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Items: 1 to 50 of 84

1.

Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis.

Petrosino S, Verde R, Vaia M, Allarà M, Iuvone T, Di Marzo V.

J Pharmacol Exp Ther. 2018 Jun;365(3):652-663. doi: 10.1124/jpet.117.244368. Epub 2018 Apr 9.

PMID:
29632236
2.

Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome.

Cremon C, Stanghellini V, Barbaro MR, Cogliandro RF, Bellacosa L, Santos J, Vicario M, Pigrau M, Alonso Cotoner C, Lobo B, Azpiroz F, Bruley des Varannes S, Neunlist M, DeFilippis D, Iuvone T, Petrosino S, Di Marzo V, Barbara G.

Aliment Pharmacol Ther. 2017 Apr;45(7):909-922. doi: 10.1111/apt.13958. Epub 2017 Feb 6.

3.

Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis.

Vaia M, Petrosino S, De Filippis D, Negro L, Guarino A, Carnuccio R, Di Marzo V, Iuvone T.

Eur J Pharmacol. 2016 Nov 15;791:669-674. doi: 10.1016/j.ejphar.2016.10.005. Epub 2016 Oct 5.

PMID:
27720681
4.

Palmitoylethanolamide Modulates Inflammation-Associated Vascular Endothelial Growth Factor (VEGF) Signaling via the Akt/mTOR Pathway in a Selective Peroxisome Proliferator-Activated Receptor Alpha (PPAR-α)-Dependent Manner.

Sarnelli G, D'Alessandro A, Iuvone T, Capoccia E, Gigli S, Pesce M, Seguella L, Nobile N, Aprea G, Maione F, de Palma GD, Cuomo R, Steardo L, Esposito G.

PLoS One. 2016 May 24;11(5):e0156198. doi: 10.1371/journal.pone.0156198. eCollection 2016.

5.

Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide.

Caiazzo E, Maione F, Morello S, Lapucci A, Paccosi S, Steckel B, Lavecchia A, Parenti A, Iuvone T, Schrader J, Ialenti A, Cicala C.

Biochem Pharmacol. 2016 Jul 15;112:72-81. doi: 10.1016/j.bcp.2016.05.006. Epub 2016 May 14.

PMID:
27188793
6.

Palmitoylethanolamide Exerts Antiproliferative Effect and Downregulates VEGF Signaling in Caco-2 Human Colon Carcinoma Cell Line Through a Selective PPAR-α-Dependent Inhibition of Akt/mTOR Pathway.

Sarnelli G, Gigli S, Capoccia E, Iuvone T, Cirillo C, Seguella L, Nobile N, D'Alessandro A, Pesce M, Steardo L, Cuomo R, Esposito G.

Phytother Res. 2016 Jun;30(6):963-70. doi: 10.1002/ptr.5601. Epub 2016 Mar 1.

PMID:
26929026
7.

Reply.

Iuvone T, Affaitati G, De Filippis D, Lopopolo M, Grassi G, Lapenna D, Negro L, Costantini R, Vaia M, Cipollone F, Ialenti A, Giamberardino MA.

Pain. 2016 Mar;157(3):770-1. doi: 10.1097/j.pain.0000000000000400. No abstract available. Erratum in: Pain. 2016 Apr;157(4):991.

PMID:
26871400
8.

Novel non-peptide small molecules preventing IKKβ/NEMO association inhibit NF-κB activation in LPS-stimulated J774 macrophages.

De Falco F, Di Giovanni C, Cerchia C, De Stefano D, Capuozzo A, Irace C, Iuvone T, Santamaria R, Carnuccio R, Lavecchia A.

Biochem Pharmacol. 2016 Mar 15;104:83-94. doi: 10.1016/j.bcp.2016.01.008. Epub 2016 Jan 14.

PMID:
26776306
9.

S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer's Disease.

Cirillo C, Capoccia E, Iuvone T, Cuomo R, Sarnelli G, Steardo L, Esposito G.

Biomed Res Int. 2015;2015:508342. doi: 10.1155/2015/508342. Epub 2015 Jul 29.

10.

Ultramicronized palmitoylethanolamide reduces viscerovisceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis: role of mast cells.

Iuvone T, Affaitati G, De Filippis D, Lopopolo M, Grassia G, Lapenna D, Negro L, Costantini R, Vaia M, Cipollone F, Ialenti A, Giamberardino MA.

Pain. 2016 Jan;157(1):80-91. doi: 10.1097/j.pain.0000000000000220.

PMID:
25974242
11.

Analysis of calretinin early expression in the rat hippocampus after beta amyloid (1-42) peptide injection.

