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Toxicity and Antigenotoxic Effect of Hispolon Derivatives: Role of Structure in Modulating Cellular Redox State and Thioredoxin Reductase.

Chethna P, Iyer SS, Gandhi VV, Kunwar A, Singh BG, Barik A, Balaji NV, Ramani MV, Subbaraju GV, Priyadarsini KI.

ACS Omega. 2018 Jun 30;3(6):5958-5970. doi: 10.1021/acsomega.8b00415. Epub 2018 Jun 1.


Basosquamous Carcinoma: A Single Centre Clinicopathological Evaluation and Proposal of an Evidence-Based Protocol.

Oldbury JW, Wain RAJ, Abas S, Dobson CM, Iyer SS.

J Skin Cancer. 2018 Jun 3;2018:6061395. doi: 10.1155/2018/6061395. eCollection 2018.


Fluid Phase Coexistence in Biological Membrane: Insights from Local Nonaffine Deformation of Lipids.

Iyer SS, Tripathy M, Srivastava A.

Biophys J. 2018 Jul 3;115(1):117-128. doi: 10.1016/j.bpj.2018.05.021.


Mast Cell Proteases Activate Astrocytes and Glia-Neurons and Release Interleukin-33 by Activating p38 and ERK1/2 MAPKs and NF-κB.

Kempuraj D, Thangavel R, Selvakumar GP, Ahmed ME, Zaheer S, Raikwar SP, Zahoor H, Saeed D, Dubova I, Giler G, Herr S, Iyer SS, Zaheer A.

Mol Neurobiol. 2018 Jun 18. doi: 10.1007/s12035-018-1177-7. [Epub ahead of print]


Discrete roles of trehalose and Hsp104 in inhibition of protein aggregation in yeast cells.

Sethi R, Iyer SS, Das E, Roy I.

FEMS Yeast Res. 2018 Sep 1;18(6). doi: 10.1093/femsyr/foy058.


Ophthalmic artery occlusion after chiropractic neck manipulation.

Regan KA, Youn TS, Iyer SSR.

Acta Ophthalmol. 2018 May 31. doi: 10.1111/aos.13738. [Epub ahead of print] No abstract available.


Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses.

Iyer SS, Gensollen T, Gandhi A, Oh SF, Neves JF, Collin F, Lavin R, Serra C, Glickman J, de Silva PSA, Sartor RB, Besra G, Hauser R, Maxwell A, Llebaria A, Blumberg RS.

Cell. 2018 May 17;173(5):1123-1134.e11. doi: 10.1016/j.cell.2018.04.037.


Targeted Gene Editing of Glia Maturation Factor in Microglia: a Novel Alzheimer's Disease Therapeutic Target.

Raikwar SP, Thangavel R, Dubova I, Selvakumar GP, Ahmed ME, Kempuraj D, Zaheer SA, Iyer SS, Zaheer A.

Mol Neurobiol. 2018 Apr 27. doi: 10.1007/s12035-018-1068-y. [Epub ahead of print]


Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming.

Elliott EI, Miller AN, Banoth B, Iyer SS, Stotland A, Weiss JP, Gottlieb RA, Sutterwala FS, Cassel SL.

J Immunol. 2018 May 1;200(9):3047-3052. doi: 10.4049/jimmunol.1701723. Epub 2018 Mar 30.


A scalable and deformable stylized model of the adult human eye for radiation dose assessment.

El Basha D, Furuta T, Iyer SSR, Bolch WE.

Phys Med Biol. 2018 May 17;63(10):105017. doi: 10.1088/1361-6560/aab955.


A Young Patient With Floaters.

Lukowski ZL, Regan KA, Iyer SSR.

JAMA Ophthalmol. 2018 Jun 1;136(6):712-713. doi: 10.1001/jamaophthalmol.2017.5485. No abstract available.


Intralenticular Ozurdex® - One Year Later.

Regan KA, Blake CR, Lukowski ZL, Iyer SSR.

Case Rep Ophthalmol. 2017 Dec 21;8(3):590-594. doi: 10.1159/000485318. eCollection 2017 Sep-Dec.


Vision loss secondary to orbital extension of rhabdomyosarcoma in an adult.

Levenson JN, Regan KA, Asirvatham JR, Iyer SS.

Clin Exp Ophthalmol. 2018 Feb 9. doi: 10.1111/ceo.13169. [Epub ahead of print] No abstract available.


Glia Maturation Factor Dependent Inhibition of Mitochondrial PGC-1α Triggers Oxidative Stress-Mediated Apoptosis in N27 Rat Dopaminergic Neuronal Cells.

