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KLF15-Wnt-Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart.

Noack C, Iyer LM, Liaw NY, Schoger E, Khadjeh S, Wagner E, Woelfer M, Zafiriou MP, Milting H, Sossalla S, Streckfuss-Boemeke K, Hasenfuß G, Zimmermann WH, Zelarayán LC.

J Am Coll Cardiol. 2019 Oct 8;74(14):1804-1819. doi: 10.1016/j.jacc.2019.07.076.


The catalytic core of DEMETER guides active DNA demethylation in Arabidopsis.

Zhang C, Hung YH, Rim HJ, Zhang D, Frost JM, Shin H, Jang H, Liu F, Xiao W, Iyer LM, Aravind L, Zhang XQ, Fischer RL, Huh JH, Hsieh TF.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17563-17571. doi: 10.1073/pnas.1907290116. Epub 2019 Aug 13.


Pharmacodynamics of romiplostim alone and in combination with pegfilgrastim on acute radiation-induced thrombocytopenia and neutropenia in non-human primates.

Wong K, Chang PY, Fielden M, Downey AM, Bunin D, Bakke J, Gahagen J, Iyer L, Doshi S, Wierzbicki W, Authier S.

Int J Radiat Biol. 2019 Jun 21:1-12. doi: 10.1080/09553002.2019.1625488. [Epub ahead of print]


Phagocytosis of Gut Bacteria by Entamoeba histolytica.

Iyer LR, Verma AK, Paul J, Bhattacharya A.

Front Cell Infect Microbiol. 2019 Feb 26;9:34. doi: 10.3389/fcimb.2019.00034. eCollection 2019.


A Computational Approach Identifies Immunogenic Features of Prognosis in Human Cancers.

Manoharan M, Mandloi N, Priyadarshini S, Patil A, Gupta R, Iyer L, Gupta R, Chaudhuri A.

Front Immunol. 2018 Dec 21;9:3017. doi: 10.3389/fimmu.2018.03017. eCollection 2018.


Comparison of imaged capillary isoelectric focusing and cation exchange chromatography for monitoring dextrose-mediated glycation of monoclonal antibodies in infusion solutions.

Demirdirek B, Lan W, Qiu D, Ding W, Iyer LK, Bolgar MS, Valente JJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jan 15;1105:156-163. doi: 10.1016/j.jchromb.2018.12.021. Epub 2018 Dec 17.


Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium.

Schlick SF, Spreckelsen F, Tiburcy M, Iyer LM, Meyer T, Zelarayan LC, Luther S, Parlitz U, Zimmermann WH, Rehfeldt F.

Prog Biophys Mol Biol. 2019 Jul;144:51-60. doi: 10.1016/j.pbiomolbio.2018.11.011. Epub 2018 Dec 12.


Representative Scale-Down Lyophilization Cycle Development Using a Seven-Vial Freeze-Dryer (MicroFD®).

Goldman JM, Chen X, Register JT, Nesarikar V, Iyer L, Wu Y, Mugheirbi N, Rowe J.

J Pharm Sci. 2019 Apr;108(4):1486-1495. doi: 10.1016/j.xphs.2018.11.018. Epub 2018 Nov 20.


Unexpected Evolution of Lesion-Recognition Modules in Eukaryotic NER and Kinetoplast DNA Dynamics Proteins from Bacterial Mobile Elements.

Krishnan A, Burroughs AM, Iyer LM, Aravind L.

iScience. 2018 Nov 30;9:192-208. doi: 10.1016/j.isci.2018.10.017. Epub 2018 Oct 23.


Pulse Proteolysis: An Orthogonal Tool for Protein Formulation Screening.

Iyer LK, Phanse R, Xu M, Lan W, Krause ME, Bolgar M, Hart S.

J Pharm Sci. 2019 Feb;108(2):842-850. doi: 10.1016/j.xphs.2018.09.018. Epub 2018 Sep 23.


Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120.

Curreli F, Belov DS, Kwon YD, Ramesh R, Furimsky AM, O'Loughlin K, Byrge PC, Iyer LV, Mirsalis JC, Kurkin AV, Altieri A, Debnath AK.

Eur J Med Chem. 2018 Jun 25;154:367-391. doi: 10.1016/j.ejmech.2018.04.062. Epub 2018 May 12.


Evolutionary convergence and divergence in archaeal chromosomal proteins and Chromo-like domains from bacteria and eukaryotes.

Kaur G, Iyer LM, Subramanian S, Aravind L.

