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The therapeutic potential of second and third generation CB1R antagonists.

Cinar R, Iyer MR, Kunos G.

Pharmacol Ther. 2020 Jan 8:107477. doi: 10.1016/j.pharmthera.2020.107477. [Epub ahead of print] Review.


Feasibility and safety of same day subcutaneous defibrillator implantation and send home (DASH) strategy.

Okabe T, Miller A, Koppert T, Cavalcanti R, Alcivar-Franco D, Osei J, Kahaly O, Afzal MR, Tyler J, Kalbfleisch SJ, Weiss R, Houmsse M, Augostini RS, Daoud EG, Andritsos MJ, Bhandary S, Dimitrova G, Fiorini K, Elsayed-Awad H, Flores A, Gorelik L, Iyer MH, Saklayen S, Stein E, Turner K, Perez W, Hummel JD, Essandoh MK.

J Interv Card Electrophysiol. 2019 Dec 7. doi: 10.1007/s10840-019-00673-1. [Epub ahead of print]


Transesophageal Echocardiography for Lung Transplantation: A New Standard of Care?

Iyer MH, Bhatt A, Kumar N, Hussain N, Essandoh MK.

J Cardiothorac Vasc Anesth. 2019 Oct 18. pii: S1053-0770(19)31098-5. doi: 10.1053/j.jvca.2019.10.025. [Epub ahead of print] No abstract available.


Implantation of subcutaneous defibrillator is feasible and safe with monitored anesthesia care.

Afzal MR, Okabe T, Koppert T, Tyler J, Houmsse M, Augostini RS, Hummel JD, Kalbfleisch SJ, Iyer MH, Flores AS, Bhandary S, Dimitrova G, Elsayed-Awad H, Fiorini K, Gorelik L, Perez W, Saklayen S, Stein E, Turner K, Franklin NP, Ryu JN, Bhatt A, Weiss R, Daoud EG, Essandoh M.

Pacing Clin Electrophysiol. 2019 Dec;42(12):1552-1557. doi: 10.1111/pace.13838. Epub 2019 Nov 18.


Human volunteer, in vitro, and molecular level evaluation of an optimized taste-masked isoniazid-chitosan spray-dried microparticle matrix.

Stagner WC, Iyer M, Rathod V, Meruva S, Staton S, Haware RV.

Int J Pharm. 2019 Dec 15;572:118774. doi: 10.1016/j.ijpharm.2019.118774. Epub 2019 Oct 31.


Mitochondrial calcium uniporter as a potential therapeutic strategy for Alzheimer's disease.

Venugopal A, Iyer M, Balasubramanian V, Vellingiri B.

Acta Neuropsychiatr. 2019 Sep 26:1-7. doi: 10.1017/neu.2019.39. [Epub ahead of print]


A qualitative study on the use of long-lasting insecticidal nets (LLINs) for the prevention of malaria in the Peruvian Amazon.

Iyer M, Skelton J, de Wildt G, Meza G.

Malar J. 2019 Sep 2;18(1):301. doi: 10.1186/s12936-019-2937-1.


Dual inhibition of cannabinoid CB1 receptor and inducible NOS attenuates obesity-induced chronic kidney disease.

Udi S, Hinden L, Ahmad M, Drori A, Iyer MR, Cinar R, Herman-Edelstein M, Tam J.

Br J Pharmacol. 2019 Aug 23. doi: 10.1111/bph.14849. [Epub ahead of print]


Activation of NPRs and UCP1-independent pathway following CB1R antagonist treatment is associated with adipose tissue beiging in fat-fed male dogs.

Iyer MS, Paszkiewicz RL, Bergman RN, Richey JM, Woolcott OO, Asare-Bediako I, Wu Q, Kim SP, Stefanovski D, Kolka CM, Clegg DJ, Kabir M.

Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E535-E547. doi: 10.1152/ajpendo.00539.2018. Epub 2019 Jun 25.


Phytochemical derivatives targeting fliJ flagellar protein from Escherichia coli.

Hemalatha CR, Abhinand PA, Iyer M, Paul BC, Jyoti Kindo A, Ravinder T, P D.

Bioinformation. 2018 Oct 30;14(9):465-470. doi: 10.6026/97320630014465. eCollection 2018.


mTOR signalling pathway - A root cause for idiopathic autism?

Ganesan H, Balasubramanian V, Iyer M, Venugopal A, Subramaniam MD, Cho SG, Vellingiri B.

BMB Rep. 2019 Jul;52(7):424-433.


Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis.

Godlewski G, Cinar R, Coffey NJ, Liu J, Jourdan T, Mukhopadhyay B, Chedester L, Liu Z, Osei-Hyiaman D, Iyer MR, Park JK, Smith RG, Iwakura H, Kunos G.

