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Items: 1 to 50 of 69

1.

Activated Hepatic Stellate Cells and Portal Fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice.

Nishio T, Hu R, Koyama Y, Liang S, Rosenthal SB, Yamamoto G, Karin D, Baglieri J, Ma HY, Xu J, Liu X, Dhar D, Iwaisako K, Taura K, Brenner DA, Kisseleva T.

J Hepatol. 2019 May 6. pii: S0168-8278(19)30273-9. doi: 10.1016/j.jhep.2019.04.012. [Epub ahead of print]

PMID:
31071368
2.

Serum Nardilysin, a Surrogate Marker for Epithelial-Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection.

Yoh T, Hatano E, Kasai Y, Fuji H, Nishi K, Toriguchi K, Sueoka H, Ohno M, Seo S, Iwaisako K, Taura K, Yamaguchi R, Kurokawa M, Fujimoto J, Kimura T, Uemoto S, Nishi E.

Clin Cancer Res. 2019 Jan 15;25(2):619-628. doi: 10.1158/1078-0432.CCR-18-0124. Epub 2018 Oct 23.

PMID:
30352908
3.

Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation.

Fuji H, Ohmae S, Noma N, Takeiri M, Yasutomi H, Izumi K, Ito M, Toyomoto M, Iwaki S, Takemoto K, Seo S, Taura K, Hida S, Aoyama M, Ishihama Y, Hagiwara M, Takeda N, Hatano E, Iwaisako K, Uemoto S, Asagiri M.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):544-549. doi: 10.1016/j.bbrc.2018.05.153. Epub 2018 Jul 7.

PMID:
29800570
4.

Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by 18F-FDG-PET is associated with the KRAS mutation status and prognosis.

Ikeno Y, Seo S, Iwaisako K, Yoh T, Nakamoto Y, Fuji H, Taura K, Okajima H, Kaido T, Sakaguchi S, Uemoto S.

J Transl Med. 2018 Apr 11;16(1):95. doi: 10.1186/s12967-018-1475-x.

5.

CAAT/enhancer binding protein-homologous protein deficiency attenuates liver ischemia/reperfusion injury in mice.

Wada S, Hatano E, Yoh T, Nakamura N, Okuda Y, Okuno M, Kasai Y, Iwaisako K, Seo S, Taura K, Uemoto S.

Liver Transpl. 2018 May;24(5):645-654. doi: 10.1002/lt.25053. Epub 2018 Apr 16.

6.

Pancreatic Stellate Cells Have Distinct Characteristics From Hepatic Stellate Cells and Are Not the Unique Origin of Collagen-Producing Cells in the Pancreas.

Yamamoto G, Taura K, Iwaisako K, Asagiri M, Ito S, Koyama Y, Tanabe K, Iguchi K, Satoh M, Nishio T, Okuda Y, Ikeno Y, Yoshino K, Seo S, Hatano E, Uemoto S.

Pancreas. 2017 Oct;46(9):1141-1151. doi: 10.1097/MPA.0000000000000901.

PMID:
28902784
7.

Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis.

Sarashina-Kida H, Negishi H, Nishio J, Suda W, Nakajima Y, Yasui-Kato M, Iwaisako K, Kang S, Endo N, Yanai H, Asagiri M, Kida H, Hattori M, Kumanogoh A, Taniguchi T.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10178-10183. doi: 10.1073/pnas.1712837114. Epub 2017 Sep 6.

8.

Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity.

Kawaguchi K, Suzuki E, Nishie M, Kii I, Kataoka TR, Hirata M, Inoue M, Pu F, Iwaisako K, Tsuda M, Yamaguchi A, Haga H, Hagiwara M, Toi M.

Cancer Immunol Immunother. 2017 Sep;66(9):1131-1142. doi: 10.1007/s00262-017-2002-2. Epub 2017 Apr 21.

PMID:
28432397
9.

Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K.

Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M.

Sci Rep. 2017 Mar 16;7:41710. doi: 10.1038/srep41710.

10.

Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.

Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner C, Heinz S, Bera T, Brenner DA, Kisseleva T.

J Clin Invest. 2017 Apr 3;127(4):1254-1270. doi: 10.1172/JCI88845. Epub 2017 Mar 13.

11.

Nardilysin promotes hepatocellular carcinoma through activation of signal transducer and activator of transcription 3.

