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Additive Duloxetine for Cancer-related Neuropathic Pain Nonresponsive or Intolerant to Opioid-Pregabalin Therapy: A Randomized Controlled Trial (JORTC-PAL08).

Matsuoka H, Iwase S, Miyaji T, Kawaguchi T, Ariyoshi K, Oyamada S, Satomi E, Ishiki H, Hasuo H, Sakuma H, Tokoro A, Shinomiya T, Otani H, Otake Y, Tsukuura H, Matsumoto Y, Hasegawa Y, Kataoka Y, Otsuka M, Sakai K, Matsuda Y, Morita T, Koyama A, Yamaguchi T.

J Pain Symptom Manage. 2019 Jun 26. pii: S0885-3924(19)30364-1. doi: 10.1016/j.jpainsymman.2019.06.020. [Epub ahead of print]


Ascitic IL-10 concentration predicts prognosis of the patients undergoing Cell-Free and Concentrated Ascites Reinfusion Therapy (CART).

Ito T, Hanafusa N, Iwase S, Noiri E, Nangaku M, Nakagawa K, Miyagawa K.

Ther Apher Dial. 2019 Jun 3. doi: 10.1111/1744-9987.12863. [Epub ahead of print]


Evaluation of Black Soldier Fly (Hermetia illucens) Larvae and Pre-Pupae Raised on Household Organic Waste, as Potential Ingredients for Poultry Feed.

Kawasaki K, Hashimoto Y, Hori A, Kawasaki T, Hirayasu H, Iwase SI, Hashizume A, Ido A, Miura C, Miura T, Nakamura S, Seyama T, Matsumoto Y, Kasai K, Fujitani Y.

Animals (Basel). 2019 Mar 19;9(3). pii: E98. doi: 10.3390/ani9030098.


Current Pharmacotherapy Does Not Improve Severity of Hypoactive Delirium in Patients with Advanced Cancer: Pharmacological Audit Study of Safety and Efficacy in Real World (Phase-R).

Okuyama T, Yoshiuchi K, Ogawa A, Iwase S, Yokomichi N, Sakashita A, Tagami K, Uemura K, Nakahara R, Akechi T; Phase‐R Delirium Study Group.

Oncologist. 2019 Jan 4. pii: theoncologist.2018-0242. doi: 10.1634/theoncologist.2018-0242. [Epub ahead of print]


Effect of spraying of fine water particles on facial skin moisture and viscoelasticity in adult women.

Nishimura N, Inoue S, Yokoyama K, Iwase S.

Skin Res Technol. 2019 May;25(3):294-298. doi: 10.1111/srt.12648. Epub 2018 Nov 6.


Ferroportin disease mutations influence manganese accumulation and cytotoxicity.

Choi EK, Nguyen TT, Iwase S, Seo YA.

FASEB J. 2019 Feb;33(2):2228-2240. doi: 10.1096/fj.201800831R. Epub 2018 Sep 24.


Morphine for Refractory Dyspnea in Interstitial Lung Disease: A Phase I Study (JORTC-PAL 05).

Matsuda Y, Morita T, Miyaji T, Ogawa T, Kato K, Kawaguchi T, Tokoro A, Iwase S, Yamaguchi T, Inoue Y.

J Palliat Med. 2018 Aug 21. doi: 10.1089/jpm.2018.0272. [Epub ahead of print]


Interleukin-6 as a diagnostic marker for infection in critically ill patients: A systematic review and meta-analysis.

Iwase S, Nakada TA, Hattori N, Takahashi W, Takahashi N, Aizimu T, Yoshida M, Morizane T, Oda S.

Am J Emerg Med. 2019 Feb;37(2):260-265. doi: 10.1016/j.ajem.2018.05.040. Epub 2018 May 22.


Prevalence of myofascial pain syndrome in patients with incurable cancer.

Ishiki H, Kinkawa J, Watanabe A, Watanabe C, Chiba T, Yasui H, Shimada N, Ariyoshi K, Nojima M, Iwase S, Tojo A, Imai K.