Altobelli GG, Cimini D, Esposito G, Iuvone T, Cimini V.

Brain Res. 2015 Jun 12;1610:89-97. doi: 10.1016/j.brainres.2015.03.029. Epub 2015 Mar 23.

PMID:
25813826
12.

Palmitoylethanolamide Regulates Production of Pro-Angiogenic Mediators in a Model of β Amyloid-Induced Astrogliosis In Vitro.

Cipriano M, Esposito G, Negro L, Capoccia E, Sarnelli G, Scuderi C, De Filippis D, Steardo L, Iuvone T.

CNS Neurol Disord Drug Targets. 2015;14(7):828-37.

PMID:
25801844
13.

Palmitoylethanolamide inhibits rMCP-5 expression by regulating MITF activation in rat chronic granulomatous inflammation.

De Filippis D, Russo A, De Stefano D, Cipriano M, Esposito D, Grassia G, Carnuccio R, Russo G, Iuvone T.

Eur J Pharmacol. 2014 Feb 15;725:64-9. doi: 10.1016/j.ejphar.2013.12.021. Epub 2014 Jan 16.

PMID:
24440533
14.

New insights in mast cell modulation by palmitoylethanolamide.

De Filippis D, Negro L, Vaia M, Cinelli MP, Iuvone T.

CNS Neurol Disord Drug Targets. 2013 Feb 1;12(1):78-83. Review.

PMID:
23394523
15.

Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching.

Maddaluno M, Grassia G, Di Lauro MV, Parisi A, Maione F, Cicala C, De Filippis D, Iuvone T, Guglielmotti A, Maffia P, Mascolo N, Ialenti A.

PLoS One. 2012;7(10):e47464. doi: 10.1371/journal.pone.0047464. Epub 2012 Oct 15.

16.

Cannabidiol in inflammatory bowel diseases: a brief overview.

Esposito G, Filippis DD, Cirillo C, Iuvone T, Capoccia E, Scuderi C, Steardo A, Cuomo R, Steardo L.

Phytother Res. 2013 May;27(5):633-6. doi: 10.1002/ptr.4781. Epub 2012 Jul 20. Review.

PMID:
22815234
17.

Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.

Esposito G, Scuderi C, Valenza M, Togna GI, Latina V, De Filippis D, Cipriano M, Carratù MR, Iuvone T, Steardo L.

PLoS One. 2011;6(12):e28668. doi: 10.1371/journal.pone.0028668. Epub 2011 Dec 5.

18.

Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.

De Filippis D, Esposito G, Cirillo C, Cipriano M, De Winter BY, Scuderi C, Sarnelli G, Cuomo R, Steardo L, De Man JG, Iuvone T.

PLoS One. 2011;6(12):e28159. doi: 10.1371/journal.pone.0028159. Epub 2011 Dec 6.

19.

Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide.

Scuderi C, Esposito G, Blasio A, Valenza M, Arietti P, Steardo L Jr, Carnuccio R, De Filippis D, Petrosino S, Iuvone T, Di Marzo V, Steardo L.

J Cell Mol Med. 2011 Dec;15(12):2664-74. doi: 10.1111/j.1582-4934.2011.01267.x.

20.

Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats.

De Filippis D, Luongo L, Cipriano M, Palazzo E, Cinelli MP, de Novellis V, Maione S, Iuvone T.

Mol Pain. 2011 Jan 10;7:3. doi: 10.1186/1744-8069-7-3.

21.

Are anti-angiogenic drugs useful in neurodegenerative disorders?

De Filippis D, Cipriano M, Esposito G, Scuderi C, Steardo L, Iuvone T.

CNS Neurol Disord Drug Targets. 2010 Dec;9(6):807-12. Review.

PMID:
20874699
22.

The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma.

Guida M, Ligresti A, De Filippis D, D'Amico A, Petrosino S, Cipriano M, Bifulco G, Simonetti S, Orlando P, Insabato L, Nappi C, Di Spiezio Sardo A, Di Marzo V, Iuvone T.

Endocrinology. 2010 Mar;151(3):921-8. doi: 10.1210/en.2009-0883. Epub 2010 Feb 4.

PMID:
20133454
23.

N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities.

Petrosino S, Iuvone T, Di Marzo V.

Biochimie. 2010 Jun;92(6):724-7. doi: 10.1016/j.biochi.2010.01.006. Epub 2010 Jan 21. Review.

PMID:
20096327
24.

Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats.

Endocannabinoid Research Group, De Filippis D, D'Amico A, Cipriano M, Petrosino S, Orlando P, Di Marzo V, Iuvone T.

