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Items: 1 to 50 of 444

1.

Endoscopic findings corresponding to multiple Lugol-voiding lesions in the esophageal background mucosa.

Matsuno K, Ishihara R, Nakagawa K, Ohmori M, Iwagami H, Inoue S, Iwatsubo T, Nakahira H, Matsuura N, Shichijyo S, Maekawa A, Takashi K, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Matsunaga T.

J Gastroenterol Hepatol. 2018 Aug 12. doi: 10.1111/jgh.14439. [Epub ahead of print]

PMID:
30101499
2.

A Novel Method to Estimate Long-term Chronological Changes from Fragmented Observations in Disease Progression.

Ishida T, Tokuda K, Hisaka A, Honma M, Kijima S, Takatoku H, Iwatsubo T, Moritoyo T, Suzuki H; Alzheimer's Disease Neuroimaging Initiative.

Clin Pharmacol Ther. 2018 Jun 28. doi: 10.1002/cpt.1166. [Epub ahead of print]

PMID:
29951994
3.

Efficacy of vonoprazan in prevention of bleeding from endoscopic submucosal dissection-induced gastric ulcers: a prospective randomized phase II study.

Hamada K, Uedo N, Tonai Y, Arao M, Suzuki S, Iwatsubo T, Kato M, Shichijo S, Yamasaki Y, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Akasaka T, Hanaoka N, Takeuchi Y, Higashino K, Ishihara R, Okada H, Iishi H, Fukui K, Shimokawa T.

J Gastroenterol. 2018 Jun 25. doi: 10.1007/s00535-018-1487-6. [Epub ahead of print]

PMID:
29943163
4.

Traction-assisted colorectal endoscopic submucosal dissection by use of clip and line for a neoplasm involving colonic diverticulum.

Iwatsubo T, Uedo N, Yamasaki Y, Takeuchi Y, Ando Y.

VideoGIE. 2017 Nov 22;2(12):337-338. doi: 10.1016/j.vgie.2017.08.012. eCollection 2017 Dec. No abstract available.

5.

Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease.

Mann DMA, Davidson YS, Robinson AC, Allen N, Hashimoto T, Richardson A, Jones M, Snowden JS, Pendleton N, Potier MC, Laquerrière A, Prasher V, Iwatsubo T, Strydom A.

Acta Neuropathol. 2018 May 16. doi: 10.1007/s00401-018-1866-3. [Epub ahead of print]

PMID:
29770843
6.

Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials.

Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H; Japanese Alzheimer's Disease Neuroimaging Initiative, Sun CK, Beckett LA, Petersen RC, Weiner MW, Aisen PS, Donohue MC; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2018 Aug;14(8):1077-1087. doi: 10.1016/j.jalz.2018.03.009. Epub 2018 May 9.

7.

Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ in vitro and brain Aβ deposition in vivo.

Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T.

J Biol Chem. 2018 May 11;293(19):7267. doi: 10.1074/jbc.AAC118.003576. No abstract available.

8.

Transoral endoscopic examination of head and neck region.

Hamada K, Ishihara R, Yamasaki Y, Akasaka T, Arao M, Iwatsubo T, Shichijo S, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Kawahara Y, Okada H.

Dig Endosc. 2018 Jul;30(4):516-521. doi: 10.1111/den.13071. Epub 2018 Apr 26.

PMID:
29637617
9.

Line-assisted complete closure for a large mucosal defect after colorectal endoscopic submucosal dissection decreased post-electrocoagulation syndrome.

Yamasaki Y, Takeuchi Y, Iwatsubo T, Kato M, Hamada K, Tonai Y, Matsuura N, Kanesaka T, Yamashina T, Arao M, Suzuki S, Shichijo S, Nakahira H, Akasaka T, Hanaoka N, Higashino K, Uedo N, Ishihara R, Okada H, Iishi H.

