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Items: 1 to 50 of 692

1.

Preschool-onset obsessive-compulsive disorder with complete remission.

Miyawaki D, Goto A, Iwakura Y, Hirai K, Miki Y, Asada N, Terakawa H, Inoue K.

Neuropsychiatr Dis Treat. 2018 Jul 3;14:1747-1753. doi: 10.2147/NDT.S169797. eCollection 2018.

PMID:
30013347
2.

BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance.

Matsushita T, Kobayashi T, Mizumaki K, Kano M, Sawada T, Tennichi M, Okamura A, Hamaguchi Y, Iwakura Y, Hasegawa M, Fujimoto M, Takehara K.

Sci Adv. 2018 Jul 11;4(7):eaas9944. doi: 10.1126/sciadv.aas9944. eCollection 2018 Jul.

PMID:
30009261
3.

Investigation into the plasma concentration of ω3 polyunsaturated fatty acids in Japanese attention-deficit hyperactivity disorder patients.

Yonezawa K, Nonaka S, Iwakura Y, Kusano Y, Funamoto Y, Kanchi N, Yamaguchi N, Kusumoto Y, Imamura A, Ozawa H.

J Neural Transm (Vienna). 2018 Jun 20. doi: 10.1007/s00702-018-1895-z. [Epub ahead of print]

PMID:
29926268
4.

Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota.

Tang C, Kakuta S, Shimizu K, Kadoki M, Kamiya T, Shimazu T, Kubo S, Saijo S, Ishigame H, Nakae S, Iwakura Y.

Nat Immunol. 2018 Jun 18. doi: 10.1038/s41590-018-0134-y. [Epub ahead of print]

PMID:
29915298
5.

Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation.

Isoda K, Akita K, Kitamura K, Sato-Okabayashi Y, Kadoguchi T, Isobe S, Ohtomo F, Sano M, Shimada K, Iwakura Y, Daida H.

Int J Cardiol. 2018 Jun 5. pii: S0167-5273(18)32833-X. doi: 10.1016/j.ijcard.2018.05.072. [Epub ahead of print]

PMID:
29884291
6.

IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.

Hashiguchi Y, Yabe R, Chung SH, Murayama MA, Yoshida K, Matsuo K, Kubo S, Saijo S, Nakamura Y, Matsue H, Iwakura Y.

J Immunol. 2018 Jul 1;201(1):167-182. doi: 10.4049/jimmunol.1701157. Epub 2018 May 23.

PMID:
29794016
7.

A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis.

Jeschke JC, Mayne CG, Ziegelbauer J, DeCiantis CL, Singh S, Kumar SN, Suchi M, Iwakura Y, Drobyski WR, Salzman NH, Williams CB.

Mucosal Immunol. 2018 Jul;11(4):1127-1137. doi: 10.1038/s41385-018-0023-6. Epub 2018 May 4.

PMID:
29728642
8.

Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells.

Tong H, Miyake Y, Mi-Ichi F, Iwakura Y, Hara H, Yoshida H.

PLoS One. 2018 Mar 29;13(3):e0195119. doi: 10.1371/journal.pone.0195119. eCollection 2018.

9.

IL-25 enhances TH17 cell-mediated contact dermatitis by promoting IL-1β production by dermal dendritic cells.

Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, Shimura E, Arae K, Asada Y, Motomura K, Kaneko M, Abe T, Matsuda A, Iwakura Y, Okumura K, Saito H, Matsumoto K, Sudo K, Nakae S.

J Allergy Clin Immunol. 2018 Mar 6. pii: S0091-6749(18)30326-9. doi: 10.1016/j.jaci.2017.12.1007. [Epub ahead of print]

PMID:
29522843
10.

Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α-deficient B cells.

Zhu G, Liu X, Fang Y, Zhai B, Xu R, Han G, Chen G, Xiao H, Hou C, Shen B, Li Y, Iwakura Y, Wang L, Jiang Z, Ma N, Liu G, Wang R.

Cell Immunol. 2018 Jun;328:9-17. doi: 10.1016/j.cellimm.2018.02.015. Epub 2018 Feb 24.

PMID:
29499909
11.

Host defense against oral microbiota by bone-damaging T cells.

Tsukasaki M, Komatsu N, Nagashima K, Nitta T, Pluemsakunthai W, Shukunami C, Iwakura Y, Nakashima T, Okamoto K, Takayanagi H.

Nat Commun. 2018 Feb 16;9(1):701. doi: 10.1038/s41467-018-03147-6.

