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Items: 1 to 50 of 247

1.

Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells.

Kanayama K, Chiba T, Oshima M, Kanzaki H, Koide S, Saraya A, Miyagi S, Mimura N, Kusakabe Y, Saito T, Ogasawara S, Suzuki E, Ooka Y, Maruyama H, Iwama A, Kato N.

Stem Cells Int. 2019 Apr 1;2019:9789240. doi: 10.1155/2019/9789240. eCollection 2019.

2.

Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm.

Kubota S, Tokunaga K, Umezu T, Yokomizo-Nakano T, Sun Y, Oshima M, Tan KT, Yang H, Kanai A, Iwanaga E, Asou N, Maeda T, Nakagata N, Iwama A, Ohyashiki K, Osato M, Sashida G.

Nat Commun. 2019 Apr 10;10(1):1653. doi: 10.1038/s41467-019-09710-z.

3.

NUP98-HBO1-fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis.

Hayashi Y, Harada Y, Kagiyama Y, Nishikawa S, Ding Y, Imagawa J, Shingai N, Kato N, Kitaura J, Hokaiwado S, Maemoto Y, Ito A, Matsui H, Kitabayashi I, Iwama A, Komatsu N, Kitamura T, Harada H.

Blood Adv. 2019 Apr 9;3(7):1047-1060. doi: 10.1182/bloodadvances.2018025007.

4.

The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.

Miyagi S, Sroczynska P, Kato Y, Nakajima-Takagi Y, Oshima M, Rizq O, Takayama N, Saraya A, Mizuno S, Sugiyama F, Takahashi S, Matsuzaki Y, Christensen J, Helin K, Iwama A.

Blood. 2019 Jun 6;133(23):2495-2506. doi: 10.1182/blood.2019000468. Epub 2019 Mar 27.

PMID:
30917958
5.

PLZF limits enhancer activity during hematopoietic progenitor aging.

Poplineau M, Vernerey J, Platet N, N'guyen L, Hérault L, Esposito M, Saurin AJ, Guilouf C, Iwama A, Duprez E.

Nucleic Acids Res. 2019 May 21;47(9):4509-4520. doi: 10.1093/nar/gkz174.

6.

Deregulated Polycomb functions in myeloproliferative neoplasms.

Sashida G, Oshima M, Iwama A.

Int J Hematol. 2019 Aug;110(2):170-178. doi: 10.1007/s12185-019-02600-6. Epub 2019 Jan 31. Review.

PMID:
30706327
7.

Genetic and transcriptional landscape of plasma cells in POEMS syndrome.

Nagao Y, Mimura N, Takeda J, Yoshida K, Shiozawa Y, Oshima M, Aoyama K, Saraya A, Koide S, Rizq O, Hasegawa Y, Shiraishi Y, Chiba K, Tanaka H, Nishijima D, Isshiki Y, Kayamori K, Kawajiri-Manako C, Oshima-Hasegawa N, Tsukamoto S, Mitsukawa S, Takeda Y, Ohwada C, Takeuchi M, Iseki T, Misawa S, Miyano S, Ohara O, Yokote K, Sakaida E, Kuwabara S, Sanada M, Iwama A, Ogawa S, Nakaseko C.

Leukemia. 2019 Jul;33(7):1723-1735. doi: 10.1038/s41375-018-0348-x. Epub 2019 Jan 11.

PMID:
30635632
8.

Emerging role of noncanonical polycomb repressive complexes in normal and malignant hematopoiesis.

Isshiki Y, Iwama A.

Exp Hematol. 2018 Dec;68:10-14. doi: 10.1016/j.exphem.2018.10.008. Epub 2018 Oct 26. Review.

PMID:
30554637
9.

Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.

Aoyama K, Oshima M, Koide S, Suzuki E, Mochizuki-Kashio M, Kato Y, Tara S, Shinoda D, Hiura N, Nakajima-Takagi Y, Sashida G, Iwama A.

iScience. 2018 Nov 30;9:161-174. doi: 10.1016/j.isci.2018.10.008. Epub 2018 Oct 15.