Kasai Y, Toriguchi K, Hatano E, Nishi K, Ohno M, Yoh T, Fukuyama K, Nishio T, Okuno M, Iwaisako K, Seo S, Taura K, Kurokawa M, Kunichika M, Uemoto S, Nishi E.

Cancer Sci. 2017 May;108(5):910-917. doi: 10.1111/cas.13204. Epub 2017 Apr 24.

12.

Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis.

Nishio T, Taura K, Iwaisako K, Koyama Y, Tanabe K, Yamamoto G, Okuda Y, Ikeno Y, Yoshino K, Kasai Y, Okuno M, Seo S, Sakurai T, Asagiri M, Hatano E, Uemoto S.

J Gastroenterol. 2017 Aug;52(8):965-976. doi: 10.1007/s00535-016-1304-z. Epub 2017 Jan 2.

PMID:
28044208
13.

Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity.

Shi G, Yoshida Y, Yuki K, Nishimura T, Kawata Y, Kawashima M, Iwaisako K, Yoshikawa K, Kurebayashi J, Toi M, Noda M.

Oncotarget. 2016 Dec 13;7(50):82158-82169. doi: 10.18632/oncotarget.8620.

14.

Controversies over the Epithelial-to-Mesenchymal Transition in Liver Fibrosis.

Taura K, Iwaisako K, Hatano E, Uemoto S.

J Clin Med. 2016 Jan 14;5(1). pii: E9. doi: 10.3390/jcm5010009. Review.

15.

Comprehensive analysis of transcriptome and metabolome analysis in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.

Murakami Y, Kubo S, Tamori A, Itami S, Kawamura E, Iwaisako K, Ikeda K, Kawada N, Ochiya T, Taguchi YH.

Sci Rep. 2015 Nov 5;5:16294. doi: 10.1038/srep16294.

16.

Evaluation of Liver Fibrosis Using Texture Analysis on Combined-Contrast-Enhanced Magnetic Resonance Images at 3.0T.

Yokoo T, Wolfson T, Iwaisako K, Peterson MR, Mani H, Goodman Z, Changchien C, Middleton MS, Gamst AC, Mazhar SM, Kono Y, Ho SB, Sirlin CB.

Biomed Res Int. 2015;2015:387653. doi: 10.1155/2015/387653. Epub 2015 Sep 1.

17.

Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune-mediated hepatitis.

Fujita T, Soontrapa K, Ito Y, Iwaisako K, Moniaga CS, Asagiri M, Majima M, Narumiya S.

Hepatology. 2016 Apr;63(4):1325-39. doi: 10.1002/hep.28112. Epub 2015 Sep 30.

18.

Diagnostic performance of (18)F-fluorodeoxyglucose PET/CT and bone scintigraphy in breast cancer patients with suspected bone metastasis.

Niikura N, Hashimoto J, Kazama T, Koizumi J, Ogiya R, Terao M, Oshitanai R, Morioka T, Tsuda B, Okamura T, Saito Y, Iwaisako K, Iwamoto T, Hayashi N, Imai Y, Tokuda Y.

Breast Cancer. 2016 Jul;23(4):662-7. doi: 10.1007/s12282-015-0621-z. Epub 2015 Jun 3.

PMID:
26037335
19.

Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells.

Noma N, Asagiri M, Takeiri M, Ohmae S, Takemoto K, Iwaisako K, Minato N, Maeda-Yamamoto M, Simizu S, Umezawa K.

Int Arch Allergy Immunol. 2015;166(2):84-90. doi: 10.1159/000371419. Epub 2015 Mar 13.

20.

Migration of splenic lymphocytes promotes liver fibrosis through modification of T helper cytokine balance in mice.

Tanabe K, Taura K, Koyama Y, Yamamoto G, Nishio T, Okuda Y, Nakamura K, Toriguchi K, Takemoto K, Yamanaka K, Iwaisako K, Seo S, Asagiri M, Hatano E, Uemoto S.

J Gastroenterol. 2015 Oct;50(10):1054-68. doi: 10.1007/s00535-015-1054-3. Epub 2015 Feb 28.

PMID:
25724556
21.

Strategies to Detect Hepatic Myofibroblasts in Liver Cirrhosis of Different Etiologies.

Iwaisako K, Taura K, Koyama Y, Takemoto K, Asagiri M.

Curr Pathobiol Rep. 2014;2(4):209-215. Review.

22.

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure.

Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, Toriguchi K, Tanabe K, Tanaka H, Seo S, Taura K, Machida K, Takeda N, Saji S, Uemoto S, Asagiri M.