12.

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion.

Marazioti A, Lilis I, Vreka M, Apostolopoulou H, Kalogeropoulou A, Giopanou I, Giotopoulou GA, Krontira AC, Iliopoulou M, Kanellakis NI, Agalioti T, Giannou AD, Jones-Paris C, Iwakura Y, Kardamakis D, Blackwell TS, Taraviras S, Spella M, Stathopoulos GT.

Nat Commun. 2018 Feb 14;9(1):672. doi: 10.1038/s41467-018-03051-z.

13.

Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation.

Ikenoue T, Terakado Y, Zhu C, Liu X, Ohsugi T, Matsubara D, Fujii T, Kakuta S, Kubo S, Shibata T, Yamaguchi K, Iwakura Y, Furukawa Y.

Sci Rep. 2018 Jan 31;8(1):2021. doi: 10.1038/s41598-018-19769-1.

14.

HER2 Overexpression Triggers an IL1α Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance.

Liu S, Lee JS, Jie C, Park MH, Iwakura Y, Patel Y, Soni M, Reisman D, Chen H.

Cancer Res. 2018 Apr 15;78(8):2040-2051. doi: 10.1158/0008-5472.CAN-17-2761. Epub 2018 Jan 30.

PMID:
29382706
15.

IL-1R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota.

Yoshida K, Murayama MA, Shimizu K, Tang C, Katagiri N, Matsuo K, Fukai F, Iwakura Y.

Biochem Biophys Res Commun. 2018 Feb 12;496(3):934-940. doi: 10.1016/j.bbrc.2018.01.116. Epub 2018 Feb 2.

PMID:
29366788
16.

NK Cells Control Tumor-Promoting Function of Neutrophils in Mice.

Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y.

Cancer Immunol Res. 2018 Jan 23. doi: 10.1158/2326-6066.CIR-17-0204. [Epub ahead of print]

PMID:
29362222
17.

Brain Interleukin-1 Facilitates Learning of a Water Maze Spatial Memory Task in Young Mice.

Takemiya T, Fumizawa K, Yamagata K, Iwakura Y, Kawakami M.

Front Behav Neurosci. 2017 Oct 23;11:202. doi: 10.3389/fnbeh.2017.00202. eCollection 2017.

18.

LC3-Associated Phagocytosis Is Required for Dendritic Cell Inflammatory Cytokine Response to Gut Commensal Yeast Saccharomyces cerevisiae.

Lamprinaki D, Beasy G, Zhekova A, Wittmann A, James S, Dicks J, Iwakura Y, Saijo S, Wang X, Chow CW, Roberts I, Korcsmaros T, Mayer U, Wileman T, Kawasaki N.

Front Immunol. 2017 Oct 25;8:1397. doi: 10.3389/fimmu.2017.01397. eCollection 2017.

19.

β-Glucans in food modify colonic microflora by inducing antimicrobial protein, calprotectin, in a Dectin-1-induced-IL-17F-dependent manner.

Kamiya T, Tang C, Kadoki M, Oshima K, Hattori M, Saijo S, Adachi Y, Ohno N, Iwakura Y.

Mucosal Immunol. 2018 May;11(3):763-773. doi: 10.1038/mi.2017.86. Epub 2017 Oct 25.

PMID:
29068000
20.

Production of low-molecular weight soluble yeast β-glucan by an acid degradation method.

Ishimoto Y, Ishibashi KI, Yamanaka D, Adachi Y, Kanzaki K, Iwakura Y, Ohno N.

Int J Biol Macromol. 2018 Feb;107(Pt B):2269-2278. doi: 10.1016/j.ijbiomac.2017.10.094. Epub 2017 Oct 16.

PMID:
29051097
21.

Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice.

Chenuet P, Fauconnier L, Madouri F, Marchiol T, Rouxel N, Ledru A, Mauny P, Lory R, Uttenhove C, van Snick J, Iwakura Y, di Padova F, Quesniaux V, Togbe D, Ryffel B.

Clin Sci (Lond). 2017 Oct 12;131(20):2533-2548. doi: 10.1042/CS20171034. Print 2017 Oct 15.

PMID:
29026003
22.

Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

Nat Med. 2017 Oct 6;23(10):1241. doi: 10.1038/nm1017-1241c.

PMID:
28985207
23.

IL-17A contributes to reducing IFN-γ/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis.

Deloer S, Nakamura R, Kikuchi M, Moriyasu T, Kalenda YDJ, Mohammed ES, Senba M, Iwakura Y, Yoshida H, Hamano S.