J Bodyw Mov Ther. 2018 Apr;22(2):328-332. doi: 10.1016/j.jbmt.2017.05.005. Epub 2017 May 17.


Development of mRNA-based body fluid identification using reverse transcription loop-mediated isothermal amplification.

Satoh T, Kouroki S, Ogawa K, Tanaka Y, Matsumura K, Iwase S.

Anal Bioanal Chem. 2018 Jul;410(18):4371-4378. doi: 10.1007/s00216-018-1088-5. Epub 2018 Apr 25.


Qualitative analysis of clinical research coordinators' role in phase I cancer clinical trials.

Fujiwara N, Ochiai R, Shirai Y, Saito Y, Nagamura F, Iwase S, Kazuma K.

Contemp Clin Trials Commun. 2017 Sep 28;8:156-161. doi: 10.1016/j.conctc.2017.09.009. eCollection 2017 Dec.


Effects of catechin-enriched ion beverage intake on thermoregulatory function in a hot environment.

Nishimura R, Nishimura N, Iwase S, Takeshita M, Katashima M, Katsuragi Y, Sato M.

J Physiol Sci. 2019 Jan;69(1):39-45. doi: 10.1007/s12576-018-0615-7. Epub 2018 Apr 23.


Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability.

Vallianatos CN, Farrehi C, Friez MJ, Burmeister M, Keegan CE, Iwase S.

Front Mol Neurosci. 2018 Apr 4;11:104. doi: 10.3389/fnmol.2018.00104. eCollection 2018.


CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development.

Yao H, Hill SF, Skidmore JM, Sperry ED, Swiderski DL, Sanchez GJ, Bartels CF, Raphael Y, Scacheri PC, Iwase S, Martin DM.

JCI Insight. 2018 Feb 22;3(4). pii: 97440. doi: 10.1172/jci.insight.97440. eCollection 2018 Feb 22.


Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders.

Choi EK, Nguyen TT, Gupta N, Iwase S, Seo YA.

Sci Rep. 2018 Feb 16;8(1):3163. doi: 10.1038/s41598-018-21464-0.


Elevated sympathetic vasomotor outflow in response to increased inspiratory muscle activity during exercise is less in young women compared with men.

Katayama K, Smith JR, Goto K, Shimizu K, Saito M, Ishida K, Koike T, Iwase S, Harms CA.

Exp Physiol. 2018 Apr 1;103(4):570-580. doi: 10.1113/EP086817. Epub 2018 Feb 11.


Electrical Matching at Metal/Molecule Contacts for Efficient Heterogeneous Charge Transfer.

Sato S, Iwase S, Namba K, Ono T, Hara K, Fukuoka A, Uosaki K, Ikeda K.

ACS Nano. 2018 Feb 27;12(2):1228-1235. doi: 10.1021/acsnano.7b07223. Epub 2018 Jan 18.


Neuron-specific alternative splicing of transcriptional machineries: Implications for neurodevelopmental disorders.

Porter RS, Jaamour F, Iwase S.

Mol Cell Neurosci. 2018 Mar;87:35-45. doi: 10.1016/j.mcn.2017.10.006. Epub 2017 Dec 15. Review.


Chromatin in nervous system development and disease.

Iwase S, Martin DM.

Mol Cell Neurosci. 2018 Mar;87:1-3. doi: 10.1016/j.mcn.2017.12.006. Epub 2017 Dec 15.


Decline of Physical Activity in Terminally Ill Patients Could Be Useful for Predicting Short-Term Survival.

Yasui H, Iwase S, Ariyoshi K, Nojima M, Yoshiuchi K.

Am J Hosp Palliat Care. 2018 May;35(5):749-753. doi: 10.1177/1049909117741472. Epub 2017 Nov 16.


Epigenetic Etiology of Intellectual Disability.

Iwase S, Bérubé NG, Zhou Z, Kasri NN, Battaglioli E, Scandaglia M, Barco A.

J Neurosci. 2017 Nov 8;37(45):10773-10782. doi: 10.1523/JNEUROSCI.1840-17.2017. Review.


Loss of Kdm5c Causes Spurious Transcription and Prevents the Fine-Tuning of Activity-Regulated Enhancers in Neurons.