FEBS Open Bio. 2014 Sep 6;4:777-87. doi: 10.1016/j.fob.2014.08.007. eCollection 2014.

23.

Intestinal ischemic preconditioning ameliorates hepatic ischemia/reperfusion injury in rats: role of heme oxygenase 1 in the second window of protection.

Kageyama S, Hata K, Tanaka H, Hirao H, Kubota T, Okamura Y, Iwaisako K, Takada Y, Uemoto S.

Liver Transpl. 2015 Jan;21(1):112-22. doi: 10.1002/lt.24006.

24.

Origin of myofibroblasts in the fibrotic liver in mice.

Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA, Hofmann AF, Iida T, Glass CK, Brenner DA, Kisseleva T.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3297-305. doi: 10.1073/pnas.1400062111. Epub 2014 Jul 29.

25.

Whey-hydrolyzed peptide-enriched immunomodulating diet prevents progression of liver cirrhosis in rats.

Jobara K, Kaido T, Hori T, Iwaisako K, Endo K, Uchida Y, Uemoto S.

Nutrition. 2014 Oct;30(10):1195-207. doi: 10.1016/j.nut.2014.02.005. Epub 2014 Feb 28.

PMID:
24976428
26.

Effects of oral intake of hydrogen water on liver fibrogenesis in mice.

Koyama Y, Taura K, Hatano E, Tanabe K, Yamamoto G, Nakamura K, Yamanaka K, Kitamura K, Narita M, Nagata H, Yanagida A, Iida T, Iwaisako K, Fujinawa H, Uemoto S.

Hepatol Res. 2014 Jun;44(6):663-677. doi: 10.1111/hepr.12165. Epub 2013 Jun 18.

PMID:
23682614
27.

Cilostazol attenuates hepatic stellate cell activation and protects mice against carbon tetrachloride-induced liver fibrosis.

Saito S, Hata K, Iwaisako K, Yanagida A, Takeiri M, Tanaka H, Kageyama S, Hirao H, Ikeda K, Asagiri M, Uemoto S.

Hepatol Res. 2014 Apr;44(4):460-73. doi: 10.1111/hepr.12140. Epub 2013 Jun 30.

28.

Origin of myofibroblasts in liver fibrosis.

Brenner DA, Kisseleva T, Scholten D, Paik YH, Iwaisako K, Inokuchi S, Schnabl B, Seki E, De Minicis S, Oesterreicher C, Taura K.

Fibrogenesis Tissue Repair. 2012 Jun 6;5(Suppl 1):S17. doi: 10.1186/1755-1536-5-S1-S17. eCollection 2012.

29.

Cell signals influencing hepatic fibrosis.

Cong M, Iwaisako K, Jiang C, Kisseleva T.

Int J Hepatol. 2012;2012:158547. doi: 10.1155/2012/158547. Epub 2012 Aug 29.

30.

Identification of small molecule activators of cryptochrome.

Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner DA, Doyle FJ 3rd, Schultz PG, Kay SA.

Science. 2012 Aug 31;337(6098):1094-7. doi: 10.1126/science.1223710. Epub 2012 Jul 12.

31.

Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9.

Nakamura K, Hatano E, Narita M, Miyagawa-Hayashino A, Koyama Y, Nagata H, Iwaisako K, Taura K, Uemoto S.

J Hepatol. 2012 Nov;57(5):1037-43. doi: 10.1016/j.jhep.2012.07.004. Epub 2012 Jul 11.

32.

Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice.

Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, Österreicher CH, Stickel F, Ley K, Brenner DA, Kisseleva T.

Gastroenterology. 2012 Sep;143(3):765-776.e3. doi: 10.1053/j.gastro.2012.05.049. Epub 2012 Jun 8.

33.

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis.

Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner DA.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9448-53. doi: 10.1073/pnas.1201840109. Epub 2012 May 7.

34.

Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist.

Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y, Sirlin C, Yu E, Yu RT, Downes M, Evans RM, Brenner DA, Schnabl B.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):E1369-76. doi: 10.1073/pnas.1202464109. Epub 2012 Apr 25.

35.

What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis.

Iwaisako K, Brenner DA, Kisseleva T.

J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:65-8. doi: 10.1111/j.1440-1746.2011.07002.x. Review.

36.

Hemifacial spasm caused by intra-axial brainstem cavernous angioma with venous angiomas.

