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Items: 1 to 50 of 454

1.

Lower Serum Calcium as a Potentially Associated Factor for Conversion of Mild Cognitive Impairment to Early Alzheimer's Disease in the Japanese Alzheimer's Disease Neuroimaging Initiative.

Sato K, Mano T, Ihara R, Suzuki K, Tomita N, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H, Iwatsubo T, Toda T, Iwata A; Alzheimer’s Disease Neuroimaging Initiative, and Japanese Alzheimer’s Disease Neuroimaging Initiative.

J Alzheimers Dis. 2019 Feb 22. doi: 10.3233/JAD-181115. [Epub ahead of print]

PMID:
30814351
2.

Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight.

Bannai T, Mano T, Chen X, Ohtomo G, Ohtomo R, Tsuchida T, Koshi-Mano K, Hashimoto T, Okazawa H, Iwatsubo T, Tsuji S, Toda T, Iwata A.

Sci Rep. 2019 Feb 26;9(1):2827. doi: 10.1038/s41598-019-39494-7.

3.

Effects of sex, educational background, and chronic kidney disease grading on longitudinal cognitive and functional decline in patients in the Japanese Alzheimer's Disease Neuroimaging Initiative study.

Iwata A, Iwatsubo T, Ihara R, Suzuki K, Matsuyama Y, Tomita N, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H; Alzheimer's Disease Neuroimaging Initiative; Japanese Alzheimer’s Disease Neuroimaging Initiative.

Alzheimers Dement (N Y). 2018 Jul 12;4:765-774. doi: 10.1016/j.trci.2018.06.008. eCollection 2018.

4.

Natural history of early gastric cancer: series of 21 cases.

Iwagami H, Ishihara R, Nakagawa K, Ohmori M, Matsuno K, Inoue S, Arao M, Iwatsubo T, Nakahira H, Matsuura N, Shichijo S, Maekawa A, Takashi K, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Miyashiro I.

Endosc Int Open. 2019 Jan;7(1):E43-E48. doi: 10.1055/a-0746-3329. Epub 2019 Jan 3.

5.

Long-term follow up of gastric squamous metaplasia.

Iwatsubo T, Ishihara R, Higuchi K.

Dig Endosc. 2019 Jan 9. doi: 10.1111/den.13338. [Epub ahead of print] No abstract available.

PMID:
30624817
6.

Impact of age at diagnosis of head and neck cancer on incidence of metachronous cancer.

Iwatsubo T, Ishihara R, Morishima T, Maekawa A, Nakagawa K, Arao M, Ohmori M, Iwagami H, Matsuno K, Inoue S, Nakahira H, Matsuura N, Shichijo S, Kanesaka T, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Miyashiro I, Higuchi K, Fujii T.

BMC Cancer. 2019 Jan 3;19(1):3. doi: 10.1186/s12885-018-5231-7.

7.

Pharyngeal observation via transoral endoscopy using a lip cover-type mouthpiece.

Iwatsubo T, Ishihara R, Nakagawa K, Ohmori M, Iwagami H, Matsuno K, Inoue S, Nakahira H, Matsuura N, Shichijo S, Maekawa A, Kanesaka T, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Higuchi K.

J Gastroenterol Hepatol. 2018 Dec 18. doi: 10.1111/jgh.14574. [Epub ahead of print]

PMID:
30561830
8.

Clinical and cognitive characteristics of preclinical Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative cohort.

Ihara R, Iwata A, Suzuki K, Ikeuchi T, Kuwano R, Iwatsubo T; Japanese Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement (N Y). 2018 Nov 26;4:645-651. doi: 10.1016/j.trci.2018.10.004. eCollection 2018.

9.

Differences in Clinical Course of Intraprocedural and Delayed Perforation Caused by Endoscopic Submucosal Dissection for Colorectal Neoplasms: A Retrospective Study.

Iwatsubo T, Takeuchi Y, Yamasaki Y, Nakagawa K, Arao M, Ohmori M, Iwagami H, Matsuno K, Inoue S, Nakahira H, Matsuura N, Shichijo S, Maekawa A, Kanesaka T, Yamamoto S, Higashino K, Uedo N, Ishihara R.