Selvakumar GP, Iyer SS, Kempuraj D, Raju M, Thangavel R, Saeed D, Ahmed ME, Zahoor H, Raikwar SP, Zaheer S, Zaheer A.

Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-018-0882-6. [Epub ahead of print]


Editorial: CD4 T Follicular Helper Cells in HIV.

Iyer SS.

Front Immunol. 2017 Dec 22;8:1894. doi: 10.3389/fimmu.2017.01894. eCollection 2017. No abstract available.


Mast Cell Activation in Brain Injury, Stress, and Post-traumatic Stress Disorder and Alzheimer's Disease Pathogenesis.

Kempuraj D, Selvakumar GP, Thangavel R, Ahmed ME, Zaheer S, Raikwar SP, Iyer SS, Bhagavan SM, Beladakere-Ramaswamy S, Zaheer A.

Front Neurosci. 2017 Dec 12;11:703. doi: 10.3389/fnins.2017.00703. eCollection 2017. Review.


Co-Expression of Glia Maturation Factor and Apolipoprotein E4 in Alzheimer's Disease Brain.

Thangavel R, Bhagavan SM, Ramaswamy SB, Surpur S, Govindarajan R, Kempuraj D, Zaheer S, Raikwar S, Ahmed ME, Selvakumar GP, Iyer SS, Zaheer A.

J Alzheimers Dis. 2018;61(2):553-560. doi: 10.3233/JAD-170777.


Multivalent oleanolic acid human serum albumin conjugate as nonglycosylated neomucin for influenza virus capture and entry inhibition.

Yang Y, He HJ, Chang H, Yu Y, Yang MB, He Y, Fan ZC, Iyer SS, Yu P.

Eur J Med Chem. 2018 Jan 1;143:1723-1731. doi: 10.1016/j.ejmech.2017.10.070. Epub 2017 Oct 28.


Effect of finishing/polishing techniques and time on surface roughness of esthetic restorative materials.

Madhyastha PS, Hegde S, Srikant N, Kotian R, Iyer SS.

Dent Res J (Isfahan). 2017 Sep-Oct;14(5):326-330.


Knowledge and Awareness of First Aid of Avulsed Tooth among Physicians and Nurses of Hospital Emergency Department.

Iyer SS, Panigrahi A, Sharma S.

J Pharm Bioallied Sci. 2017 Apr-Jun;9(2):94-98. doi: 10.4103/jpbs.JPBS_343_16.


Highly specific and rapid glycan based amperometric detection of influenza viruses.

Cui X, Das A, Dhawane AN, Sweeney J, Zhang X, Chivukula V, Iyer SS.

Chem Sci. 2017 May 1;8(5):3628-3634. doi: 10.1039/c6sc03720h. Epub 2017 Feb 14.


Glia Maturation Factor and Mitochondrial Uncoupling Proteins 2 and 4 Expression in the Temporal Cortex of Alzheimer's Disease Brain.

Thangavel R, Kempuraj D, Zaheer S, Raikwar S, Ahmed ME, Selvakumar GP, Iyer SS, Zaheer A.

Front Aging Neurosci. 2017 May 18;9:150. doi: 10.3389/fnagi.2017.00150. eCollection 2017.


Characteristics of HIV target CD4 T cells collected using different sampling methods from the genital tract of HIV seronegative women.

Iyer SS, Sabula MJ, Mehta CC, Haddad LB, Brown NL, Amara RR, Ofotokun I, Sheth AN.

PLoS One. 2017 Jun 1;12(6):e0178193. doi: 10.1371/journal.pone.0178193. eCollection 2017.


Neuroinflammation Induces Neurodegeneration.

Kempuraj D, Thangavel R, Natteru PA, Selvakumar GP, Saeed D, Zahoor H, Zaheer S, Iyer SS, Zaheer A.

J Neurol Neurosurg Spine. 2016;1(1). pii: 1003. Epub 2016 Nov 18.


Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness.

Iyer SS, Bibollet-Ruche F, Sherrill-Mix S, Learn GH, Plenderleith L, Smith AG, Barbian HJ, Russell RM, Gondim MV, Bahari CY, Shaw CM, Li Y, Decker T, Haynes BF, Shaw GM, Sharp PM, Borrow P, Hahn BH.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E590-E599. doi: 10.1073/pnas.1620144114. Epub 2017 Jan 9.


Fascia iliaca block vs intravenous fentanyl as an analgesic technique before positioning for spinal anesthesia in patients undergoing surgery for femur fractures-a randomized trial.