10.

[Dyserythropoiesis in myelodysplastic syndrome].

Iwama A.

Rinsho Ketsueki. 2018;59(10):2036-2041. doi: 10.11406/rinketsu.59.2036. Review. Japanese.

PMID:
30305506
11.

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome.

Tara S, Isshiki Y, Nakajima-Takagi Y, Oshima M, Aoyama K, Tanaka T, Shinoda D, Koide S, Saraya A, Miyagi S, Manabe I, Matsui H, Koseki H, Bardwell VJ, Iwama A.

Blood. 2018 Dec 6;132(23):2470-2483. doi: 10.1182/blood-2018-01-827964. Epub 2018 Sep 18.

PMID:
30228234
12.

Forkhead box protein A1 confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation.

Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, Yamaguchi N.

J Cell Biochem. 2018 Sep 11. doi: 10.1002/jcb.27551. [Epub ahead of print]

PMID:
30206966
13.

GLI1 Inhibitors Identified by Target Protein Oriented Natural Products Isolation (TPO-NAPI) with Hedgehog Inhibition.

Arai MA, Ochi F, Makita Y, Chiba T, Higashi K, Suganami A, Tamura Y, Toida T, Iwama A, Sadhu SK, Ahmed F, Ishibashi M.

ACS Chem Biol. 2018 Sep 21;13(9):2551-2559. doi: 10.1021/acschembio.8b00492. Epub 2018 Sep 7.

PMID:
30160475
14.

Ezh2 loss propagates hypermethylation at T cell differentiation-regulating genes to promote leukemic transformation.

Wang C, Oshima M, Sato D, Matsui H, Kubota S, Aoyama K, Nakajima-Takagi Y, Koide S, Matsubayashi J, Mochizuki-Kashio M, Nakano-Yokomizo T, Bai J, Nagao T, Kanai A, Iwama A, Sashida G.

J Clin Invest. 2018 Aug 31;128(9):3872-3886. doi: 10.1172/JCI94645. Epub 2018 Aug 6.

15.

[Ineffective erythropoiesis in myelodysplastic syndrome].

Iwama A.

Rinsho Ketsueki. 2018;59(6):793-797. doi: 10.11406/rinketsu.59.793. Review. Japanese.

PMID:
29973461
16.

Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.

Si S, Nakajima-Takagi Y, Iga T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, Iwama A.

Exp Hematol. 2018 Jul;63:41-51.e1. doi: 10.1016/j.exphem.2018.04.006. Epub 2018 Apr 27.

PMID:
29709619
17.

Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms.

Ueda K, Ikeda K, Ikezoe T, Harada-Shirado K, Ogawa K, Hashimoto Y, Sano T, Ohkawara H, Kimura S, Shichishima-Nakamura A, Nakamura Y, Shikama Y, Mori T, Mason PJ, Bessler M, Morishita S, Komatsu N, Shide K, Shimoda K, Koide S, Aoyama K, Oshima M, Iwama A, Takeishi Y.

Blood Adv. 2017 Jun 14;1(15):1001-1015. doi: 10.1182/bloodadvances.2017004457. eCollection 2017 Jun 27.

18.

A New Conditionally Immortalized Human Fetal Brain Pericyte Cell Line: Establishment and Functional Characterization as a Promising Tool for Human Brain Pericyte Studies.

Umehara K, Sun Y, Hiura S, Hamada K, Itoh M, Kitamura K, Oshima M, Iwama A, Saito K, Anzai N, Chiba K, Akita H, Furihata T.

Mol Neurobiol. 2018 Jul;55(7):5993-6006. doi: 10.1007/s12035-017-0815-9. Epub 2017 Nov 11.

PMID:
29128907
19.

Dual inhibition of EZH1/2 breaks the quiescence of leukemia stem cells in acute myeloid leukemia.

Fujita S, Honma D, Adachi N, Araki K, Takamatsu E, Katsumoto T, Yamagata K, Akashi K, Aoyama K, Iwama A, Kitabayashi I.

