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Items: 1 to 50 of 64

1.

Activation of α1A -adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing.

Arce C, Vicente D, Segura V, Flacco N, Montó F, Almenar L, Agüero J, Rueda J, Jiménez-Altayó F, Vila E, Noguera MA, D'Ocon P, Ivorra MD.

Br J Pharmacol. 2017 Jul;174(13):2015-2030. doi: 10.1111/bph.13800. Epub 2017 May 10.

2.

β2- and β1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases.

Montó F, Oliver E, Vicente D, Buendía F, Rueda J, Agüero J, Almenar L, Valldecabres C, Rovira E, Muedra V, Noguera MA, Ivorra MD, DʼOcon P.

J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299.

PMID:
26248277
3.

Changes in adrenoceptors and G-protein-coupled receptor kinase 2 in L-NAME-induced hypertension compared to spontaneous hypertension in rats.

Oliver E, Flacco N, Arce C, Ivorra MD, D'Ocon MP, Noguera MA.

J Vasc Res. 2014;51(3):209-20. doi: 10.1159/000360400. Epub 2014 Jun 14.

PMID:
24942010
4.

β-Adrenoceptors differentially regulate vascular tone and angiogenesis of rat aorta via ERK1/2 and p38.

Perez-Aso M, Flacco N, Carpena N, Montesinos MC, D'Ocon P, Ivorra MD.

Vascul Pharmacol. 2014 May-Jun;61(2-3):80-9. doi: 10.1016/j.vph.2014.04.003. Epub 2014 Apr 24.

PMID:
24768830
5.

Action of an extract from the seeds of Fraxinus excelsior L. on metabolic disorders in hypertensive and obese animal models.

Montó F, Arce C, Noguera MA, Ivorra MD, Flanagan J, Roller M, Issaly N, D'Ocon P.

Food Funct. 2014 Apr;5(4):786-96. doi: 10.1039/c3fo60539f.

PMID:
24573510
6.

Antihypertensive mechanism of lactoferrin-derived peptides: angiotensin receptor blocking effect.

Fernández-Musoles R, Castelló-Ruiz M, Arce C, Manzanares P, Ivorra MD, Salom JB.

J Agric Food Chem. 2014 Jan 8;62(1):173-81. doi: 10.1021/jf404616f. Epub 2013 Dec 26.

PMID:
24354413
7.

α1D-Adrenoceptors are responsible for the high sensitivity and the slow time-course of noradrenaline-mediated contraction in conductance arteries.

Flacco N, Parés J, Serna E, Segura V, Vicente D, Pérez-Aso M, Noguera MA, Ivorra MD, McGrath JC, D'Ocon P.

Pharmacol Res Perspect. 2013 Oct;1(1):e00001. doi: 10.1002/prp2.1. Epub 2013 Aug 28.

8.

2,3,9- and 2,3,11-trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands.

Párraga J, Cabedo N, Andujar S, Piqueras L, Moreno L, Galán A, Angelina E, Enriz RD, Ivorra MD, Sanz MJ, Cortes D.

Eur J Med Chem. 2013 Oct;68:150-66. doi: 10.1016/j.ejmech.2013.07.036. Epub 2013 Aug 11.

PMID:
23974015
9.

3,4-Dihydroxy- and 3,4-methylenedioxy- phenanthrene-type alkaloids with high selectivity for D2 dopamine receptor.

Moreno L, Cabedo N, Ivorra MD, Sanz MJ, Castel AL, Carmen Álvarez M, Cortes D.

Bioorg Med Chem Lett. 2013 Sep 1;23(17):4824-7. doi: 10.1016/j.bmcl.2013.06.078. Epub 2013 Jul 4.

PMID:
23886690
10.

Different β-adrenoceptor subtypes coupling to cAMP or NO/cGMP pathways: implications in the relaxant response of rat conductance and resistance vessels.

Flacco N, Segura V, Perez-Aso M, Estrada S, Seller JF, Jiménez-Altayó F, Noguera MA, D'Ocon P, Vila E, Ivorra MD.

Br J Pharmacol. 2013 May;169(2):413-25. doi: 10.1111/bph.12121.

11.

Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables.

Montó F, Oliver E, Vicente D, Rueda J, Agüero J, Almenar L, Ivorra MD, Barettino D, D'Ocon P.

Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H368-76. doi: 10.1152/ajpheart.01061.2011. Epub 2012 Jun 8.

12.

Alpha1-adrenoceptors in the rat cerebral cortex: new insights into the characterization of alpha1L- and alpha1D-adrenoceptors.

Segura V, Flacco N, Oliver E, Barettino D, D'Ocon P, Ivorra MD.

Eur J Pharmacol. 2010 Sep 1;641(1):41-8. doi: 10.1016/j.ejphar.2010.05.016. Epub 2010 May 23.

13.

Structure-activity relationship of dopaminergic halogenated 1-benzyl-tetrahydroisoquinoline derivatives.

El Aouad N, Berenguer I, Romero V, Marín P, Serrano A, Andujar S, Suvire F, Bermejo A, Ivorra MD, Enriz RD, Cabedo N, Cortes D.

Eur J Med Chem. 2009 Nov;44(11):4616-21. doi: 10.1016/j.ejmech.2009.06.033. Epub 2009 Jul 4.

PMID:
19628309
14.

Tetrahydroisoquinolines as dopaminergic ligands: 1-Butyl-7-chloro-6-hydroxy-tetrahydroisoquinoline, a new compound with antidepressant-like activity in mice.

Berenguer I, El Aouad N, Andujar S, Romero V, Suvire F, Freret T, Bermejo A, Ivorra MD, Enriz RD, Boulouard M, Cabedo N, Cortes D.

Bioorg Med Chem. 2009 Jul 15;17(14):4968-80. doi: 10.1016/j.bmc.2009.05.079. Epub 2009 Jun 6.

PMID:
19540762
15.

The impact of alpha1-adrenoceptors up-regulation accompanied by the impairment of beta-adrenergic vasodilatation in hypertension.

Oliver E, Martí D, Montó F, Flacco N, Moreno L, Barettino D, Ivorra MD, D'Ocon P.

J Pharmacol Exp Ther. 2009 Mar;328(3):982-90. doi: 10.1124/jpet.108.146043. Epub 2008 Dec 5. Erratum in: J Pharmacol Exp Ther. 2010 Aug;334(2):679.

PMID:
19060223
16.

8-NH2-boldine, an antagonist of alpha1A and alpha1B adrenoceptors without affinity for the alpha1D subtype: structural requirements for aporphines at alpha1-adrenoceptor subtypes.

Ivorra MD, Valiente M, Martínez S, Madrero Y, Noguera MA, Cassels BK, Sobarzo EM, D'Ocon P.

Planta Med. 2005 Oct;71(10):897-903.

PMID:
16254819
17.

Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neurtrophil recruitment in vivo.

Estellés R, Milian L, Nabah YNA, Mateo T, Cerdá-Nicolás M, Losada M, Ivorra MD, Issekutz AC, Cortijo J, Morcillo EJ, Blázquez MA, Sanz MJ.

J Leukoc Biol. 2005 Sep;78(3):696-704. doi: 10.1189/jlb.0105048.

PMID:
29350806
18.

Comparison of the alpha-adrenoceptor-mediated effects of beta3-adrenoceptor ligands in rat pulmonary artery.

Leblais V, Pourageaud F, Ivorra MD, Marthan R, Muller B.

Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):535-9. Epub 2005 Jul 13.

PMID:
16012871
19.

Correlation between mRNA levels and functional role of alpha1-adrenoceptor subtypes in arteries: evidence of alpha1L as a functional isoform of the alpha1A-adrenoceptor.

Martí D, Miquel R, Ziani K, Gisbert R, Ivorra MD, Anselmi E, Moreno L, Villagrasa V, Barettino D, D'Ocon P.

Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H1923-32. Epub 2005 Jun 10.

20.

Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neutrophil recruitment in vivo.

Estellés R, Milian L, Nabah YN, Mateo T, Cerdá-Nicolás M, Losada M, Ivorra MD, Issekutz AC, Cortijo J, Morcillo EJ, Blázquez MA, Sanz MJ.

J Leukoc Biol. 2005 Sep;78(3):696-704. Epub 2005 Jun 8.

PMID:
15944212
21.

Acute and chronic captopril, but not prazosin or nifedipine, normalize alterations in adrenergic intracellular Ca2+ handling observed in the mesenteric arterial tree of spontaneously hypertensive rats.

