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Items: 1 to 50 of 169

1.

Oncostatin-M-Reactive Pericytes Aggravate Blood-Brain Barrier Dysfunction by Activating JAK/STAT3 Signaling In Vitro.

Takata F, Dohgu S, Sakaguchi S, Sakai K, Yamanaka G, Iwao T, Matsumoto J, Kimura I, Sezaki Y, Tanaka Y, Yamauchi A, Kataoka Y.

Neuroscience. 2019 Nov 6. pii: S0306-4522(19)30700-6. doi: 10.1016/j.neuroscience.2019.10.014. [Epub ahead of print]

PMID:
31705893
2.

Pancreaticoduodenectomy following total occlusion of the superior mesenteric artery: a case report and literature review.

Ohtsuka R, Amano H, Hashimoto M, Iwao T.

Surg Case Rep. 2019 Nov 4;5(1):168. doi: 10.1186/s40792-019-0718-2.

PMID:
31686292
3.

Oligodendrocytes upregulate blood-brain barrier function through mechanisms other than the PDGF-BB/PDGFRα pathway in the barrier-tightening effect of oligodendrocyte progenitor cells.

Kimura I, Dohgu S, Takata F, Matsumoto J, Watanabe T, Iwao T, Yamauchi A, Kataoka Y.

Neurosci Lett. 2019 Oct 31:134594. doi: 10.1016/j.neulet.2019.134594. [Epub ahead of print]

PMID:
31678431
4.

[Generation of human iPS cell-derived hepatocytes and enterocytes for application to drug disposition studies].

Iwao T, Matsunaga T.

Nihon Yakurigaku Zasshi. 2019;154(2):72-77. doi: 10.1254/fpj.154.72. Review. Japanese.

PMID:
31406046
5.

Development of an in vitro cholestatic drug-induced liver injury evaluation system using HepG2-hNTCP-C4 cells in sandwich configuration.

Sakai Y, Okumura H, Iwao T, Watashi K, Ito K, Matsunaga T.

Toxicol In Vitro. 2019 Dec;61:104619. doi: 10.1016/j.tiv.2019.104619. Epub 2019 Aug 5.

PMID:
31394163
6.

In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome.

Sakai Y, Iwao T, Susukida T, Nukaga T, Takemura A, Sekine S, Ito K, Matsunaga T.

Drug Metab Pharmacokinet. 2019 Aug;34(4):264-271. doi: 10.1016/j.dmpk.2019.04.004. Epub 2019 May 10.

PMID:
31285099
7.

Isolation of induced pluripotent stem cell-derived endothelial progenitor cells from sac-like structures.

Aoki H, Yamashita M, Hashita T, Nakayama M, Yagi M, Iwao T, Matsunaga T.

Biochem Biophys Res Commun. 2019 Aug 6;515(4):672-678. doi: 10.1016/j.bbrc.2019.05.179. Epub 2019 Jun 7.

PMID:
31178142
8.

Comparison of mRNA expression profiles of drug-metabolizing enzymes and transporters in fresh and cryopreserved cynomolgus monkey hepatocytes.

Koeda A, Iwao T, Nakanishi A, Mizuno S, Yamashita M, Sakai Y, Nakamura K, Matsunaga T.

Drug Metab Pharmacokinet. 2019 Aug;34(4):253-263. doi: 10.1016/j.dmpk.2019.04.003. Epub 2019 Apr 11.

PMID:
31174977
9.

Clinical features of isolated proximal-type immunoglobulin G4-related sclerosing cholangitis.

Takagi Y, Kubota K, Takayanagi T, Kurita Y, Ishii K, Hasegawa S, Iwasaki A, Sato T, Fujita Y, Kato S, Kagawa K, Watanabe S, Sekino Y, Hosono K, Matsuhashi N, Yamanaka S, Iwao T, Yoshida K, Nakajima A.

