Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 170

1.

Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand-independent functions.

Annalora AJ, Jozic M, Marcus CB, Iversen PL.

Toxicol Appl Pharmacol. 2019 Feb 1;364:55-67. doi: 10.1016/j.taap.2018.12.009. Epub 2018 Dec 12.

PMID:
30552932
2.

A k-mer based transcriptomics approach for antisense drug discovery targeting the Ewing's family of tumors.

Annalora AJ, O'Neil S, Bushman JD, Summerton JE, Marcus CB, Iversen PL.

Oncotarget. 2018 Jul 17;9(55):30568-30586. doi: 10.18632/oncotarget.25736. eCollection 2018 Jul 17.

3.

Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism.

Annalora AJ, Marcus CB, Iversen PL.

Drug Metab Dispos. 2017 Apr;45(4):375-389. doi: 10.1124/dmd.116.073254. Epub 2017 Feb 10. Review.

PMID:
28188297
4.

Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques.

Warren TK, Whitehouse CA, Wells J, Welch L, Charleston JS, Heald A, Nichols DK, Mattix ME, Palacios G, Kugleman JR, Iversen PL, Bavari S.

PLoS Negl Trop Dis. 2016 Feb 22;10(2):e0004456. doi: 10.1371/journal.pntd.0004456. eCollection 2016 Feb.

5.

AVI-7288 for Marburg Virus in Nonhuman Primates and Humans.

Heald AE, Charleston JS, Iversen PL, Warren TK, Saoud JB, Al-Ibrahim M, Wells J, Warfield KL, Swenson DL, Welch LS, Sazani P, Wong M, Berry D, Kaye EM, Bavari S.

N Engl J Med. 2015 Jul 23;373(4):339-48. doi: 10.1056/NEJMoa1410345.

6.

A single phosphorodiamidate morpholino oligomer targeting VP24 protects rhesus monkeys against lethal Ebola virus infection.

Warren TK, Whitehouse CA, Wells J, Welch L, Heald AE, Charleston JS, Sazani P, Reid SP, Iversen PL, Bavari S.

MBio. 2015 Feb 10;6(1). pii: e02344-14. doi: 10.1128/mBio.02344-14.

7.

Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against ebola virus and marburg virus: results of two single-ascending-dose studies.

Heald AE, Iversen PL, Saoud JB, Sazani P, Charleston JS, Axtelle T, Wong M, Smith WB, Vutikullird A, Kaye E.

Antimicrob Agents Chemother. 2014 Nov;58(11):6639-47. doi: 10.1128/AAC.03442-14. Epub 2014 Aug 25.

8.

Induced IL-10 splice altering approach to antiviral drug discovery.

Panchal RG, Mourich DV, Bradfute S, Hauck LL, Warfield KL, Iversen PL, Bavari S.

Nucleic Acid Ther. 2014 Jun;24(3):179-85. doi: 10.1089/nat.2013.0457. Epub 2014 Mar 21.

PMID:
24655055
9.

Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease.

Punj S, Kopparapu P, Jang HS, Phillips JL, Pennington J, Rohlman D, O'Donnell E, Iversen PL, Kolluri SK, Kerkvliet NI.

PLoS One. 2014 Feb 19;9(2):e88726. doi: 10.1371/journal.pone.0088726. eCollection 2014.

10.

Alternative splice forms of CTLA-4 induced by antisense mediated splice-switching influences autoimmune diabetes susceptibility in NOD mice.

Mourich DV, Oda SK, Schnell FJ, Crumley SL, Hauck LL, Moentenich CA, Marshall NB, Hinrichs DJ, Iversen PL.

Nucleic Acid Ther. 2014 Apr;24(2):114-26. doi: 10.1089/nat.2013.0449. Epub 2014 Feb 4.

PMID:
24494586
11.

Gene-silencing antisense oligomers inhibit acinetobacter growth in vitro and in vivo.

Geller BL, Marshall-Batty K, Schnell FJ, McKnight MM, Iversen PL, Greenberg DE.

J Infect Dis. 2013 Nov 15;208(10):1553-60. doi: 10.1093/infdis/jit460. Epub 2013 Oct 14.

12.

Development of novel bioanalytical methods to determine the effective concentrations of phosphorodiamidate morpholino oligomers in tissues and cells.

