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Items: 41


Systematic identification of recognition motifs for the hub protein LC8.

Jespersen N, Estelle A, Waugh N, Davey NE, Blikstad C, Ammon YC, Akhmanova A, Ivarsson Y, Hendrix DA, Barbar E.

Life Sci Alliance. 2019 Jul 2;2(4). pii: e201900366. doi: 10.26508/lsa.201900366. Print 2019 Aug.


Editorial overview: Folding and binding.

Ivarsson Y, Jemth P.

Curr Opin Struct Biol. 2019 Feb;54:139-140. doi: 10.1016/ Epub 2019 Mar 20. No abstract available.


Affinity and specificity of motif-based protein-protein interactions.

Ivarsson Y, Jemth P.

Curr Opin Struct Biol. 2019 Feb;54:26-33. doi: 10.1016/ Epub 2018 Oct 24. Review.


Proteome-wide analysis of phospho-regulated PDZ domain interactions.

Sundell GN, Arnold R, Ali M, Naksukpaiboon P, Orts J, Güntert P, Chi CN, Ivarsson Y.

Mol Syst Biol. 2018 Aug 20;14(8):e8129. doi: 10.15252/msb.20178129.


High-throughput discovery of functional disordered regions.

Ali M, Ivarsson Y.

Mol Syst Biol. 2018 May 22;14(5):e8377. doi: 10.15252/msb.20188377. No abstract available.


PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis.

Wu CG, Chen H, Guo F, Yadav VK, Mcilwain SJ, Rowse M, Choudhary A, Lin Z, Li Y, Gu T, Zheng A, Xu Q, Lee W, Resch E, Johnson B, Day J, Ge Y, Ong IM, Burkard ME, Ivarsson Y, Xing Y.

Cell Discov. 2017 Aug 8;3:17027. doi: 10.1038/celldisc.2017.27. eCollection 2017.


Let There Be Light!

Raykova D, Koos B, Asplund A, Gelléri M, Ivarsson Y, Danielson UH, Söderberg O.

Proteomes. 2016 Nov 29;4(4). pii: E36. doi: 10.3390/proteomes4040036. Review.


Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome.

Davey NE, Seo MH, Yadav VK, Jeon J, Nim S, Krystkowiak I, Blikstad C, Dong D, Markova N, Kim PM, Ivarsson Y.

FEBS J. 2017 Feb;284(3):485-498. doi: 10.1111/febs.13995. Epub 2017 Jan 18.


Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions.

Karlsson OA, Sundell GN, Andersson E, Ivarsson Y, Jemth P.

Sci Rep. 2016 Oct 3;6:34269. doi: 10.1038/srep34269.


Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.

Egea-Jimenez AL, Gallardo R, Garcia-Pino A, Ivarsson Y, Wawrzyniak AM, Kashyap R, Loris R, Schymkowitz J, Rousseau F, Zimmermann P.

Nat Commun. 2016 Jul 8;7:12101. doi: 10.1038/ncomms12101.


Pooled screening for antiproliferative inhibitors of protein-protein interactions.

Nim S, Jeon J, Corbi-Verge C, Seo MH, Ivarsson Y, Moffat J, Tarasova N, Kim PM.

Nat Chem Biol. 2016 Apr;12(4):275-81. doi: 10.1038/nchembio.2026. Epub 2016 Feb 22.


Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin.

Garrido-Urbani S, Garg P, Ghossoub R, Arnold R, Lembo F, Sundell GN, Kim PM, Lopez M, Zimmermann P, Sidhu SS, Ivarsson Y.

FEBS Lett. 2016 Jan;590(1):3-12. doi: 10.1002/1873-3468.12037. Epub 2016 Jan 8.


Structural basis of Sorcin-mediated calcium-dependent signal transduction.

Ilari A, Fiorillo A, Poser E, Lalioti VS, Sundell GN, Ivarsson Y, Genovese I, Colotti G.

Sci Rep. 2015 Nov 18;5:16828. doi: 10.1038/srep16828.


High-throughput methods for identification of protein-protein interactions involving short linear motifs.

