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Items: 35

1.

Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients.

Burghuber CK, Manook M, Ezekian B, Gibby AC, Leopardi FV, Song M, Jenks J, Saccoccio F, Permar S, Farris AB, Iwakoshi NN, Kwun J, Knechtle SJ.

Am J Transplant. 2019 Mar;19(3):724-736. doi: 10.1111/ajt.15067. Epub 2018 Sep 17.

PMID:
30102844
2.

T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice.

Espinosa JR, Mou D, Adams BW, DiBernardo LR, MacDonald AL, McRae M, Miller AN, Song M, Stempora LL, Wang J, Iwakoshi NN, Kirk AD.

Front Immunol. 2018 Jun 15;9:1371. doi: 10.3389/fimmu.2018.01371. eCollection 2018.

3.

Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology.

Burghuber CK, Kwun J, Page EJ, Manook M, Gibby AC, Leopardi FV, Song M, Farris AB 3rd, Hong JJ, Villinger F, Adams AB, Iwakoshi NN, Knechtle SJ.

Am J Transplant. 2016 Jun;16(6):1726-38. doi: 10.1111/ajt.13688. Epub 2016 Mar 25.

4.

Viral-induced CD28 loss evokes costimulation independent alloimmunity.

Mou D, Espinosa JE, Stempora L, Iwakoshi NN, Kirk AD.

J Surg Res. 2015 Jun 15;196(2):241-6. doi: 10.1016/j.jss.2015.02.033. Epub 2015 Feb 21.

5.

Bcl-xL protein protects from C/EBP homologous protein (CHOP)-dependent apoptosis during plasma cell differentiation.

Gaudette BT, Iwakoshi NN, Boise LH.

J Biol Chem. 2014 Aug 22;289(34):23629-40. doi: 10.1074/jbc.M114.569376. Epub 2014 Jul 14.

6.

Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.

Kim EJ, Kwun J, Gibby AC, Hong JJ, Farris AB 3rd, Iwakoshi NN, Villinger F, Kirk AD, Knechtle SJ.

Am J Transplant. 2014 Jan;14(1):59-69. doi: 10.1111/ajt.12526.

7.

A novel monoclonal antibody to CD40 prolongs islet allograft survival.

Lowe M, Badell IR, Thompson P, Martin B, Leopardi F, Strobert E, Price AA, Abdulkerim HS, Wang R, Iwakoshi NN, Adams AB, Kirk AD, Larsen CP, Reimann KA.

Am J Transplant. 2012 Aug;12(8):2079-87. doi: 10.1111/j.1600-6143.2012.04054.x. Epub 2012 May 8.

8.

Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.

Kwun J, Oh BC, Gibby AC, Ruhil R, Lu VT, Kim DW, Page EK, Bulut OP, Song MQ, Farris AB, Kirk AD, Knechtle SJ, Iwakoshi NN.

Am J Transplant. 2012 Oct;12(10):2641-51. doi: 10.1111/j.1600-6143.2012.04181.x. Epub 2012 Jul 3.

9.

Partial tolerance of autoreactive B and T cells to erythrocyte-specific self-antigens in mice.

Hudson KE, Hendrickson JE, Cadwell CM, Iwakoshi NN, Zimring JC.

Haematologica. 2012 Dec;97(12):1836-44. doi: 10.3324/haematol.2012.065144. Epub 2012 Jun 24.

10.

Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates.

Badell IR, Thompson PW, Turner AP, Russell MC, Avila JG, Cano JA, Robertson JM, Leopardi FV, Strobert EA, Iwakoshi NN, Reimann KA, Ford ML, Kirk AD, Larsen CP.

Am J Transplant. 2012 Jan;12(1):126-35. doi: 10.1111/j.1600-6143.2011.03736.x. Epub 2011 Sep 15.

11.

B cells and transplantation tolerance.

Kirk AD, Turgeon NA, Iwakoshi NN.

Nat Rev Nephrol. 2010 Oct;6(10):584-93. doi: 10.1038/nrneph.2010.111. Epub 2010 Aug 24. Review.

PMID:
20736924
12.

Functional aspects of factor VIII expression after transplantation of genetically-modified hematopoietic stem cells for hemophilia A.

Ide LM, Iwakoshi NN, Gangadharan B, Jobe S, Moot R, McCarty D, Doering CB, Spencer HT.

J Gene Med. 2010 Apr;12(4):333-44. doi: 10.1002/jgm.1442.