Schnell FJ, Crumley SL, Mourich DV, Iversen PL.

Biores Open Access. 2013 Feb;2(1):61-6. doi: 10.1089/biores.2012.0276.

13.

Lymphocytic choriomeningitis virus infection in FVB mouse produces hemorrhagic disease.

Schnell FJ, Sundholm S, Crumley S, Iversen PL, Mourich DV.

PLoS Pathog. 2012 Dec;8(12):e1003073. doi: 10.1371/journal.ppat.1003073. Epub 2012 Dec 27.

14.

Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections.

Iversen PL, Warren TK, Wells JB, Garza NL, Mourich DV, Welch LS, Panchal RG, Bavari S.

Viruses. 2012 Nov 6;4(11):2806-30. doi: 10.3390/v4112806.

15.

Bacterial resistance to antisense peptide phosphorodiamidate morpholino oligomers.

Puckett SE, Reese KA, Mitev GM, Mullen V, Johnson RC, Pomraning KR, Mellbye BL, Tilley LD, Iversen PL, Freitag M, Geller BL.

Antimicrob Agents Chemother. 2012 Dec;56(12):6147-53. doi: 10.1128/AAC.00850-12. Epub 2012 Sep 17.

16.

Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.

Panchal RG, Geller BL, Mellbye B, Lane D, Iversen PL, Bavari S.

Nucleic Acid Ther. 2012 Oct;22(5):316-22. doi: 10.1089/nat.2012.0362. Epub 2012 Sep 14.

17.

Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function.

Morse MA, Hobeika A, Serra D, Aird K, McKinney M, Aldrich A, Clay T, Mourich D, Lyerly HK, Iversen PL, Devi GR.

Cancer Gene Ther. 2012 Jan;19(1):30-7. doi: 10.1038/cgt.2011.63. Epub 2011 Oct 14.

PMID:
21997230
18.

Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs.

Ma W, Lin Y, Xuan W, Iversen PL, Smith LJ, Benchimol S.

Oncogene. 2012 Feb 23;31(8):1024-33. doi: 10.1038/onc.2011.300. Epub 2011 Jul 18.

PMID:
21765469
19.

Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum.

Du L, Kayali R, Bertoni C, Fike F, Hu H, Iversen PL, Gatti RA.

Hum Mol Genet. 2011 Aug 15;20(16):3151-60. doi: 10.1093/hmg/ddr217. Epub 2011 May 16.

20.

Advanced antisense therapies for postexposure protection against lethal filovirus infections.

Warren TK, Warfield KL, Wells J, Swenson DL, Donner KS, Van Tongeren SA, Garza NL, Dong L, Mourich DV, Crumley S, Nichols DK, Iversen PL, Bavari S.

Nat Med. 2010 Sep;16(9):991-4. doi: 10.1038/nm.2202. Epub 2010 Aug 22.

PMID:
20729866
21.

Antisense phosphorodiamidate morpholino oligomers targeted to an essential gene inhibit Burkholderia cepacia complex.

Greenberg DE, Marshall-Batty KR, Brinster LR, Zarember KA, Shaw PA, Mellbye BL, Iversen PL, Holland SM, Geller BL.

J Infect Dis. 2010 Jun 15;201(12):1822-30. doi: 10.1086/652807.

22.

Cationic phosphorodiamidate morpholino oligomers efficiently prevent growth of Escherichia coli in vitro and in vivo.

Mellbye BL, Weller DD, Hassinger JN, Reeves MD, Lovejoy CE, Iversen PL, Geller BL.

J Antimicrob Chemother. 2010 Jan;65(1):98-106. doi: 10.1093/jac/dkp392.

PMID:
19884121
23.

Cellular uptake of neutral phosphorodiamidate morpholino oligomers.

Iversen PL, Aird KM, Wu R, Morse MM, Devi GR.

Curr Pharm Biotechnol. 2009 Sep;10(6):579-88. Epub 2009 Sep 1.

PMID:
19619124
24.

Inhibition of intracellular growth of Salmonella enterica serovar Typhimurium in tissue culture by antisense peptide-phosphorodiamidate morpholino oligomer.

Mitev GM, Mellbye BL, Iversen PL, Geller BL.

