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Comparing the Utility and Surgical Outcomes of Harmonic Focus Ultrasonic Scalpel with Ligasure Small Jaw Bipolar Device in Thyroidectomies: A Prospective Randomized Controlled Trial.

Lee SH, Nguyen TK, Ong WS, Haaland B, Tay GC, Tan NC, Tan HK, Ng JCF, Iyer NG.

Ann Surg Oncol. 2019 Dec;26(13):4414-4422. doi: 10.1245/s10434-019-07806-w. Epub 2019 Sep 11.


Circulating extracellular vesicle-associated TGFβ3 modulates response to cytotoxic therapy in head and neck squamous cell carcinoma.

Rodrigues-Junior DM, Tan SS, Lim SK, Leong HS, Melendez ME, Ramos CRN, Viana LS, Tan DSW, Carvalho AL, Iyer NG, Vettore AL.

Carcinogenesis. 2019 Aug 22. pii: bgz148. doi: 10.1093/carcin/bgz148. [Epub ahead of print]


Factors driving frequent attendance at emergency departments for patients with head and neck cancer.

Tan AL, Iyer NG, Putri N, Nadkarni N, Skanthakumar T, Wong TH, Tay GCA.

Head Neck. 2019 Nov;41(11):3798-3805. doi: 10.1002/hed.25916. Epub 2019 Aug 18.


Is high-risk cutaneous squamous cell carcinoma of the head and neck a suitable candidate for current targeted therapies?

Zilberg C, Lee MW, Kraitsek S, Ashford B, Ranson M, Shannon K, Iyer NG, Ch'ng S, Low TH, Palme C, Clark J, Gupta R, Yu B.

J Clin Pathol. 2019 Jul 12. pii: jclinpath-2019-206038. doi: 10.1136/jclinpath-2019-206038. [Epub ahead of print]


A preliminary investigation of circulating extracellular vesicles and biomarker discovery associated with treatment response in head and neck squamous cell carcinoma.

Rodrigues-Junior DM, Tan SS, de Souza Viana L, Carvalho AL, Lim SK, Iyer NG, Vettore AL.

BMC Cancer. 2019 Apr 23;19(1):373. doi: 10.1186/s12885-019-5565-9.


Genomics of radiation sensitivity in squamous cell carcinomas.

Thiagarajan A, Iyer NG.

Pharmacogenomics. 2019 Apr;20(6):457-466. doi: 10.2217/pgs-2018-0154. Epub 2019 Apr 15.


The effect of parathyroidectomy on patients' symptoms in tertiary hyperparathyroidism.

See A, Lim AEL, Wong J, Choong HL, Iyer NG, Tan HK, Tan NC, Ng JCF.

Head Neck. 2019 Aug;41(8):2748-2755. doi: 10.1002/hed.25750. Epub 2019 Apr 7.


Mutational Signatures in Mandibular Ameloblastoma Correlate with Smoking.

Guan P, Wong SF, Lim JQ, Ng CCY, Soong PL, Sim CQX, Ong CK, Rajasegaran V, Myint SS, Lee JY, Tan HK, Iyer NG, Soo KC, Teh BT, Tay ABG.

J Dent Res. 2019 Jun;98(6):652-658. doi: 10.1177/0022034519837248. Epub 2019 Mar 27.


High expression of MLANA in the plasma of patients with head and neck squamous cell carcinoma as a predictor of tumor progression.

Rodrigues-Junior DM, Tan SS, Lim SK, de Souza Viana L, Carvalho AL, Vettore AL, Iyer NG.

Head Neck. 2019 May;41(5):1199-1205. doi: 10.1002/hed.25510. Epub 2019 Feb 25.


Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer.

Lai GGY, Lim TH, Lim J, Liew PJR, Kwang XL, Nahar R, Aung ZW, Takano A, Lee YY, Lau DPX, Tan GS, Tan SH, Tan WL, Ang MK, Toh CK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Yuan J, Lim TKH, Lim AST, Hillmer AM, Lim WT, Iyer NG, Tam WL, Zhai W, Tan EH, Tan DSW.

