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The machinery for endocytosis of epidermal growth factor receptor coordinates the transport of incoming hepatitis B virus to the endosomal network.

Iwamoto M, Saso W, Nishioka K, Ohashi H, Sugiyama R, Ryo A, Ohki M, Yun JH, Park SY, Ohshima T, Suzuki R, Aizaki H, Muramatsu M, Matano T, Iwami S, Sureau C, Wakita T, Watashi K.

J Biol Chem. 2020 Jan 17;295(3):800-807. doi: 10.1074/jbc.AC119.010366. Epub 2019 Dec 12.


Revealing uninfected and infected target cell dynamics from peripheral blood data in highly and less pathogenic simian/human immunodeficiency virus infected Rhesus macaque.

Hara A, Iwanami S, Ito Y, Miura T, Nakaoka S, Iwami S.

J Theor Biol. 2019 Oct 21;479:29-36. doi: 10.1016/j.jtbi.2019.07.005. Epub 2019 Jul 9.


Phase resetting of circadian peripheral clocks using human and rodent diets in mouse models of type 2 diabetes and chronic kidney disease.

Yasuda S, Iwami S, Tamura K, Ikeda Y, Kamagata M, Sasaki H, Haraguchi A, Miyamatsu M, Hanashi S, Takato Y, Shibata S.

Chronobiol Int. 2019 Jun;36(6):851-869. doi: 10.1080/07420528.2019.1594245. Epub 2019 Apr 16.


Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization.

Iwamoto M, Saso W, Sugiyama R, Ishii K, Ohki M, Nagamori S, Suzuki R, Aizaki H, Ryo A, Yun JH, Park SY, Ohtani N, Muramatsu M, Iwami S, Tanaka Y, Sureau C, Wakita T, Watashi K.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8487-8492. doi: 10.1073/pnas.1811064116. Epub 2019 Apr 5.


Mathematical Analysis of a Transformed ODE from a PDE Multiscale Model of Hepatitis C Virus Infection.

Kitagawa K, Kuniya T, Nakaoka S, Asai Y, Watashi K, Iwami S.

Bull Math Biol. 2019 May;81(5):1427-1441. doi: 10.1007/s11538-018-00564-y. Epub 2019 Jan 14.


Dynamics of HIV-1 coinfection in different susceptible target cell populations during cell-free infection.

Ito Y, Tauzin A, Remion A, Ejima K, Mammano F, Iwami S.

J Theor Biol. 2018 Oct 14;455:39-46. doi: 10.1016/j.jtbi.2018.06.025. Epub 2018 Jul 7.


A PDE multiscale model of hepatitis C virus infection can be transformed to a system of ODEs.

Kitagawa K, Nakaoka S, Asai Y, Watashi K, Iwami S.

J Theor Biol. 2018 Jul 7;448:80-85. doi: 10.1016/j.jtbi.2018.04.006. Epub 2018 Apr 7.


Glucagon and/or IGF-1 Production Regulates Resetting of the Liver Circadian Clock in Response to a Protein or Amino Acid-only Diet.

Ikeda Y, Kamagata M, Hirao M, Yasuda S, Iwami S, Sasaki H, Tsubosaka M, Hattori Y, Todoh A, Tamura K, Shiga K, Ohtsu T, Shibata S.

EBioMedicine. 2018 Feb;28:210-224. doi: 10.1016/j.ebiom.2018.01.012. Epub 2018 Jan 31.


Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells.

Mahgoub M, Yasunaga JI, Iwami S, Nakaoka S, Koizumi Y, Shimura K, Matsuoka M.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1269-E1278. doi: 10.1073/pnas.1715724115. Epub 2018 Jan 22.


Night eating model shows time-specific depression-like behavior in the forced swimming test.

Haraguchi A, Fukuzawa M, Iwami S, Nishimura Y, Motohashi H, Tahara Y, Shibata S.

Sci Rep. 2018 Jan 18;8(1):1081. doi: 10.1038/s41598-018-19433-8.


Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo.

Yamada E, Nakaoka S, Klein L, Reith E, Langer S, Hopfensperger K, Iwami S, Schreiber G, Kirchhoff F, Koyanagi Y, Sauter D, Sato K.

Cell Host Microbe. 2018 Jan 10;23(1):110-120.e7. doi: 10.1016/j.chom.2017.12.009.


Correction: HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation.

Nakano Y, Misawa N, Juarez-Fernandez G, Moriwaki M, Nakaoka S, Funo T, Yamada E, Soper A, Yoshikawa R, Ebrahimi D, Tachiki Y, Iwami S, Harris RS, Koyanagi Y, Sato K.