Dig Endosc. 2019 Jul;31(4):422-430. doi: 10.1111/den.13320. Epub 2019 Feb 11.

PMID:
30570170
10.

Theoretical evaluation of thermal decomposition of dichlorosilane for plasma-enhanced atomic layer deposition of silicon nitride: the important role of surface hydrogen.

Hartmann G, Ventzek PLG, Iwao T, Ishibashi K, Hwang GS.

Phys Chem Chem Phys. 2018 Nov 28;20(46):29152-29158. doi: 10.1039/c8cp06272b.

PMID:
30426994
11.

Contribution of rat embryonic stem cells to xenogeneic chimeras in blastocyst or 8-cell embryo injection and aggregation.

Okumura H, Nakanishi A, Toyama S, Yamanoue M, Yamada K, Ukai A, Hashita T, Iwao T, Miyamoto T, Tagawa YI, Hirabayashi M, Miyoshi I, Matsunaga T.

Xenotransplantation. 2019 Jan;26(1):e12468. doi: 10.1111/xen.12468. Epub 2018 Oct 30.

PMID:
30375053
12.

Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage.

Kondo S, Mizuno S, Hashita T, Iwao T, Matsunaga T.

Inflamm Res. 2018 Dec;67(11-12):975-984. doi: 10.1007/s00011-018-1193-0. Epub 2018 Oct 13.

PMID:
30317465
13.
14.

Extraction and Standardization of Patient Complaints from Electronic Medication Histories for Pharmacovigilance: Natural Language Processing Analysis in Japanese.

Usui M, Aramaki E, Iwao T, Wakamiya S, Sakamoto T, Mochizuki M.

JMIR Med Inform. 2018 Sep 27;6(3):e11021. doi: 10.2196/11021.

15.

Effect of Celecoxib on Differentiation of Human Induced Pluripotent Stem Cells into Hepatocytes Involves STAT5 Activation.

Okumura H, Nakanishi A, Hashita T, Iwao T, Matsunaga T.

Drug Metab Dispos. 2018 Nov;46(11):1519-1527. doi: 10.1124/dmd.118.082982. Epub 2018 Aug 29.

PMID:
30158250
16.

Massive retroperitoneal hematoma following colonoscopy: A case report.

Ohtsuka R, Amano H, Niida K, Yoshino T, Owari M, Takano R, Akama Y, Watanabe Y, Iwao T.

Medicine (Baltimore). 2018 Aug;97(31):e11723. doi: 10.1097/MD.0000000000011723.

17.

Cyclic AMP Signaling Promotes the Differentiation of Human Induced Pluripotent Stem Cells into Intestinal Epithelial Cells.

Kabeya T, Qiu S, Hibino M, Nagasaki M, Kodama N, Iwao T, Matsunaga T.

Drug Metab Dispos. 2018 Oct;46(10):1411-1419. doi: 10.1124/dmd.118.082123. Epub 2018 Aug 1.

PMID:
30068521
18.

Enhancement of Warfarin Anticoagulant Reaction in Patients with Repeated Oral Tolvaptan Administration.

Saito M, Ajioka M, Iwao T, Suzuki T.

Biol Pharm Bull. 2018 Jul 1;41(7):1014-1016. doi: 10.1248/bpb.b17-01008. Epub 2018 May 11.

19.

Efficient Generation of Cynomolgus Monkey Induced Pluripotent Stem Cell-Derived Intestinal Organoids with Pharmacokinetic Functions.

Onozato D, Yamashita M, Fukuyama R, Akagawa T, Kida Y, Koeda A, Hashita T, Iwao T, Matsunaga T.

Stem Cells Dev. 2018 Aug 1;27(15):1033-1045. doi: 10.1089/scd.2017.0216. Epub 2018 Jun 29.

PMID:
29742964
20.

Nationwide survey of severe postpartum hemorrhage in Japan: an exploratory study using the national database of health insurance claims.

