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Factors contributing to the systemic clearance of infliximab with long-term administration in Japanese patients with Crohn's disease: Analysis using population pharmacokinetics

Matsuoka K, Hamada S, Shimizu M, Nanki K, Mizuno S, Kiyohara H, Arai M, Sugimoto S, Iwao Y, Ogata H, Hisamatsu T, Nagauma M, Kanai T, Mochizuki M, Hashiguchi M.

Int J Clin Pharmacol Ther. 2019 Oct 28. doi: 10.5414/CP203569. [Epub ahead of print]


Controlled-Release Fine Particles Prepared by Melt Adsorption for Orally Disintegrating Tablets.

Shiino K, Oshima T, Sonoda R, Kimura SI, Itai S, Iwao Y.

Chem Pharm Bull (Tokyo). 2019;67(10):1152-1159. doi: 10.1248/cpb.c19-00554.


Development of muco-adhesive orally disintegrating tablets containing tamarind gum-coated tea powders for oral care.

Kiniwa R, Miyake M, Kimura SI, Itai S, Kondo H, Iwao Y.

Int J Pharm X. 2019 Apr 4;1:100012. doi: 10.1016/j.ijpx.2019.100012. eCollection 2019 Dec.


Fabrication of Zero-Order Sustained-Release Floating Tablets via Fused Depositing Modeling 3D Printer.

Kimura SI, Ishikawa T, Iwao Y, Itai S, Kondo H.

Chem Pharm Bull (Tokyo). 2019;67(9):992-999. doi: 10.1248/cpb.c19-00290.


Crystal Structures of Flavone C-Glycosides from Oolong Tea Leaves: Chafuroside A Dihydrate and Chafuroside B Monohydrate.

Iwao Y, Ishida H, Kimura SI, Wakimoto T, Kondo H, Itai S, Noguchi S.

Chem Pharm Bull (Tokyo). 2019;67(9):935-939. doi: 10.1248/cpb.c19-00166.


Pancreatic fat content may increase the risk of imaging progression in low-risk branch duct intraductal papillary mucinous neoplasm.

Kashiwagi K, Minami K, Seino T, Hirata K, Iwasaki E, Inoue N, Iwao Y, Kanai T.

J Dig Dis. 2019 Oct;20(10):557-562. doi: 10.1111/1751-2980.12801. Epub 2019 Aug 30.


Physiological polyspermy: Selection of a sperm nucleus for the development of diploid genomes in amphibians.

Iwao Y, Kimoto C, Fujimoto A, Suda A, Hara Y.

Mol Reprod Dev. 2019 Jul 16. doi: 10.1002/mrd.23235. [Epub ahead of print] Review.


Intramucosal poorly differentiated and signet-ring cell components in patients with ulcerative colitis-associated high-grade dysplasia.

Sugimoto S, Shimoda M, Iwao Y, Mutaguchi M, Nanki K, Mizuno S, Kameyama K, Ogata H, Naganuma M, Kanai T.

Dig Endosc. 2019 Nov;31(6):706-711. doi: 10.1111/den.13482. Epub 2019 Aug 22.


Predictive model for survival after liver resection for noncolorectal liver metastases in the modern era: a Japanese multicenter analysis.

Wakabayashi T, Hibi T, Yoneda G, Iwao Y, Sawada Y, Hoshino H, Uemura S, Ban D, Kudo A, Takemura Y, Mishima K, Shinoda M, Itano O, Otsubo T, Endo I, Kitagawa Y, Tanabe M, Egawa H, Yamamoto M.

J Hepatobiliary Pancreat Sci. 2019 Oct;26(10):441-448. doi: 10.1002/jhbp.654. Epub 2019 Jul 28.


Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis.

Yoshimatsu Y, Naganuma M, Sugimoto S, Tanemoto S, Umeda S, Fukuda T, Nomura E, Yoshida K, Ono K, Mutaguchi M, Nanki K, Mizuno S, Mikami Y, Fukuhara K, Sujino T, Takabayashi K, Ogata H, Iwao Y, Kanai T.

Digestion. 2019 Jun 25:1-7. doi: 10.1159/000501152. [Epub ahead of print]


Comparative study of alternative Geant4 hadronic ion inelastic physics models for prediction of positron-emitting radionuclide production in carbon and oxygen ion therapy.