Sci Rep. 2018 Apr 18;8(1):6196. doi: 10.1038/s41598-018-24467-z.


Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys.

Holland SJ, Berghuis LM, King JJ, Iyer LM, Sikora K, Fifield H, Peter S, Quinlan EM, Sugahara F, Shingate P, Trancoso I, Iwanami N, Temereva E, Strohmeier C, Kuratani S, Venkatesh B, Evanno G, Aravind L, Schorpp M, Larijani M, Boehm T.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3211-E3220. doi: 10.1073/pnas.1720871115. Epub 2018 Mar 19.


Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread roles in immunity.

Krishnan A, Iyer LM, Holland SJ, Boehm T, Aravind L.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3201-E3210. doi: 10.1073/pnas.1720897115. Epub 2018 Mar 19.


A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.

Iyer LM, Nagarajan S, Woelfer M, Schoger E, Khadjeh S, Zafiriou MP, Kari V, Herting J, Pang ST, Weber T, Rathjens FS, Fischer TH, Toischer K, Hasenfuss G, Noack C, Johnsen SA, Zelarayán LC.

Nucleic Acids Res. 2018 Apr 6;46(6):2850-2867. doi: 10.1093/nar/gky049.


2-Methoxyestradiol causes matrix metalloproteinase 9-mediated transactivation of epidermal growth factor receptor and angiotensin type 1 receptor downregulation in rat aortic smooth muscle cells.

Ogola B, Zhang Y, Iyer L, Thekkumkara T.

Am J Physiol Cell Physiol. 2018 May 1;314(5):C554-C568. doi: 10.1152/ajpcell.00152.2017. Epub 2018 Jan 24.


A Nonhemolytic Group B Streptococcus Strain Exhibits Hypervirulence.

Gendrin C, Vornhagen J, Armistead B, Singh P, Whidbey C, Merillat S, Knupp D, Parker R, Rogers LM, Quach P, Iyer LM, Aravind L, Manning SD, Aronoff DM, Rajagopal L.

J Infect Dis. 2018 Mar 5;217(6):983-987. doi: 10.1093/infdis/jix646.


Molecular and Functional Properties of Regional Astrocytes in the Adult Brain.

Morel L, Chiang MSR, Higashimori H, Shoneye T, Iyer LK, Yelick J, Tai A, Yang Y.

J Neurosci. 2017 Sep 6;37(36):8706-8717. doi: 10.1523/JNEUROSCI.3956-16.2017. Epub 2017 Aug 7.


Polyvalent Proteins, a Pervasive Theme in the Intergenomic Biological Conflicts of Bacteriophages and Conjugative Elements.

Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L.

J Bacteriol. 2017 Jul 11;199(15). pii: e00245-17. doi: 10.1128/JB.00245-17. Print 2017 Aug 1.


TRAP-seq Profiling and RNAi-Based Genetic Screens Identify Conserved Glial Genes Required for Adult Drosophila Behavior.

Ng FS, Sengupta S, Huang Y, Yu AM, You S, Roberts MA, Iyer LK, Yang Y, Jackson FR.

Front Mol Neurosci. 2016 Dec 22;9:146. doi: 10.3389/fnmol.2016.00146. eCollection 2016.


Unliganded estrogen receptor alpha regulates vascular cell function and gene expression.

Lu Q, Schnitzler GR, Vallaster CS, Ueda K, Erdkamp S, Briggs CE, Iyer LK, Jaffe IZ, Karas RH.

Mol Cell Endocrinol. 2017 Feb 15;442:12-23. doi: 10.1016/j.mce.2016.11.019. Epub 2016 Nov 22.


MicroRNA-Offset RNA Alters Gene Expression and Cell Proliferation.

Zhao J, Schnitzler GR, Iyer LK, Aronovitz MJ, Baur WE, Karas RH.

PLoS One. 2016 Jun 8;11(6):e0156772. doi: 10.1371/journal.pone.0156772. eCollection 2016.


Correction: Paternal B Vitamin Intake Is a Determinant of Growth, Hepatic Lipid Metabolism and Intestinal Tumor Volume in Female Apc1638N Mouse Offspring.

Sabet JA, Park LK, Iyer LK, Tai AK, Koh GY, Pfalzer AC, Parnell LD, Mason JB, Liu Z, Byun AJ, Crott JW.

PLoS One. 2016 Apr 28;11(4):e0154979. doi: 10.1371/journal.pone.0154979. eCollection 2016.


Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy.

Clasadonte J, Morel L, Barrios-Camacho CM, Chiang MS, Zhang J, Iyer L, Haydon PG, Yang Y.