Miquel R, Gisbert R, Serna E, Perez-Vizcaino F, Anselmi E, Noguera MA, Ivorra MD, D'Ocon MP.

J Pharmacol Exp Ther. 2005 Apr;313(1):359-67. Epub 2004 Dec 22.

PMID:
15615866
22.
23.

Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery.

Leblais V, Pourageaud F, Ivorra MD, Guibert C, Marthan R, Muller B.

J Pharmacol Exp Ther. 2004 Apr;309(1):137-45. Epub 2004 Jan 12.

PMID:
14718590
24.

Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo.

Estellés R, López-Martín J, Milian L, O'Connor JE, Martínez-Losa M, Cerdá-Nicolás M, Anam EM, Ivorra MD, Issekutz AC, Cortijo J, Morcillo EJ, Blázquez MA, Sanz MJ.

Br J Pharmacol. 2003 Nov;140(6):1057-67. Epub 2003 Oct 14. Erratum in: Br J Pharmacol. 2004 May;142(1):229.

25.

Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action.

Iturriaga-Vásquez P, Miquel R, Ivorra MD, D'Ocon MP, Cassels BK.

J Nat Prod. 2003 Jul;66(7):954-7.

PMID:
12880313
26.

Cytosolic Ca2+ and phosphoinositide hydrolysis linked to constitutively active alpha 1D-adrenoceptors in vascular smooth muscle.

Gisbert R, Pérez-Vizcaino F, Cogolludo AL, Noguera MA, Ivorra MD, Tamargo J, D'Ocon P.

J Pharmacol Exp Ther. 2003 Jun;305(3):1006-14. Epub 2003 Mar 6.

PMID:
12626653
27.

Functional characterization of alpha 1-adrenoceptor subtypes in vascular tissues using different experimental approaches: a comparative study.

Gisbert R, Madrero Y, Sabino V, Noguera MA, Ivorra MD, D'Ocon P.

Br J Pharmacol. 2003 Jan;138(2):359-68.

28.

Alterations by age of calcium handling in rat resistance arteries.

Rubio C, Moreno A, Briones A, Ivorra MD, D'Ocon P, Vila E.

J Cardiovasc Pharmacol. 2002 Dec;40(6):832-40.

PMID:
12451316
29.

Modulatory role of a constitutively active population of alpha(1D)-adrenoceptors in conductance arteries.

Ziani K, Gisbert R, Noguera MA, Ivorra MD, D'Ocon P.

Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H475-81.

30.

Pathological role of a constitutively active population of alpha(1D)-adrenoceptors in arteries of spontaneously hypertensive rats.

Gisbert R, Ziani K, Miquel R, Noguera MA, Ivorra MD, Anselmi E, D'Ocon P.

Br J Pharmacol. 2002 Jan;135(1):206-16.

31.

Role of cyclic nucleotide phosphodiesterase isoenzymes in contractile responses of denuded rat aorta related to various Ca2+ sources.

Noguera MA, Ivorra MD, Lugnier C, D'Ocon P.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Jun;363(6):612-9.

PMID:
11414656
32.

Functional evidence of a constitutively active population of alpha(1D)-adrenoceptors in rat aorta.

Gisbert R, Noguera MA, Ivorra MD, D'Ocon P.

J Pharmacol Exp Ther. 2000 Nov;295(2):810-7.

PMID:
11046122
33.

Mechanism of vascular relaxation by thaligrisine: functional and binding assays.

Tur R, Magraner J, Catret M, Elorriaga M, Ivorra MD, D'Ocon P, Bermejo A, Cabedo N, Cortes D, Anselmi E.

Life Sci. 2000 Aug 18;67(13):1535-48.

PMID:
10983849
34.

Effect of divalent cations on KCl- and noradrenaline-induced contractile responses in rat aorta after nifedipine treatment.

Noguera MA, Chuliá S, Ivorra MD, D'Ocon MP.

Gen Pharmacol. 1999 Jul;33(1):43-50.

PMID:
10428015
35.

Halogenated derivatives of boldine with high selectivity for alpha1A-adrenoceptors in rat cerebral cortex.

Martinez S, Madrero Y, Elorriaga M, Noguera MA, Cassels B, Sobarzo E, D'Ocon P, Ivorra MD.