Chacon A, Guatelli S, Rutherford H, Bolst D, Mohammadi A, Ahmed A, Nitta M, Nishikido F, Iwao Y, Tashima H, Yoshida E, Akamatsu G, Takyu S, Kitagawa A, Hofmann T, Pinto M, Franklin DR, Parodi K, Yamaya T, Rosenfeld A, Safavi-Naeini M.

Phys Med Biol. 2019 Aug 7;64(15):155014. doi: 10.1088/1361-6560/ab2752.


Difference in the clinical characteristic and prognosis of colitis-associated cancer and sporadic neoplasia in ulcerative colitis patients.

Mutaguchi M, Naganuma M, Sugimoto S, Fukuda T, Nanki K, Mizuno S, Hosoe N, Shimoda M, Ogata H, Iwao Y, Kanai T.

Dig Liver Dis. 2019 Sep;51(9):1257-1264. doi: 10.1016/j.dld.2019.05.003.


Range verification of radioactive ion beams of 11C and 15O using in-beam PET imaging.

Mohammadi A, Tashima H, Iwao Y, Takyu S, Akamatsu G, Nishikido F, Yoshida E, Kitagawa A, Parodi K, Yamaya T.

Phys Med Biol. 2019 Jul 16;64(14):145014. doi: 10.1088/1361-6560/ab25ce.


Seated versus supine: consideration of the optimum measurement posture for brain-dedicated PET.

Iwao Y, Tashima H, Yoshida E, Nishikido F, Ida T, Yamaya T.

Phys Med Biol. 2019 Jun 10;64(12):125003. doi: 10.1088/1361-6560/ab221d.


Clinical and endoscopic findings to assist the early detection of duodenal adenoma and adenocarcinoma.

Matsuzaki J, Suzuki H, Shimoda M, Mori H, Fukuhara S, Miyoshi S, Masaoka T, Iwao Y, Kanai Y, Kanai T.

United European Gastroenterol J. 2019 Mar;7(2):250-260. doi: 10.1177/2050640618817689. Epub 2018 Dec 3.


Novel Dissolution Approach for Tacrolimus-Loaded Microspheres Using a Dialysis Membrane for in Vitro-in Vivo Correlation.

Kaihara M, Hojo K, Tajiri T, Kambayashi A, Yoshida T, Katakawa Y, Motonaga K, Kimura SI, Iwao Y, Kondo H.

Chem Pharm Bull (Tokyo). 2019;67(5):467-475. doi: 10.1248/cpb.c18-01018.


Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine.

Akiyama S, Matsuoka K, Fukuda K, Hamada S, Shimizu M, Nanki K, Mizuno S, Kiyohara H, Arai M, Sugimoto S, Iwao Y, Ogata H, Hisamatsu T, Naganuma M, Motobayashi M, Suzuki K, Takenaka K, Fujii T, Saito E, Nagahori M, Ohtsuka K, Mochizuki M, Watanabe M, Hashiguchi M, Kanai T.

J Gastroenterol Hepatol. 2019 Oct;34(10):1751-1757. doi: 10.1111/jgh.14693. Epub 2019 Jun 26.


In vivo temperature-sensitive drug release system trigged by cooling using low-melting-point microcrystalline wax.

Matsumoto K, Kimura SI, Itai S, Kondo H, Iwao Y.

J Control Release. 2019 Jun 10;303:281-288. doi: 10.1016/j.jconrel.2019.04.029. Epub 2019 Apr 23.


Monte Carlo investigation of the characteristics of radioactive beams for heavy ion therapy.

Chacon A, Safavi-Naeini M, Bolst D, Guatelli S, Franklin DR, Iwao Y, Akamatsu G, Tashima H, Yoshida E, Nishikido F, Kitagawa A, Mohammadi A, Gregoire MC, Yamaya T, Rosenfeld AB.

Sci Rep. 2019 Apr 25;9(1):6537. doi: 10.1038/s41598-019-43073-1.


Negative effect of fatty liver on visualization of pancreatic cystic lesions at screening transabdominal ultrasonography.

Kashiwagi K, Seino T, Makino K, Shimizu-Hirota R, Takayama M, Yoshida T, Iwasaki E, Sugino Y, Inoue N, Iwao Y, Kanai T.