Neurobiol Dis. 2016 Jul;91:315-25. doi: 10.1016/j.nbd.2016.03.024. Epub 2016 Apr 7.


Transposons to toxins: the provenance, architecture and diversification of a widespread class of eukaryotic effectors.

Zhang D, Burroughs AM, Vidal ND, Iyer LM, Aravind L.

Nucleic Acids Res. 2016 May 5;44(8):3513-33. doi: 10.1093/nar/gkw221. Epub 2016 Apr 8.


Process and Formulation Effects on Protein Structure in Lyophilized Solids Using Mass Spectrometric Methods.

Iyer LK, Sacha GA, Moorthy BS, Nail SL, Topp EM.

J Pharm Sci. 2016 May;105(5):1684-1692. doi: 10.1016/j.xphs.2016.02.033. Epub 2016 Apr 1.


ER Alpha Rapid Signaling Is Required for Estrogen Induced Proliferation and Migration of Vascular Endothelial Cells.

Lu Q, Schnitzler GR, Ueda K, Iyer LK, Diomede OI, Andrade T, Karas RH.

PLoS One. 2016 Apr 1;11(4):e0152807. doi: 10.1371/journal.pone.0152807. eCollection 2016.


Paternal B Vitamin Intake Is a Determinant of Growth, Hepatic Lipid Metabolism and Intestinal Tumor Volume in Female Apc1638N Mouse Offspring.

Sabet JA, Park LK, Iyer LK, Tai AK, Koh GY, Pfalzer AC, Parnell LD, Mason JB, Liu Z, Byun AJ, Crott JW.

PLoS One. 2016 Mar 11;11(3):e0151579. doi: 10.1371/journal.pone.0151579. eCollection 2016. Erratum in: PLoS One. 2016;11(4):e0154979.


Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification.

Iyer LM, Zhang D, Aravind L.

Bioessays. 2016 Jan;38(1):27-40. doi: 10.1002/bies.201500104. Epub 2015 Dec 12. Review.


Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling.

Burroughs AM, Zhang D, Schäffer DE, Iyer LM, Aravind L.

Nucleic Acids Res. 2015 Dec 15;43(22):10633-54. doi: 10.1093/nar/gkv1267. Epub 2015 Nov 20.


The right track for you in biotech and biomedical sciences.

Iyer LR, Sriram S.

Nat Biotechnol. 2015 Oct;33(10):1110-1. doi: 10.1038/nbt.3376. No abstract available.


Characterizing Protein Structure, Dynamics and Conformation in Lyophilized Solids.

Moorthy BS, Iyer LK, Topp EM.

Curr Pharm Des. 2015;21(40):5845-53. Review.


Diet- and Genetically-Induced Obesity Differentially Affect the Fecal Microbiome and Metabolome in Apc1638N Mice.

Pfalzer AC, Nesbeth PD, Parnell LD, Iyer LK, Liu Z, Kane AV, Chen CY, Tai AK, Bowman TA, Obin MS, Mason JB, Greenberg AS, Choi SW, Selhub J, Paul L, Crott JW.

PLoS One. 2015 Aug 18;10(8):e0135758. doi: 10.1371/journal.pone.0135758. eCollection 2015.


Transcription factors, chromatin proteins and the diversification of Hemiptera.

Vidal NM, Grazziotin AL, Iyer LM, Aravind L, Venancio TM.

Insect Biochem Mol Biol. 2016 Feb;69:1-13. doi: 10.1016/j.ibmb.2015.07.001. Epub 2015 Jul 29.


Photolytic Cross-Linking to Probe Protein-Protein and Protein-Matrix Interactions in Lyophilized Powders.

Iyer LK, Moorthy BS, Topp EM.

Mol Pharm. 2015 Sep 8;12(9):3237-49. doi: 10.1021/acs.molpharmaceut.5b00183. Epub 2015 Aug 7.


A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA.

Sci Transl Med. 2015 Jul 15;7(296):296ra111. doi: 10.1126/scitranslmed.aaa6645.


Effects of oral eicosapentaenoic acid versus docosahexaenoic acid on human peripheral blood mononuclear cell gene expression.

Tsunoda F, Lamon-Fava S, Asztalos BF, Iyer LK, Richardson K, Schaefer EJ.

Atherosclerosis. 2015 Aug;241(2):400-8. doi: 10.1016/j.atherosclerosis.2015.05.015. Epub 2015 May 19.