Pharmacol Res. 2010 Apr;61(4):321-8. doi: 10.1016/j.phrs.2009.11.005. Epub 2009 Nov 17.

PMID:
19931394
25.

Protective role of palmitoylethanolamide in contact allergic dermatitis.

Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tüting T, Bisogno T, De Filippis D, D'Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V.

Allergy. 2010 Jun 1;65(6):698-711. doi: 10.1111/j.1398-9995.2009.02254.x. Epub 2009 Nov 11.

PMID:
19909294
26.

Increased mucosal nitric oxide production in ulcerative colitis is mediated in part by the enteroglial-derived S100B protein.

Cirillo C, Sarnelli G, Esposito G, Grosso M, Petruzzelli R, Izzo P, Calì G, D'Armiento FP, Rocco A, Nardone G, Iuvone T, Steardo L, Cuomo R.

Neurogastroenterol Motil. 2009 Nov;21(11):1209-e112. doi: 10.1111/j.1365-2982.2009.01346.x. Epub 2009 Jun 24.

PMID:
19558426
27.

A glance over the cannabinoid machinery to design new anti-angiogenic compounds.

De Filippis D, Iuvone T.

Mini Rev Med Chem. 2009 May;9(5):590-5. Review.

PMID:
19456289
28.

Oligonucleotide decoy to NF-kappaB slowly released from PLGA microspheres reduces chronic inflammation in rat.

De Stefano D, De Rosa G, Maiuri MC, Ungaro F, Quaglia F, Iuvone T, Cinelli MP, La Rotonda MI, Carnuccio R.

Pharmacol Res. 2009 Jul;60(1):33-40. doi: 10.1016/j.phrs.2009.03.012. Epub 2009 Mar 25.

PMID:
19427583
29.

Differential cannabinoid receptor expression during reactive gliosis: a possible implication for a nonpsychotropic neuroprotection.

De Filippis D, Steardo A, D'Amico A, Scuderi C, Cipriano M, Esposito G, Iuvone T.

ScientificWorldJournal. 2009 Mar 31;9:229-35. doi: 10.1100/tsw.2009.31. Review.

30.

Cannabidiol: a promising drug for neurodegenerative disorders?

Iuvone T, Esposito G, De Filippis D, Scuderi C, Steardo L.

CNS Neurosci Ther. 2009 Winter;15(1):65-75. doi: 10.1111/j.1755-5949.2008.00065.x. Review.

31.

NF-kappaB blockade upregulates Bax, TSP-1, and TSP-2 expression in rat granulation tissue.

De Stefano D, Nicolaus G, Maiuri MC, Cipolletta D, Galluzzi L, Cinelli MP, Tajana G, Iuvone T, Carnuccio R.

J Mol Med (Berl). 2009 May;87(5):481-92. doi: 10.1007/s00109-009-0443-6. Epub 2009 Feb 3.

PMID:
19189070
32.

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.

Scuderi C, Filippis DD, Iuvone T, Blasio A, Steardo A, Esposito G.

Phytother Res. 2009 May;23(5):597-602. doi: 10.1002/ptr.2625. Review.

PMID:
18844286
33.

Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5.

De Filippis D, Russo A, D'Amico A, Esposito G, Pietropaolo C, Cinelli M, Russo G, Iuvone T.

Br J Pharmacol. 2008 Aug;154(8):1672-9. doi: 10.1038/bjp.2008.211. Epub 2008 Jun 16. Erratum in: Br J Pharmacol. 2008 Aug;154(8):1701. Concetta, P [corrected to Pietropaolo, C].

34.

S100B induces tau protein hyperphosphorylation via Dickopff-1 up-regulation and disrupts the Wnt pathway in human neural stem cells.

Esposito G, Scuderi C, Lu J, Savani C, De Filippis D, Iuvone T, Steardo L Jr, Sheen V, Steardo L.

J Cell Mol Med. 2008 Jun;12(3):914-27. doi: 10.1111/j.1582-4934.2008.00159.x.

35.

Cannabinomimetic control of mast cell mediator release: new perspective in chronic inflammation.

De Filippis D, D'Amico A, Iuvone T.

J Neuroendocrinol. 2008 May;20 Suppl 1:20-5. doi: 10.1111/j.1365-2826.2008.01674.x. Review.

PMID:
18426495
36.

Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats.

De Filippis D, D'Amico A, Cinelli MP, Esposito G, Di Marzo V, Iuvone T.

J Cell Mol Med. 2009 Jun;13(6):1086-95. doi: 10.1111/j.1582-4934.2008.00353.x. Epub 2008 Apr 18.

37.

Selective CB2 up-regulation in women affected by endometrial inflammation.