Dig Endosc. 2018 Mar 24. doi: 10.1111/den.13052. [Epub ahead of print]

PMID:
29573468
10.

Impact of electrosurgical unit mode on post esophageal endoscopic submucosal dissection stricture in an in vivo porcine model.

Tonai Y, Ishihara R, Yamasaki Y, Arao M, Iwatsubo T, Kato M, Suzuki S, Hamada K, Shichijo S, Matsuura N, Kanesaka T, Nakahira H, Yamamoto S, Akasaka T, Hanaoka N, Takeuchi Y, Higashino K, Uedo N, Tomita Y, Iishi H.

Endosc Int Open. 2018 Mar;6(3):E376-E381. doi: 10.1055/s-0043-122883. Epub 2018 Mar 7.

11.

Extracellular α-synuclein levels are regulated by neuronal activity.

Yamada K, Iwatsubo T.

Mol Neurodegener. 2018 Feb 22;13(1):9. doi: 10.1186/s13024-018-0241-0.

12.

Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.

Matsumoto T, Matsukawa K, Watanabe N, Kishino Y, Kunugi H, Ihara R, Wakabayashi T, Hashimoto T, Iwatsubo T.

Hum Mol Genet. 2018 Apr 15;27(8):1353-1365. doi: 10.1093/hmg/ddy046.

PMID:
29425337
13.

Multiple convex demarcation line for prediction of benign depressed gastric lesions in magnifying narrow-band imaging.

Kanesaka T, Uedo N, Yao K, Ezoe Y, Doyama H, Oda I, Kaneko K, Kawahara Y, Yokoi C, Sugiura Y, Ishikawa H, Takeuchi Y, Arao M, Iwatsubo T, Iwagami H, Matsuno K, Muto M, Saito Y, Tomita Y.

Endosc Int Open. 2018 Feb;6(2):E145-E155. doi: 10.1055/s-0043-121267. Epub 2018 Feb 1.

14.

Safety of cold snare polypectomy for duodenal adenomas in familial adenomatous polyposis: a prospective exploratory study.

Hamada K, Takeuchi Y, Ishikawa H, Ezoe Y, Arao M, Suzuki S, Iwatsubo T, Kato M, Tonai Y, Shichijo S, Yamasaki Y, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Akasaka T, Hanaoka N, Higashino K, Uedo N, Ishihara R, Okada H, Iishi H.

Endoscopy. 2018 May;50(5):511-517. doi: 10.1055/s-0043-124765. Epub 2018 Jan 19.

PMID:
29351704
15.

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.

Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T.

EMBO Mol Med. 2018 Mar;10(3). pii: e8184. doi: 10.15252/emmm.201708184.

16.

Comparison of ENDO CUT mode and FORCED COAG mode for the formation of stricture after esophageal endoscopic submucosal dissection in an in vivo porcine model.

Arao M, Ishihara R, Tonai Y, Iwatsubo T, Shichijyo S, Matsuura N, Nakahira H, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Nakatsuka S.

Surg Endosc. 2018 Jun;32(6):2902-2906. doi: 10.1007/s00464-017-6000-4. Epub 2018 Jan 4.

PMID:
29302739
17.

The past, present, and future of disease-modifying therapies for Alzheimer's disease.

Suzuki K, Iwata A, Iwatsubo T.

Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(10):757-771. doi: 10.2183/pjab.93.048.

18.

Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology.

Fujimoto T, Kuwahara T, Eguchi T, Sakurai M, Komori T, Iwatsubo T.

Biochem Biophys Res Commun. 2018 Jan 8;495(2):1708-1715. doi: 10.1016/j.bbrc.2017.12.024. Epub 2017 Dec 6.

PMID:
29223392
19.

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.

Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido TC, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M, Iwata A.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9645-E9654. doi: 10.1073/pnas.1707151114. Epub 2017 Oct 17.

20.

Underwater endoscopic mucosal resection for superficial nonampullary duodenal adenomas.