Cell Metab. 2019 Jun 4;29(6):1320-1333.e8. doi: 10.1016/j.cmet.2019.04.012. Epub 2019 May 16.


Safety and efficacy of endovascular ultrasound renal denervation in resistant hypertension: 12-month results from the ACHIEVE study.

Daemen J, Mahfoud F, Kuck KH, Andersson B, Böhm M, Graf T, Sievert H, Kahlert P, Iyer M, Zeller T.

J Hypertens. 2019 Sep;37(9):1906-1912. doi: 10.1097/HJH.0000000000002120.


A Comparison of National Pediatric Procedures Training Guidelines With Actual Clinical Practice in Ohio.

Iyer MS, Way DP, Kline J, Wallihan R, Stanley RM.

J Grad Med Educ. 2019 Apr;11(2):159-167. doi: 10.4300/JGME-D-18-00746.1.


GenDiS database update with improved approach and features to recognize homologous sequences of protein domain superfamilies.

Iyer MS, Bhargava K, Pavalam M, Sowdhamini R.

Database (Oxford). 2019 Jan 1;2019. pii: baz042. doi: 10.1093/database/baz042.


Pulmonary cuff dysfunction after lung transplant surgery: A systematic review of the evidence and analysis of its clinical implications.

Kumar N, Essandoh M, Bhatt A, Whitson BA, Sawyer TR, Flores A, Awad H, Dimitrova G, Gorelik L, Bhandary S, Perez WJ, Iyer MH, Stein E, Fiorini K, Turner K, Saklayen S, Hussain N.

J Heart Lung Transplant. 2019 May;38(5):530-544. doi: 10.1016/j.healun.2019.01.005. Epub 2019 Jan 7.


Crystal Structure of the Human Cannabinoid Receptor CB2.

Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, Wang J, Wu M, Katritch V, Zhao S, Kunos G, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ.

Cell. 2019 Jan 24;176(3):459-467.e13. doi: 10.1016/j.cell.2018.12.011. Epub 2019 Jan 10.


Cancer3D 2.0: interactive analysis of 3D patterns of cancer mutations in cancer subsets.

Sedova M, Iyer M, Li Z, Jaroszewski L, Post KW, Hrabe T, Porta-Pardo E, Godzik A.

Nucleic Acids Res. 2019 Jan 8;47(D1):D895-D899. doi: 10.1093/nar/gky1098.


Transesophageal Echocardiography Diagnosis of Tricuspid Valve Injury During AngioVac Percutaneous Pulmonary Embolectomy.

Boisen ML, Iyer MH.

CASE (Phila). 2018 Jul 27;2(5):181-185. doi: 10.1016/ eCollection 2018 Oct. No abstract available.


Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist.

Uhl GR, Martinez MJ, Paik P, Sulima A, Bi GH, Iyer MR, Gardner E, Rice KC, Xi ZX.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11597-11602. doi: 10.1073/pnas.1720446115. Epub 2018 Oct 22.


The cost-effectiveness of alternative vision screening models among preschool children in rural China.

Wang L, Congdon N, Hogg RE, Zhang S, Li M, Shi Y, Jin L, He F, Wang H, Boswell M, Iyer M.

Acta Ophthalmol. 2019 May;97(3):e419-e425. doi: 10.1111/aos.13954. Epub 2018 Oct 21.


Identification of discrete, intermingled hypocretin neuronal populations.

Iyer M, Essner RA, Klingenberg B, Carter ME.

J Comp Neurol. 2018 Dec 15;526(18):2937-2954. doi: 10.1002/cne.24490. Epub 2018 Nov 14.


Genome-wide survey of remote homologues for protein domain superfamilies of known structure reveals unequal distribution across structural classes.

Iyer MS, Joshi AG, Sowdhamini R.

Mol Omics. 2018 Aug 6;14(4):266-280. doi: 10.1039/c8mo00008e.


Transesophageal Echocardiography Guidance for Robot-assisted Level III Inferior Vena Cava Tumor Thrombectomy: A Novel Approach to Intraoperative Care.

Essandoh M, Tang J, Essandoh G, Iyer MH, Kuhn J, Opat K, Mandoff VL, Box GN.

J Cardiothorac Vasc Anesth. 2018 Dec;32(6):2623-2627. doi: 10.1053/j.jvca.2018.05.017. Epub 2018 Jun 13. No abstract available.


Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression.

Zhang Y, Pitchiaya S, Cieślik M, Niknafs YS, Tien JC, Hosono Y, Iyer MK, Yazdani S, Subramaniam S, Shukla SK, Jiang X, Wang L, Liu TY, Uhl M, Gawronski AR, Qiao Y, Xiao L, Dhanasekaran SM, Juckette KM, Kunju LP, Cao X, Patel U, Batish M, Shukla GC, Paulsen MT, Ljungman M, Jiang H, Mehra R, Backofen R, Sahinalp CS, Freier SM, Watt AT, Guo S, Wei JT, Feng FY, Malik R, Chinnaiyan AM.