Madabushi R, Rajappa GC, Thammanna PP, Iyer SS.

J Clin Anesth. 2016 Dec;35:398-403. doi: 10.1016/j.jclinane.2016.09.014. Epub 2016 Oct 14.


Toward the Development of the Next Generation of a Rapid Diagnostic Test: Synthesis of Glycophosphatidylinositol (GPI) Analogues of Plasmodium falciparum and Immunological Characterization.

Gurale BP, He Y, Cui X, Dinh H, Dhawane AN, Lucchi NW, Udhayakumar V, Iyer SS.

Bioconjug Chem. 2016 Dec 21;27(12):2886-2899. doi: 10.1021/acs.bioconjchem.6b00542. Epub 2016 Dec 1.


Multivalent S-sialoside protein conjugates block influenza hemagglutinin and neuraminidase.

Yang Y, Liu HP, Yu Q, Yang MB, Wang DM, Jia TW, He HJ, He Y, Xiao HX, Iyer SS, Fan ZC, Meng X, Yu P.

Carbohydr Res. 2016 Nov 29;435:68-75. doi: 10.1016/j.carres.2016.09.017. Epub 2016 Sep 28.


Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction.

Foster TL, Wilson H, Iyer SS, Coss K, Doores K, Smith S, Kellam P, Finzi A, Borrow P, Hahn BH, Neil SJD.

Cell Host Microbe. 2016 Oct 12;20(4):429-442. doi: 10.1016/j.chom.2016.08.006. Epub 2016 Sep 15.


Hookah addiction among adolescents of five major cities in Central India.

Khandelwal V, Nayak UA, Nayak PA, Iyer SS, Bafna Y.

Int J Adolesc Med Health. 2016 Aug 19;29(6). pii: /j/ijamh.2017.29.issue-6/ijamh-2016-0025/ijamh-2016-0025.xml. doi: 10.1515/ijamh-2016-0025.


Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance.

Kmiec D, Iyer SS, Stürzel CM, Sauter D, Hahn BH, Kirchhoff F.

MBio. 2016 Aug 16;7(4). pii: e00934-16. doi: 10.1128/mBio.00934-16.


Induction of Th1-Biased T Follicular Helper (Tfh) Cells in Lymphoid Tissues during Chronic Simian Immunodeficiency Virus Infection Defines Functionally Distinct Germinal Center Tfh Cells.

Velu V, Mylvaganam GH, Gangadhara S, Hong JJ, Iyer SS, Gumber S, Ibegbu CC, Villinger F, Amara RR.

J Immunol. 2016 Sep 1;197(5):1832-42. doi: 10.4049/jimmunol.1600143. Epub 2016 Aug 1.


Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques.

Iyer SS, Gangadhara S, Victor B, Shen X, Chen X, Nabi R, Kasturi SP, Sabula MJ, Labranche CC, Reddy PB, Tomaras GD, Montefiori DC, Moss B, Spearman P, Pulendran B, Kozlowski PA, Amara RR.

J Virol. 2016 Sep 12;90(19):8842-54. doi: 10.1128/JVI.01163-16. Print 2016 Oct 1.


Synthesis and Evaluation of Biotinylated Bivalent HistoBlood Group Antigens for Capturing Human Noroviruses.

Dhawane AN, Diez-Valcarce M, Gurale BP, Dinh H, Vinjé J, Iyer SS.

Bioconjug Chem. 2016 Aug 17;27(8):1822-9. doi: 10.1021/acs.bioconjchem.6b00226. Epub 2016 Jul 28.


The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model.

Cadena C, Stavrou S, Manzoni T, Iyer SS, Bibollet-Ruche F, Zhang W, Hahn BH, Browne EP, Ross SR.

Retrovirology. 2016 Jun 30;13(1):45. doi: 10.1186/s12977-016-0280-y.


Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol.

Rahman K, Desai C, Iyer SS, Thorn NE, Kumar P, Liu Y, Smith T, Neish AS, Li H, Tan S, Wu P, Liu X, Yu Y, Farris AB, Nusrat A, Parkos CA, Anania FA.

Gastroenterology. 2016 Oct;151(4):733-746.e12. doi: 10.1053/j.gastro.2016.06.022. Epub 2016 Jun 21.


Polyvalent effect enhances diglycosidic antiplasmodial activity.

Zhang WQ, He Y, Yu Q, Liu HP, Wang DM, Li XB, Luo J, Meng X, Qin HJ, Lucchi NW, Udhayakumar V, Iyer SS, Yang Y, Yu P.