PLoS Pathog. 2017 Sep 7;13(9):e1006606. doi: 10.1371/journal.ppat.1006606. eCollection 2017 Sep.


Number of infection events per cell during HIV-1 cell-free infection.

Ito Y, Remion A, Tauzin A, Ejima K, Nakaoka S, Iwasa Y, Iwami S, Mammano F.

Sci Rep. 2017 Jul 26;7(1):6559. doi: 10.1038/s41598-017-03954-9.


Potent synchronization of peripheral circadian clocks by glucocorticoid injections in PER2::LUC-Clock/Clock mice.

Kamagata M, Ikeda Y, Sasaki H, Hattori Y, Yasuda S, Iwami S, Tsubosaka M, Ishikawa R, Todoh A, Tamura K, Tahara Y, Shibata S.

Chronobiol Int. 2017;34(8):1067-1082. doi: 10.1080/07420528.2017.1338716. Epub 2017 Jul 13.


Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments.

Ohashi H, Koizumi Y, Fukano K, Wakita T, Perelson AS, Iwami S, Watashi K.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4527-E4529. doi: 10.1073/pnas.1705234114. Epub 2017 May 16. No abstract available.


HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation.

Nakano Y, Misawa N, Juarez-Fernandez G, Moriwaki M, Nakaoka S, Funo T, Yamada E, Soper A, Yoshikawa R, Ebrahimi D, Tachiki Y, Iwami S, Harris RS, Koyanagi Y, Sato K.

PLoS Pathog. 2017 May 5;13(5):e1006348. doi: 10.1371/journal.ppat.1006348. eCollection 2017 May. Erratum in: PLoS Pathog. 2017 Sep 7;13(9):e1006606.


A highly pathogenic simian/human immunodeficiency virus effectively produces infectious virions compared with a less pathogenic virus in cell culture.

Iwanami S, Kakizoe Y, Morita S, Miura T, Nakaoka S, Iwami S.

Theor Biol Med Model. 2017 Apr 21;14(1):9. doi: 10.1186/s12976-017-0055-8.


A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation.

Fujiu K, Shibata M, Nakayama Y, Ogata F, Matsumoto S, Noshita K, Iwami S, Nakae S, Komuro I, Nagai R, Manabe I.

Nat Med. 2017 May;23(5):611-622. doi: 10.1038/nm.4326. Epub 2017 Apr 10.


Case report of a pregnant patient with systemic lupus erythematosus with uterine atony and very thin myometrium with uterine fibrosis.

Tokushige Y, Iwami S, Nonogaki T, Shibayama T, Shimada T, Minamiguchi S.

Int J Gynaecol Obstet. 2017 May;137(2):201-202. doi: 10.1002/ijgo.12118. Epub 2017 Mar 1. No abstract available.


Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection.

Koizumi Y, Ohashi H, Nakajima S, Tanaka Y, Wakita T, Perelson AS, Iwami S, Watashi K.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1922-1927. doi: 10.1073/pnas.1610197114. Epub 2017 Feb 7. Erratum in: Proc Natl Acad Sci U S A. 2017 Mar 21;114(12 ):E2540-E2541.


Association of sleep habits with blood pressure in elderly people.

Sasaki N, Ozono R, Yamashita H, Ashimen H, Miyamoto Y, Iwami S, Yuzono N, Fujiwara S, Kihara Y.

Clin Exp Hypertens. 2016;38(8):733-737. doi: 10.1080/10641963.2016.1200066. Epub 2016 Dec 12.


(In)validating experimentally derived knowledge about influenza A defective interfering particles.

Liao LE, Iwami S, Beauchemin CA.

J R Soc Interface. 2016 Nov;13(124). pii: 20160412.


Modelling Ebola virus dynamics: Implications for therapy.

Martyushev A, Nakaoka S, Sato K, Noda T, Iwami S.

Antiviral Res. 2016 Nov;135:62-73. doi: 10.1016/j.antiviral.2016.10.004. Epub 2016 Oct 12.


The involvement of central nervous system histamine receptors in psychological stress-induced exacerbation of allergic airway inflammation in mice.

Miyasaka T, Okuyama-Dobashi K, Masuda C, Iwami S, Sato M, Mizoguchi H, Kawano T, Ohkawara Y, Sakurada S, Takayanagi M, Ohno I.

Allergol Int. 2016 Sep;65 Suppl:S38-44. doi: 10.1016/j.alit.2016.05.015. Epub 2016 Aug 11.


