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Items: 31


Prevalent and diverse intratumoral oncoprotein-specific CD8+ T cells within polyoma virus-driven Merkel cell carcinomas.

Jing L, Ott M, Church CD, Kulikauskas RM, Ibrani D, Iyer JG, Afanasiev OK, Colunga A, Cook MM, Xie H, Greninger AL, Paulson KG, Chapuis AG, Bhatia S, Nghiem P, Koelle DM.

Cancer Immunol Res. 2020 Mar 16. pii: canimm.0647.2019. doi: 10.1158/2326-6066.CIR-19-0647. [Epub ahead of print]


Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma.

Bhatia S, Longino NV, Miller NJ, Kulikauskas R, Iyer JG, Ibrani D, Blom A, Byrd DR, Parvathaneni U, Twitty CG, Campbell JS, Le MH, Gargosky S, Pierce RH, Heller R, Daud AI, Nghiem P.

Clin Cancer Res. 2020 Feb 1;26(3):598-607. doi: 10.1158/1078-0432.CCR-19-0972. Epub 2019 Oct 3.


Human CD4+ T Cells Specific for Merkel Cell Polyomavirus Localize to Merkel Cell Carcinomas and Target a Required Oncogenic Domain.

Longino NV, Yang J, Iyer JG, Ibrani D, Chow IT, Laing KJ, Campbell VL, Paulson KG, Kulikauskas RM, Church CD, James EA, Nghiem P, Kwok WW, Koelle DM.

Cancer Immunol Res. 2019 Oct;7(10):1727-1739. doi: 10.1158/2326-6066.CIR-19-0103. Epub 2019 Aug 12.


Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA.

Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG.

Nat Commun. 2018 Sep 24;9(1):3868. doi: 10.1038/s41467-018-06300-3.


Clinical Updates in Women's Health Care Primary and Preventive Care Review Summary: Common Dermatologic Conditions.

Khorsand KO, Iyer JG, Abson KG.

Obstet Gynecol. 2018 Jan;131(1):200. doi: 10.1097/AOG.0000000000002454. Review.


Postoperative radiation therapy is associated with a reduced risk of local recurrence among low risk Merkel cell carcinomas of the head and neck.

Takagishi SR, Marx TE, Lewis C, Tarabadkar ES, Juhlin ID, Blom A, Iyer JG, Liao JJ, Tseng YD, Fu T, Nghiem P, Parvathaneni U.

Adv Radiat Oncol. 2016 Oct 20;1(4):244-251. doi: 10.1016/j.adro.2016.10.003. eCollection 2016 Oct-Dec.


Response rates and durability of chemotherapy among 62 patients with metastatic Merkel cell carcinoma.

Iyer JG, Blom A, Doumani R, Lewis C, Tarabadkar ES, Anderson A, Ma C, Bestick A, Parvathaneni U, Bhatia S, Nghiem P.

Cancer Med. 2016 Sep;5(9):2294-301. doi: 10.1002/cam4.815. Epub 2016 Jul 19.


Adjuvant Radiation Therapy and Chemotherapy in Merkel Cell Carcinoma: Survival Analyses of 6908 Cases From the National Cancer Data Base.

Bhatia S, Storer BE, Iyer JG, Moshiri A, Parvathaneni U, Byrd D, Sober AJ, Sondak VK, Gershenwald JE, Nghiem P.

J Natl Cancer Inst. 2016 May 31;108(9). pii: djw042. doi: 10.1093/jnci/djw042. Print 2016 Sep.


Paraneoplastic syndromes (PNS) associated with Merkel cell carcinoma (MCC): A case series of 8 patients highlighting different clinical manifestations.

Iyer JG, Parvathaneni K, Bhatia S, Tarabadkar ES, Blom A, Doumani R, McKenzie J, Asgari MM, Nghiem P.

J Am Acad Dermatol. 2016 Sep;75(3):541-547. doi: 10.1016/j.jaad.2016.04.040. Epub 2016 May 11.


Prognostic factors and immunobiologic insights into Merkel cell carcinoma.

Han D, Iyer JG.

Cancer. 2015 Sep 15;121(18):3193-6. doi: 10.1002/cncr.29453. Epub 2015 Jun 2. No abstract available.


