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Items: 29


Electron microscopy examination of platelet whole mount preparations to quantitate platelet dense granule numbers: Implications for diagnosing suspected platelet function disorders due to dense granule deficiency.

Brunet JG, Iyer JK, Badin MS, Graf L, Moffat KA, Timleck M, Spitzer E, Hayward CPM.

Int J Lab Hematol. 2018 Aug;40(4):400-407. doi: 10.1111/ijlh.12801. Epub 2018 Mar 6.


Nanodiamonds facilitate killing of intracellular uropathogenic E. coli in an in vitro model of urinary tract infection pathogenesis.

Iyer JK, Dickey A, Rouhani P, Kaul A, Govindaraju N, Singh RN, Kaul R.

PLoS One. 2018 Jan 11;13(1):e0191020. doi: 10.1371/journal.pone.0191020. eCollection 2018.


Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis.

Iyer JK, Kalra M, Kaul A, Payton ME, Kaul R.

World J Gastroenterol. 2017 Oct 7;23(37):6802-6816. doi: 10.3748/wjg.v23.i37.6802.


Can the Antimicrobial Resistance Benchmark blaze a new trail?

Iyer JK, Mendelson M.

Lancet. 2017 Nov 25;390(10110):2334-2335. doi: 10.1016/S0140-6736(17)32670-3. Epub 2017 Oct 13. No abstract available.


Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum.

Iyer JK, Koh CY, Kazimirova M, Roller L, Jobichen C, Swaminathan K, Mizuguchi J, Iwanaga S, Nuttall PA, Chan MY, Kini RM.

FASEB J. 2017 Jul;31(7):2981-2995. doi: 10.1096/fj.201601216R. Epub 2017 Mar 31.


Molecular phenotype and bleeding risks of an inherited platelet disorder in a family with a RUNX1 frameshift mutation.

Badin MS, Iyer JK, Chong M, Graf L, Rivard GE, Waye JS, Paterson AD, Pare G, Hayward CPM.

Haemophilia. 2017 May;23(3):e204-e213. doi: 10.1111/hae.13169. Epub 2017 Feb 8.


Variability in platelet dense granule adenosine triphosphate release findings amongst patients tested multiple times as part of an assessment for a bleeding disorder.

Badin MS, Graf L, Iyer JK, Moffat KA, Seecharan JL, Hayward CP.

Int J Lab Hematol. 2016 Dec;38(6):648-657. doi: 10.1111/ijlh.12553. Epub 2016 Aug 30.


Daboxin P, a Major Phospholipase A2 Enzyme from the Indian Daboia russelii russelii Venom Targets Factor X and Factor Xa for Its Anticoagulant Activity.

Sharma M, Iyer JK, Shih N, Majumder M, Mattaparthi VS, Mukhopadhyay R, Doley R.

PLoS One. 2016 Apr 18;11(4):e0153770. doi: 10.1371/journal.pone.0153770. eCollection 2016.


Purification and functionalization of nanodiamond to serve as a platform for amoxicillin delivery.

Rouhani P, Govindaraju N, Iyer JK, Kaul R, Kaul A, Singh RN.

Mater Sci Eng C Mater Biol Appl. 2016 Jun;63:323-32. doi: 10.1016/j.msec.2016.02.075. Epub 2016 Feb 27.


At-line nanofractionation with parallel mass spectrometry and bioactivity assessment for the rapid screening of thrombin and factor Xa inhibitors in snake venoms.

Mladic M, Zietek BM, Iyer JK, Hermarij P, Niessen WM, Somsen GW, Kini RM, Kool J.

Toxicon. 2016 Feb;110:79-89. doi: 10.1016/j.toxicon.2015.12.008. Epub 2015 Dec 19.


Access to hepatitis C medicines.

Edwards DJ, Coppens DG, Prasad TL, Rook LA, Iyer JK.

Bull World Health Organ. 2015 Nov 1;93(11):799-805. doi: 10.2471/BLT.15.157784. Epub 2015 Oct 8.


Microfluidic Chip-Based Online Screening Coupled to Mass Spectrometry: Identification of Inhibitors of Thrombin and Factor Xa.

Iyer JK, Otvos RA, Kool J, Kini RM.

J Biomol Screen. 2016 Feb;21(2):212-20. doi: 10.1177/1087057115602648. Epub 2015 Aug 31.


Unveiling the complexities of Daboia russelii venom, a medically important snake of India, by tandem mass spectrometry.

Sharma M, Das D, Iyer JK, Kini RM, Doley R.

Toxicon. 2015 Dec 1;107(Pt B):266-81. doi: 10.1016/j.toxicon.2015.06.027. Epub 2015 Jul 6.


Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.

Otvos RA, Iyer JK, van Elk R, Ulens C, Niessen WM, Somsen GW, Kini RM, Smit AB, Kool J.

Toxins (Basel). 2015 Jun 24;7(7):2336-53. doi: 10.3390/toxins7072336.