Nat Genet. 2018 Jun;50(6):814-824. doi: 10.1038/s41588-018-0120-1. Epub 2018 May 28.


Effect of a Local Vision Care Center on Eyeglasses Use and School Performance in Rural China: A Cluster Randomized Clinical Trial.

Ma Y, Congdon N, Shi Y, Hogg R, Medina A, Boswell M, Rozelle S, Iyer M.

JAMA Ophthalmol. 2018 Jul 1;136(7):731-737. doi: 10.1001/jamaophthalmol.2018.1329.


Synthesis of 13 C6 -labeled, dual-target inhibitor of cannabinoid-1 receptor (CB1 R) and inducible nitric oxide synthase (iNOS).

Iyer MR, Cinar R, Coffey NJ, Kunos G.

J Labelled Comp Radiopharm. 2018 May 23. doi: 10.1002/jlcr.3639. [Epub ahead of print]


Health Seeking Behavior among Rural Left-Behind Children: Evidence from Shaanxi and Gansu Provinces in China.

Guan H, Wang H, Huang J, Du K, Zhao J, Boswell M, Shi Y, Iyer M, Rozelle S.

Int J Environ Res Public Health. 2018 Apr 28;15(5). pii: E883. doi: 10.3390/ijerph15050883.


Higher Mallampati Scores Are Not Associated with More Adverse Events During Pediatric Procedural Sedation and Analgesia.

Iyer MS, Pitetti RD, Vitale M.

West J Emerg Med. 2018 Mar;19(2):430-436. doi: 10.5811/westjem.2017.11.35913. Epub 2018 Feb 26.


Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain.

Gontier G, Iyer M, Shea JM, Bieri G, Wheatley EG, Ramalho-Santos M, Villeda SA.

Cell Rep. 2018 Feb 20;22(8):1974-1981. doi: 10.1016/j.celrep.2018.02.001.


Systolic Anterior Motion of the Mitral Valve Causing Dynamic Left Ventricular Outflow Tract Obstruction: An Underappreciated Complication During Lung Transplantation.

Iyer MH, Essandoh M.

J Cardiothorac Vasc Anesth. 2018 Apr;32(2):e40-e41. doi: 10.1053/j.jvca.2017.07.006. Epub 2017 Jul 10. No abstract available.


Chiropractic Management Using Multimodal Therapies on 2 Pediatric Patients With Constipation.

Iyer MM, Skokos E, Piombo D.

J Chiropr Med. 2017 Dec;16(4):340-345. doi: 10.1016/j.jcm.2017.06.004. Epub 2017 Dec 7.


Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA.

Hosono Y, Niknafs YS, Prensner JR, Iyer MK, Dhanasekaran SM, Mehra R, Pitchiaya S, Tien J, Escara-Wilke J, Poliakov A, Chu SC, Saleh S, Sankar K, Su F, Guo S, Qiao Y, Freier SM, Bui HH, Cao X, Malik R, Johnson TM, Beer DG, Feng FY, Zhou W, Chinnaiyan AM.

Cell. 2017 Dec 14;171(7):1559-1572.e20. doi: 10.1016/j.cell.2017.11.040.


Insulin Access to Skeletal Muscle is Preserved in Obesity Induced by Polyunsaturated Diet.

Broussard JL, Bergman RN, Bediako IA, Paszkiewicz RL, Iyer MS, Kolka CM.

Obesity (Silver Spring). 2018 Jan;26(1):119-125. doi: 10.1002/oby.22057. Epub 2017 Nov 30.


One Ion to Rule Them All: Combined Antibacterial, Osteoinductive and Anticancer Properties of Selenite-Incorporated Hydroxyapatite.

Uskoković V, Iyer MA, Wu VM.

J Mater Chem B. 2017;5(7):1430-1445. doi: 10.1039/C6TB03387C. Epub 2017 Jan 23.


Quality of life in patients with vitiligo using the Short Form-36.

Yang Y, Zapata L, Rodgers C, Hernandez K, Iyer M, Jia G, Hynan LS, Pandya AG.

Br J Dermatol. 2017 Dec;177(6):1764-1766. doi: 10.1111/bjd.15936. Epub 2017 Nov 15. No abstract available.


Development of Glatopa® (Glatiramer Acetate): The First FDA-Approved Generic Disease-Modifying Therapy for Relapsing Forms of Multiple Sclerosis.

Bell C, Anderson J, Ganguly T, Prescott J, Capila I, Lansing JC, Sachleben R, Iyer M, Fier I, Roach J, Storey K, Miller P, Hall S, Kantor D, Greenberg BM, Nair K, Glajch J.