Sato M, Kondoh E, Iwao T, Hiragi S, Okamoto K, Tamura H, Mogami H, Chigusa Y, Kuroda T, Mandai M, Konishi I, Kato G.

J Matern Fetal Neonatal Med. 2019 Nov;32(21):3537-3542. doi: 10.1080/14767058.2018.1465921. Epub 2018 Apr 26.

PMID:
29656684
21.

Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells.

Onozato D, Yamashita M, Nakanishi A, Akagawa T, Kida Y, Ogawa I, Hashita T, Iwao T, Matsunaga T.

Drug Metab Dispos. 2018 Nov;46(11):1572-1580. doi: 10.1124/dmd.118.080374. Epub 2018 Apr 3.

PMID:
29615438
22.

Evaluation of NISHIJIN e-textile for 12-lead ECG measurement through automatic ECG analyzer.

Kuroda T, Shiomi H, Minamino-Muta E, Yamashita Y, Iwao T, Tamura H, Ueshima K, Kimura T.

Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:1234-1237. doi: 10.1109/EMBC.2017.8037054.

PMID:
29060099
23.

Functional analysis of carboxylesterase in human induced pluripotent stem cell-derived enterocytes.

Kabeya T, Matsumura W, Iwao T, Hosokawa M, Matsunaga T.

Biochem Biophys Res Commun. 2017 Apr 22;486(1):143-148. doi: 10.1016/j.bbrc.2017.03.014. Epub 2017 Mar 8.

PMID:
28285137
24.

Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates.

Takenaka T, Kazuki K, Harada N, Kuze J, Chiba M, Iwao T, Matsunaga T, Abe S, Oshimura M, Kazuki Y.

Drug Metab Pharmacokinet. 2017 Feb;32(1):61-68. doi: 10.1016/j.dmpk.2016.08.004. Epub 2016 Aug 26.

PMID:
28139373
25.

Characteristic Analysis of Intestinal Transport in Enterocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells.

Kodama N, Iwao T, Katano T, Ohta K, Yuasa H, Matsunaga T.

Drug Metab Dispos. 2016 Oct;44(10):0. doi: 10.1124/dmd.116.069336. Epub 2016 Jul 14.

PMID:
27417181
26.

Inhibition of mitogen-activated protein kinase kinase, DNA methyltransferase, and transforming growth factor-β promotes differentiation of human induced pluripotent stem cells into enterocytes.

Kodama N, Iwao T, Kabeya T, Horikawa T, Niwa T, Kondo Y, Nakamura K, Matsunaga T.

Drug Metab Pharmacokinet. 2016 Jun;31(3):193-200. doi: 10.1016/j.dmpk.2016.02.002. Epub 2016 Feb 17.

PMID:
27161454
27.

Application of a Human Intestinal Epithelial Cell Monolayer to the Prediction of Oral Drug Absorption in Humans as a Superior Alternative to the Caco-2 Cell Monolayer.

Takenaka T, Harada N, Kuze J, Chiba M, Iwao T, Matsunaga T.

J Pharm Sci. 2016 Feb;105(2):915-924. doi: 10.1016/j.xphs.2015.11.035.

PMID:
26869436
28.

Generation of enterocyte-like cells with pharmacokinetic functions from human induced pluripotent stem cells using small-molecule compounds.

Iwao T, Kodama N, Kondo Y, Kabeya T, Nakamura K, Horikawa T, Niwa T, Kurose K, Matsunaga T.

Drug Metab Dispos. 2015 Apr;43(4):603-10. doi: 10.1124/dmd.114.062604. Epub 2015 Feb 3.

PMID:
25650381
29.

Human small intestinal epithelial cells differentiated from adult intestinal stem cells as a novel system for predicting oral drug absorption in humans.

Takenaka T, Harada N, Kuze J, Chiba M, Iwao T, Matsunaga T.