Life Sci. 1999;64(14):1205-14.

PMID:
10210263
36.

Alpha-adrenoceptor interaction of tetrandrine and isotetrandrine in the rat: functional and binding assays.

Catret M, Anselmi E, Ivorra MD, Elorriaga M, Tur R, D'Ocón MP.

J Pharm Pharmacol. 1998 Nov;50(11):1267-73.

PMID:
9877313
37.

The 5-HT and alpha-adrenoceptor antagonist effect of four benzylisoquinoline alkaloids on rat aorta.

Catret M, Ivorra MD, D'Ocón MP, Anselmi E.

J Pharm Pharmacol. 1998 Mar;50(3):317-22.

PMID:
9600725
38.

Characterization of two different Ca2+ entry pathways dependent on depletion of internal Ca2+ pools in rat aorta.

Noguera MA, Madrero Y, Ivorra MD, D'Ocon P.

Naunyn Schmiedebergs Arch Pharmacol. 1998 Feb;357(2):92-9.

PMID:
9521481
39.

Relationships between structure and vascular activity in a series of benzylisoquinolines.

Chulia S, Ivorra MD, Martinez S, Elorriaga M, Valiente M, Noguera MA, Lugnier C, Advenier C, D'Ocon P.

Br J Pharmacol. 1997 Oct;122(3):409-16.

40.

Capacitative Ca2+ entry associated with alpha1-adrenoceptors in rat aorta.

Noguera MA, Ivorra MD, Chuliá S, D'Ocon P.

Naunyn Schmiedebergs Arch Pharmacol. 1997 Jul;356(1):83-9.

PMID:
9228194
41.

A possible structural determinant of selectivity of boldine and derivatives for the alpha 1A-adrenoceptor subtype.

Madrero Y, Elorriaga M, Martinez S, Noguera MA, Cassels BK, D'Ocon P, Ivorra MD.

Br J Pharmacol. 1996 Dec;119(8):1563-8.

42.

The effect of S-(+)-boldine on the alpha 1-adrenoceptor of the guinea-pig aorta.

Chuliá S, Moreau J, Naline E, Noguera MA, Ivorra MD, D'Ocón MP, Advenier C.

Br J Pharmacol. 1996 Dec;119(7):1305-12.

43.

Functional evidence of inverse agonism in vascular smooth muscle.

Noguera MA, Ivorra MD, D'Ocon P.

Br J Pharmacol. 1996 Sep;119(1):158-64.

44.

Effect of divalent cations on the contractile response of rat aorta to depolarization before and after nifedipine treatment.

Noguera MA, Chulia S, Elorriaga M, Ivorra MD, D'Ocon P.

Pharmacology. 1996 Aug;53(2):98-108.

PMID:
8902874
45.

Relaxant activity of three aporphine alkaloids from Annona cherimolia on isolated aorta of rat.

Chuliá S, Ivorra MD, Cavé A, Cortés D, Noguera MA, D'Ocón MP.

J Pharm Pharmacol. 1995 Aug;47(8):647-50.

PMID:
8583365
46.

Vasodilator effects of liriodenine and norushinsunine, two aporphine alkaloids isolated from Annona cherimolia, in rat aorta.

Chuliá S, Noguera MA, Ivorra MD, Cortes D, D'Ocón MP.

Pharmacology. 1995 Jun;50(6):380-7.

PMID:
7568337
47.

Effect of different treatments in calcium-free medium on basal tone and contractile responses of guinea pig tracheae.

Noguera MA, Chuliá S, Ivorra MD, D'Ocon MP.

Pharmacology. 1995 May;50(5):313-23.

PMID:
7667393
48.

Different actions of some relaxant agents acting via the cAMP system in rat uterus.

Chulia S, Noguera MA, Fayos G, Anselmi E, Ivorra MD, D'Ocon MP.

Methods Find Exp Clin Pharmacol. 1995 Jan-Feb;17(1):39-45.

PMID:
7623519
49.

Mechanism of the cardiovascular activity of laudanosine: comparison with papaverine and other benzylisoquinolines.

Chuliá S, Ivorra MD, Lugnier C, Vila E, Noguera MA, D'Ocon P.

Br J Pharmacol. 1994 Dec;113(4):1377-85.

50.

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