J Clin Oncol. 2019 Apr 10;37(11):876-884. doi: 10.1200/JCO.18.00177. Epub 2019 Jan 24.


Elderly Patients with Advanced Head and Neck Carcinoma: Does Aggressive Treatment Result in Better Outcomes?

Jang IJH, Skanthakumar T, Tan HK, Tan NC, Soo KC, Iyer NG.

Otolaryngol Head Neck Surg. 2019 Apr;160(4):642-650. doi: 10.1177/0194599818815065. Epub 2018 Dec 18.


Multidisciplinary team meetings - challenges of implementation science.

Iyer NG, Chua MLK.

Nat Rev Clin Oncol. 2019 Apr;16(4):205-206. doi: 10.1038/s41571-018-0148-2. No abstract available.


Concurrent Single-Cell RNA and Targeted DNA Sequencing on an Automated Platform for Comeasurement of Genomic and Transcriptomic Signatures.

Kong SL, Li H, Tai JA, Courtois ET, Poh HM, Lau DP, Haw YX, Iyer NG, Tan DSW, Prabhakar S, Ruff D, Hillmer AM.

Clin Chem. 2019 Feb;65(2):272-281. doi: 10.1373/clinchem.2018.295717. Epub 2018 Dec 6.


Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy.

Sharma A, Cao EY, Kumar V, Zhang X, Leong HS, Wong AML, Ramakrishnan N, Hakimullah M, Teo HMV, Chong FT, Chia S, Thangavelu MT, Kwang XL, Gupta R, Clark JR, Periyasamy G, Iyer NG, DasGupta R.

Nat Commun. 2018 Nov 22;9(1):4931. doi: 10.1038/s41467-018-07261-3.


Cancer patients as frequent attenders in emergency departments: A national cohort study.

Wong TH, Lau ZY, Ong WS, Tan KB, Wong YJ, Farid M, Teo MCC, Yee ACP, Nguyen HV, Ong MEH, Iyer NG.

Cancer Med. 2018 Sep;7(9):4434-4446. doi: 10.1002/cam4.1728. Epub 2018 Aug 17.


Use of the EndoMaster robot-assisted surgical system in transoral robotic surgery: A cadaveric study.

Tay G, Tan HK, Nguyen TK, Phee SJ, Iyer NG.

Int J Med Robot. 2018 Aug;14(4):e1930. doi: 10.1002/rcs.1930. Epub 2018 Jun 5.


Mutational Aberrations Detected in Mucinous Epithelial Ovarian Cancer of Asian Women.

Chay WY, Kwok LL, Tiong WN, Krisna SS, Lim KH, Iyer NG, Goh LK, Tan DS.

Int J Gynecol Cancer. 2018 Mar;28(3):428-436. doi: 10.1097/IGC.0000000000001138.


Salivary fistula: Blue dye testing as part of an algorithm for early diagnosis.

Kiong KL, Tan NC, Skanthakumar T, Teo CEH, Soo KC, Tan HK, Roche E, Yee K, Iyer NG.

Laryngoscope Investig Otolaryngol. 2017 Oct 12;2(6):363-368. doi: 10.1002/lio2.112. eCollection 2017 Dec.


GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.

Rasheed SAK, Leong HS, Lakshmanan M, Raju A, Dadlani D, Chong FT, Shannon NB, Rajarethinam R, Skanthakumar T, Tan EY, Hwang JSG, Lim KH, Tan DS, Ceppi P, Wang M, Tergaonkar V, Casey PJ, Iyer NG.

Oncogene. 2018 Mar;37(10):1340-1353. doi: 10.1038/s41388-017-0038-6. Epub 2017 Dec 19.


Meta-analysis of induction chemotherapy as a selection marker for chemoradiation in the head and neck.

Kiong KL, de Souza NN, Sultana R, Iyer NG.

Laryngoscope. 2018 Jul;128(7):1594-1601. doi: 10.1002/lary.27011. Epub 2017 Nov 24.


A three gene immunohistochemical panel serves as an adjunct to clinical staging of patients with head and neck cancer.

