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Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection.

Bensing BA, Li L, Yakovenko O, Wong M, Barnard KN, Iverson TM, Lebrilla CB, Parrish CR, Thomas WE, Xiong Y, Sullam PM.

PLoS Pathog. 2019 Jun 24;15(6):e1007896. doi: 10.1371/journal.ppat.1007896. [Epub ahead of print]


A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.

Sammons RM, Perry NA, Li Y, Cho EJ, Piserchio A, Zamora-Olivares DP, Ghose R, Kaoud TS, Debevec G, Bartholomeusz C, Gurevich VV, Iverson TM, Giulianotti M, Houghten RA, Dalby KN.

ACS Chem Biol. 2019 May 13. doi: 10.1021/acschembio.9b00093. [Epub ahead of print]


Crystal structure of the SH3 domain of human Lyn non-receptor tyrosine kinase.

Berndt S, Gurevich VV, Iverson TM.

PLoS One. 2019 Apr 10;14(4):e0215140. doi: 10.1371/journal.pone.0215140. eCollection 2019.


Using In Vitro Pull-Down and In-Cell Overexpression Assays to Study Protein Interactions with Arrestin.

Perry NA, Zhan X, Gurevich EV, Iverson TM, Gurevich VV.

Methods Mol Biol. 2019;1957:107-120. doi: 10.1007/978-1-4939-9158-7_7.


Maturation of the respiratory complex II flavoprotein.

Sharma P, Maklashina E, Cecchini G, Iverson TM.

Curr Opin Struct Biol. 2019 Mar 6;59:38-46. doi: 10.1016/ [Epub ahead of print] Review.


An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding.

McCulloch KM, Yamakawa I, Shifrin DA Jr, McConnell RE, Foegeding NJ, Singh PK, Mao S, Tyska MJ, Iverson TM.

J Biol Chem. 2019 Mar 8;294(10):3454-3463. doi: 10.1074/jbc.RA118.004571. Epub 2019 Jan 4.


Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification.

Perry NA, Kaoud TS, Ortega OO, Kaya AI, Marcus DJ, Pleinis JM, Berndt S, Chen Q, Zhan X, Dalby KN, Lopez CF, Iverson TM, Gurevich VV.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):810-815. doi: 10.1073/pnas.1819230116. Epub 2018 Dec 27.


The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains.

Starbird CA, Perry NA, Chen Q, Berndt S, Yamakawa I, Loukachevitch LV, Limbrick EM, Bachmann BO, Iverson TM, McCulloch KM.

Biochemistry. 2018 Dec 18;57(50):6827-6837. doi: 10.1021/acs.biochem.8b00836. Epub 2018 Dec 7.


Structural Basis of Arrestin-Dependent Signal Transduction.

Chen Q, Iverson TM, Gurevich VV.

Trends Biochem Sci. 2018 Jun;43(6):412-423. doi: 10.1016/j.tibs.2018.03.005. Epub 2018 Apr 7. Review.


The unassembled flavoprotein subunits of human and bacterial complex II have impaired catalytic activity and generate only minor amounts of ROS.

Maklashina E, Rajagukguk S, Iverson TM, Cecchini G.

J Biol Chem. 2018 May 18;293(20):7754-7765. doi: 10.1074/jbc.RA118.001977. Epub 2018 Apr 2.


Crystal structure of an assembly intermediate of respiratory Complex II.

Sharma P, Maklashina E, Cecchini G, Iverson TM.

Nat Commun. 2018 Jan 18;9(1):274. doi: 10.1038/s41467-017-02713-8.


New crystal forms of the integral membrane Escherichia coli quinol:fumarate reductase suggest that ligands control domain movement.

Starbird CA, Tomasiak TM, Singh PK, Yankovskaya V, Maklashina E, Eisenbach M, Cecchini G, Iverson TM.

J Struct Biol. 2018 Apr;202(1):100-104. doi: 10.1016/j.jsb.2017.11.004. Epub 2017 Nov 20.