Leukemia. 2018 Apr;32(4):855-864. doi: 10.1038/leu.2017.300. Epub 2017 Sep 27.

PMID:
28951561
20.

Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies.

Tanaka T, Nakajima-Takagi Y, Aoyama K, Tara S, Oshima M, Saraya A, Koide S, Si S, Manabe I, Sanada M, Nakayama M, Masuko M, Sone H, Koseki H, Iwama A.

J Exp Med. 2017 Oct 2;214(10):2901-2913. doi: 10.1084/jem.20170167. Epub 2017 Aug 21.

21.

Regulation of tumour related genes by dynamic epigenetic alteration at enhancer regions in gastric epithelial cells infected by Epstein-Barr virus.

Okabe A, Funata S, Matsusaka K, Namba H, Fukuyo M, Rahmutulla B, Oshima M, Iwama A, Fukayama M, Kaneda A.

Sci Rep. 2017 Aug 11;7(1):7924. doi: 10.1038/s41598-017-08370-7.

22.

Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription.

Oishi Y, Hayashi S, Isagawa T, Oshima M, Iwama A, Shimba S, Okamura H, Manabe I.

Sci Rep. 2017 Aug 1;7(1):7086. doi: 10.1038/s41598-017-07100-3.

23.

Deregulated polycomb complex function in the pathogenesis of MDS.

Iwama A.

Rinsho Ketsueki. 2017;58(6):654-660. doi: 10.11406/rinketsu.58.654. Japanese.

PMID:
28679998
24.

Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia.

Seki M, Kimura S, Isobe T, Yoshida K, Ueno H, Nakajima-Takagi Y, Wang C, Lin L, Kon A, Suzuki H, Shiozawa Y, Kataoka K, Fujii Y, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Masuda K, Kawamoto H, Ohki K, Kato M, Arakawa Y, Koh K, Hanada R, Moritake H, Akiyama M, Kobayashi R, Deguchi T, Hashii Y, Imamura T, Sato A, Kiyokawa N, Oka A, Hayashi Y, Takagi M, Manabe A, Ohara A, Horibe K, Sanada M, Iwama A, Mano H, Miyano S, Ogawa S, Takita J.

Nat Genet. 2017 Aug;49(8):1274-1281. doi: 10.1038/ng.3900. Epub 2017 Jul 3.

PMID:
28671687
25.

Identification of BMI1 Promoter Inhibitors from Beaumontia murtonii and Eugenia operculata.

Kaneta Y, Arai MA, Ishikawa N, Toume K, Koyano T, Kowithayakorn T, Chiba T, Iwama A, Ishibashi M.

J Nat Prod. 2017 Jun 23;80(6):1853-1859. doi: 10.1021/acs.jnatprod.7b00138. Epub 2017 Jun 9.

PMID:
28598616
26.

Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition.

Rizq O, Mimura N, Oshima M, Saraya A, Koide S, Kato Y, Aoyama K, Nakajima-Takagi Y, Wang C, Chiba T, Ma A, Jin J, Iseki T, Nakaseko C, Iwama A.

Clin Cancer Res. 2017 Aug 15;23(16):4817-4830. doi: 10.1158/1078-0432.CCR-16-2735. Epub 2017 May 10.

27.

Polycomb repressive complexes in hematological malignancies.

Iwama A.

Blood. 2017 Jul 6;130(1):23-29. doi: 10.1182/blood-2017-02-739490. Epub 2017 May 8. Review.

28.

Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia.

Togasaki E, Takeda J, Yoshida K, Shiozawa Y, Takeuchi M, Oshima M, Saraya A, Iwama A, Yokote K, Sakaida E, Hirase C, Takeshita A, Imai K, Okumura H, Morishita Y, Usui N, Takahashi N, Fujisawa S, Shiraishi Y, Chiba K, Tanaka H, Kiyoi H, Ohnishi K, Ohtake S, Asou N, Kobayashi Y, Miyazaki Y, Miyano S, Ogawa S, Matsumura I, Nakaseko C, Naoe T.