Ong CJ, Shannon NB, Mueller S, Lek SM, Qiu X, Chong FT, Li K, Koh KKN, Tay GCA, Skanthakumar T, Hwang JSG, Hon Lim TK, Ang MK, Tan DSW, Tan NC, Tan HK, Soo KC, Iyer NG.

Oncotarget. 2017 Jun 19;8(45):79556-79566. doi: 10.18632/oncotarget.18568. eCollection 2017 Oct 3.


Predictive value of the 8th edition American Joint Commission Cancer (AJCC) nodal staging system for patients with cutaneous squamous cell carcinoma of the head and neck.

Liu J, Ebrahimi A, Low TH, Gao K, Palme CE, Sydney C, Ashford BG, Iyer NG, Clark JR, Gupta R.

J Surg Oncol. 2018 Mar;117(4):765-772. doi: 10.1002/jso.24883. Epub 2017 Oct 19.


Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma.

Zilberg C, Lee MW, Yu B, Ashford B, Kraitsek S, Ranson M, Shannon K, Cowley M, Iyer NG, Palme CE, Ch'ng S, Low TH, O'Toole S, Clark JR, Gupta R.

Mod Pathol. 2018 Feb;31(2):275-287. doi: 10.1038/modpathol.2017.128. Epub 2017 Oct 6.


Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma.

Tan DSW, Chong FT, Leong HS, Toh SY, Lau DP, Kwang XL, Zhang X, Sundaram GM, Tan GS, Chang MM, Chua BT, Lim WT, Tan EH, Ang MK, Lim TKH, Sampath P, Chowbay B, Skanderup AJ, DasGupta R, Iyer NG.

Nat Med. 2017 Oct;23(10):1167-1175. doi: 10.1038/nm.4401. Epub 2017 Sep 18.


A 3D printed microfluidic perfusion device for multicellular spheroid cultures.

Ong LJY, Islam A, DasGupta R, Iyer NG, Leo HL, Toh YC.

Biofabrication. 2017 Sep 11;9(4):045005. doi: 10.1088/1758-5090/aa8858.


Distant metastasis as the sole initial manifestation of well-differentiated thyroid carcinoma.

See A, Iyer NG, Tan NC, Teo C, Ng J, Soo KC, Tan HK.

Eur Arch Otorhinolaryngol. 2017 Jul;274(7):2877-2882. doi: 10.1007/s00405-017-4532-9. Epub 2017 Apr 5.


Reviewing the genetic alterations in high-risk cutaneous squamous cell carcinoma: A search for prognostic markers and therapeutic targets.

Ashford BG, Clark J, Gupta R, Iyer NG, Yu B, Ranson M.

Head Neck. 2017 Jul;39(7):1462-1469. doi: 10.1002/hed.24765. Epub 2017 Apr 3. Review.


Survival of patients with head and neck squamous cell carcinoma by housing subsidy in a tiered public housing system.

Wong TH, Skanthakumar T, Nadkarni N, Nguyen HV, Iyer NG.

Cancer. 2017 Jun 1;123(11):1998-2005. doi: 10.1002/cncr.30557. Epub 2017 Jan 30.


Nasopharyngectomy with operating microscope: A case series.

Jang JH, Tan HK, Iyer NG, Soo KC, Tan NC.

Am J Otolaryngol. 2017 Jan - Feb;38(1):82-86. doi: 10.1016/j.amjoto.2016.07.008. Epub 2016 Sep 25.


Changing epidemiology of oral squamous cell carcinoma of the tongue: A global study.

Ng JH, Iyer NG, Tan MH, Edgren G.

Head Neck. 2017 Feb;39(2):297-304. doi: 10.1002/hed.24589. Epub 2016 Oct 3.


Novel technique of creating a seal for the vacuum-assisted closure system application in complex head and neck wounds.

Tian B, Iyer NG, Tan HK, Tay AC, Soo KC, Tan NC.

Head Neck. 2016 Dec;38(12):E2523-E2526. doi: 10.1002/hed.24563. Epub 2016 Aug 18.