Structural basis of arrestin-3 activation and signaling.

Chen Q, Perry NA, Vishnivetskiy SA, Berndt S, Gilbert NC, Zhuo Y, Singh PK, Tholen J, Ohi MD, Gurevich EV, Brautigam CA, Klug CS, Gurevich VV, Iverson TM.

Nat Commun. 2017 Nov 10;8(1):1427. doi: 10.1038/s41467-017-01218-8.


Using two-site binding models to analyze microscale thermophoresis data.

Tso SC, Chen Q, Vishnivetskiy SA, Gurevich VV, Iverson TM, Brautigam CA.

Anal Biochem. 2018 Jan 1;540-541:64-75. doi: 10.1016/j.ab.2017.10.013. Epub 2017 Oct 18.


Structural and biochemical analyses reveal insights into covalent flavinylation of the Escherichia coli Complex II homolog quinol:fumarate reductase.

Starbird CA, Maklashina E, Sharma P, Qualls-Histed S, Cecchini G, Iverson TM.

J Biol Chem. 2017 Aug 4;292(31):12921-12933. doi: 10.1074/jbc.M117.795120. Epub 2017 Jun 14.


Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors.

Prokop S, Perry NA, Vishnivetskiy SA, Toth AD, Inoue A, Milligan G, Iverson TM, Hunyady L, Gurevich VV.

Cell Signal. 2017 Aug;36:98-107. doi: 10.1016/j.cellsig.2017.04.021. Epub 2017 Apr 28.


Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand.

Loukachevitch LV, Bensing BA, Yu H, Zeng J, Chen X, Sullam PM, Iverson TM.

Biochemistry. 2016 Oct 25;55(42):5927-5937. doi: 10.1021/acs.biochem.6b00704. Epub 2016 Oct 11.


A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor.

Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE.

J Biol Chem. 2016 Sep 9;291(37):19674-86. doi: 10.1074/jbc.M116.745513. Epub 2016 Jul 26.


Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins.

Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM.

Glycobiology. 2016 Nov;26(11):1222-1234. doi: 10.1093/glycob/cww042. Epub 2016 Apr 1.


Peptide mini-scaffold facilitates JNK3 activation in cells.

Zhan X, Stoy H, Kaoud TS, Perry NA, Chen Q, Perez A, Els-Heindl S, Slagis JV, Iverson TM, Beck-Sickinger AG, Gurevich EV, Dalby KN, Gurevich VV.

Sci Rep. 2016 Feb 12;6:21025. doi: 10.1038/srep21025.


Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.

Bensing BA, Loukachevitch LV, McCulloch KM, Yu H, Vann KR, Wawrzak Z, Anderson S, Chen X, Sullam PM, Iverson TM.

J Biol Chem. 2016 Apr 1;291(14):7230-40. doi: 10.1074/jbc.M115.701425. Epub 2016 Feb 1.


Binding of the Covalent Flavin Assembly Factor to the Flavoprotein Subunit of Complex II.

Maklashina E, Rajagukguk S, Starbird CA, McDonald WH, Koganitsky A, Eisenbach M, Iverson TM, Cecchini G.

J Biol Chem. 2016 Feb 5;291(6):2904-16. doi: 10.1074/jbc.M115.690396. Epub 2015 Dec 7.


Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.

McCulloch KM, McCranie EK, Smith JA, Sarwar M, Mathieu JL, Gitschlag BL, Du Y, Bachmann BO, Iverson TM.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11547-52. doi: 10.1073/pnas.1500964112. Epub 2015 Aug 3.


The rhodopsin-arrestin-1 interaction in bicelles.

Chen Q, Vishnivetskiy SA, Zhuang T, Cho MK, Thaker TM, Sanders CR, Gurevich VV, Iverson TM.

Methods Mol Biol. 2015;1271:77-95. doi: 10.1007/978-1-4939-2330-4_6.


Functional stability of rhodopsin in a bicelle system: evaluating G protein activation by rhodopsin in bicelles.