Dig Dis. 2019;37(1):53-62. doi: 10.1159/000492868. Epub 2018 Sep 18.

PMID:
30227392
10.

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.

Eguchi T, Kuwahara T, Sakurai M, Komori T, Fujimoto T, Ito G, Yoshimura SI, Harada A, Fukuda M, Koike M, Iwatsubo T.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9115-E9124. doi: 10.1073/pnas.1812196115. Epub 2018 Sep 12.

11.

Endoscopic findings corresponding to multiple Lugol-voiding lesions in the esophageal background mucosa.

Matsuno K, Ishihara R, Nakagawa K, Ohmori M, Iwagami H, Inoue S, Iwatsubo T, Nakahira H, Matsuura N, Shichijyo S, Maekawa A, Takashi K, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Matsunaga T.

J Gastroenterol Hepatol. 2019 Feb;34(2):390-396. doi: 10.1111/jgh.14439. Epub 2018 Sep 10.

PMID:
30101499
12.

A Novel Method to Estimate Long-Term Chronological Changes From Fragmented Observations in Disease Progression.

Ishida T, Tokuda K, Hisaka A, Honma M, Kijima S, Takatoku H, Iwatsubo T, Moritoyo T, Suzuki H; Alzheimer's Disease Neuroimaging Initiative.

Clin Pharmacol Ther. 2019 Feb;105(2):436-447. doi: 10.1002/cpt.1166. Epub 2018 Aug 20.

PMID:
29951994
13.

Efficacy of vonoprazan in prevention of bleeding from endoscopic submucosal dissection-induced gastric ulcers: a prospective randomized phase II study.

Hamada K, Uedo N, Tonai Y, Arao M, Suzuki S, Iwatsubo T, Kato M, Shichijo S, Yamasaki Y, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Akasaka T, Hanaoka N, Takeuchi Y, Higashino K, Ishihara R, Okada H, Iishi H, Fukui K, Shimokawa T.

J Gastroenterol. 2019 Feb;54(2):122-130. doi: 10.1007/s00535-018-1487-6. Epub 2018 Jun 25.

PMID:
29943163
14.

Traction-assisted colorectal endoscopic submucosal dissection by use of clip and line for a neoplasm involving colonic diverticulum.

Iwatsubo T, Uedo N, Yamasaki Y, Takeuchi Y, Ando Y.

VideoGIE. 2017 Nov 22;2(12):337-338. doi: 10.1016/j.vgie.2017.08.012. eCollection 2017 Dec. No abstract available.

15.

Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease.

Mann DMA, Davidson YS, Robinson AC, Allen N, Hashimoto T, Richardson A, Jones M, Snowden JS, Pendleton N, Potier MC, Laquerrière A, Prasher V, Iwatsubo T, Strydom A.

Acta Neuropathol. 2018 Oct;136(4):569-587. doi: 10.1007/s00401-018-1866-3. Epub 2018 May 16.

16.

Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials.

Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H; Japanese Alzheimer's Disease Neuroimaging Initiative, Sun CK, Beckett LA, Petersen RC, Weiner MW, Aisen PS, Donohue MC; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2018 Aug;14(8):1077-1087. doi: 10.1016/j.jalz.2018.03.009. Epub 2018 May 9.

17.

Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ in vitro and brain Aβ deposition in vivo.

Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T.

J Biol Chem. 2018 May 11;293(19):7267. doi: 10.1074/jbc.AAC118.003576. No abstract available.

18.

Transoral endoscopic examination of head and neck region.

Hamada K, Ishihara R, Yamasaki Y, Akasaka T, Arao M, Iwatsubo T, Shichijo S, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Kawahara Y, Okada H.

Dig Endosc. 2018 Jul;30(4):516-521. doi: 10.1111/den.13071. Epub 2018 Apr 26. Review.

PMID:
29637617
19.

Line-assisted complete closure for a large mucosal defect after colorectal endoscopic submucosal dissection decreased post-electrocoagulation syndrome.