Blood Cancer J. 2017 Apr 28;7(4):e559. doi: 10.1038/bcj.2017.36.

29.

Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway.

Kinoshita D, Nagasawa A, Shimizu I, Ito TK, Yoshida Y, Tsuchida M, Iwama A, Hayano T, Minamino T.

Oncotarget. 2017 May 23;8(21):34045-34056. doi: 10.18632/oncotarget.15973.

30.

Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma.

Yokoyama M, Chiba T, Zen Y, Oshima M, Kusakabe Y, Noguchi Y, Yuki K, Koide S, Tara S, Saraya A, Aoyama K, Mimura N, Miyagi S, Inoue M, Wakamatsu T, Saito T, Ogasawara S, Suzuki E, Ooka Y, Tawada A, Otsuka M, Miyazaki M, Yokosuka O, Iwama A.

Oncotarget. 2017 Mar 28;8(13):21315-21326. doi: 10.18632/oncotarget.15528.

31.

The nicotinic acetylcholine receptor α7 subunit is an essential negative regulator of bone mass.

Mito K, Sato Y, Kobayashi T, Miyamoto K, Nitta E, Iwama A, Matsumoto M, Nakamura M, Sato K, Miyamoto T.

Sci Rep. 2017 Mar 28;7:45597. doi: 10.1038/srep45597.

32.

Comparison between in vitro properties of washed platelet concentrates suspended in M-sol and those in BRS-A, both of which were prepared with an automated cell processor.

Iwama A, Hirayama J, Nogawa M, Shiba M, Satake M, Takamoto S, Tadokoro K.

Transfus Apher Sci. 2017 Apr;56(2):241-244. doi: 10.1016/j.transci.2017.01.007. Epub 2017 Feb 9.

PMID:
28237840
33.

The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.

Nishida Y, Maeda A, Kim MJ, Cao L, Kubota Y, Ishizawa J, AlRawi A, Kato Y, Iwama A, Fujisawa M, Matsue K, Weetall M, Dumble M, Andreeff M, Davis TW, Branstrom A, Kimura S, Kojima K.

Blood Cancer J. 2017 Feb 17;7(2):e527. doi: 10.1038/bcj.2017.8.

34.

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.

Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.

Cancer Discov. 2017 May;7(5):522-538. doi: 10.1158/2159-8290.CD-16-0932. Epub 2017 Feb 15.

35.

Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies.

Sashida G, Iwama A.

Int J Hematol. 2017 Jan;105(1):23-30. doi: 10.1007/s12185-016-2124-x. Epub 2016 Nov 9. Review.

PMID:
27830540
36.

Epigenetic dysregulation in hematological malignancies.

Iwama A.

Int J Hematol. 2017 Jan;105(1):5-6. doi: 10.1007/s12185-016-2125-9. Epub 2016 Nov 7. No abstract available.

PMID:
27822916
37.

Focal Sinusoidal Obstruction Syndrome Caused by Oxaliplatin-Induced Chemotherapy: A Case Report.

Kawai T, Yamazaki S, Iwama A, Higaki T, Sugitani M, Takayama T.

Hepat Mon. 2016 Aug 21;16(9):e37572. eCollection 2016 Sep.

38.

Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia.

Shimizu R, Muto T, Aoyama K, Choi K, Takeuchi M, Koide S, Hasegawa N, Isshiki Y, Togasaki E, Kawajiri-Manako C, Nagao Y, Tsukamoto S, Sakai S, Takeda Y, Mimura N, Ohwada C, Sakaida E, Iseki T, Starczynowski DT, Iwama A, Yokote K, Nakaseko C.

Leuk Res. 2016 Nov;50:85-94. doi: 10.1016/j.leukres.2016.09.018. Epub 2016 Sep 26.

39.

Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.

Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K, Kaneda A, Shimoda K, Nakaseko C, Yokote K, Iwama A.

Leukemia. 2017 Apr;31(4):861-871. doi: 10.1038/leu.2016.268. Epub 2016 Oct 3.

PMID:
27694924
40.

