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Items: 23

1.

Interleukin-20 plays a critical role in maintenance and development of psoriasis in the human xenograft transplantation model.

Stenderup K, Rosada C, Worsaae A, Dagnaes-Hansen F, Steiniche T, Hasselager E, Iversen LF, Zahn S, Wöldike H, Holmberg HL, Rømer J, Kragballe K, Clausen JT, Dam TN.

Br J Dermatol. 2009 Feb;160(2):284-96. doi: 10.1111/j.1365-2133.2008.08890.x. Epub 2008 Oct 20.

PMID:
18945296
2.

Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B.

Pedersen AK, Peters G Gü, Møller KB, Iversen LF, Kastrup JS.

Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1527-34. Epub 2004 Aug 26.

PMID:
15333922
3.

Residue 259 in protein-tyrosine phosphatase PTP1B and PTPalpha determines the flexibility of glutamine 262.

Peters GH, Iversen LF, Andersen HS, Møller NP, Olsen OH.

Biochemistry. 2004 Jul 6;43(26):8418-28.

PMID:
15222753
4.

Identification, synthesis, and characterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site.

Kristiansen M, Andersen B, Iversen LF, Westergaard N.

J Med Chem. 2004 Jul 1;47(14):3537-45.

PMID:
15214781
5.

Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase beta.

Lund IK, Andersen HS, Iversen LF, Olsen OH, Møller KB, Pedersen AK, Ge Y, Holsworth DD, Newman MJ, Axe FU, Møller NP.

J Biol Chem. 2004 Jun 4;279(23):24226-35. Epub 2004 Mar 15.

6.

Affinity purification of recombinant protein-tyrosine phosphatase 1B using a highly selective inhibitor.

Pedersen AK, Branner S, Mortensen SB, Andersen HS, Klausen KM, Møller KB, Møller NP, Iversen LF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jan 5;799(1):1-8.

PMID:
14659430
7.

Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis.

Pedersen AK, Guo XL, Møller KB, Peters GH, Andersen HS, Kastrup JS, Mortensen SB, Iversen LF, Zhang ZY, Møller NP.

Biochem J. 2004 Mar 1;378(Pt 2):421-33.

8.

Ligand-induced conformational changes: improved predictions of ligand binding conformations and affinities.

Frimurer TM, Peters GH, Iversen LF, Andersen HS, Møller NP, Olsen OH.

Biophys J. 2003 Apr;84(4):2273-81.

9.

Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.

Andersen HS, Olsen OH, Iversen LF, Sørensen AL, Mortensen SB, Christensen MS, Branner S, Hansen TK, Lau JF, Jeppesen L, Moran EJ, Su J, Bakir F, Judge L, Shahbaz M, Collins T, Vo T, Newman MJ, Ripka WC, Møller NP.

J Med Chem. 2002 Sep 26;45(20):4443-59.

PMID:
12238924
10.

Structure determination of T cell protein-tyrosine phosphatase.

Iversen LF, Moller KB, Pedersen AK, Peters GH, Petersen AS, Andersen HS, Branner S, Mortensen SB, Moller NP.

J Biol Chem. 2002 May 31;277(22):19982-90. Epub 2002 Mar 20.

11.

Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases.

Iversen LF, Andersen HS, Møller KB, Olsen OH, Peters GH, Branner S, Mortensen SB, Hansen TK, Lau J, Ge Y, Holsworth DD, Newman MJ, Hundahl Møller NP.

Biochemistry. 2001 Dec 11;40(49):14812-20.

PMID:
11732900
12.

Heparin-binding protein (HBP/CAP37): a missing link in neutrophil-evoked alteration of vascular permeability.

Gautam N, Olofsson AM, Herwald H, Iversen LF, Lundgren-Akerlund E, Hedqvist P, Arfors KE, Flodgaard H, Lindbom L.

Nat Med. 2001 Oct;7(10):1123-7.

PMID:
11590435
13.

Structural and evolutionary relationships among protein tyrosine phosphatase domains.

Andersen JN, Mortensen OH, Peters GH, Drake PG, Iversen LF, Olsen OH, Jansen PG, Andersen HS, Tonks NK, Møller NP.

Mol Cell Biol. 2001 Nov;21(21):7117-36. Review. No abstract available.

14.

Two mutants of human heparin binding protein (CAP37): toward the understanding of the nature of lipid A/LPS and BPTI binding.

Kastrup JS, Linde V, Pedersen AK, Stoffer B, Iversen LF, Larsen IK, Rasmussen PB, Flodgaard HJ, Bjørn SE.

Proteins. 2001 Mar 1;42(4):442-51.

PMID:
11170199
15.

Protein tyrosine phosphatases (PTPs) as drug targets: inhibitors of PTP-1B for the treatment of diabetes.

Møller NP, Iversen LF, Andersen HS, McCormack JG.

Curr Opin Drug Discov Devel. 2000 Sep;3(5):527-40.

PMID:
19649881
16.

Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha.

Peters GH, Iversen LF, Branner S, Andersen HS, Mortensen SB, Olsen OH, Moller KB, Moller NP.

J Biol Chem. 2000 Jun 16;275(24):18201-9.

17.

Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.

Iversen LF, Andersen HS, Branner S, Mortensen SB, Peters GH, Norris K, Olsen OH, Jeppesen CB, Lundt BF, Ripka W, Møller KB, Møller NP.

J Biol Chem. 2000 Apr 7;275(14):10300-7.

18.

2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.

Andersen HS, Iversen LF, Jeppesen CB, Branner S, Norris K, Rasmussen HB, Møller KB, Møller NP.

J Biol Chem. 2000 Mar 10;275(10):7101-8.

19.

Structure and function of the N-linked glycans of HBP/CAP37/azurocidin: crystal structure determination and biological characterization of nonglycosylated HBP.

Iversen LF, Kastrup JS, Bjørn SE, Wiberg FC, Larsen IK, Flodgaard HJ, Rasmussen PB.

Protein Sci. 1999 Oct;8(10):2019-26.

20.

Atomic resolution structure of human HBP/CAP37/azurocidin.

Karlsen S, Iversen LF, Larsen IK, Flodgaard HJ, Kastrup JS.

Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):598-609.

PMID:
9761855
21.

Characterization of the allosteric binding pocket of human liver fructose-1,6-bisphosphatase by protein crystallography and inhibitor activity studies.

Iversen LF, Brzozowski M, Hastrup S, Hubbard R, Kastrup JS, Larsen IK, Naerum L, Nørskov-Lauridsen L, Rasmussen PB, Thim L, Wiberg FC, Lundgren K.

Protein Sci. 1997 May;6(5):971-82.

22.

Structure of HBP, a multifunctional protein with a serine proteinase fold.

Iversen LF, Kastrup JS, Bjørn SE, Rasmussen PB, Wiberg FC, Flodgaard HJ, Larsen IK.

Nat Struct Biol. 1997 Apr;4(4):265-8.

PMID:
9095193
23.

Crystallization and molecular replacement solution of human heparin binding protein.

Iversen LF, Kastrup JS, Larsen IK, Bjørn SE, Rasmussen PB, Wiberg FC, Flodgaard HJ.

Acta Crystallogr D Biol Crystallogr. 1996 Nov 1;52(Pt 6):1222-3.

PMID:
15299593

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