Antimicrob Agents Chemother. 2009 Sep;53(9):3700-4. doi: 10.1128/AAC.00099-09. Epub 2009 Jul 6.

25.
26.

Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis.

Panchal RG, Ulrich RL, Bradfute SB, Lane D, Ruthel G, Kenny TA, Iversen PL, Anderson AO, Gussio R, Raschke WC, Bavari S.

J Biol Chem. 2009 May 8;284(19):12874-85. doi: 10.1074/jbc.M809633200. Epub 2009 Mar 6.

27.

Antisense targeting of cFLIP sensitizes activated T cells to undergo apoptosis and desensitizes responses to contact dermatitis.

Mourich DV, Jendrzejewski JL, Marshall NB, Hinrichs DJ, Iversen PL, Brand RM.

J Invest Dermatol. 2009 Aug;129(8):1945-53. doi: 10.1038/jid.2009.16. Epub 2009 Feb 19.

28.

Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection.

Swenson DL, Warfield KL, Warren TK, Lovejoy C, Hassinger JN, Ruthel G, Blouch RE, Moulton HM, Weller DD, Iversen PL, Bavari S.

Antimicrob Agents Chemother. 2009 May;53(5):2089-99. doi: 10.1128/AAC.00936-08. Epub 2009 Feb 17.

29.

Inhibition of measles virus infections in cell cultures by peptide-conjugated morpholino oligomers.

Sleeman K, Stein DA, Tamin A, Reddish M, Iversen PL, Rota PA.

Virus Res. 2009 Mar;140(1-2):49-56. doi: 10.1016/j.virusres.2008.10.018. Epub 2009 Jan 6.

PMID:
19059443
30.

Variations in amino acid composition of antisense peptide-phosphorodiamidate morpholino oligomer affect potency against Escherichia coli in vitro and in vivo.

Mellbye BL, Puckett SE, Tilley LD, Iversen PL, Geller BL.

Antimicrob Agents Chemother. 2009 Feb;53(2):525-30. doi: 10.1128/AAC.00917-08. Epub 2008 Nov 17.

31.

By-passing the nonsense mutation in the 4 CV mouse model of muscular dystrophy by induced exon skipping.

Mitrpant C, Fletcher S, Iversen PL, Wilton SD.

J Gene Med. 2009 Jan;11(1):46-56. doi: 10.1002/jgm.1265.

PMID:
19006096
32.

Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer.

Wu B, Moulton HM, Iversen PL, Jiang J, Li J, Li J, Spurney CF, Sali A, Guerron AD, Nagaraju K, Doran T, Lu P, Xiao X, Lu QL.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14814-9. doi: 10.1073/pnas.0805676105. Epub 2008 Sep 19.

33.

Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure-activity studies.

Abes R, Moulton HM, Clair P, Yang ST, Abes S, Melikov K, Prevot P, Youngblood DS, Iversen PL, Chernomordik LV, Lebleu B.

Nucleic Acids Res. 2008 Nov;36(20):6343-54. doi: 10.1093/nar/gkn541. Epub 2008 Sep 16.

34.

Treatment of AG129 mice with antisense morpholino oligomers increases survival time following challenge with dengue 2 virus.

Stein DA, Huang CY, Silengo S, Amantana A, Crumley S, Blouch RE, Iversen PL, Kinney RM.

J Antimicrob Chemother. 2008 Sep;62(3):555-65. doi: 10.1093/jac/dkn221. Epub 2008 Jun 19.

PMID:
18567576
35.

Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.

Jearawiriyapaisarn N, Moulton HM, Buckley B, Roberts J, Sazani P, Fucharoen S, Iversen PL, Kole R.

Mol Ther. 2008 Sep;16(9):1624-9. doi: 10.1038/mt.2008.120. Epub 2008 Jun 10.

36.

Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers.

Paessler S, Rijnbrand R, Stein DA, Ni H, Yun NE, Dziuba N, Borisevich V, Seregin A, Ma Y, Blouch R, Iversen PL, Zacks MA.

Virology. 2008 Jul 5;376(2):357-70. doi: 10.1016/j.virol.2008.03.032. Epub 2008 May 12.

37.

Inhibition of respiratory syncytial virus infections with morpholino oligomers in cell cultures and in mice.