Hematopoietic stem cell aging and hematopoietic malignancies.

Nitta E, Iwama A.

Nihon Rinsho. 2016 Sep;74(9):1502-1507. Review. Japanese.

PMID:
30557484
41.

Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.

Yong KJ, Basseres DS, Welner RS, Zhang WC, Yang H, Yan B, Alberich-Jorda M, Zhang J, de Figueiredo-Pontes LL, Battelli C, Hetherington CJ, Ye M, Zhang H, Maroni G, O'Brien K, Magli MC, Borczuk AC, Varticovski L, Kocher O, Zhang P, Moon YC, Sydorenko N, Cao L, Davis TW, Thakkar BM, Soo RA, Iwama A, Lim B, Halmos B, Neuberg D, Tenen DG, Levantini E.

Sci Transl Med. 2016 Aug 3;8(350):350ra104. doi: 10.1126/scitranslmed.aad6066.

PMID:
27488898
42.

The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.

Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A.

J Exp Med. 2016 Jul 25;213(8):1459-77. doi: 10.1084/jem.20151121. Epub 2016 Jul 11.

43.

Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model.

Kuribayashi W, Takizawa K, Sugata K, Kuramitsu M, Momose H, Sasaki E, Hiradate Y, Furuhata K, Asada Y, Iwama A, Matsuoka M, Mizukami T, Hamaguchi I.

Oncotarget. 2016 Aug 9;7(32):51027-51043. doi: 10.18632/oncotarget.10210.

44.

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.

Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y, Iwama A.

Blood. 2016 Aug 4;128(5):638-49. doi: 10.1182/blood-2016-01-694810. Epub 2016 Jun 14.

45.

Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction.

Kanda M, Nagai T, Takahashi T, Liu ML, Kondou N, Naito AT, Akazawa H, Sashida G, Iwama A, Komuro I, Kobayashi Y.

PLoS One. 2016 May 26;11(5):e0156562. doi: 10.1371/journal.pone.0156562. eCollection 2016.

46.

Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells.

Si S, Nakajima-Takagi Y, Aoyama K, Oshima M, Saraya A, Sugishita H, Nakayama M, Ishikura T, Koseki H, Iwama A.

PLoS One. 2016 May 2;11(5):e0154561. doi: 10.1371/journal.pone.0154561. eCollection 2016.

47.

Prominin-1/CD133 expression as potential tissue-resident vascular endothelial progenitor cells in the pulmonary circulation.

Sekine A, Nishiwaki T, Nishimura R, Kawasaki T, Urushibara T, Suda R, Suzuki T, Takayanagi S, Terada J, Sakao S, Tada Y, Iwama A, Tatsumi K.

Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1130-42. doi: 10.1152/ajplung.00375.2014. Epub 2016 Apr 8.

48.

Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation.

Kurimoto R, Iwasawa S, Ebata T, Ishiwata T, Sekine I, Tada Y, Tatsumi K, Koide S, Iwama A, Takiguchi Y.

Int J Oncol. 2016 May;48(5):1825-36. doi: 10.3892/ijo.2016.3419. Epub 2016 Mar 4.

49.

An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned.

Seed TM, Xiao S, Manley N, Nikolich-Zugich J, Pugh J, Van den Brink M, Hirabayashi Y, Yasutomo K, Iwama A, Koyasu S, Shterev I, Sempowski G, Macchiarini F, Nakachi K, Kunugi KC, Hammer CG, Dewerd LA.

Int J Radiat Biol. 2016;92(2):59-70. doi: 10.3109/09553002.2015.1106024. Epub 2015 Nov 17.

50.

Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells.

Oshima M, Hasegawa N, Mochizuki-Kashio M, Muto T, Miyagi S, Koide S, Yabata S, Wendt GR, Saraya A, Wang C, Shimoda K, Suzuki Y, Iwama A.

Exp Hematol. 2016 Apr;44(4):282-96.e3. doi: 10.1016/j.exphem.2015.12.009. Epub 2016 Jan 7.

PMID:
26773568

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