Drug Metab Dispos. 2014 Nov;42(11):1947-54. doi: 10.1124/dmd.114.059493. Epub 2014 Sep 8.

PMID:
25200868
30.

Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells.

Kondo Y, Iwao T, Yoshihashi S, Mimori K, Ogihara R, Nagata K, Kurose K, Saito M, Niwa T, Suzuki T, Miyata N, Ohmori S, Nakamura K, Matsunaga T.

PLoS One. 2014 Aug 1;9(8):e104010. doi: 10.1371/journal.pone.0104010. eCollection 2014.

31.

Meaning of upper limit of normal range of post-load 1-h plasma glucose level defined by oral glucose tolerance test in Japanese subjects.

Iwao T, Sakai K, Ando E.

J Diabetes Investig. 2013 Jul 8;4(4):372-5. doi: 10.1111/jdi.12060. Epub 2013 Apr 2.

32.

Selective culture method for hepatocyte-like cells differentiated from human induced pluripotent stem cells.

Kondo Y, Yoshihashi S, Mimori K, Ogihara R, Kanehama Y, Maki Y, Enosawa S, Kurose K, Iwao T, Nakamura K, Matsunaga T.

Drug Metab Pharmacokinet. 2014;29(5):407-13. Epub 2014 Apr 29.

34.

An efficient method for differentiation of human induced pluripotent stem cells into hepatocyte-like cells retaining drug metabolizing activity.

Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S.

Drug Metab Pharmacokinet. 2014;29(3):237-43. Epub 2013 Dec 10.

35.

Differentiation of human induced pluripotent stem cells into functional enterocyte-like cells using a simple method.

Iwao T, Toyota M, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A, Nagata K, Matsunaga T.

Drug Metab Pharmacokinet. 2014;29(1):44-51. Epub 2013 Jul 2.

36.

Upper limit of fasting plasma glucose level defined by oral glucose tolerance test in Japanese subjects.

Iwao T, Sakai K, Ando E.

Diabetes Res Clin Pract. 2013 Mar;99(3):272-6. doi: 10.1016/j.diabres.2012.12.015. Epub 2013 Jan 12.

PMID:
23317759
37.

Postprandial serum C-peptide is a useful parameter in the prediction of successful switching to liraglutide monotherapy from complex insulin therapy in Japanese patients with type 2 diabetes.

Iwao T, Sakai K, Sata M.

J Diabetes Complications. 2013 Jan-Feb;27(1):87-91. doi: 10.1016/j.jdiacomp.2012.07.001. Epub 2012 Aug 3.

PMID:
22863615
38.

Intraductal papillary neoplasm arising from peribiliary glands connecting with the inferior branch of the bile duct of the anterior segment of the liver.

Nakanishi Y, Nakanuma Y, Ohara M, Iwao T, Kimura N, Ishidate T, Kijima H.

Pathol Int. 2011 Dec;61(12):773-7. doi: 10.1111/j.1440-1827.2011.02738.x.

PMID:
22126388
39.

Hepatocyte growth factor is a significant risk factor for white matter lesions in Japanese type 2 diabetic patients.

Anan F, Masaki T, Jikumaru K, Iwao T, Eshima N, Saikawa T, Yoshimatsu H.

Eur J Clin Invest. 2010 Jul;40(7):585-90. doi: 10.1111/j.1365-2362.2010.02301.x. Epub 2010 May 23.

PMID:
20497462
40.

Association between plasma high-sensitivity C-reactive protein and insulin resistance and white matter lesions in Japanese type 2 diabetic patients.

Anan F, Masaki T, Kikuchi H, Iwao T, Shimomura T, Umeno Y, Eshima N, Saikawa T, Yoshimatsu H.

Diabetes Res Clin Pract. 2010 Feb;87(2):233-9. doi: 10.1016/j.diabres.2009.10.017. Epub 2009 Nov 20.

PMID:
19931932
41.