Yamasaki Y, Takeuchi Y, Iwatsubo T, Kato M, Hamada K, Tonai Y, Matsuura N, Kanesaka T, Yamashina T, Arao M, Suzuki S, Shichijo S, Nakahira H, Akasaka T, Hanaoka N, Higashino K, Uedo N, Ishihara R, Okada H, Iishi H.

Dig Endosc. 2018 Sep;30(5):633-641. doi: 10.1111/den.13052. Epub 2018 Apr 29.

PMID:
29573468
20.

Impact of electrosurgical unit mode on post esophageal endoscopic submucosal dissection stricture in an in vivo porcine model.

Tonai Y, Ishihara R, Yamasaki Y, Arao M, Iwatsubo T, Kato M, Suzuki S, Hamada K, Shichijo S, Matsuura N, Kanesaka T, Nakahira H, Yamamoto S, Akasaka T, Hanaoka N, Takeuchi Y, Higashino K, Uedo N, Tomita Y, Iishi H.

Endosc Int Open. 2018 Mar;6(3):E376-E381. doi: 10.1055/s-0043-122883. Epub 2018 Mar 7.

21.

Extracellular α-synuclein levels are regulated by neuronal activity.

Yamada K, Iwatsubo T.

Mol Neurodegener. 2018 Feb 22;13(1):9. doi: 10.1186/s13024-018-0241-0.

22.

Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.

Matsumoto T, Matsukawa K, Watanabe N, Kishino Y, Kunugi H, Ihara R, Wakabayashi T, Hashimoto T, Iwatsubo T.

Hum Mol Genet. 2018 Apr 15;27(8):1353-1365. doi: 10.1093/hmg/ddy046.

PMID:
29425337
23.

Multiple convex demarcation line for prediction of benign depressed gastric lesions in magnifying narrow-band imaging.

Kanesaka T, Uedo N, Yao K, Ezoe Y, Doyama H, Oda I, Kaneko K, Kawahara Y, Yokoi C, Sugiura Y, Ishikawa H, Takeuchi Y, Arao M, Iwatsubo T, Iwagami H, Matsuno K, Muto M, Saito Y, Tomita Y.

Endosc Int Open. 2018 Feb;6(2):E145-E155. doi: 10.1055/s-0043-121267. Epub 2018 Feb 1.

24.

Safety of cold snare polypectomy for duodenal adenomas in familial adenomatous polyposis: a prospective exploratory study.

Hamada K, Takeuchi Y, Ishikawa H, Ezoe Y, Arao M, Suzuki S, Iwatsubo T, Kato M, Tonai Y, Shichijo S, Yamasaki Y, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Akasaka T, Hanaoka N, Higashino K, Uedo N, Ishihara R, Okada H, Iishi H.

Endoscopy. 2018 May;50(5):511-517. doi: 10.1055/s-0043-124765. Epub 2018 Jan 19.

PMID:
29351704
25.

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.

Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T.

EMBO Mol Med. 2018 Mar;10(3). pii: e8184. doi: 10.15252/emmm.201708184.

26.

Comparison of ENDO CUT mode and FORCED COAG mode for the formation of stricture after esophageal endoscopic submucosal dissection in an in vivo porcine model.

Arao M, Ishihara R, Tonai Y, Iwatsubo T, Shichijyo S, Matsuura N, Nakahira H, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Nakatsuka S.

Surg Endosc. 2018 Jun;32(6):2902-2906. doi: 10.1007/s00464-017-6000-4. Epub 2018 Jan 4.

PMID:
29302739
27.

The past, present, and future of disease-modifying therapies for Alzheimer's disease.

Suzuki K, Iwata A, Iwatsubo T.

Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(10):757-771. doi: 10.2183/pjab.93.048. Review.

28.

Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology.

Fujimoto T, Kuwahara T, Eguchi T, Sakurai M, Komori T, Iwatsubo T.

Biochem Biophys Res Commun. 2018 Jan 8;495(2):1708-1715. doi: 10.1016/j.bbrc.2017.12.024. Epub 2017 Dec 6.

PMID:
29223392
29.