Blikstad C, Ivarsson Y.

Cell Commun Signal. 2015 Aug 22;13:38. doi: 10.1186/s12964-015-0116-8.


Selectivity of aggregation-determining interactions.

Ganesan A, Debulpaep M, Wilkinson H, Van Durme J, De Baets G, Jonckheere W, Ramakers M, Ivarsson Y, Zimmermann P, Van Eldere J, Schymkowitz J, Rousseau F.

J Mol Biol. 2015 Jan 30;427(2):236-47. doi: 10.1016/j.jmb.2014.09.027. Epub 2014 Nov 7.


Interaction analysis through proteomic phage display.

Sundell GN, Ivarsson Y.

Biomed Res Int. 2014;2014:176172. doi: 10.1155/2014/176172. Epub 2014 Sep 11. Review.


A structural portrait of the PDZ domain family.

Ernst A, Appleton BA, Ivarsson Y, Zhang Y, Gfeller D, Wiesmann C, Sidhu SS.

J Mol Biol. 2014 Oct 23;426(21):3509-19. doi: 10.1016/j.jmb.2014.08.012. Epub 2014 Aug 23.


Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.

Ivarsson Y, Arnold R, McLaughlin M, Nim S, Joshi R, Ray D, Liu B, Teyra J, Pawson T, Moffat J, Li SS, Sidhu SS, Kim PM.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2542-7. doi: 10.1073/pnas.1312296111. Epub 2014 Feb 3.


A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin.

Hämälistö S, Pouwels J, de Franceschi N, Saari M, Ivarsson Y, Zimmermann P, Brech A, Stenmark H, Ivaska J.

PLoS One. 2013 Aug 13;8(8):e70696. doi: 10.1371/journal.pone.0070696. eCollection 2013.


Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments.

Ivarsson Y, Wawrzyniak AM, Kashyap R, Polanowska J, Betzi S, Lembo F, Vermeiren E, Chiheb D, Lenfant N, Morelli X, Borg JP, Reboul J, Zimmermann P.

PLoS One. 2013;8(2):e54581. doi: 10.1371/journal.pone.0054581. Epub 2013 Feb 4.


Extensions of PSD-95/discs large/ZO-1 (PDZ) domains influence lipid binding and membrane targeting of syntenin-1.

Wawrzyniak AM, Vermeiren E, Zimmermann P, Ivarsson Y.

FEBS Lett. 2012 May 21;586(10):1445-51. doi: 10.1016/j.febslet.2012.04.024. Epub 2012 Apr 21.


Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

Baietti MF, Zhang Z, Mortier E, Melchior A, Degeest G, Geeraerts A, Ivarsson Y, Depoortere F, Coomans C, Vermeiren E, Zimmermann P, David G.

Nat Cell Biol. 2012 Jun 3;14(7):677-85. doi: 10.1038/ncb2502.


Plasticity of PDZ domains in ligand recognition and signaling.

Ivarsson Y.

FEBS Lett. 2012 Aug 14;586(17):2638-47. doi: 10.1016/j.febslet.2012.04.015. Epub 2012 Apr 21. Review.


Syntenin, a syndecan adaptor and an Arf6 phosphatidylinositol 4,5-bisphosphate effector, is essential for epiboly and gastrulation cell movements in zebrafish.

Lambaerts K, Van Dyck S, Mortier E, Ivarsson Y, Degeest G, Luyten A, Vermeiren E, Peers B, David G, Zimmermann P.

J Cell Sci. 2012 Mar 1;125(Pt 5):1129-40. doi: 10.1242/jcs.089987. Epub 2012 Mar 7.


Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulin.

Ivarsson Y, Wawrzyniak AM, Wuytens G, Kosloff M, Vermeiren E, Raport M, Zimmermann P.

J Biol Chem. 2011 Dec 30;286(52):44669-78. doi: 10.1074/jbc.M111.285734. Epub 2011 Oct 27.


Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.