J Eval Clin Pract. 2019 Apr 22. doi: 10.1111/jep.13138. [Epub ahead of print]


Performance evaluation of a whole-body prototype PET scanner with four-layer DOI detectors.

Akamatsu G, Tashima H, Iwao Y, Wakizaka H, Maeda T, Mohammadi A, Takyu S, Nitta M, Nishikido F, Rutherford H, Chacon A, Safavi-Naeini M, Yoshida E, Yamaya T.

Phys Med Biol. 2019 Apr 29;64(9):095014. doi: 10.1088/1361-6560/ab18b2.


Right Ventricle-Specific Three-Dimensional Wall Motion Tracking for Visualization of Regional Wall Motion Abnormality in Patients With Pulmonary Arterial Hypertension.

Moriyama H, Murata M, Kataoka M, Kawakami T, Endo J, Kohno T, Itabashi Y, Seo Y, Iwao Y, Fukuda K.

Circ Cardiovasc Imaging. 2019 Apr;12(4):e008795. doi: 10.1161/CIRCIMAGING.118.008795. No abstract available.


Mechanism of Drug Release From Temperature-Sensitive Formulations Composed of Low-Melting-Point Microcrystalline Wax.

Matsumoto K, Kimura SI, Noguchi S, Itai S, Kondo H, Iwao Y.

J Pharm Sci. 2019 Jun;108(6):2086-2093. doi: 10.1016/j.xphs.2019.01.010. Epub 2019 Jan 21.


First prototyping of a dedicated PET system with the hemisphere detector arrangement.

Tashima H, Yoshida E, Iwao Y, Wakizaka H, Maeda T, Seki C, Kimura Y, Takado Y, Higuchi M, Suhara T, Yamashita T, Yamaya T.

Phys Med Biol. 2019 Mar 8;64(6):065004. doi: 10.1088/1361-6560/ab012c.


The electrical block to polyspermy induced by an intracellular Ca2+ increase at fertilization of the clawed frogs, Xenopus laevis and Xenopus tropicalis.

Watabe M, Izaki K, Fujino S, Maruyama M, Kojima C, Hiraiwa A, Ueno S, Iwao Y.

Mol Reprod Dev. 2019 Apr;86(4):387-403. doi: 10.1002/mrd.23115. Epub 2019 Jan 25.


Dose reconstruction from PET images in carbon ion therapy: a deconvolution approach.

Hofmann T, Pinto M, Mohammadi A, Nitta M, Nishikido F, Iwao Y, Tashima H, Yoshida E, Chacon A, Safavi-Naeini M, Rosenfeld A, Yamaya T, Parodi K.

Phys Med Biol. 2019 Jan 10;64(2):025011. doi: 10.1088/1361-6560/aaf676.


A multimodal (FACILE) classification for optical diagnosis of inflammatory bowel disease associated neoplasia.

Iacucci M, McQuaid K, Gui XS, Iwao Y, Lethebe BC, Lowerison M, Matsumoto T, Shivaji UN, Smith SCL, Subramanian V, Uraoka T, Sanduleanu S, Ghosh S, Kiesslich R.

Endoscopy. 2019 Feb;51(2):133-141. doi: 10.1055/a-0757-7759. Epub 2018 Dec 12.


Combination of Roll Grinding and High-Pressure Homogenization Can Prepare Stable Bicelles for Drug Delivery.

Matsuo S, Higashi K, Moribe K, Kimura SI, Itai S, Kondo H, Iwao Y.

Nanomaterials (Basel). 2018 Dec 3;8(12). pii: E998. doi: 10.3390/nano8120998.


5-Aminosalicylic acid aggravates colitis mimicking exacerbation of ulcerative colitis.

Miyoshi J, Matsuoka K, Yoshida A, Naganuma M, Hisamatsu T, Yajima T, Inoue N, Okamoto S, Iwao Y, Ogata H, Ueno F, Hibi T, Kanai T.

Intest Res. 2018 Oct;16(4):635-640. doi: 10.5217/ir.2018.00015. Epub 2018 Oct 10.


Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease.

Matsuoka K, Hamada S, Shimizu M, Nanki K, Mizuno S, Kiyohara H, Arai M, Sugimoto S, Iwao Y, Ogata H, Hisamatsu T, Naganuma M, Kanai T, Mochizuki M, Hashiguchi M.