Yamasaki Y, Uedo N, Takeuchi Y, Higashino K, Hanaoka N, Akasaka T, Kato M, Hamada K, Tonai Y, Matsuura N, Kanesaka T, Arao M, Suzuki S, Iwatsubo T, Shichijo S, Nakahira H, Ishihara R, Iishi H.

Endoscopy. 2018 Feb;50(2):154-158. doi: 10.1055/s-0043-119214. Epub 2017 Sep 29.

PMID:
28962044
21.

Efficacy and Safety of Endoscopic Resection Followed by Chemoradiotherapy for Superficial Esophageal Squamous Cell Carcinoma: A Retrospective Study.

Hamada K, Ishihara R, Yamasaki Y, Hanaoka N, Yamamoto S, Arao M, Suzuki S, Iwatsubo T, Kato M, Tonai Y, Shichijo S, Matsuura N, Nakahira H, Kanesaka T, Akasaka T, Takeuchi Y, Higashino K, Uedo N, Iishi H, Kanayama N, Hirata T, Kawaguchi Y, Konishi K, Teshima T.

Clin Transl Gastroenterol. 2017 Aug 3;8(8):e110. doi: 10.1038/ctg.2017.36.

22.

[Toward Preclinical Trials for Alzheimer's Disease].

Miyagawa T, Iwatsubo T.

Brain Nerve. 2017 Jul;69(7):711-722. doi: 10.11477/mf.1416200812. Japanese.

PMID:
28739984
23.

[DIAN/DIAN-J/DIAN-TU].

Shimada H, Shoji M, Ikeuchi T, Suzuki K, Senda M, Ishii K, Matsuda H, Iwata A, Ihara R, Iwatsubo T, Mutoh K, Nakazawa E, Sekijima Y, Mori E, Ikeda M, Ikeda M, Kawakatsu S, Nakanishi A, Hashimoto M, Nunomura A, Matsubara E, Fukui M, Shirato T, Hirai K, Sakamoto M, Fujii H, Mori H.

Brain Nerve. 2017 Jul;69(7):701-709. doi: 10.11477/mf.1416200811. Japanese.

PMID:
28739983
24.

Notable Drug-Drug Interaction Between Etizolam and Itraconazole in Poor Metabolizers of Cytochrome P450 2C19.

Yamamoto T, Furihata K, Hisaka A, Moritoyo T, Ogoe K, Kusayama S, Motohashi K, Mori A, Iwatsubo T, Suzuki H.

J Clin Pharmacol. 2017 Nov;57(11):1491-1499. doi: 10.1002/jcph.956. Epub 2017 Jul 5.

PMID:
28679023
25.

Duodenal adenoma overlying a lipoma treated with laparoscopic endoscopic collaborative surgery.

Iwatsubo T, Takeuchi Y, Yamasaki Y.

Dig Endosc. 2017 Nov;29(7):812-813. doi: 10.1111/den.12912. Epub 2017 Jul 26. No abstract available.

PMID:
28664621
26.

Technical feasibility of line-assisted complete closure technique for large mucosal defects after colorectal endoscopic submucosal dissection.

Kato M, Takeuchi Y, Yamasaki Y, Arao M, Suzuki S, Iwatsubo T, Hamada K, Tonai Y, Shichijo S, Matsuura N, Nakahira H, Kanesaka T, Akasaka T, Hanaoka N, Higashino K, Uedo N, Ishihara R, Iishi H.

Endosc Int Open. 2017 Jan;5(1):E11-E16. doi: 10.1055/s-0042-121002.

27.

Primary gastric choriocarcinoma developed in a Helicobacter pylori-negative patient.

Iwatsubo T, Uedo N, Ishibashi K.

Dig Endosc. 2017 May;29(3):392-393. doi: 10.1111/den.12838. Epub 2017 Mar 19. No abstract available.

PMID:
28181701
28.