Iuvone T, De Filippis D, Di Spiezio Sardo A, D'Amico A, Simonetti S, Sparice S, Esposito G, Bifulco G, Insabato L, Nappi C, Guida M.

J Cell Mol Med. 2008 Apr;12(2):661-70. doi: 10.1111/j.1582-4934.2007.00085.x.

38.

Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase.

de Filippis D, Iuvone T, d'amico A, Esposito G, Steardo L, Herman AG, Pelckmans PA, de Winter BY, de Man JG.

Neurogastroenterol Motil. 2008 Aug;20(8):919-27. doi: 10.1111/j.1365-2982.2008.01114.x. Epub 2008 Mar 27.

PMID:
18373655
39.

Melatonin reverses lipopolysaccharide-induced gastro-intestinal motility disturbances through the inhibition of oxidative stress.

De Filippis D, Iuvone T, Esposito G, Steardo L, Arnold GH, Paul AP, De Man Joris G, De Winter Benedicte Y.

J Pineal Res. 2008 Jan;44(1):45-51.

PMID:
18078447
40.

Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury.

Esposito G, Imitola J, Lu J, De Filippis D, Scuderi C, Ganesh VS, Folkerth R, Hecht J, Shin S, Iuvone T, Chesnut J, Steardo L, Sheen V.

Hum Mol Genet. 2008 Feb 1;17(3):440-57. Epub 2007 Nov 5.

PMID:
17984171
41.

Enteric glial-derived S100B protein stimulates nitric oxide production in celiac disease.

Esposito G, Cirillo C, Sarnelli G, De Filippis D, D'Armiento FP, Rocco A, Nardone G, Petruzzelli R, Grosso M, Izzo P, Iuvone T, Cuomo R.

Gastroenterology. 2007 Sep;133(3):918-25. Epub 2007 Jun 20.

PMID:
17678654
42.

Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro.

Iuvone T, Esposito G, De Filippis D, Bisogno T, Petrosino S, Scuderi C, Di Marzo V, Steardo L; Endocannabinoid Research Group.

J Mol Med (Berl). 2007 Dec;85(12):1379-92. Epub 2007 Jul 17.

PMID:
17639288
43.

Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression.

Esposito G, Scuderi C, Savani C, Steardo L Jr, De Filippis D, Cottone P, Iuvone T, Cuomo V, Steardo L.

Br J Pharmacol. 2007 Aug;151(8):1272-9. Epub 2007 Jun 25.

44.

Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence.

Esposito G, Iuvone T, Savani C, Scuderi C, De Filippis D, Papa M, Di Marzo V, Steardo L.

J Pharmacol Exp Ther. 2007 Sep;322(3):1144-52. Epub 2007 Jun 1.

PMID:
17545311
45.

Local administration of WIN 55,212-2 reduces chronic granuloma-associated angiogenesis in rat by inhibiting NF-kappaB activation.

De Filippis D, Russo A, De Stefano D, Maiuri MC, Esposito G, Cinelli MP, Pietropaolo C, Carnuccio R, Russo G, Iuvone T.

J Mol Med (Berl). 2007 Jun;85(6):635-45. Epub 2007 Apr 20.

PMID:
17447045
46.

Oxalomalate affects the inducible nitric oxide synthase expression and activity.

Irace C, Esposito G, Maffettone C, Rossi A, Festa M, Iuvone T, Santamaria R, Sautebin L, Carnuccio R, Colonna A.

Life Sci. 2007 Mar 13;80(14):1282-91. Epub 2006 Dec 22.

PMID:
17257628
47.

CB1 receptor selective activation inhibits beta-amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons.

Esposito G, De Filippis D, Steardo L, Scuderi C, Savani C, Cuomo V, Iuvone T.

Neurosci Lett. 2006 Sep 1;404(3):342-6. Epub 2006 Jul 11.

PMID:
16837132
48.

Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels.

van der Stelt M, Mazzola C, Esposito G, Matias I, Petrosino S, De Filippis D, Micale V, Steardo L, Drago F, Iuvone T, Di Marzo V.

Cell Mol Life Sci. 2006 Jun;63(12):1410-24.

PMID:
16732431
49.

The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-beta peptide-induced neurotoxicity.

Iuvone T, De Filippis D, Esposito G, D'Amico A, Izzo AA.

J Pharmacol Exp Ther. 2006 Jun;317(3):1143-9. Epub 2006 Feb 22.

PMID:
16495207
50.

Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement.

Esposito G, De Filippis D, Maiuri MC, De Stefano D, Carnuccio R, Iuvone T.

Neurosci Lett. 2006 May 15;399(1-2):91-5. Epub 2006 Feb 21.

PMID:
16490313

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