Eur J Med Chem. 2016 Oct 4;121:640-648. doi: 10.1016/j.ejmech.2016.05.069. Epub 2016 Jun 2.


Graphene oxide supported copper oxide nanoneedles: An efficient hybrid material for removal of toxic azo dyes.

Rajesh R, Iyer SS, Ezhilan J, Kumar SS, Venkatesan R.

Spectrochim Acta A Mol Biomol Spectrosc. 2016 Sep 5;166:49-55. doi: 10.1016/j.saa.2016.05.002. Epub 2016 May 4.


Neuraminidase Resistant Sialosides for the Detection of Influenza Viruses.

He Y, Yang Y, Iyer SS.

Bioconjug Chem. 2016 Jun 15;27(6):1509-17. doi: 10.1021/acs.bioconjchem.6b00150. Epub 2016 May 26.


How colonization by microbiota in early life shapes the immune system.

Gensollen T, Iyer SS, Kasper DL, Blumberg RS.

Science. 2016 Apr 29;352(6285):539-44. doi: 10.1126/science.aad9378. Review.


Reply to the comments on "Setup error analysis in helical tomotherapy based image-guided radiation therapy treatments" by Slav Yartsev.

Thondykandy BA, Swamidas JV, Agarwal JP, Gupta T, Laskar SG, Mahantshetty U, Iyer SS, Mukherjee IU, Shrivastava SK, Deshpande DD.

J Med Phys. 2016 Jan-Mar;41(1):72. doi: 10.4103/0971-6203.177282. No abstract available.


Indirect Detection of Glycosidases Using Amperometry.

Gurale BP, Dhawane AN, Cui X, Das A, Zhang X, Iyer SS.

Anal Chem. 2016 Apr 19;88(8):4248-53. doi: 10.1021/acs.analchem.5b03943. Epub 2016 Mar 30.


A Phase 3, Double-Blind, Randomized Study of Arterolane Maleate-Piperaquine Phosphate vs Artemether-Lumefantrine for Falciparum Malaria in Adolescent and Adult Patients in Asia and Africa.

Toure OA, Valecha N, Tshefu AK, Thompson R, Krudsood S, Gaye O, Rao BHK, Sagara I, Bose TK, Mohanty S, Rao BS, Anvikar AR, Mwapasa V, Noedl H, Arora S, Roy A, Iyer SS, Sharma P, Saha N, Jalali RK; AM–PQP Study Team, Tiacoh L, Enosse S, Tangpukdee N, Kokolomami J, Ndiaye JL, Rao D, Yumva NN, Sidibe B, Mohanty R, Jha AC, Nyirenda M, Starzengruber P, Swoboda P.

Clin Infect Dis. 2016 Apr 15;62(8):964-971. doi: 10.1093/cid/ciw029. Epub 2016 Feb 21.


Critical Care in Resource-Restricted Settings.

Dondorp AM, Iyer SS, Schultz MJ.

JAMA. 2016 Feb 23;315(8):753-4. doi: 10.1001/jama.2016.0976. No abstract available.


Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation.

Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, Horng T.

Elife. 2016 Feb 19;5. pii: e11612. doi: 10.7554/eLife.11612.


Setup error analysis in helical tomotherapy based image-guided radiation therapy treatments.

Thondykandy BA, Swamidas JV, Agarwal J, Gupta T, Laskar SG, Mahantshetty U, Iyer SS, Mukherjee IU, Shrivastava SK, Deshpande DD.

J Med Phys. 2015 Oct-Dec;40(4):233-9. doi: 10.4103/0971-6203.170796.


Comparison of the safety and efficacy of fixed-dose combination of arterolane maleate and piperaquine phosphate with chloroquine in acute, uncomplicated Plasmodium vivax malaria: a phase III, multicentric, open-label study.

Valecha N, Savargaonkar D, Srivastava B, Rao BH, Tripathi SK, Gogtay N, Kochar SK, Kumar NB, Rajadhyaksha GC, Lakhani JD, Solanki BB, Jalali RK, Arora S, Roy A, Saha N, Iyer SS, Sharma P, Anvikar AR.

Malar J. 2016 Jan 27;15:42. doi: 10.1186/s12936-016-1084-1.


Efficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate dispersible tablets in paediatric patients with acute uncomplicated Plasmodium falciparum malaria: a phase II, multicentric, open-label study.

Toure OA, Rulisa S, Anvikar AR, Rao BS, Mishra P, Jalali RK, Arora S, Roy A, Saha N, Iyer SS, Sharma P, Valecha N.

Malar J. 2015 Nov 25;14:469. doi: 10.1186/s12936-015-0982-y.

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