Forced rather than voluntary exercise entrains peripheral clocks via a corticosterone/noradrenaline increase in PER2::LUC mice.

Sasaki H, Hattori Y, Ikeda Y, Kamagata M, Iwami S, Yasuda S, Tahara Y, Shibata S.

Sci Rep. 2016 Jun 8;6:27607. doi: 10.1038/srep27607.


Phase shifts in circadian peripheral clocks caused by exercise are dependent on the feeding schedule in PER2::LUC mice.

Sasaki H, Hattori Y, Ikeda Y, Kamagata M, Iwami S, Yasuda S, Shibata S.

Chronobiol Int. 2016;33(7):849-62. doi: 10.3109/07420528.2016.1171775. Epub 2016 Apr 28.


Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model.

Ikeda H, Nakaoka S, de Boer RJ, Morita S, Misawa N, Koyanagi Y, Aihara K, Sato K, Iwami S.

Retrovirology. 2016 Apr 18;13:23. doi: 10.1186/s12977-016-0252-2.


Dynamics of HIV infection in lymphoid tissue network.

Nakaoka S, Iwami S, Sato K.

J Math Biol. 2016 Mar;72(4):909-938. doi: 10.1007/s00285-015-0940-x. Epub 2015 Oct 27.


Corrigendum: Quantifying the Antiviral Effect of IFN on HIV-1 Replication in Cell Culture.

Ikeda H, Godinho-Santos A, Rato S, Vanwalscappel B, Clavel F, Aihara K, Iwami S, Mammano F.

Sci Rep. 2015 Oct 22;5:15679. doi: 10.1038/srep15679. No abstract available.


Dynamically rich, yet parameter-sparse models for spatial epidemiology: Comment on "Coupled disease-behavior dynamics on complex networks: A review" by Z. Wang et al.

Jusup M, Iwami S, Podobnik B, Stanley HE.

Phys Life Rev. 2015 Dec;15:43-6. doi: 10.1016/j.plrev.2015.09.006. Epub 2015 Oct 9. No abstract available.


Cell-to-cell infection by HIV contributes over half of virus infection.

Iwami S, Takeuchi JS, Nakaoka S, Mammano F, Clavel F, Inaba H, Kobayashi T, Misawa N, Aihara K, Koyanagi Y, Sato K.

Elife. 2015 Oct 6;4. doi: 10.7554/eLife.08150.


Pandemic HIV-1 Vpu overcomes intrinsic herd immunity mediated by tetherin.

Iwami S, Sato K, Morita S, Inaba H, Kobayashi T, Takeuchi JS, Kimura Y, Misawa N, Ren F, Iwasa Y, Aihara K, Koyanagi Y.

Sci Rep. 2015 Jul 17;5:12256. doi: 10.1038/srep12256.


Quantifying the Antiviral Effect of IFN on HIV-1 Replication in Cell Culture.

Ikeda H, Godinho-Santos A, Rato S, Vanwalscappel B, Clavel F, Aihara K, Iwami S, Mammano F.

Sci Rep. 2015 Jun 29;5:11761. doi: 10.1038/srep11761. Erratum in: Sci Rep. 2015;5:15679.


A method to determine the duration of the eclipse phase for in vitro infection with a highly pathogenic SHIV strain.

Kakizoe Y, Nakaoka S, Beauchemin CA, Morita S, Mori H, Igarashi T, Aihara K, Miura T, Iwami S.

Sci Rep. 2015 May 21;5:10371. doi: 10.1038/srep10371.


A conservation law for virus infection kinetics in vitro.

Kakizoe Y, Morita S, Nakaoka S, Takeuchi Y, Sato K, Miura T, Beauchemin CA, Iwami S.

J Theor Biol. 2015 Jul 7;376:39-47. doi: 10.1016/j.jtbi.2015.03.034. Epub 2015 Apr 14.


Successful delivery after abdominal radical trachelectomy followed by adjuvant chemotherapy for advanced invasive uterine cervical cancer: a case report and literature review.

Hanada T, Tsuji N, Miyata H, Kadogami D, Seo K, Deguchi M, Yamamoto R, Butsuhara Y, Jimi T, Kozono Y, Iwami S, Terakawa K, Nagano T.

Int Cancer Conf J. 2015 Apr 2;5(1):9-12. doi: 10.1007/s13691-015-0215-9. eCollection 2016 Jan.


APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model.

Sato K, Takeuchi JS, Misawa N, Izumi T, Kobayashi T, Kimura Y, Iwami S, Takaori-Kondo A, Hu WS, Aihara K, Ito M, An DS, Pathak VK, Koyanagi Y.