PLoS One. 2018 Oct 4;13(10):e0204632. doi: 10.1371/journal.pone.0204632. eCollection 2018.


Efficacy of Therapeutic Intervention for Patients With an Ulcerative Colitis Mayo Endoscopic Score of 1.

Fukuda T, Naganuma M, Sugimoto S, Ono K, Nanki K, Mizuno S, Kimura K, Mutaguchi M, Nakazato Y, Takabayashi K, Inoue N, Ogata H, Iwao Y, Kanai T.

Inflamm Bowel Dis. 2019 Mar 14;25(4):782-788. doi: 10.1093/ibd/izy300.


Pancreatic Fat Content Detected by Computed Tomography and Its Significant Relationship With Intraductal Papillary Mucinous Neoplasm.

Kashiwagi K, Seino T, Fukuhara S, Minami K, Horibe M, Iwasaki E, Takaishi H, Itoh K, Sugino Y, Inoue N, Iwao Y, Kanai T.

Pancreas. 2018 Oct;47(9):1087-1092. doi: 10.1097/MPA.0000000000001103.


Integrated treatment using intraperitoneal radioimmunotherapy and positron emission tomography-guided surgery with 64Cu-labeled cetuximab to treat early- and late-phase peritoneal dissemination in human gastrointestinal cancer xenografts.

Yoshii Y, Yoshimoto M, Matsumoto H, Tashima H, Iwao Y, Takuwa H, Yoshida E, Wakizaka H, Yamaya T, Zhang MR, Sugyo A, Hanadate S, Tsuji AB, Higashi T.

Oncotarget. 2018 Jun 22;9(48):28935-28950. doi: 10.18632/oncotarget.25649. eCollection 2018 Jun 22.


Phase transitions of antibiotic clarithromycin forms I, IV and new form VII crystals.

Ito M, Shiba R, Watanabe M, Iwao Y, Itai S, Noguchi S.

Int J Pharm. 2018 Aug 25;547(1-2):258-264. doi: 10.1016/j.ijpharm.2018.05.073. Epub 2018 Jun 1.


Stabilization Mechanism of Roxithromycin Tablets Under Gastric pH Conditions.

Inukai K, Noguchi S, Kimura SI, Itai S, Iwao Y.

J Pharm Sci. 2018 Sep;107(9):2514-2518. doi: 10.1016/j.xphs.2018.05.014. Epub 2018 May 31.


The Study of Nursing NAVI.

Iwao Y, Tsuru S, Omori M, Inoue M.

Stud Health Technol Inform. 2018;250:91-92.


Use of Mixer Torque Rheometer to Clarify the Relationship between the Kneading States of Wet Mass and the Dissolution of Final Product in High Shear Granulation.

Otsuka T, Kuroiwa Y, Sato K, Yamashita K, Hakomori T, Kimura SI, Iwao Y, Itai S.

Chem Pharm Bull (Tokyo). 2018;66(5):554-561. doi: 10.1248/cpb.c17-01040.


Mechanism of the formation of hollow spherical granules using a high shear granulator.

Asada T, Nishikawa M, Ochiai Y, Noguchi S, Kimura SI, Iwao Y, Itai S.

Eur J Pharm Sci. 2018 May 30;117:371-378. doi: 10.1016/j.ejps.2018.03.009. Epub 2018 Mar 7.


Formulation of a poorly water-soluble drug in sustained-release hollow granules with a high viscosity water-soluble polymer using a fluidized bed rotor granulator.

Asada T, Yoshihara N, Ochiai Y, Kimura SI, Iwao Y, Itai S.

Int J Pharm. 2018 Apr 25;541(1-2):246-252. doi: 10.1016/j.ijpharm.2018.02.043. Epub 2018 Feb 27.


Effects of tablet formulation and subsequent film coating on the supersaturated dissolution behavior of amorphous solid dispersions.

Sakai T, Hirai D, Kimura SI, Iwao Y, Itai S.

Int J Pharm. 2018 Apr 5;540(1-2):171-177. doi: 10.1016/j.ijpharm.2018.02.013. Epub 2018 Feb 12.