Novel therapeutic targets on the horizon for lung cancer.

Tan WL, Jain A, Takano A, Newell EW, Iyer NG, Lim WT, Tan EH, Zhai W, Hillmer AM, Tam WL, Tan DSW.

Lancet Oncol. 2016 Aug;17(8):e347-e362. doi: 10.1016/S1470-2045(16)30123-1. Review.


Diagnostic pitfall: Adenoid cystic carcinoma of the tongue presenting as an isolated hypoglossal nerve palsy, case report and literature review.

Wee HE, Azhar R, Tang PY, Teo TH, Iyer NG, Tan HK, Tan NC.

Int J Surg Case Rep. 2016;25:102-5. doi: 10.1016/j.ijscr.2016.05.060. Epub 2016 Jun 4.


Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: A pilot study.

Morosin T, Ashford B, Ranson M, Gupta R, Clark J, Iyer NG, Spring K.

Oncotarget. 2016 Jul 26;7(30):47111-47115. doi: 10.18632/oncotarget.9946.


Outcomes and Prognostic Factors of Radiation-Induced and De Novo Head and Neck Squamous Cell Carcinomas.

Tay GC, Iyer NG, Ong WS, Tai D, Ang MK, Ha TC, Soo KC, Tan HK.

Otolaryngol Head Neck Surg. 2016 May;154(5):880-7. doi: 10.1177/0194599816631726. Epub 2016 Mar 8.


Microarray profiling shows distinct differences between primary tumors and commonly used preclinical models in hepatocellular carcinoma.

Wang W, Iyer NG, Tay HT, Wu Y, Lim TK, Zheng L, Song IC, Kwoh CK, Huynh H, Tan PO, Chow PK.

BMC Cancer. 2015 Oct 31;15:828. doi: 10.1186/s12885-015-1814-8.


Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.

Vettore AL, Ramnarayanan K, Poore G, Lim K, Ong CK, Huang KK, Leong HS, Chong FT, Lim TK, Lim WK, Cutcutache I, Mcpherson JR, Suzuki Y, Zhang S, Skanthakumar T, Wang W, Tan DS, Cho BC, Teh BT, Rozen S, Tan P, Iyer NG.

Genome Med. 2015 Sep 23;7:98. doi: 10.1186/s13073-015-0219-2.


Prognostic Performance of Current Stage III Oral Cancer Patients After Curative Intent Resection: Evidence to Support a Revision of the American Joint Committee on Cancer Staging System.

Amit M, Yen TC, Liao CT, Chaturvedi P, Agarwal JP, Kowalski LP, Kohler HF, Ebrahimi A, Clark JR, Cernea CR, Brandao SJ, Kreppel M, Zöller J, Fliss MD, Bachar G, Shpitzer T, Bolzoni VA, Patel PR, Jonnalagadda S, Robbins KT, Iyer NG, Skanthakumar T, Shah JP, Patel SG, Gil Z.

Ann Surg Oncol. 2015 Dec;22 Suppl 3:S985-91. doi: 10.1245/s10434-015-4842-3. Epub 2015 Aug 28.


Metastasectomy for metachronous pulmonary and hepatic metastases from nasopharyngeal carcinoma: Report of 6 cases and review of the literature.

Lim SJ, Iyer NG, Ooi LL, Koong HN, Chung AY, Tan HK, Soo KC, Tan NC.

Head Neck. 2016 Feb;38(2):E37-40. doi: 10.1002/hed.24099. Epub 2015 Jul 15. Review.


Prognostic significance of lymph node density in squamous cell carcinoma of the tongue.

Ong W, Zhao R, Lui B, Tan W, Ebrahimi A, Clark JR, Soo KC, Tan NC, Tan HK, Iyer NG.

Head Neck. 2016 Apr;38 Suppl 1:E859-66. doi: 10.1002/hed.24113. Epub 2015 Jul 15.


Transaxillary thyroidectomies: a comparative learning experience of robotic vs endoscopic thyroidectomies.