Scandaglia M, Lopez-Atalaya JP, Medrano-Fernandez A, Lopez-Cascales MT, Del Blanco B, Lipinski M, Benito E, Olivares R, Iwase S, Shi Y, Barco A.

Cell Rep. 2017 Oct 3;21(1):47-59. doi: 10.1016/j.celrep.2017.09.014.


[The Overview of Two Programs to Support Cancer Survivor's Advocacy by CancerNet Japan].

Kawakami S, Ohtomo M, Ogino C, Konishi T, Iwase S.

Gan To Kagaku Ryoho. 2017 Aug;44(8):627-631. Japanese.


Study protocol for a multi-institutional, randomised, double-blinded, placebo-controlled phase III trial investigating additive efficacy of duloxetine for neuropathic cancer pain refractory to opioids and gabapentinoids: the DIRECT study.

Matsuoka H, Ishiki H, Iwase S, Koyama A, Kawaguchi T, Kizawa Y, Morita T, Matsuda Y, Miyaji T, Ariyoshi K, Yamaguchi T.

BMJ Open. 2017 Aug 28;7(8):e017280. doi: 10.1136/bmjopen-2017-017280.


Group A Streptococcal Peritonitis and Toxic Shock Syndrome in a Postmenopausal Woman.

Iwata Y, Iwase S.

Intern Med. 2017 Sep 15;56(18):2523-2527. doi: 10.2169/internalmedicine.8552-16. Epub 2017 Aug 21.


Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice.

Sogawa Y, Nagasu H, Iwase S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Horng T, Kashihara N.

Sci Rep. 2017 Aug 18;7(1):8801. doi: 10.1038/s41598-017-08054-2.


Conserved hydrophobic residues in the CARP/β-sheet domain of cyclase-associated protein are involved in actin monomer regulation.

Iwase S, Ono S.

Cytoskeleton (Hoboken). 2017 Sep;74(9):343-355. doi: 10.1002/cm.21385. Epub 2017 Jul 21.


Additive effect of rikkunshito, an herbal medicine, on chemotherapy-induced nausea, vomiting, and anorexia in uterine cervical or corpus cancer patients treated with cisplatin and paclitaxel: results of a randomized phase II study (JORTC KMP-02).

Ohnishi S, Watari H, Kanno M, Ohba Y, Takeuchi S, Miyaji T, Oyamada S, Nomura E, Kato H, Sugiyama T, Asaka M, Sakuragi N, Yamaguchi T, Uezono Y, Iwase S.

J Gynecol Oncol. 2017 Sep;28(5):e44. doi: 10.3802/jgo.2017.28.e44. Epub 2017 Mar 17.


Transcriptome Analysis Revealed Impaired cAMP Responsiveness in PHF21A-Deficient Human Cells.

Porter RS, Murata-Nakamura Y, Nagasu H, Kim HG, Iwase S.

Neuroscience. 2018 Feb 1;370:170-180. doi: 10.1016/j.neuroscience.2017.05.031. Epub 2017 May 29.


The Superiority of Vonoprazan-based First-line Triple Therapy with Clarithromycin: A Prospective Multi-center Cohort Study on Helicobacter pylori Eradication.

Sue S, Kuwashima H, Iwata Y, Oka H, Arima I, Fukuchi T, Sanga K, Inokuchi Y, Ishii Y, Kanno M, Terada M, Amano H, Naito M, Iwase S, Okazaki H, Komatsu K, Kokawa A, Kawana I, Morimoto M, Saito T, Kunishi Y, Ikeda A, Takahashi D, Miwa H, Sasaki T, Tamura T, Kondo M, Shibata W, Maeda S.

Intern Med. 2017;56(11):1277-1285. doi: 10.2169/internalmedicine.56.7833. Epub 2017 Jun 1.


Predictors of Delirium in Corticosteroid-Treated Patients with Advanced Cancer: An Exploratory, Multicenter, Prospective, Observational Study.