Is the pharmaceutical industry improving with regard to access to essential medicines?

Hogerzeil HV, Iyer JK, Urlings L, Prasad T, Brewer S.

Lancet Glob Health. 2014 Mar;2(3):e139-40. doi: 10.1016/S2214-109X(13)70159-1. Epub 2014 Jan 31. No abstract available.


Toxin inhibition of antimicrobial factors induced by Bacillus anthracis peptidoglycan in human blood.

Barua S, Iyer JK, Larabee JL, Raisley B, Hughes MA, Coggeshall KM, Ballard JD.

Infect Immun. 2013 Oct;81(10):3693-702. doi: 10.1128/IAI.00709-13. Epub 2013 Jul 22.


Anti-peptidoglycan antibodies and Fcγ receptors are the key mediators of inflammation in Gram-positive sepsis.

Sun D, Raisley B, Langer M, Iyer JK, Vedham V, Ballard JL, James JA, Metcalf J, Coggeshall KM.

J Immunol. 2012 Sep 1;189(5):2423-31. doi: 10.4049/jimmunol.1201302. Epub 2012 Jul 18.


Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-β1.

Cimica V, Chen HC, Iyer JK, Reich NC.

PLoS One. 2011;6(5):e20188. doi: 10.1371/journal.pone.0020188. Epub 2011 May 19.


Cutting edge: primary innate immune cells respond efficiently to polymeric peptidoglycan, but not to peptidoglycan monomers.

Iyer JK, Coggeshall KM.

J Immunol. 2011 Apr 1;186(7):3841-5. doi: 10.4049/jimmunol.1004058. Epub 2011 Feb 25.


Inflammatory cytokine response to Bacillus anthracis peptidoglycan requires phagocytosis and lysosomal trafficking.

Iyer JK, Khurana T, Langer M, West CM, Ballard JD, Metcalf JP, Merkel TJ, Coggeshall KM.

Infect Immun. 2010 Jun;78(6):2418-28. doi: 10.1128/IAI.00170-10. Epub 2010 Mar 22.


Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer.

Pajic M, Iyer JK, Kersbergen A, van der Burg E, Nygren AO, Jonkers J, Borst P, Rottenberg S.

Cancer Res. 2009 Aug 15;69(16):6396-404. doi: 10.1158/0008-5472.CAN-09-0041. Epub 2009 Aug 4.


Regulation of flagellar length in Chlamydomonas.

Wilson NF, Iyer JK, Buchheim JA, Meek W.

Semin Cell Dev Biol. 2008 Dec;19(6):494-501. doi: 10.1016/j.semcdb.2008.07.005. Epub 2008 Jul 25. Review.


Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites.

Gao X, Yeo KP, Aw SS, Kuss C, Iyer JK, Genesan S, Rajamanonmani R, Lescar J, Bozdech Z, Preiser PR.

PLoS Pathog. 2008 Jul 11;4(7):e1000104. doi: 10.1371/journal.ppat.1000104.


The C-terminal segment of the cysteine-rich interdomain of Plasmodium falciparum erythrocyte membrane protein 1 determines CD36 binding and elicits antibodies that inhibit adhesion of parasite-infected erythrocytes.

Mo M, Lee HC, Kotaka M, Niang M, Gao X, Iyer JK, Lescar J, Preiser P.

Infect Immun. 2008 May;76(5):1837-47. doi: 10.1128/IAI.00480-07. Epub 2008 Feb 25.


Variable expression of the 235 kDa rhoptry protein of Plasmodium yoelii mediate host cell adaptation and immune evasion.

Iyer JK, Amaladoss A, Genesan S, Preiser PR.

Mol Microbiol. 2007 Jul;65(2):333-46. Epub 2007 Jun 21. Erratum in: Mol Microbiol. 2007 Sep;65(6):1596. Ganesan, Saraswathy [corrected to Genesan, Saraswathy].


Differences in the copy number of the py235 gene family in virulent and avirulent lines of Plasmodium yoelii.

Iyer JK, Fuller K, Preiser PR.

Mol Biochem Parasitol. 2006 Dec;150(2):186-91. Epub 2006 Aug 28.


Identification of tetratricopeptide repeat domain 9, a hormonally regulated protein.

Cao S, Iyer JK, Lin V.

Biochem Biophys Res Commun. 2006 Jun 23;345(1):310-7. Epub 2006 Apr 27.


Zinc protoporphyrin IX binds heme crystals to inhibit the process of crystallization in Plasmodium falciparum.

Iyer JK, Shi L, Shankar AH, Sullivan DJ Jr.

Mol Med. 2003 May-Aug;9(5-8):175-82.


Plasmodium falciparum cross-resistance between trimethoprim and pyrimethamine.

Iyer JK, Milhous WK, Cortese JF, Kublin JG, Plowe CV.

Lancet. 2001 Sep 29;358(9287):1066-7.


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