Lai SH, Stein DA, Guerrero-Plata A, Liao SL, Ivanciuc T, Hong C, Iversen PL, Casola A, Garofalo RP.

Mol Ther. 2008 Jun;16(6):1120-8. doi: 10.1038/mt.2008.81. Epub 2008 Apr 29.

38.

Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers.

Lupfer C, Stein DA, Mourich DV, Tepper SE, Iversen PL, Pastey M.

Arch Virol. 2008;153(5):929-37. doi: 10.1007/s00705-008-0067-0. Epub 2008 Mar 28.

PMID:
18369525
39.

Blockade of viral interleukin-6 expression of Kaposi's sarcoma-associated herpesvirus.

Zhang YJ, Bonaparte RS, Patel D, Stein DA, Iversen PL.

Mol Cancer Ther. 2008 Mar;7(3):712-20. doi: 10.1158/1535-7163.MCT-07-2036.

40.

A morpholino oligomer targeting highly conserved internal ribosome entry site sequence is able to inhibit multiple species of picornavirus.

Stone JK, Rijnbrand R, Stein DA, Ma Y, Yang Y, Iversen PL, Andino R.

Antimicrob Agents Chemother. 2008 Jun;52(6):1970-81. doi: 10.1128/AAC.00011-08. Epub 2008 Mar 17.

41.

Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus.

Gabriel G, Nordmann A, Stein DA, Iversen PL, Klenk HD.

J Gen Virol. 2008 Apr;89(Pt 4):939-48. doi: 10.1099/vir.0.83449-0.

PMID:
18343835
42.

West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions.

Zhang B, Dong H, Stein DA, Iversen PL, Shi PY.

Virology. 2008 Mar 30;373(1):1-13. doi: 10.1016/j.virol.2008.01.016. Epub 2008 Feb 6.

43.

Virus-specific antiviral treatment for controlling severe and fatal outbreaks of feline calicivirus infection.

Smith AW, Iversen PL, O'Hanley PD, Skilling DE, Christensen JR, Weaver SS, Longley K, Stone MA, Poet SE, Matson DO.

Am J Vet Res. 2008 Jan;69(1):23-32. doi: 10.2460/ajvr.69.1.23.

PMID:
18167083
44.

c-MYC antisense phosphosphorodiamidate morpholino oligomer inhibits lung metastasis in a murine tumor model.

Sekhon HS, London CA, Sekhon M, Iversen PL, Devi GR.

Lung Cancer. 2008 Jun;60(3):347-54. Epub 2007 Dec 21.

PMID:
18096271
45.

Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction.

Silvestri LS, Ruthel G, Kallstrom G, Warfield KL, Swenson DL, Nelle T, Iversen PL, Bavari S, Aman MJ.

J Infect Dis. 2007 Nov 15;196 Suppl 2:S264-70.

PMID:
17940959
46.

Cell penetrating peptide conjugates of steric block oligonucleotides.

Lebleu B, Moulton HM, Abes R, Ivanova GD, Abes S, Stein DA, Iversen PL, Arzumanov AA, Gait MJ.

Adv Drug Deliv Rev. 2008 Mar 1;60(4-5):517-29. Epub 2007 Oct 22. Review.

PMID:
18037527
47.

Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replication.

Patel D, Opriessnig T, Stein DA, Halbur PG, Meng XJ, Iversen PL, Zhang YJ.

Antiviral Res. 2008 Feb;77(2):95-107. Epub 2007 Oct 4.

PMID:
17959259
48.

Inhibition of foot-and-mouth disease virus infections in cell cultures with antisense morpholino oligomers.

Vagnozzi A, Stein DA, Iversen PL, Rieder E.

J Virol. 2007 Nov;81(21):11669-80. Epub 2007 Aug 29.

49.

Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing.

Marshall NB, Oda SK, London CA, Moulton HM, Iversen PL, Kerkvliet NI, Mourich DV.

J Immunol Methods. 2007 Aug 31;325(1-2):114-26. Epub 2007 Jul 27.

PMID:
17673254
50.

Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity.

Wu RP, Youngblood DS, Hassinger JN, Lovejoy CE, Nelson MH, Iversen PL, Moulton HM.

Nucleic Acids Res. 2007;35(15):5182-91. Epub 2007 Aug 1.

Supplemental Content

Loading ...
Support Center