Matsuo N, Morita T, Matsuda Y, Okamoto K, Matsumoto Y, Kaneishi K, Odagiri T, Sakurai H, Katayama H, Mori I, Yamada H, Watanabe H, Yokoyama T, Yamaguchi T, Nishi T, Shirado A, Hiramoto S, Watanabe T, Kohara H, Shimoyama S, Aruga E, Baba M, Sumita K, Iwase S.

J Palliat Med. 2017 Apr;20(4):352-359. doi: 10.1089/jpm.2016.0323. Epub 2017 Feb 28.


Intracellular oxygen tension limits muscle contraction-induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion.

Takakura H, Ojino M, Jue T, Yamada T, Furuichi Y, Hashimoto T, Iwase S, Masuda K.

Physiol Rep. 2017 Jan;5(2). pii: e13112. doi: 10.14814/phy2.13112.


Japanese translation and linguistic validation of the US National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE).

Miyaji T, Iioka Y, Kuroda Y, Yamamoto D, Iwase S, Goto Y, Tsuboi M, Odagiri H, Tsubota Y, Kawaguchi T, Sakata N, Basch E, Yamaguchi T.

J Patient Rep Outcomes. 2017;1(1):8. doi: 10.1186/s41687-017-0012-7. Epub 2017 Dec 5.


Predictors of response to corticosteroids for dyspnea in advanced cancer patients: a preliminary multicenter prospective observational study.

Mori M, Shirado AN, Morita T, Okamoto K, Matsuda Y, Matsumoto Y, Yamada H, Sakurai H, Aruga E, Kaneishi K, Watanabe H, Yamaguchi T, Odagiri T, Hiramoto S, Kohara H, Matsuo N, Katayama H, Nishi T, Matsui T, Iwase S.

Support Care Cancer. 2017 Apr;25(4):1169-1181. doi: 10.1007/s00520-016-3507-5. Epub 2016 Nov 29.


Yin-yang actions of histone methylation regulatory complexes in the brain.

Garay PM, Wallner MA, Iwase S.

Epigenomics. 2016 Dec;8(12):1689-1708. Epub 2016 Nov 18. Review.


Revised guideline for the diagnosis and treatment of acquired idiopathic generalized anhidrosis in Japan.

Munetsugu T, Fujimoto T, Oshima Y, Sano K, Murota H, Satoh T, Iwase S, Asahina M, Nakazato Y, Yokozeki H.

J Dermatol. 2017 Apr;44(4):394-400. doi: 10.1111/1346-8138.13649. Epub 2016 Oct 24.


Quality of life and functional status of terminally ill head and neck cancer patients: a nation-wide, prospective observational study at tertiary cancer centers in Japan.

Shinozaki T, Ebihara M, Iwase S, Yamaguchi T, Hirakawa H, Shimbashi W, Kamijo T, Okamoto M, Beppu T, Ohori J, Matsuura K, Suzuki M, Nishino H, Sato Y, Ishiki H.

Jpn J Clin Oncol. 2017 Jan;47(1):47-53. doi: 10.1093/jjco/hyw138. Epub 2016 Sep 27.


Predictors of responses to corticosteroids for anorexia in advanced cancer patients: a multicenter prospective observational study.

Matsuo N, Morita T, Matsuda Y, Okamoto K, Matsumoto Y, Kaneishi K, Odagiri T, Sakurai H, Katayama H, Mori I, Yamada H, Watanabe H, Yokoyama T, Yamaguchi T, Nishi T, Shirado A, Hiramoto S, Watanabe T, Kohara H, Shimoyama S, Aruga E, Baba M, Sumita K, Iwase S.

Support Care Cancer. 2017 Jan;25(1):41-50. Epub 2016 Aug 18.


Corrigendum to "Interferon-α repressed telomerase along with G1-accumulation of Daudi cells" [Cancer Letters 142 (1) (1999) 23-30].

Akiyama M, Iwase S, Horiguchi-Yamada J, Saito S, Furukawa Y, Yamada O, Mizoguchi H, Ohno T, Yamada H.

Cancer Lett. 2016 Oct 1;380(2):611. doi: 10.1016/j.canlet.2016.07.025. Epub 2016 Jul 26. No abstract available.


Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells.