Sample Size Estimation for Alzheimer's Disease Trials from Japanese ADNI Serial Magnetic Resonance Imaging.

Fujishima M, Kawaguchi A, Maikusa N, Kuwano R, Iwatsubo T, Matsuda H; Japanese Alzheimer’s Disease Neuroimaging Initiative (ADNI); Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI).

J Alzheimers Dis. 2017;56(1):75-88. doi: 10.3233/JAD-160621.

29.

Phantom criteria for qualification of brain FDG and amyloid PET across different cameras.

Ikari Y, Akamatsu G, Nishio T, Ishii K, Ito K, Iwatsubo T, Senda M.

EJNMMI Phys. 2016 Dec;3(1):23. Epub 2016 Oct 6.

30.

Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43.

Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T.

J Biol Chem. 2016 Nov 4;291(45):23464-23476. Epub 2016 Sep 15.

31.

Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo.

Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T.

Hum Mol Genet. 2016 Sep 15;25(18):3988-3997. doi: 10.1093/hmg/ddw239. Epub 2016 Jul 27.

PMID:
27466196
32.

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts.

Kuwahara T, Inoue K, D'Agati VD, Fujimoto T, Eguchi T, Saha S, Wolozin B, Iwatsubo T, Abeliovich A.

Sci Rep. 2016 Jul 18;6:29945. doi: 10.1038/srep29945.

33.

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.

Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Young Chang M, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T.

Hum Mol Genet. 2016 Jul 15;25(14):2948-2958. Epub 2016 May 14.

PMID:
27179792
34.

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.

Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T.

Sci Rep. 2016 Apr 4;6:23969. doi: 10.1038/srep23969.

35.

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production.

Tominaga A, Cai T, Takagi-Niidome S, Iwatsubo T, Tomita T.

J Neurosci. 2016 Jan 27;36(4):1362-72. doi: 10.1523/JNEUROSCI.5090-14.2016.

36.

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau.

Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M, Akiyama H, Robinson A, Mann DMA, Iwatsubo T, Hasegawa M.

Acta Neuropathol. 2016 Feb;131(2):267-280. doi: 10.1007/s00401-015-1503-3. Epub 2015 Nov 4.

37.

Efficacy of recombinant human soluble thrombomodulin in preventing walled-off necrosis in severe acute pancreatitis patients.

Eguchi T, Tsuji Y, Yamashita H, Fukuchi T, Kanamori A, Matsumoto K, Hasegawa T, Koizumi A, Kitada R, Tsujimae M, Iwatsubo T, Koyama S, Ubukata S, Fujita M, Okada A.

Pancreatology. 2015 Sep-Oct;15(5):485-490. doi: 10.1016/j.pan.2015.08.002. Epub 2015 Aug 21.

38.

Novel Prokinetic Acotiamide Reduces Transient Lower Esophageal Sphincter Relaxation in Healthy Subjects.

Yamashita H, Kanamori A, Fukuchi T, Tsujimae M, Koizumi A, Iwatsubo T, Koyama S, Eguchi T, Ubukata S, Fujita M, Okada A.

Digestion. 2015;92(2):90-8. doi: 10.1159/000437301. Epub 2015 Aug 5.

PMID:
26279051
39.

The Worldwide Alzheimer's Disease Neuroimaging Initiative: An update.

Hendrix JA, Finger B, Weiner MW, Frisoni GB, Iwatsubo T, Rowe CC, Kim SY, Guinjoan SM, Sevlever G, Carrillo MC.

Alzheimers Dement. 2015 Jul;11(7):850-9. doi: 10.1016/j.jalz.2015.05.008. Review.

PMID:
26194318
40.

Formation of Hydroxyapatite Skeletal Materials from Hydrogel Matrices via Artificial Biomineralization.

Iwatsubo T, Kishi R, Miura T, Ohzono T, Yamaguchi T.