Midbrain dopamine neurons in Parkinson's disease exhibit a dysregulated miRNA and target-gene network.

Briggs CE, Wang Y, Kong B, Woo TU, Iyer LK, Sonntag KC.

Brain Res. 2015 Aug 27;1618:111-21. doi: 10.1016/j.brainres.2015.05.021. Epub 2015 Jun 3.


Mass spectrometric approaches to study protein structure and interactions in lyophilized powders.

Moorthy BS, Iyer LK, Topp EM.

J Vis Exp. 2015 Apr 14;(98):52503. doi: 10.3791/52503.


Proteasomal control of cytokinin synthesis protects Mycobacterium tuberculosis against nitric oxide.

Samanovic MI, Tu S, Novák O, Iyer LM, McAllister FE, Aravind L, Gygi SP, Hubbard SR, Strnad M, Darwin KH.

Mol Cell. 2015 Mar 19;57(6):984-994. doi: 10.1016/j.molcel.2015.01.024. Epub 2015 Feb 26.


In vitro metabolism and stability of the actinide chelating agent 3,4,3-LI(1,2-HOPO).

Choi TA, Furimsky AM, Swezey R, Bunin DI, Byrge P, Iyer LV, Chang PY, Abergel RJ.

J Pharm Sci. 2015 May;104(5):1832-8. doi: 10.1002/jps.24394. Epub 2015 Feb 27.


Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists.

Sasmal PK, Krishna CV, Adabala SS, Roshaiah M, Rawoof KA, Thadi E, Sukumar KP, Cheera S, Abbineni C, Rao KV, Prasanthi A, Nijhawan K, Jaleel M, Iyer LR, Chaitanya TK, Tiwari NK, Krishna NL, Potluri V, Khanna I, Frimurer TM, Lückmann M, Rist Ø, Elster L, Högberg T.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):887-92. doi: 10.1016/j.bmcl.2014.12.064. Epub 2015 Jan 6.


Genome-wide DNA methylation analysis identifies a metabolic memory profile in patient-derived diabetic foot ulcer fibroblasts.

Park LK, Maione AG, Smith A, Gerami-Naini B, Iyer LK, Mooney DJ, Veves A, Garlick JA.

Epigenetics. 2014 Oct;9(10):1339-49. doi: 10.4161/15592294.2014.967584.


Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea.

Chavez L, Huang Y, Luong K, Agarwal S, Iyer LM, Pastor WA, Hench VK, Frazier-Bowers SA, Korol E, Liu S, Tahiliani M, Wang Y, Clark TA, Korlach J, Pukkila PJ, Aravind L, Rao A.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):E5149-58. doi: 10.1073/pnas.1419513111. Epub 2014 Nov 18.


Multiple enzymatic activities of ParB/Srx superfamily mediate sexual conflict among conjugative plasmids.

Maindola P, Raina R, Goyal P, Atmakuri K, Ojha A, Gupta S, Christie PJ, Iyer LM, Aravind L, Arockiasamy A.

Nat Commun. 2014 Oct 31;5:5322. doi: 10.1038/ncomms6322.


Selection of the lamprey VLRC antigen receptor repertoire.

Holland SJ, Gao M, Hirano M, Iyer LM, Luo M, Schorpp M, Cooper MD, Aravind L, Mariuzza RA, Boehm T.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14834-9. doi: 10.1073/pnas.1415655111. Epub 2014 Sep 16.


Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates.

Das S, Li J, Holland SJ, Iyer LM, Hirano M, Schorpp M, Aravind L, Cooper MD, Boehm T.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14828-33. doi: 10.1073/pnas.1415580111. Epub 2014 Sep 16.


The natural history of ADP-ribosyltransferases and the ADP-ribosylation system.

Aravind L, Zhang D, de Souza RF, Anand S, Iyer LM.

Curr Top Microbiol Immunol. 2015;384:3-32. doi: 10.1007/82_2014_414. Review.


Differential expression and immunolocalization of antioxidant enzymes in Entamoeba histolytica isolates during metronidazole stress.

Iyer LR, Singh N, Verma AK, Paul J.

Biomed Res Int. 2014;2014:704937. doi: 10.1155/2014/704937. Epub 2014 Jun 12.


Research resource: Aorta- and liver-specific ERα-binding patterns and gene regulation by estrogen.

Gordon FK, Vallaster CS, Westerling T, Iyer LK, Brown M, Schnitzler GR.

Mol Endocrinol. 2014 Aug;28(8):1337-51. doi: 10.1210/me.2013-1395. Epub 2014 Jul 3.

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