PLoS Pathog. 2014 Oct 16;10(10):e1004453. doi: 10.1371/journal.ppat.1004453. eCollection 2014 Oct.


Mathematical modeling of multi-drugs therapy: a challenge for determining the optimal combinations of antiviral drugs.

Koizumi Y, Iwami S.

Theor Biol Med Model. 2014 Sep 25;11:41. doi: 10.1186/1742-4682-11-41.


Improving the estimation of the death rate of infected cells from time course data during the acute phase of virus infections: application to acute HIV-1 infection in a humanized mouse model.

Ikeda H, de Boer RJ, Sato K, Morita S, Misawa N, Koyanagi Y, Aihara K, Iwami S.

Theor Biol Med Model. 2014 May 21;11:22. doi: 10.1186/1742-4682-11-22.


Quantification of deaminase activity-dependent and -independent restriction of HIV-1 replication mediated by APOBEC3F and APOBEC3G through experimental-mathematical investigation.

Kobayashi T, Koizumi Y, Takeuchi JS, Misawa N, Kimura Y, Morita S, Aihara K, Koyanagi Y, Iwami S, Sato K.

J Virol. 2014 May;88(10):5881-7. doi: 10.1128/JVI.00062-14. Epub 2014 Mar 12.


HIV-1 Vpr accelerates viral replication during acute infection by exploitation of proliferating CD4+ T cells in vivo.

Sato K, Misawa N, Iwami S, Satou Y, Matsuoka M, Ishizaka Y, Ito M, Aihara K, An DS, Koyanagi Y.

PLoS Pathog. 2013;9(12):e1003812. doi: 10.1371/journal.ppat.1003812. Epub 2013 Dec 5.


Quantification of viral infection dynamics in animal experiments.

Iwami S, Koizumi Y, Ikeda H, Kakizoe Y.

Front Microbiol. 2013 Sep 10;4:264. doi: 10.3389/fmicb.2013.00264. Review.


Quantification of the dynamics of enterovirus 71 infection by experimental-mathematical investigation.

Fukuhara M, Iwami S, Sato K, Nishimura Y, Shimizu H, Aihara K, Koyanagi Y.

J Virol. 2013 Jan;87(1):701-5. doi: 10.1128/JVI.01453-12. Epub 2012 Oct 24.


Identifying viral parameters from in vitro cell cultures.

Iwami S, Sato K, De Boer RJ, Aihara K, Miura T, Koyanagi Y.

Front Microbiol. 2012 Sep 4;3:319. doi: 10.3389/fmicb.2012.00319. eCollection 2012.


Quantification system for the viral dynamics of a highly pathogenic simian/human immunodeficiency virus based on an in vitro experiment and a mathematical model.

Iwami S, Holder BP, Beauchemin CA, Morita S, Tada T, Sato K, Igarashi T, Miura T.

Retrovirology. 2012 Feb 25;9:18. doi: 10.1186/1742-4690-9-18.


A race between tumor immunoescape and genome maintenance selects for optimum levels of (epi)genetic instability.

Iwami S, Haeno H, Michor F.

PLoS Comput Biol. 2012;8(2):e1002370. doi: 10.1371/journal.pcbi.1002370. Epub 2012 Feb 16.


Vpu augments the initial burst phase of HIV-1 propagation and downregulates BST2 and CD4 in humanized mice.

Sato K, Misawa N, Fukuhara M, Iwami S, An DS, Ito M, Koyanagi Y.

J Virol. 2012 May;86(9):5000-13. doi: 10.1128/JVI.07062-11. Epub 2012 Feb 22.


Lymph nodes harbor viral reservoirs that cause rebound of plasma viremia in SIV-infected macaques upon cessation of combined antiretroviral therapy.

Horiike M, Iwami S, Kodama M, Sato A, Watanabe Y, Yasui M, Ishida Y, Kobayashi T, Miura T, Igarashi T.

Virology. 2012 Feb 20;423(2):107-18. doi: 10.1016/j.virol.2011.11.024. Epub 2011 Dec 21.


Phylogeny-based design of a B-subunit of DNA gyrase and its ATPase domain using a small set of homologous amino acid sequences.

Akanuma S, Iwami S, Yokoi T, Nakamura N, Watanabe H, Yokobori S, Yamagishi A.

J Mol Biol. 2011 Sep 16;412(2):212-25. doi: 10.1016/j.jmb.2011.07.042. Epub 2011 Jul 27.


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