PMID:
20209485
13.

Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes.

Liang X, Collins CM, Mendel JB, Iwakoshi NN, Speck SH.

PLoS Pathog. 2009 Nov;5(11):e1000677. doi: 10.1371/journal.ppat.1000677. Epub 2009 Nov 26.

14.

Long-term metabolic control of autoimmune diabetes in spontaneously diabetic nonobese diabetic mice by nonvascularized microencapsulated adult porcine islets.

Cui H, Tucker-Burden C, Cauffiel SM, Barry AK, Iwakoshi NN, Weber CJ, Safley SA.

Transplantation. 2009 Jul 27;88(2):160-9. doi: 10.1097/TP.0b013e3181abbfc1.

PMID:
19623010
15.

Differential effects of donor-specific alloantibody.

Turgeon NA, Kirk AD, Iwakoshi NN.

Transplant Rev (Orlando). 2009 Jan;23(1):25-33. doi: 10.1016/j.trre.2008.08.001. Epub 2008 Oct 31. Review.

PMID:
18951778
16.

The transcription factor XBP-1 is essential for the development and survival of dendritic cells.

Iwakoshi NN, Pypaert M, Glimcher LH.

J Exp Med. 2007 Oct 1;204(10):2267-75. Epub 2007 Sep 17.

17.

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha.

Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, Antonsson B, Brandt GS, Iwakoshi NN, Schinzel A, Glimcher LH, Korsmeyer SJ.

Science. 2006 Apr 28;312(5773):572-6.

18.

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands.

Lee AH, Chu GC, Iwakoshi NN, Glimcher LH.

EMBO J. 2005 Dec 21;24(24):4368-80. Epub 2005 Dec 15.

19.

Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response.

Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL.

J Biol Chem. 2006 Mar 3;281(9):5852-60. Epub 2005 Dec 6.

20.
21.
22.

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil GS.

Science. 2004 Oct 15;306(5695):457-61.

23.

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.

Shaffer AL, Shapiro-Shelef M, Iwakoshi NN, Lee AH, Qian SB, Zhao H, Yu X, Yang L, Tan BK, Rosenwald A, Hurt EM, Petroulakis E, Sonenberg N, Yewdell JW, Calame K, Glimcher LH, Staudt LM.

Immunity. 2004 Jul;21(1):81-93.

24.

It's a good year for Blimp-1 (and plasma cells).

Iwakoshi NN, Lee AH, Glimcher LH.

Immunity. 2003 Oct;19(4):466-8. No abstract available.

25.
26.

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells.

Lee AH, Iwakoshi NN, Anderson KC, Glimcher LH.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9946-51. Epub 2003 Aug 5.

27.
28.

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.

Iwakoshi NN, Lee AH, Vallabhajosyula P, Otipoby KL, Rajewsky K, Glimcher LH.

Nat Immunol. 2003 Apr;4(4):321-9. Epub 2003 Mar 3.

PMID:
12612580
29.

Skin allograft maintenance in a new synchimeric model system of tolerance.

Iwakoshi NN, Markees TG, Turgeon N, Thornley T, Cuthbert A, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA.

J Immunol. 2001 Dec 1;167(11):6623-30.

30.

Plasma cell differentiation requires the transcription factor XBP-1.

Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH.

Nature. 2001 Jul 19;412(6844):300-7.

PMID:
11460154
31.

Virus infection abrogates cd8(+) t cell deletion induced by donor-specific transfusion and anti-cd154 monoclonal antibody.

Turgeon NA, Iwakoshi NN, Meyers WC, Welsh RM, Greiner DL, Mordes JP, Rossini AA.

Curr Surg. 2000 Sep 1;57(5):505-506. No abstract available.

PMID:
11064087
32.

Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade.

Turgeon NA, Iwakoshi NN, Phillips NE, Meyers WC, Welsh RM, Greiner DL, Mordes JP, Rossini AA.

J Surg Res. 2000 Sep;93(1):63-9.

PMID:
10945944
34.

Diabetes prone BB rats are severely deficient in natural killer T cells.

Iwakoshi NN, Greiner DL, Rossini AA, Mordes JP.

Autoimmunity. 1999;31(1):1-14.

PMID:
10593564
35.

High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes-prone BioBreeding rats.

Iwakoshi NN, Goldschneider I, Tausche F, Mordes JP, Rossini AA, Greiner DL.

J Immunol. 1998 Jun 15;160(12):5838-50.

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