[Case of gallbladder cancer in which the surface structure of gallbladder was clarified using the endoscopic double contrast cholecystography].

Miyata H, Sato K, Iwao T, Yoshida K, Usio J, Sato M, Ishino A, Nagata Y, Kawase T, Nomura Y, Morimoto S, Takamori S, Ajioka Y.

Nihon Shokakibyo Gakkai Zasshi. 2009 May;106(5):684-90. Japanese.

PMID:
19420873
42.

Visceral fat accumulation is a significant risk factor for white matter lesions in Japanese type 2 diabetic patients.

Anan F, Masaki T, Eto T, Iwao T, Shimomura T, Umeno Y, Eshima N, Saikawa T, Yoshimatsu H.

Eur J Clin Invest. 2009 May;39(5):368-74. doi: 10.1111/j.1365-2362.2009.02103.x.

PMID:
19320939
43.

Early atorvastatin therapy improves cardiac function in patients with acute myocardial infarction.

Teshima Y, Yufu K, Akioka H, Iwao T, Anan F, Nakagawa M, Yonemochi H, Takahashi N, Hara M, Saikawa T.

J Cardiol. 2009 Feb;53(1):58-64. doi: 10.1016/j.jjcc.2008.08.008. Epub 2008 Oct 14.

44.

Predictors for prehypertension in patients with impaired glucose tolerance.

Anan F, Masaki T, Ono E, Eto T, Iwao T, Eshima N, Saikawa T, Yoshimatsu H.

Hypertens Res. 2008 Oct;31(10):1913-20. doi: 10.1291/hypres.31.1913.

PMID:
19015599
45.

Postchallenge plasma glucose and glycemic spikes are associated with pulse pressure in patients with impaired glucose tolerance and essential hypertension.

Anan F, Masaki T, Eto T, Fukunaga N, Iwao T, Kaneda K, Eshima N, Saikawa T, Yoshimatsu H.

Hypertens Res. 2008 Aug;31(8):1565-71. doi: 10.1291/hypres.31.1565.

PMID:
18971531
46.

The role of microalbuminuria and insulin resistance as significant risk factors for white matter lesions in Japanese type 2 diabetic patients.

Anan F, Masaki T, Iwao T, Eto T, Shimomura T, Umeno Y, Eshima N, Saikawa T, Yoshimatsu H.

Curr Med Res Opin. 2008 Jun;24(6):1561-7. doi: 10.1185/03007990802061818. Epub 2008 Apr 17.

PMID:
18423105
47.

Correlations of visceral fat accumulation and atherosclerosis in Japanese patients with type 2 diabetes mellitus.

Anan F, Masaki T, Umeno Y, Iwao T, Yonemochi H, Eshima N, Saikawa T, Yoshimatsu H.

Metabolism. 2008 Feb;57(2):280-4. doi: 10.1016/j.metabol.2007.09.013.

PMID:
18191061
48.

Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients.

Anan F, Masaki T, Umeno Y, Iwao T, Yonemochi H, Eshima N, Saikawa T, Yoshimatsu H.

Eur J Endocrinol. 2007 Sep;157(3):311-7.

PMID:
17766713
49.

Pioglitazone shift circadian rhythm of blood pressure from non-dipper to dipper type in type 2 diabetes mellitus.

Anan F, Masaki T, Fukunaga N, Teshima Y, Iwao T, Kaneda K, Umeno Y, Okada K, Wakasugi K, Yonemochi H, Eshima N, Saikawa T, Yoshimatsu H.

Eur J Clin Invest. 2007 Sep;37(9):709-14.

PMID:
17696960
50.

Effect of Lactobacillus casei on the absorption of nifedipine from rat small intestine.

Kato R, Yuasa H, Inoue K, Iwao T, Tanaka K, Ooi K, Hayashi Y.

Drug Metab Pharmacokinet. 2007 Apr;22(2):96-102.

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