Kiong KL, Iyer NG, Skanthakumar T, Ng JC, Tan NC, Tay HN, Tan HK.

Otolaryngol Head Neck Surg. 2015 May;152(5):820-6. doi: 10.1177/0194599815573003. Epub 2015 Mar 31.


Detailed Analysis of Clinicopathologic Factors Demonstrate Distinct Difference in Outcome and Prognostic Factors Between Surgically Treated HPV-Positive and Negative Oropharyngeal Cancer.

Iyer NG, Dogan S, Palmer F, Rahmati R, Nixon IJ, Lee N, Patel SG, Shah JP, Ganly I.

Ann Surg Oncol. 2015 Dec;22(13):4411-21. doi: 10.1245/s10434-015-4525-0. Epub 2015 Mar 24.


Randomized trial comparing surgery and adjuvant radiotherapy versus concurrent chemoradiotherapy in patients with advanced, nonmetastatic squamous cell carcinoma of the head and neck: 10-year update and subset analysis.

Iyer NG, Tan DS, Tan VK, Wang W, Hwang J, Tan NC, Sivanandan R, Tan HK, Lim WT, Ang MK, Wee J, Soo KC, Tan EH.

Cancer. 2015 May 15;121(10):1599-607. doi: 10.1002/cncr.29251. Epub 2015 Jan 29. Erratum in: Cancer. 2015 Oct 1;121(19):3560.


Paracrine factors of human fetal MSCs inhibit liver cancer growth through reduced activation of IGF-1R/PI3K/Akt signaling.

Yulyana Y, Ho IA, Sia KC, Newman JP, Toh XY, Endaya BB, Chan JK, Gnecchi M, Huynh H, Chung AY, Lim KH, Leong HS, Iyer NG, Hui KM, Lam PY.

Mol Ther. 2015 Apr;23(4):746-56. doi: 10.1038/mt.2015.13. Epub 2015 Jan 26.


An eleven gene molecular signature for extra-capsular spread in oral squamous cell carcinoma serves as a prognosticator of outcome in patients without nodal metastases.

Wang W, Lim WK, Leong HS, Chong FT, Lim TK, Tan DS, Teh BT, Iyer NG.

Oral Oncol. 2015 Apr;51(4):355-62. doi: 10.1016/j.oraloncology.2014.12.012. Epub 2015 Jan 2.


Radiation-induced sarcomas of the head and neck.

Thiagarajan A, Iyer NG.

World J Clin Oncol. 2014 Dec 10;5(5):973-81. doi: 10.5306/wjco.v5.i5.973. Review.


Tongue carcinoma infrequently harbor common actionable genetic alterations.

Tan DS, Wang W, Leong HS, Sew PH, Lau DP, Chong FT, Krisna SS, Lim TK, Iyer NG.

BMC Cancer. 2014 Sep 19;14:679. doi: 10.1186/1471-2407-14-679.


Targeting cancer stem cell plasticity through modulation of epidermal growth factor and insulin-like growth factor receptor signaling in head and neck squamous cell cancer.

Leong HS, Chong FT, Sew PH, Lau DP, Wong BH, Teh BT, Tan DS, Iyer NG.

Stem Cells Transl Med. 2014 Sep;3(9):1055-65. doi: 10.5966/sctm.2013-0214. Epub 2014 Jul 14.


Serglycin expression: An independent marker of distant metastases in nasopharyngeal carcinoma.

Chia CS, Ong WS, Li XJ, Soong YL, Chong FT, Tan HK, Soo KC, Qian CN, Teh BT, Iyer NG.

Head Neck. 2016 Jan;38(1):21-8. doi: 10.1002/hed.23841. Epub 2015 Jan 27.


Subcutaneous injection is a simple and reproducible option to restore parathyroid function after total parathyroidectomy in patients with secondary hyperparathyroidism.

Ng JC, Wang W, Chua MJ, Tan MS, Tan NC, Soo KC, Tan HK, Iyer NG.

Surgery. 2014 Apr;155(4):682-8. doi: 10.1016/j.surg.2013.12.019. Epub 2013 Dec 25.


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