J Pharm Pract. 2018 Oct;31(5):481-488. doi: 10.1177/0897190017725984. Epub 2017 Aug 29. Review.


Indirect Regulation of Endogenous Glucose Production by Insulin: The Single Gateway Hypothesis Revisited.

Bergman RN, Iyer MS.

Diabetes. 2017 Jul;66(7):1742-1747. doi: 10.2337/db16-1320. Review.


Synthesis of S-2-((S)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-(methyl-d3 )butanamide-d5 , octadeuterated JD5037.

Iyer MR, Cinar R, Coffey NJ, Chorvat RJ, Kunos G.

J Labelled Comp Radiopharm. 2017 Aug;60(10):460-465. doi: 10.1002/jlcr.3521. Epub 2017 Aug 2.


Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis.

Cinar R, Gochuico BR, Iyer MR, Jourdan T, Yokoyama T, Park JK, Coffey NJ, Pri-Chen H, Szanda G, Liu Z, Mackie K, Gahl WA, Kunos G.

JCI Insight. 2017 Apr 20;2(8). pii: 92281. doi: 10.1172/jci.insight.92281. eCollection 2017 Apr 20.


Gpr126 Is Critical for Schwann Cell Function during Peripheral Nerve Regeneration.

Fernandez C, Iyer M, Low I.

J Neurosci. 2017 Mar 22;37(12):3106-3108. doi: 10.1523/JNEUROSCI.0127-17.2017. No abstract available.


Con: Atrial Fibrillation Prophylaxis Is Not Necessary in Patients Undergoing Major Thoracic Surgery.

Hasson Charles R, Shabsigh M, Sacchet-Cardozo F, Dong L, Iyer M, Essandoh M.

J Cardiothorac Vasc Anesth. 2017 Apr;31(2):751-754. doi: 10.1053/j.jvca.2016.11.004. Epub 2016 Nov 2. No abstract available.


Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB1R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis.

Iyer MR, Cinar R, Katz A, Gao M, Erdelyi K, Jourdan T, Coffey NJ, Pacher P, Kunos G.

J Med Chem. 2017 Feb 9;60(3):1126-1141. doi: 10.1021/acs.jmedchem.6b01504. Epub 2017 Jan 27.


The South Carolina rural-urban HIV continuum of care.

Edun B, Iyer M, Albrecht H, Weissman S.

AIDS Care. 2017 Jul;29(7):817-822. doi: 10.1080/09540121.2016.1270397. Epub 2016 Dec 16.


TACO produces robust multisample transcriptome assemblies from RNA-seq.

Niknafs YS, Pandian B, Iyer HK, Chinnaiyan AM, Iyer MK.

Nat Methods. 2017 Jan;14(1):68-70. doi: 10.1038/nmeth.4078. Epub 2016 Nov 21.


Genome-Wide STAT3 Binding Analysis after Histone Deacetylase Inhibition Reveals Novel Target Genes in Dendritic Cells.

Sun Y, Iyer M, McEachin R, Zhao M, Wu YM, Cao X, Oravecz-Wilson K, Zajac C, Mathewson N, Wu SJ, Rossi C, Toubai T, Qin ZS, Chinnaiyan AM, Reddy P.

J Innate Immun. 2017;9(2):126-144. doi: 10.1159/000450681. Epub 2016 Nov 19.


The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression.

Niknafs YS, Han S, Ma T, Speers C, Zhang C, Wilder-Romans K, Iyer MK, Pitchiaya S, Malik R, Hosono Y, Prensner JR, Poliakov A, Singhal U, Xiao L, Kregel S, Siebenaler RF, Zhao SG, Uhl M, Gawronski A, Hayes DF, Pierce LJ, Cao X, Collins C, Backofen R, Sahinalp CS, Rae JM, Chinnaiyan AM, Feng FY.

Nat Commun. 2016 Sep 26;7:12791. doi: 10.1038/ncomms12791.


Insulin access to skeletal muscle is impaired during the early stages of diet-induced obesity.

Broussard JL, Castro AV, Iyer M, Paszkiewicz RL, Bediako IA, Szczepaniak LS, Szczepaniak EW, Bergman RN, Kolka CM.

Obesity (Silver Spring). 2016 Sep;24(9):1922-8. doi: 10.1002/oby.21562.


Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis.

Cinar R, Iyer MR, Liu Z, Cao Z, Jourdan T, Erdelyi K, Godlewski G, Szanda G, Liu J, Park JK, Mukhopadhyay B, Rosenberg AZ, Liow JS, Lorenz RG, Pacher P, Innis RB, Kunos G.

JCI Insight. 2016 Jul 21;1(11). pii: 87336. doi: 10.1172/jci.insight.87336.

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