Kaya AI, Iverson TM, Hamm HE.

Methods Mol Biol. 2015;1271:67-76. doi: 10.1007/978-1-4939-2330-4_5.


Arrestin expression in E. coli and purification.

Vishnivetskiy SA, Zhan X, Chen Q, Iverson TM, Gurevich VV.

Curr Protoc Pharmacol. 2014 Dec 1;67:Unit 2.11.1-19. doi: 10.1002/0471141755.ph0211s67.


A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit.

Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE.

J Biol Chem. 2014 Aug 29;289(35):24475-87. doi: 10.1074/jbc.M114.572875. Epub 2014 Jul 18.


Bioretrosynthetic construction of a didanosine biosynthetic pathway.

Birmingham WR, Starbird CA, Panosian TD, Nannemann DP, Iverson TM, Bachmann BO.

Nat Chem Biol. 2014 May;10(5):392-9. doi: 10.1038/nchembio.1494. Epub 2014 Mar 23.


A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.

Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM.

J Biol Chem. 2014 Apr 18;289(16):11331-41. doi: 10.1074/jbc.M113.539064. Epub 2014 Mar 4.


Characterization of fibrinogen binding by glycoproteins Srr1 and Srr2 of Streptococcus agalactiae.

Seo HS, Minasov G, Seepersaud R, Doran KS, Dubrovska I, Shuvalova L, Anderson WF, Iverson TM, Sullam PM.

J Biol Chem. 2013 Dec 13;288(50):35982-96. doi: 10.1074/jbc.M113.513358. Epub 2013 Oct 28.


Plasticity of the quinone-binding site of the complex II homolog quinol:fumarate reductase.

Singh PK, Sarwar M, Maklashina E, Kotlyar V, Rajagukguk S, Tomasiak TM, Cecchini G, Iverson TM.

J Biol Chem. 2013 Aug 23;288(34):24293-301. doi: 10.1074/jbc.M113.487082. Epub 2013 Jul 8.


Sexism: A revealing experiment.

Iverson TM.

Nature. 2013 Apr 4;496(7443):31. doi: 10.1038/496031b. No abstract available.


Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin.

Zhuang T, Chen Q, Cho MK, Vishnivetskiy SA, Iverson TM, Gurevich VV, Sanders CR.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):942-7. doi: 10.1073/pnas.1215176110. Epub 2012 Dec 31.


Engineering visual arrestin-1 with special functional characteristics.

Vishnivetskiy SA, Chen Q, Palazzo MC, Brooks EK, Altenbach C, Iverson TM, Hubbell WL, Gurevich VV.

J Biol Chem. 2013 Feb 1;288(5):3394-405. doi: 10.1074/jbc.M112.445437. Epub 2012 Dec 17.


Crystal structures of acetate kinases from the eukaryotic pathogens Entamoeba histolytica and Cryptococcus neoformans.

Thaker TM, Tanabe M, Fowler ML, Preininger AM, Ingram-Smith C, Smith KS, Iverson TM.

J Struct Biol. 2013 Feb;181(2):185-9. doi: 10.1016/j.jsb.2012.11.001. Epub 2012 Nov 16.


Catalytic mechanisms of complex II enzymes: a structural perspective.

Iverson TM.

Biochim Biophys Acta. 2013 May;1827(5):648-57. doi: 10.1016/j.bbabio.2012.09.008. Epub 2012 Sep 18. Review.


Structural basis for malfunction in complex II.

Iverson TM, Maklashina E, Cecchini G.

J Biol Chem. 2012 Oct 12;287(42):35430-8. doi: 10.1074/jbc.R112.408419. Epub 2012 Aug 17. Review.


Molecular differences between a mutase and a phosphatase: investigations of the activation step in Bacillus cereus phosphopentomutase.

Iverson TM, Panosian TD, Birmingham WR, Nannemann DP, Bachmann BO.

Biochemistry. 2012 Mar 6;51(9):1964-75. doi: 10.1021/bi201761h. Epub 2012 Feb 21.