Inflamed site-specific drug delivery system based on the interaction of human serum albumin nanoparticles with myeloperoxidase in a murine model of experimental colitis.

Iwao Y, Tomiguchi I, Domura A, Mantaira Y, Minami A, Suzuki T, Ikawa T, Kimura SI, Itai S.

Eur J Pharm Biopharm. 2018 Apr;125:141-147. doi: 10.1016/j.ejpb.2018.01.016. Epub 2018 Jan 31.


Roles of the three Mycobacterium smegmatis katG genes for peroxide detoxification and isoniazid susceptibility.

Iwao Y, Nakata N.

Microbiol Immunol. 2018 Mar;62(3):158-167. doi: 10.1111/1348-0421.12574.


A Scale-up Approach for Film Coating Process Based on Surface Roughness as the Critical Quality Attribute.

Yoshino H, Hara Y, Dohi M, Yamashita K, Hakomori T, Kimura SI, Iwao Y, Itai S.

AAPS PharmSciTech. 2018 Apr;19(3):1243-1253. doi: 10.1208/s12249-017-0940-9. Epub 2018 Jan 5.


The impact of visceral adipose tissue as best predictor for difficult colonoscopy and the clinical utility of a long small-caliber scope as rescue.

Kashiwagi K, Inoue N, Yoshida T, Bessho R, Yoneno K, Imaeda H, Ogata H, Kanai T, Sugino Y, Iwao Y.

PLoS One. 2017 Dec 21;12(12):e0189817. doi: 10.1371/journal.pone.0189817. eCollection 2017.


Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis.

Iwao Y, Ojima H, Kobayashi T, Kishi Y, Nara S, Esaki M, Shimada K, Hiraoka N, Tanabe M, Kanai Y.

World J Hepatol. 2017 Nov 18;9(32):1227-1238. doi: 10.4254/wjh.v9.i32.1227.


New scale-down methodology from commercial to lab scale to optimize plant-derived soft gel capsule formulations on a commercial scale.

Oishi S, Kimura SI, Noguchi S, Kondo M, Kondo Y, Shimokawa Y, Iwao Y, Itai S.

Int J Pharm. 2018 Jan 15;535(1-2):371-378. doi: 10.1016/j.ijpharm.2017.11.029. Epub 2017 Nov 14.


The role of colorectal endoscopic submucosal dissection in patients with ulcerative colitis.

Kinoshita S, Uraoka T, Nishizawa T, Naganuma M, Iwao Y, Ochiai Y, Fujimoto A, Goto O, Shimoda M, Ogata H, Kanai T, Yahagi N.

Gastrointest Endosc. 2018 Apr;87(4):1079-1084. doi: 10.1016/j.gie.2017.10.035. Epub 2017 Nov 6.


Genomic comparison between Staphylococcus aureus GN strains clinically isolated from a familial infection case: IS1272 transposition through a novel inverted repeat-replacing mechanism.

Wan TW, Higuchi W, Khokhlova OE, Hung WC, Iwao Y, Wakayama M, Inomata N, Takano T, Lin YT, Peryanova OV, Kojima KK, Salmina AB, Teng LJ, Yamamoto T.

PLoS One. 2017 Nov 8;12(11):e0187288. doi: 10.1371/journal.pone.0187288. eCollection 2017.


The risk factor of clinical relapse in ulcerative colitis patients with low dose 5-aminosalicylic acid as maintenance therapy: A report from the IBD registry.

Fukuda T, Naganuma M, Sugimoto S, Nanki K, Mizuno S, Mutaguchi M, Nakazato Y, Inoue N, Ogata H, Iwao Y, Kanai T.

PLoS One. 2017 Nov 6;12(11):e0187737. doi: 10.1371/journal.pone.0187737. eCollection 2017.


Dual Therapeutic Effects of an Albumin-Based Nitric Oxide Donor on 2 Experimental Models of Chronic Kidney Disease.

Oshiro S, Ishima Y, Maeda H, Honda N, Bi J, Kinoshita R, Ikeda M, Iwao Y, Imafuku T, Nishida K, Miyamura S, Watanabe H, Otagiri M, Maruyama T.

J Pharm Sci. 2018 Mar;107(3):848-855. doi: 10.1016/j.xphs.2017.10.023. Epub 2017 Oct 24.


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