J Phys Chem B. 2015 Jul 16;119(28):8793-9. doi: 10.1021/acs.jpcb.5b03181. Epub 2015 Jul 6.

PMID:
26101802
41.

Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer's disease.

Doody RS, Raman R, Sperling RA, Seimers E, Sethuraman G, Mohs R, Farlow M, Iwatsubo T, Vellas B, Sun X, Ernstrom K, Thomas RG, Aisen PS; Alzheimer’s Disease Cooperative Study.

Alzheimers Res Ther. 2015 Jun 10;7(1):36. doi: 10.1186/s13195-015-0121-6. eCollection 2015.

42.

Chronic optogenetic activation augments aβ pathology in a mouse model of Alzheimer disease.

Yamamoto K, Tanei ZI, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K, Iwatsubo T.

Cell Rep. 2015 May 12;11(6):859-865. doi: 10.1016/j.celrep.2015.04.017. Epub 2015 Apr 30.

43.

Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO.

Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T.

J Biol Chem. 2015 Jun 12;290(24):15163-74. doi: 10.1074/jbc.M114.622209. Epub 2015 Apr 27. Erratum in: J Biol Chem. 2018 May 11;293(19):7267.

44.

Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis.

Kukharsky MS, Quintiero A, Matsumoto T, Matsukawa K, An H, Hashimoto T, Iwatsubo T, Buchman VL, Shelkovnikova TA.

Mol Neurodegener. 2015 Apr 10;10:20. doi: 10.1186/s13024-015-0014-y.

45.

Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase.

Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, Tomita T.

J Neurosci. 2015 Feb 11;35(6):2646-56. doi: 10.1523/JNEUROSCI.3164-14.2015.

46.

Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity.

Takasugi N, Sasaki T, Shinohara M, Iwatsubo T, Tomita T.

Biochem Biophys Res Commun. 2015 Feb 6;457(2):194-9. doi: 10.1016/j.bbrc.2014.12.087. Epub 2014 Dec 27.

PMID:
25545059
47.

Imago Mundi, Imago AD, Imago ADNI.

Villemagne VL, Kim SY, Rowe CC, Iwatsubo T.

Alzheimers Res Ther. 2014 Aug 29;6(5):62. doi: 10.1186/s13195-014-0062-5. eCollection 2014. Review.

48.

Influence of parameter settings in voxel-based morphometry 8. Using DARTEL and region-of-interest on reproducibility in gray matter volumetry.

Goto M, Abe O, Aoki S, Hayashi N, Miyati T, Takao H, Matsuda H, Yamashita F, Iwatsubo T, Mori H, Kunimatsu A, Ino K, Yano K, Ohtomo K; Japanese Alzheimer’s Disease Neuroimaging Initiative.

Methods Inf Med. 2015;54(2):171-8. doi: 10.3414/ME14-01-0049. Epub 2014 Oct 27.

PMID:
25345402
49.

Absorption, distribution, metabolism and excretion of novel phosphodiesterase type 4 inhibitor ASP3258 in rats.

Ohtsu Y, Sonoda T, Susaki Y, Tohda T, Fukunaga Y, Iwatsubo T, Noguchi K.

Biopharm Drug Dispos. 2015 Jan;36(1):34-48. doi: 10.1002/bdd.1921. Epub 2014 Nov 22.

PMID:
25277346
50.

Longitudinal gray-matter volume change in the default-mode network: utility of volume standardized with global gray-matter volume for Alzheimer's disease: a preliminary study.

Goto M, Abe O, Aoki S, Hayashi N, Ohtsu H, Takao H, Miyati T, Matsuda H, Yamashita F, Iwatsubo T, Mori H, Kunimatsu A, Ino K, Yano K, Ohtomo K.

Radiol Phys Technol. 2015 Jan;8(1):64-72. doi: 10.1007/s12194-014-0295-9. Epub 2014 Sep 27.

PMID:
25261344

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