Wei G, Deng X, Agarwal S, Iwase S, Disteche C, Xu J.

J Mol Neurosci. 2016 Sep;60(1):33-45. doi: 10.1007/s12031-016-0770-3. Epub 2016 Jul 16.


Cancer Transitional Care for Terminally Ill Cancer Patients Can Reduce the Number of Emergency Admissions and Emergency Department Visits.

Shimada N, Ishiki H, Iwase S, Chiba T, Fujiwara N, Watanabe A, Kinkawa J, Nojima M, Tojo A, Imai K.

Am J Hosp Palliat Care. 2017 Nov;34(9):831-837. doi: 10.1177/1049909116658641. Epub 2016 Jul 13.


Predictors of Responses to Corticosteroids for Cancer-Related Fatigue in Advanced Cancer Patients: A Multicenter, Prospective, Observational Study.

Matsuo N, Morita T, Matsuda Y, Okamoto K, Matsumoto Y, Kaneishi K, Odagiri T, Sakurai H, Katayama H, Mori I, Yamada H, Watanabe H, Yokoyama T, Yamaguchi T, Nishi T, Shirado A, Hiramoto S, Watanabe T, Kohara H, Shimoyama S, Aruga E, Baba M, Sumita K, Iwase S.

J Pain Symptom Manage. 2016 Jul;52(1):64-72. doi: 10.1016/j.jpainsymman.2016.01.015. Epub 2016 May 24.


Differences in autonomic neural activity during exercise between the second and third trimesters of pregnancy.

Nakagaki A, Inami T, Minoura T, Baba R, Iwase S, Sato M.

J Obstet Gynaecol Res. 2016 Aug;42(8):951-9. doi: 10.1111/jog.12990. Epub 2016 Apr 28.


An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability.

Labonne JD, Lee KH, Iwase S, Kong IK, Diamond MP, Layman LC, Kim CH, Kim HG.

Hum Genet. 2016 Jul;135(7):757-71. doi: 10.1007/s00439-016-1668-4. Epub 2016 Apr 22.


Respiratory modulation of human autonomic function: long-term neuroplasticity in space.

Eckberg DL, Diedrich A, Cooke WH, Biaggioni I, Buckey JC Jr, Pawelczyk JA, Ertl AC, Cox JF, Kuusela TA, Tahvanainen KU, Mano T, Iwase S, Baisch FJ, Levine BD, Adams-Huet B, Robertson D, Blomqvist CG.

J Physiol. 2016 Oct 1;594(19):5629-46. doi: 10.1113/JP271656. Epub 2016 Jul 26.


Respiratory modulation of human autonomic function on Earth.

Eckberg DL, Cooke WH, Diedrich A, Biaggioni I, Buckey JC Jr, Pawelczyk JA, Ertl AC, Cox JF, Kuusela TA, Tahvanainen KU, Mano T, Iwase S, Baisch FJ, Levine BD, Adams-Huet B, Robertson D, Blomqvist CG.

J Physiol. 2016 Oct 1;594(19):5611-27. doi: 10.1113/JP271654. Epub 2016 Jul 26. Erratum in: J Physiol. 2018 Apr 1;596(7):1309.


Use of olanzapine for the relief of nausea and vomiting in patients with advanced cancer: a multicenter survey in Japan.

Kaneishi K, Nishimura K, Sakurai N, Imai K, Matsuo N, Takahashi N, Okamoto K, Suga A, Sano H, Maeda I, Nishina H, Yamaguchi T, Morita T, Iwase S.

Support Care Cancer. 2016 Jun;24(6):2393-5. doi: 10.1007/s00520-016-3101-x. Epub 2016 Feb 2.


A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation.

Iwase S, Brookes E, Agarwal S, Badeaux AI, Ito H, Vallianatos CN, Tomassy GS, Kasza T, Lin G, Thompson A, Gu L, Kwan KY, Chen C, Sartor MA, Egan B, Xu J, Shi Y.

Cell Rep. 2016 Feb 9;14(5):1000-1009. doi: 10.1016/j.celrep.2015.12.091. Epub 2016 Jan 21.

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