hilgendorff A, Windhorst A, Klein M, Tchatalbachev S, Windemuth-Kieselbach C, Kreuder J, Heckmann M, Gkatzoflia A, Ehrhardt H, Mysliwietz J, Maier M, Izar B, Billion A, Gortner L, Chakraborty T, Hossain H.

J Mol Med (Berl). 2017 Feb;95(2):169-180. doi: 10.1007/s00109-016-1466-4. Epub 2016 Aug 30.

17.

Bidirectional cross talk between patient-derived melanoma and cancer-associated fibroblasts promotes invasion and proliferation.

Izar B, Joyce CE, Goff S, Cho NL, Shah PM, Sharma G, Li J, Ibrahim N, Gold J, Hodi FS, Garraway LA, Novina CD, Bertagnolli MM, Yoon CH.

Pigment Cell Melanoma Res. 2016 Nov;29(6):656-668. doi: 10.1111/pcmr.12513. Epub 2016 Sep 22.

PMID:
27482935
18.

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.

Tirosh I, Izar B, Prakadan SM, Wadsworth MH 2nd, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin JR, Cohen O, Shah P, Lu D, Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, Gaillard A, Kolb KE, Villani AC, Johannessen CM, Andreev AY, Van Allen EM, Bertagnolli M, Sorger PK, Sullivan RJ, Flaherty KT, Frederick DT, Jané-Valbuena J, Yoon CH, Rozenblatt-Rosen O, Shalek AK, Regev A, Garraway LA.

Science. 2016 Apr 8;352(6282):189-96. doi: 10.1126/science.aad0501.

19.

Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation.

Rotem A, Janzer A, Izar B, Ji Z, Doench JG, Garraway LA, Struhl K.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5708-13. doi: 10.1073/pnas.1505979112. Epub 2015 Apr 20.

20.

Current status of antisense RNA-mediated gene regulation in Listeria monocytogenes.

Schultze T, Izar B, Qing X, Mannala GK, Hain T.

Front Cell Infect Microbiol. 2014 Sep 30;4:135. doi: 10.3389/fcimb.2014.00135. eCollection 2014. Review.

21.

The prognostic impact of KRAS, its codon and amino acid specific mutations, on survival in resected stage I lung adenocarcinoma.

Izar B, Zhou H, Heist RS, Azzoli CG, Muzikansky A, Scribner EE, Bernardo LA, Dias-Santagata D, Iafrate AJ, Lanuti M.

J Thorac Oncol. 2014 Sep;9(9):1363-9. doi: 10.1097/JTO.0000000000000266.

22.

Pharmacokinetics, clinical indications, and resistance mechanisms in molecular targeted therapies in cancer.

Izar B, Rotow J, Gainor J, Clark J, Chabner B.

Pharmacol Rev. 2013 Oct 3;65(4):1351-95. doi: 10.1124/pr.113.007807. Print 2013. Review.

PMID:
24092887
23.

The impact of EGFR mutation status on outcomes in patients with resected stage I non-small cell lung cancers.

Izar B, Sequist L, Lee M, Muzikansky A, Heist R, Iafrate J, Dias-Santagata D, Mathisen D, Lanuti M.

Ann Thorac Surg. 2013 Sep;96(3):962-8. doi: 10.1016/j.athoracsur.2013.05.091. Epub 2013 Aug 8.

PMID:
23932319
24.

Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes.

Hain T, Ghai R, Billion A, Kuenne CT, Steinweg C, Izar B, Mohamed W, Mraheil MA, Domann E, Schaffrath S, Kärst U, Goesmann A, Oehm S, Pühler A, Merkl R, Vorwerk S, Glaser P, Garrido P, Rusniok C, Buchrieser C, Goebel W, Chakraborty T.

BMC Genomics. 2012 Apr 24;13:144. doi: 10.1186/1471-2164-13-144.

25.

microRNA response to Listeria monocytogenes infection in epithelial cells.

Izar B, Mannala GK, Mraheil MA, Chakraborty T, Hain T.

Int J Mol Sci. 2012;13(1):1173-85. doi: 10.3390/ijms13011173. Epub 2012 Jan 20.

26.

Universal stress proteins are important for oxidative and acid stress resistance and growth of Listeria monocytogenes EGD-e in vitro and in vivo.

Seifart Gomes C, Izar B, Pazan F, Mohamed W, Mraheil MA, Mukherjee K, Billion A, Aharonowitz Y, Chakraborty T, Hain T.

PLoS One. 2011;6(9):e24965. doi: 10.1371/journal.pone.0024965. Epub 2011 Sep 30.

27.

Comparison of devices used for stent-assisted coiling of intracranial aneurysms.

Izar B, Rai A, Raghuram K, Rotruck J, Carpenter J.

PLoS One. 2011;6(9):e24875. doi: 10.1371/journal.pone.0024875. Epub 2011 Sep 22.

28.

Identification and role of regulatory non-coding RNAs in Listeria monocytogenes.

Izar B, Mraheil MA, Hain T.

Int J Mol Sci. 2011;12(8):5070-9. doi: 10.3390/ijms12085070. Epub 2011 Aug 10. Review.

29.

Hepatocellular adenoma in men: a rare cause for liver resection.

Theruvath TP, Izar B, McGillicuddy J, Stewar E, Reuben A, Chavin KD.

Am Surg. 2011 Mar;77(3):373-6. No abstract available.

PMID:
21375862

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