Exploring the role of topological frustration in actin refolding with molecular simulations.

Lee JY, Duan L, Iverson TM, Dima RI.

J Phys Chem B. 2012 Feb 9;116(5):1677-86. doi: 10.1021/jp209340y. Epub 2012 Jan 30.


Allosteric mechanisms of G protein-Coupled Receptor signaling: a structural perspective.

Thaker TM, Kaya AI, Preininger AM, Hamm HE, Iverson TM.

Methods Mol Biol. 2012;796:133-74. doi: 10.1007/978-1-61779-334-9_8.


A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors.

Pyburn TM, Bensing BA, Xiong YQ, Melancon BJ, Tomasiak TM, Ward NJ, Yankovskaya V, Oliver KM, Cecchini G, Sulikowski GA, Tyska MJ, Sullam PM, Iverson TM.

PLoS Pathog. 2011 Jul;7(7):e1002112. doi: 10.1371/journal.ppat.1002112. Epub 2011 Jul 7. Erratum in: PLoS Pathog. 2012 December; 8(12): 10.1371/annotation/9bb4b6f9-d220-4c81-bdbc-ebdb33e6d892.


Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma.

Kuchtey J, Olson LM, Rinkoski T, Mackay EO, Iverson TM, Gelatt KN, Haines JL, Kuchtey RW.

PLoS Genet. 2011 Feb;7(2):e1001306. doi: 10.1371/journal.pgen.1001306. Epub 2011 Feb 17.


Coupling efficiency of rhodopsin and transducin in bicelles.

Kaya AI, Thaker TM, Preininger AM, Iverson TM, Hamm HE.

Biochemistry. 2011 Apr 19;50(15):3193-203. doi: 10.1021/bi200037j. Epub 2011 Mar 25.


Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle.

Panosian TD, Nannemann DP, Watkins GR, Phelan VV, McDonald WH, Wadzinski BE, Bachmann BO, Iverson TM.

J Biol Chem. 2011 Mar 11;286(10):8043-54. doi: 10.1074/jbc.M110.201350. Epub 2010 Dec 30.


Molecular investigations into the mechanics of actin in different nucleotide states.

Lee JY, Iverson TM, Dima RI.

J Phys Chem B. 2011 Jan 13;115(1):186-95. doi: 10.1021/jp108249g. Epub 2010 Dec 9.


Geometric restraint drives on- and off-pathway catalysis by the Escherichia coli menaquinol:fumarate reductase.

Tomasiak TM, Archuleta TL, Andréll J, Luna-Chávez C, Davis TA, Sarwar M, Ham AJ, McDonald WH, Yankovskaya V, Stern HA, Johnston JN, Maklashina E, Cecchini G, Iverson TM.

J Biol Chem. 2011 Jan 28;286(4):3047-56. doi: 10.1074/jbc.M110.192849. Epub 2010 Nov 23.


Purification, crystallization and preliminary X-ray diffraction analysis of the carbohydrate-binding region of the Streptococcus gordonii adhesin GspB.

Pyburn TM, Yankovskaya V, Bensing BA, Cecchini G, Sullam PM, Iverson TM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1503-7. doi: 10.1107/S1744309110036535. Epub 2010 Oct 29.


Structure and mechanism of ORF36, an amino sugar oxidizing enzyme in everninomicin biosynthesis .

Vey JL, Al-Mestarihi A, Hu Y, Funk MA, Bachmann BO, Iverson TM.

Biochemistry. 2010 Nov 2;49(43):9306-17. doi: 10.1021/bi101336u.


Crystallization and preliminary X-ray analysis of a phosphopentomutase from Bacillus cereus.

Panosian TD, Nannemann DP, Bachmann BO, Iverson TM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jul 1;66(Pt 7):811-4. doi: 10.1107/S1744309110017549. Epub 2010 Jun 24.


Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB.

Tanabe M, Nimigean CM, Iverson TM.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6811-6. doi: 10.1073/pnas.0912115107. Epub 2010 Mar 29.

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