Parasitol Int. 2017 Dec;66(6):817-823. doi: 10.1016/j.parint.2017.09.011. Epub 2017 Sep 18.

PMID:
28927906
24.

Interleukin-17A-Deficient Mice Are Highly Susceptible to Toxoplasma gondii Infection Due to Excessively Induced T. gondii HSP70 and Interferon Gamma Production.

Moroda M, Takamoto M, Iwakura Y, Nakayama J, Aosai F.

Infect Immun. 2017 Nov 17;85(12). pii: e00399-17. doi: 10.1128/IAI.00399-17. Print 2017 Dec.

25.

IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury.

Geha M, Tsokos MG, Bosse RE, Sannikova T, Iwakura Y, Dalle Lucca JJ, De Waal Malefyt R, Tsokos GC.

J Immunol. 2017 Oct 15;199(8):2921-2929. doi: 10.4049/jimmunol.1700655. Epub 2017 Sep 6.

PMID:
28877988
26.

The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation.

Wang J, Ge P, Qiang L, Tian F, Zhao D, Chai Q, Zhu M, Zhou R, Meng G, Iwakura Y, Gao GF, Liu CH.

Nat Commun. 2017 Aug 15;8(1):244. doi: 10.1038/s41467-017-00279-z.

27.

Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism.

Brown BR, Lee EJ, Snow PE, Vance EE, Iwakura Y, Ohno N, Miura N, Lin X, Brown GD, Wells CA, Smith JR, Caspi RR, Rosenzweig HL.

Clin Exp Immunol. 2017 Dec;190(3):293-303. doi: 10.1111/cei.13021. Epub 2017 Aug 30.

PMID:
28763100
28.

An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells.

St Leger AJ, Desai JV, Drummond RA, Kugadas A, Almaghrabi F, Silver P, Raychaudhuri K, Gadjeva M, Iwakura Y, Lionakis MS, Caspi RR.

Immunity. 2017 Jul 18;47(1):148-158.e5. doi: 10.1016/j.immuni.2017.06.014. Epub 2017 Jul 11.

PMID:
28709803
29.

Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.

Maruyama K, Takayama Y, Kondo T, Ishibashi KI, Sahoo BR, Kanemaru H, Kumagai Y, Martino MM, Tanaka H, Ohno N, Iwakura Y, Takemura N, Tominaga M, Akira S.

Cell Rep. 2017 Jun 27;19(13):2730-2742. doi: 10.1016/j.celrep.2017.06.002.

30.

Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor.

Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, Enomoto H, Nawa H.

Neurosci Lett. 2017 Jul 27;654:99-106. doi: 10.1016/j.neulet.2017.06.005. Epub 2017 Jun 21.

PMID:
28645787
31.

Quantification of bleeding volume using computed tomography and clinical complications after percutaneous renal biopsy.

Chikamatsu Y, Matsuda K, Takeuchi Y, Kagaya S, Ojima Y, Fukami H, Sato H, Saito A, Iwakura Y, Nagasawa T.

Clin Kidney J. 2017 Feb;10(1):9-15. doi: 10.1093/ckj/sfw131. Epub 2017 Jan 25.

32.

Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.

Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM.

J Neurosci. 2017 Jul 26;37(30):7125-7139. doi: 10.1523/JNEUROSCI.2519-16.2017. Epub 2017 Jun 21.

33.

Epidermal growth factor signals attenuate phenotypic and functional development of neocortical GABA neurons.

Namba H, Nagano T, Jodo E, Eifuku S, Horie M, Takebayashi H, Iwakura Y, Sotoyama H, Takei N, Nawa H.

J Neurochem. 2017 Jun 13. doi: 10.1111/jnc.14097. [Epub ahead of print]

34.

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

Nat Med. 2017 Jul;23(7):829-838. doi: 10.1038/nm.4346. Epub 2017 Jun 12. Erratum in: Nat Med. 2017 Oct 6;23 (10 ):1241.

35.

Modulation of an innate immune response by soluble yeast β-glucan prepared by a heat degradation method.

Ishimoto Y, Ishibashi KI, Yamanaka D, Adachi Y, Kanzaki K, Okita K, Iwakura Y, Ohno N.

Int J Biol Macromol. 2017 Nov;104(Pt A):367-376. doi: 10.1016/j.ijbiomac.2017.06.036. Epub 2017 Jun 8.

PMID:
28602993
36.

Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity.