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.

Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido TC, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M, Iwata A.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9645-E9654. doi: 10.1073/pnas.1707151114. Epub 2017 Oct 17.

30.

Underwater endoscopic mucosal resection for superficial nonampullary duodenal adenomas.

Yamasaki Y, Uedo N, Takeuchi Y, Higashino K, Hanaoka N, Akasaka T, Kato M, Hamada K, Tonai Y, Matsuura N, Kanesaka T, Arao M, Suzuki S, Iwatsubo T, Shichijo S, Nakahira H, Ishihara R, Iishi H.

Endoscopy. 2018 Feb;50(2):154-158. doi: 10.1055/s-0043-119214. Epub 2017 Sep 29.

PMID:
28962044
31.

Efficacy and Safety of Endoscopic Resection Followed by Chemoradiotherapy for Superficial Esophageal Squamous Cell Carcinoma: A Retrospective Study.

Hamada K, Ishihara R, Yamasaki Y, Hanaoka N, Yamamoto S, Arao M, Suzuki S, Iwatsubo T, Kato M, Tonai Y, Shichijo S, Matsuura N, Nakahira H, Kanesaka T, Akasaka T, Takeuchi Y, Higashino K, Uedo N, Iishi H, Kanayama N, Hirata T, Kawaguchi Y, Konishi K, Teshima T.

Clin Transl Gastroenterol. 2017 Aug 3;8(8):e110. doi: 10.1038/ctg.2017.36.

32.

[Toward Preclinical Trials for Alzheimer's Disease].

Miyagawa T, Iwatsubo T.

Brain Nerve. 2017 Jul;69(7):711-722. doi: 10.11477/mf.1416200812. Japanese.

PMID:
28739984
33.

[DIAN/DIAN-J/DIAN-TU].

Shimada H, Shoji M, Ikeuchi T, Suzuki K, Senda M, Ishii K, Matsuda H, Iwata A, Ihara R, Iwatsubo T, Mutoh K, Nakazawa E, Sekijima Y, Mori E, Ikeda M, Ikeda M, Kawakatsu S, Nakanishi A, Hashimoto M, Nunomura A, Matsubara E, Fukui M, Shirato T, Hirai K, Sakamoto M, Fujii H, Mori H.

Brain Nerve. 2017 Jul;69(7):701-709. doi: 10.11477/mf.1416200811. Japanese.

PMID:
28739983
34.

Notable Drug-Drug Interaction Between Etizolam and Itraconazole in Poor Metabolizers of Cytochrome P450 2C19.

Yamamoto T, Furihata K, Hisaka A, Moritoyo T, Ogoe K, Kusayama S, Motohashi K, Mori A, Iwatsubo T, Suzuki H.

J Clin Pharmacol. 2017 Nov;57(11):1491-1499. doi: 10.1002/jcph.956. Epub 2017 Jul 5.

PMID:
28679023
35.

Duodenal adenoma overlying a lipoma treated with laparoscopic endoscopic collaborative surgery.

Iwatsubo T, Takeuchi Y, Yamasaki Y.

Dig Endosc. 2017 Nov;29(7):812-813. doi: 10.1111/den.12912. Epub 2017 Jul 26. No abstract available.

PMID:
28664621
36.

Technical feasibility of line-assisted complete closure technique for large mucosal defects after colorectal endoscopic submucosal dissection.

Kato M, Takeuchi Y, Yamasaki Y, Arao M, Suzuki S, Iwatsubo T, Hamada K, Tonai Y, Shichijo S, Matsuura N, Nakahira H, Kanesaka T, Akasaka T, Hanaoka N, Higashino K, Uedo N, Ishihara R, Iishi H.

Endosc Int Open. 2017 Jan;5(1):E11-E16. doi: 10.1055/s-0042-121002.

37.

Primary gastric choriocarcinoma developed in a Helicobacter pylori-negative patient.

Iwatsubo T, Uedo N, Ishibashi K.

Dig Endosc. 2017 May;29(3):392-393. doi: 10.1111/den.12838. Epub 2017 Mar 19. No abstract available.