Fugier C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, Lopez de Munain A, Sergeant N, Laquerrière A, Thibault C, Deryckere F, Auboeuf D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I, Bassez G, Laporte J, Furling D, Charlet-Berguerand N.

Nat Med. 2011 Jun;17(6):720-5. doi: 10.1038/nm.2374. Epub 2011 May 29.


Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain.

Gianni S, Ivarsson Y, De Simone A, Travaglini-Allocatelli C, Brunori M, Vendruscolo M.

Nat Struct Mol Biol. 2010 Dec;17(12):1431-7. doi: 10.1038/nsmb.1956. Epub 2010 Nov 14.


Structural diversity of PDZ-lipid interactions.

Gallardo R, Ivarsson Y, Schymkowitz J, Rousseau F, Zimmermann P.

Chembiochem. 2010 Mar 1;11(4):456-67. doi: 10.1002/cbic.200900616. Review.


Engineered symmetric connectivity of secondary structure elements highlights malleability of protein folding pathways.

Ivarsson Y, Travaglini-Allocatelli C, Brunori M, Gianni S.

J Am Chem Soc. 2009 Aug 26;131(33):11727-33. doi: 10.1021/ja900438b.


Folding and stability of globular proteins and implications for function.

Travaglini-Allocatelli C, Ivarsson Y, Jemth P, Gianni S.

Curr Opin Struct Biol. 2009 Feb;19(1):3-7. doi: 10.1016/ Epub 2009 Jan 21. Review.


Folding and misfolding in a naturally occurring circularly permuted PDZ domain.

Ivarsson Y, Travaglini-Allocatelli C, Brunori M, Gianni S.

J Biol Chem. 2008 Apr 4;283(14):8954-60. doi: 10.1074/jbc.M707424200. Epub 2008 Feb 7.


Mechanisms of protein folding.

Ivarsson Y, Travaglini-Allocatelli C, Brunori M, Gianni S.

Eur Biophys J. 2008 Jul;37(6):721-8. doi: 10.1007/s00249-007-0256-x. Epub 2008 Jan 9. Review.


The folding pathway of an engineered circularly permuted PDZ domain.

Ivarsson Y, Travaglini-Allocatelli C, Morea V, Brunori M, Gianni S.

Protein Eng Des Sel. 2008 Mar;21(3):155-60. doi: 10.1093/protein/gzm077. Epub 2008 Jan 5.


Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics.

Gianni S, Ivarsson Y, Bah A, Bush-Pelc LA, Di Cera E.

Biophys Chem. 2007 Dec;131(1-3):111-4. Epub 2007 Sep 29.


Engineering the enantioselectivity of glutathione transferase by combined active-site mutations and chemical modifications.

Ivarsson Y, Norrgård MA, Hellman U, Mannervik B.

Biochim Biophys Acta. 2007 Sep;1770(9):1374-81. Epub 2007 Jun 16.


Identification and characterization of protein folding intermediates.

Gianni S, Ivarsson Y, Jemth P, Brunori M, Travaglini-Allocatelli C.

Biophys Chem. 2007 Jul;128(2-3):105-13. Epub 2007 Apr 24. Review.


An on-pathway intermediate in the folding of a PDZ domain.

Ivarsson Y, Travaglini-Allocatelli C, Jemth P, Malatesta F, Brunori M, Gianni S.

J Biol Chem. 2007 Mar 23;282(12):8568-72. Epub 2007 Jan 24.


Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution.

Norrgård MA, Ivarsson Y, Tars K, Mannervik B.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4876-81. Epub 2006 Mar 20.


Regio- and enantioselectivities in epoxide conjugations are modulated by residue 210 in Mu class glutathione transferases.

Ivarsson Y, Mannervik B.

Protein Eng Des Sel. 2005 Dec;18(12):607-16. Epub 2005 Oct 26.


Identification of residues in glutathione transferase capable of driving functional diversification in evolution. A novel approach to protein redesign.

Ivarsson Y, Mackey AJ, Edalat M, Pearson WR, Mannervik B.

J Biol Chem. 2003 Mar 7;278(10):8733-8. Epub 2002 Dec 16.

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