Zhang C, Feng J, Du J, Zhuo Z, Yang S, Zhang W, Wang W, Zhang S, Iwakura Y, Meng G, Fu YX, Hou B, Tang H.

Cell Mol Immunol. 2017 May 15. doi: 10.1038/cmi.2017.22. [Epub ahead of print]

PMID:
28504245
37.

Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity.

Kanemaru K, Nakamura Y, Totoki K, Fukuyama T, Shoji M, Kaneko H, Shiratori K, Yoneda A, Inoue T, Iwakura Y, Kabashima K, Fukami K.

Cell Death Differ. 2017 Jun;24(6):1079-1090. doi: 10.1038/cdd.2017.56. Epub 2017 Apr 21.

38.

Elevation of pro-inflammatory cytokine levels following anti-resorptive drug treatment is required for osteonecrosis development in infectious osteomyelitis.

Morita M, Iwasaki R, Sato Y, Kobayashi T, Watanabe R, Oike T, Nakamura S, Keneko Y, Miyamoto K, Ishihara K, Iwakura Y, Ishii K, Matsumoto M, Nakamura M, Kawana H, Nakagawa T, Miyamoto T.

Sci Rep. 2017 Apr 7;7:46322. doi: 10.1038/srep46322.

39.

Megakaryocytes compensate for Kit insufficiency in murine arthritis.

Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura Y, Ware J, Gurish MF, Italiano JE, Boilard E, Nigrovic PA.

J Clin Invest. 2017 May 1;127(5):1714-1724. doi: 10.1172/JCI84598. Epub 2017 Apr 4.

40.

Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons.

Iwakura Y, Wang R, Inamura N, Araki K, Higashiyama S, Takei N, Nawa H.

PLoS One. 2017 Mar 28;12(3):e0174780. doi: 10.1371/journal.pone.0174780. eCollection 2017.

41.

Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction.

Yan X, Zhang H, Fan Q, Hu J, Tao R, Chen Q, Iwakura Y, Shen W, Lu L, Zhang Q, Zhang R.

Circ Res. 2017 Mar 31;120(7):1116-1129. doi: 10.1161/CIRCRESAHA.116.310260. Epub 2017 Feb 13.

42.

Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation.

Furukawa K, Fuse I, Iwakura Y, Sotoyama H, Hanyu O, Nawa H, Sone H, Takei N.

Cardiovasc Diabetol. 2017 Feb 8;16(1):20. doi: 10.1186/s12933-017-0505-y.

43.

Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice.

Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y, Inaba K, Takahara K.

Eur J Immunol. 2017 Apr;47(4):704-712. doi: 10.1002/eji.201646814. Epub 2017 Feb 22.

44.

Preferentially expanding Vγ1+ γδ T cells are associated with protective immunity against Plasmodium infection in mice.

Inoue SI, Niikura M, Asahi H, Iwakura Y, Kawakami Y, Kobayashi F.

Eur J Immunol. 2017 Apr;47(4):685-691. doi: 10.1002/eji.201646699. Epub 2017 Jan 11.

45.

Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.

Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.

Immunity. 2016 Dec 20;45(6):1299-1310. doi: 10.1016/j.immuni.2016.11.010.

46.

Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection.

Umemura M, Okamoto-Yoshida Y, Yahagi A, Touyama S, Nakae S, Iwakura Y, Matsuzaki G.

Immun Inflamm Dis. 2016 Aug 24;4(4):401-412. eCollection 2016 Dec.

47.

The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.

Kimura Y, Inoue A, Hangai S, Saijo S, Negishi H, Nishio J, Yamasaki S, Iwakura Y, Yanai H, Taniguchi T.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14097-14102. Epub 2016 Nov 21.

48.

Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells.

Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H.

J Immunol. 2017 Jan 1;198(1):61-70. Epub 2016 Nov 16.

49.

Pre-Transplantation Blockade of TNF-α-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells.

Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.

Stem Cells. 2017 Apr;35(4):989-1002. doi: 10.1002/stem.2524. Epub 2016 Nov 11.

50.

Activated Intrarenal Renin Angiotensin Systems Is the Primary Source of Progressing Renal Damage in Primary Aldosteronism.

Satoh F, Iwakura Y, Morimoto R, Ono Y, Tezuka Y, Omata K, Nezu M, Igarashi Y, Kudo M, Ito S.

J Am Soc Hypertens. 2016 Jul;10 Suppl 1:e9. doi: 10.1016/j.jash.2016.06.026. No abstract available.

PMID:
27677148

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