Single-fraction radiation therapy in patients with metastatic Merkel cell carcinoma.

Iyer JG, Parvathaneni U, Gooley T, Miller NJ, Markowitz E, Blom A, Lewis CW, Doumani RF, Parvathaneni K, Anderson A, Bestick A, Liao J, Kane G, Bhatia S, Paulson K, Nghiem P.

Cancer Med. 2015 Aug;4(8):1161-70. doi: 10.1002/cam4.458. Epub 2015 Apr 23.


CD8+ lymphocyte intratumoral infiltration as a stage-independent predictor of Merkel cell carcinoma survival: a population-based study.

Paulson KG, Iyer JG, Simonson WT, Blom A, Thibodeau RM, Schmidt M, Pietromonaco S, Sokil M, Warton EM, Asgari MM, Nghiem P.

Am J Clin Pathol. 2014 Oct;142(4):452-8. doi: 10.1309/AJCPIKDZM39CRPNC.


Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma.

Paulson KG, Tegeder A, Willmes C, Iyer JG, Afanasiev OK, Schrama D, Koba S, Thibodeau R, Nagase K, Simonson WT, Seo A, Koelle DM, Madeleine M, Bhatia S, Nakajima H, Sano S, Hardwick JS, Disis ML, Cleary MA, Becker JC, Nghiem P.

Cancer Immunol Res. 2014 Nov;2(11):1071-9. doi: 10.1158/2326-6066.CIR-14-0005. Epub 2014 Aug 12.


Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma.

Iyer JG, Storer BE, Paulson KG, Lemos B, Phillips JL, Bichakjian CK, Zeitouni N, Gershenwald JE, Sondak V, Otley CC, Yu SS, Johnson TM, Liegeois NJ, Byrd D, Sober A, Nghiem P.

J Am Acad Dermatol. 2014 Apr;70(4):637-643. doi: 10.1016/j.jaad.2013.11.031. Epub 2014 Feb 9.


Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of re-inducing HLA class-I.

Chapuis AG, Afanasiev OK, Iyer JG, Paulson KG, Parvathaneni U, Hwang JH, Lai I, Roberts IM, Sloan HL, Bhatia S, Shibuya KC, Gooley T, Desmarais C, Koelle DM, Yee C, Nghiem P.

Cancer Immunol Res. 2014 Jan;2(1):27-36. doi: 10.1158/2326-6066.CIR-13-0087.


Clinical utility of a circulating tumor cell assay in Merkel cell carcinoma.

Blom A, Bhatia S, Pietromonaco S, Koehler K, Iyer JG, Nagase K, Paulson K, Sabath DE, Nghiem P.

J Am Acad Dermatol. 2014 Mar;70(3):449-55. doi: 10.1016/j.jaad.2013.10.051. Epub 2013 Dec 31.


p63 expression in Merkel cell carcinoma predicts poorer survival yet may have limited clinical utility.

Stetsenko GY, Malekirad J, Paulson KG, Iyer JG, Thibodeau RM, Nagase K, Schmidt M, Storer BE, Argenyi ZB, Nghiem P.

Am J Clin Pathol. 2013 Dec;140(6):838-44. doi: 10.1309/AJCPE4PK6CTBNQJY.


Pathologic nodal evaluation is increasingly commonly performed for patients with Merkel cell carcinoma.

Paulson KG, Iyer JG, Byrd DR, Nghiem P.

J Am Acad Dermatol. 2013 Oct;69(4):653-4. doi: 10.1016/j.jaad.2013.06.002. No abstract available.


Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers.

Afanasiev OK, Yelistratova L, Miller N, Nagase K, Paulson K, Iyer JG, Ibrani D, Koelle DM, Nghiem P.

Clin Cancer Res. 2013 Oct 1;19(19):5351-60. doi: 10.1158/1078-0432.CCR-13-0035. Epub 2013 Aug 6.


Emerging and mechanism-based therapies for recurrent or metastatic Merkel cell carcinoma.

Miller NJ, Bhatia S, Parvathaneni U, Iyer JG, Nghiem P.

Curr Treat Options Oncol. 2013 Jun;14(2):249-63. doi: 10.1007/s11864-013-0225-9.


Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage.

Paulson KG, Iyer JG, Blom A, Warton EM, Sokil M, Yelistratova L, Schuman L, Nagase K, Bhatia S, Asgari MM, Nghiem P.

J Invest Dermatol. 2013 Mar;133(3):642-646. doi: 10.1038/jid.2012.388. Epub 2012 Nov 29.


Diagnostic biopsy does not commonly induce intratumoral CD8 T cell infiltration in Merkel cell carcinoma.

Koba S, Paulson KG, Nagase K, Tegeder A, Thibodeau R, Iyer JG, Narisawa Y, Nghiem P.

PLoS One. 2012;7(7):e41465. doi: 10.1371/journal.pone.0041465. Epub 2012 Jul 31. Erratum in: PLoS One. 2012;7(10). doi: 10.1371/annotation/c4df91b0-618f-464d-a613-d99758de3f3d.


Merkel cell polyomavirus-specific CD8⁺ and CD4⁺ T-cell responses identified in Merkel cell carcinomas and blood.

Iyer JG, Afanasiev OK, McClurkan C, Paulson K, Nagase K, Jing L, Marshak JO, Dong L, Carter J, Lai I, Farrar E, Byrd D, Galloway D, Yee C, Koelle DM, Nghiem P.

Clin Cancer Res. 2011 Nov 1;17(21):6671-80. doi: 10.1158/1078-0432.CCR-11-1513. Epub 2011 Sep 9.


Asymmetric lateral distribution of melanoma and Merkel cell carcinoma in the United States.

Paulson KG, Iyer JG, Nghiem P.

J Am Acad Dermatol. 2011 Jul;65(1):35-9. doi: 10.1016/j.jaad.2010.05.026. Epub 2011 Apr 21.


Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival.

Paulson KG, Iyer JG, Tegeder AR, Thibodeau R, Schelter J, Koba S, Schrama D, Simonson WT, Lemos BD, Byrd DR, Koelle DM, Galloway DA, Leonard JH, Madeleine MM, Argenyi ZB, Disis ML, Becker JC, Cleary MA, Nghiem P.

J Clin Oncol. 2011 Apr 20;29(12):1539-46. doi: 10.1200/JCO.2010.30.6308. Epub 2011 Mar 21.


Merkel cell carcinoma associated with HIV: review of 14 patients.

Izikson L, Nornhold E, Iyer JG, Nghiem P, Zeitouni NC.

AIDS. 2011 Jan 2;25(1):119-21. doi: 10.1097/QAD.0b013e328340a19c. No abstract available.


Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients.

Paulson KG, Carter JJ, Johnson LG, Cahill KW, Iyer JG, Schrama D, Becker JC, Madeleine MM, Nghiem P, Galloway DA.

Cancer Res. 2010 Nov 1;70(21):8388-97. doi: 10.1158/0008-5472.CAN-10-2128. Epub 2010 Oct 19.


Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system.

Lemos BD, Storer BE, Iyer JG, Phillips JL, Bichakjian CK, Fang LC, Johnson TM, Liegeois-Kwon NJ, Otley CC, Paulson KG, Ross MI, Yu SS, Zeitouni NC, Byrd DR, Sondak VK, Gershenwald JE, Sober AJ, Nghiem P.

J Am Acad Dermatol. 2010 Nov;63(5):751-61. doi: 10.1016/j.jaad.2010.02.056. Epub 2010 Jun 19.


Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma.

Carter JJ, Paulson KG, Wipf GC, Miranda D, Madeleine MM, Johnson LG, Lemos BD, Lee S, Warcola AH, Iyer JG, Nghiem P, Galloway DA.

J Natl Cancer Inst. 2009 Nov 4;101(21):1510-22. doi: 10.1093/jnci/djp332. Epub 2009 Sep 23.


Pleiotropic phenotypes of a Yersinia enterocolitica flhD mutant include reduced lethality in a chicken embryo model.

Townsend MK, Carr NJ, Iyer JG, Horne SM, Gibbs PS, Prüss BM.

BMC Microbiol. 2008 Jan 23;8:12. doi: 10.1186/1471-2180-8-12.

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