Arita H, Kishima H, Hosomi K, Iwaisako K, Hashimoto N, Saitoh Y, Yoshimine T.

Br J Neurosurg. 2012 Apr;26(2):281-3. doi: 10.3109/02688697.2011.609605. Epub 2011 Oct 25.

PMID:
22026472
37.

Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells.

Yanagida A, Iwaisako K, Hatano E, Taura K, Sato F, Narita M, Nagata H, Asechi H, Uemoto S, Kinoshita M.

Biochim Biophys Acta. 2011 Nov;1812(11):1403-11. doi: 10.1016/j.bbadis.2011.06.015. Epub 2011 Jul 6.

38.

Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase.

Brenner DA, Seki E, Taura K, Kisseleva T, Deminicis S, Iwaisako K, Inokuchi S, Schnabl B, Oesterreicher CH, Paik YH, Miura K, Kodama Y.

Hepatol Res. 2011 Jul;41(7):683-6. doi: 10.1111/j.1872-034X.2011.00814.x.

39.
40.

The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice.

Paik YH, Iwaisako K, Seki E, Inokuchi S, Schnabl B, Osterreicher CH, Kisseleva T, Brenner DA.

Hepatology. 2011 May;53(5):1730-41. doi: 10.1002/hep.24281.

41.

"Bonnet" bypass to proximal trunk of middle cerebral artery with a radial artery interposition graft: technical note.

Sanada Y, Kamiyama H, Iwaisako K, Yoshimine T, Kato A.

Minim Invasive Neurosurg. 2010 Aug;53(4):203-6. doi: 10.1055/s-0030-1263109. Epub 2010 Dec 3.

PMID:
21132614
42.

Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice.

Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G, Brenner DA, Kisseleva T.

Gastroenterology. 2010 Sep;139(3):987-98. doi: 10.1053/j.gastro.2010.05.005. Epub 2010 Jun 20.

43.

Resistance to cisplatin-induced apoptosis via PI3K-dependent survivin expression in a rat hepatoma cell line.

Asechi H, Hatano E, Nitta T, Tada M, Iwaisako K, Tamaki N, Nagata H, Narita M, Yanagida A, Ikai I, Uemoto S.

Int J Oncol. 2010 Jul;37(1):89-96.

PMID:
20514400
44.

Fixation and protective method for the interposition graft in bonnet bypass--technical note.

Toyota S, Iwaisako K, Wakayama A, Yoshimine T.

Neurol Med Chir (Tokyo). 2010;50(3):263-6.

45.

Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice.

Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA.

Hepatology. 2010 Mar;51(3):1027-36. doi: 10.1002/hep.23368.

46.

A case of cytokeratin 20-positive large-cell neuroendocrine carcinoma of the breast.

Okoshi K, Saiga T, Hisamori S, Iwaisako K, Kobayashi H, Ogawa H.

Breast Cancer. 2012 Oct;19(4):360-4. doi: 10.1007/s12282-009-0160-6. Epub 2009 Aug 11.

PMID:
19669861
47.

c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice.

Kodama Y, Kisseleva T, Iwaisako K, Miura K, Taura K, De Minicis S, Osterreicher CH, Schnabl B, Seki E, Brenner DA.

Gastroenterology. 2009 Oct;137(4):1467-1477.e5. doi: 10.1053/j.gastro.2009.06.045. Epub 2009 Jun 21.

48.

Intracerebral hemorrhage caused by ruptured intracavernous carotid artery aneurysm. Case report.

Iwaisako K, Toyota S, Ishihara M, Shibano K, Harada Y, Iwatsuki K, Yoshimine T.

Neurol Med Chir (Tokyo). 2009 Apr;49(4):155-8.

49.

P-glycoprotein expression affects 18F-fluorodeoxyglucose accumulation in hepatocellular carcinoma in vivo and in vitro.

Seo S, Hatano E, Higashi T, Nakajima A, Nakamoto Y, Tada M, Tamaki N, Iwaisako K, Kitamura K, Ikai I, Uemoto S.

Int J Oncol. 2009 May;34(5):1303-12.

PMID:
19360342
50.

Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis.

Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, Kodama Y, Miura K, Ikai I, Uemoto S, Brenner DA.

Gastroenterology. 2008 Nov;135(5):1729-38. doi: 10.1053/j.gastro.2008.07.065. Epub 2008 Aug 3.

PMID:
18823985

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