PMID:
28181701
38.

Sample Size Estimation for Alzheimer's Disease Trials from Japanese ADNI Serial Magnetic Resonance Imaging.

Fujishima M, Kawaguchi A, Maikusa N, Kuwano R, Iwatsubo T, Matsuda H; Japanese Alzheimer’s Disease Neuroimaging Initiative (ADNI); Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI).

J Alzheimers Dis. 2017;56(1):75-88. doi: 10.3233/JAD-160621.

39.

Phantom criteria for qualification of brain FDG and amyloid PET across different cameras.

Ikari Y, Akamatsu G, Nishio T, Ishii K, Ito K, Iwatsubo T, Senda M.

EJNMMI Phys. 2016 Dec;3(1):23. Epub 2016 Oct 6.

40.

Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43.

Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T.

J Biol Chem. 2016 Nov 4;291(45):23464-23476. Epub 2016 Sep 15.

41.

Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo.

Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T.

Hum Mol Genet. 2016 Sep 15;25(18):3988-3997. doi: 10.1093/hmg/ddw239. Epub 2016 Jul 27.

PMID:
27466196
42.

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts.

Kuwahara T, Inoue K, D'Agati VD, Fujimoto T, Eguchi T, Saha S, Wolozin B, Iwatsubo T, Abeliovich A.

Sci Rep. 2016 Jul 18;6:29945. doi: 10.1038/srep29945.

43.

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.

Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Young Chang M, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T.

Hum Mol Genet. 2016 Jul 15;25(14):2948-2958. Epub 2016 May 14.

PMID:
27179792
44.

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.

Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T.

Sci Rep. 2016 Apr 4;6:23969. doi: 10.1038/srep23969.

45.

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production.

Tominaga A, Cai T, Takagi-Niidome S, Iwatsubo T, Tomita T.

J Neurosci. 2016 Jan 27;36(4):1362-72. doi: 10.1523/JNEUROSCI.5090-14.2016.

46.

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau.

Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M, Akiyama H, Robinson A, Mann DMA, Iwatsubo T, Hasegawa M.

Acta Neuropathol. 2016 Feb;131(2):267-280. doi: 10.1007/s00401-015-1503-3. Epub 2015 Nov 4.

47.

Efficacy of recombinant human soluble thrombomodulin in preventing walled-off necrosis in severe acute pancreatitis patients.

Eguchi T, Tsuji Y, Yamashita H, Fukuchi T, Kanamori A, Matsumoto K, Hasegawa T, Koizumi A, Kitada R, Tsujimae M, Iwatsubo T, Koyama S, Ubukata S, Fujita M, Okada A.

Pancreatology. 2015 Sep-Oct;15(5):485-490. doi: 10.1016/j.pan.2015.08.002. Epub 2015 Aug 21.

48.

Novel Prokinetic Acotiamide Reduces Transient Lower Esophageal Sphincter Relaxation in Healthy Subjects.

Yamashita H, Kanamori A, Fukuchi T, Tsujimae M, Koizumi A, Iwatsubo T, Koyama S, Eguchi T, Ubukata S, Fujita M, Okada A.

Digestion. 2015;92(2):90-8. doi: 10.1159/000437301. Epub 2015 Aug 5.

PMID:
26279051
49.

The Worldwide Alzheimer's Disease Neuroimaging Initiative: An update.

Hendrix JA, Finger B, Weiner MW, Frisoni GB, Iwatsubo T, Rowe CC, Kim SY, Guinjoan SM, Sevlever G, Carrillo MC.

Alzheimers Dement. 2015 Jul;11(7):850-9. doi: 10.1016/j.jalz.2015.05.008. Review.

PMID:
26194318
50.

Formation of Hydroxyapatite Skeletal Materials from Hydrogel Matrices via Artificial Biomineralization.

Iwatsubo T, Kishi R, Miura T, Ohzono T, Yamaguchi T.

J Phys Chem B. 2015 Jul 16;119(28):8793-9. doi: 10.1021/acs.jpcb.5b03181. Epub 2015 Jul 6.

PMID:
26101802

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