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Items: 1 to 50 of 84

1.

Context-Dependent Energetics of Loop Extensions in a Family of Tandem-Repeat Proteins.

Perez-Riba A, Lowe AR, Main ERG, Itzhaki LS.

Biophys J. 2018 Jun 5;114(11):2552-2562. doi: 10.1016/j.bpj.2018.03.038.

2.

Folding cooperativity and allosteric function in the tandem-repeat protein class.

Perez-Riba A, Synakewicz M, Itzhaki LS.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 19;373(1749). pii: 20170188. doi: 10.1098/rstb.2017.0188. Review.

PMID:
29735741
3.

Programmed Protein Self-Assembly Driven by Genetically Encoded Intein-Mediated Native Chemical Ligation.

Harvey JA, Itzhaki LS, Main ERG.

ACS Synth Biol. 2018 Apr 20;7(4):1067-1074. doi: 10.1021/acssynbio.7b00447. Epub 2018 Mar 8.

PMID:
29474065
4.

PyFolding: Open-Source Graphing, Simulation, and Analysis of the Biophysical Properties of Proteins.

Lowe AR, Perez-Riba A, Itzhaki LS, Main ERG.

Biophys J. 2018 Feb 6;114(3):516-521. doi: 10.1016/j.bpj.2017.11.3779.

PMID:
29414697
5.

Nanoscale click-reactive scaffolds from peptide self-assembly.

Guttenplan APM, Young LJ, Matak-Vinkovic D, Kaminski CF, Knowles TPJ, Itzhaki LS.

J Nanobiotechnology. 2017 Oct 6;15(1):70. doi: 10.1186/s12951-017-0300-7.

6.

A method for rapid high-throughput biophysical analysis of proteins.

Perez-Riba A, Itzhaki LS.

Sci Rep. 2017 Aug 22;7(1):9071. doi: 10.1038/s41598-017-08664-w.

7.

A New Methodology for Incorporating Chiral Linkers into Stapled Peptides.

Serrano JC, Sipthorp J, Xu W, Itzhaki LS, Ley SV.

Chembiochem. 2017 Jun 19;18(12):1066-1071. doi: 10.1002/cbic.201700075. Epub 2017 May 18.

8.

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvönen M, Verma C, Spring DR, Itzhaki LS.

J Am Chem Soc. 2017 Feb 15;139(6):2245-2256. doi: 10.1021/jacs.6b10234. Epub 2017 Feb 7.

9.

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.

Wiedmann MM, Tan YS, Wu Y, Aibara S, Xu W, Sore HF, Verma CS, Itzhaki L, Stewart M, Brenton JD, Spring DR.

Angew Chem Int Ed Engl. 2017 Jan 9;56(2):524-529. doi: 10.1002/anie.201609427. Epub 2016 Dec 5.

10.

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.

Chattopadhyay A, O'Connor CJ, Zhang F, Galvagnion C, Galloway WR, Tan YS, Stokes JE, Rahman T, Verma C, Spring DR, Itzhaki LS.

Sci Rep. 2016 Apr 5;6:23732. doi: 10.1038/srep23732.

11.

Mapping the Topography of a Protein Energy Landscape.

Hutton RD, Wilkinson J, Faccin M, Sivertsson EM, Pelizzola A, Lowe AR, Bruscolini P, Itzhaki LS.

J Am Chem Soc. 2015 Nov 25;137(46):14610-25. doi: 10.1021/jacs.5b07370. Epub 2015 Nov 12.

PMID:
26561984
12.

Dissecting and reprogramming the folding and assembly of tandem-repeat proteins.

Rowling PJ, Sivertsson EM, Perez-Riba A, Main ER, Itzhaki LS.

Biochem Soc Trans. 2015 Oct;43(5):881-8. doi: 10.1042/BST20150099. Review.

PMID:
26517898
13.

Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity.

Gaboriau DC, Rowling PJ, Morrison CG, Itzhaki LS.

Biochem J. 2015 Mar 15;466(3):613-24. doi: 10.1042/BJ20141077.

PMID:
25748678
14.

Single-molecule FRET reveals hidden complexity in a protein energy landscape.

Tsytlonok M, Ibrahim SM, Rowling PJE, Xu W, Ruedas-Rama MJ, Orte A, Klenerman D, Itzhaki LS.

Structure. 2015 Jan 6;23(1):190-198. doi: 10.1016/j.str.2014.10.023.

15.

A virus that can take the heat.

Sivertsson EM, Itzhaki LS.

Structure. 2014 Nov 4;22(11):1549-50. doi: 10.1016/j.str.2014.10.003. Epub 2014 Nov 4.

16.

Protein folding: When ribosomes pick the structure.

Sivertsson EM, Itzhaki LS.

Nat Chem. 2014 May;6(5):378-9. doi: 10.1038/nchem.1926. No abstract available.

PMID:
24755584
17.

Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.

Kelly SE, Meisl G, Rowling PJ, McLaughlin SH, Knowles T, Itzhaki LS.

Phys Chem Chem Phys. 2014 Apr 14;16(14):6448-59. doi: 10.1039/c3cp54818j. Epub 2014 Feb 18.

18.

Complex energy landscape of a giant repeat protein.

Tsytlonok M, Craig PO, Sivertsson E, Serquera D, Perrett S, Best RB, Wolynes PG, Itzhaki LS.

Structure. 2013 Nov 5;21(11):1954-65. doi: 10.1016/j.str.2013.08.028. Epub 2013 Oct 10.

19.

Subdomain architecture and stability of a giant repeat protein.

Tsytlonok M, Sormanni P, Rowling PJ, Vendruscolo M, Itzhaki LS.

J Phys Chem B. 2013 Oct 24;117(42):13029-37. doi: 10.1021/jp402360x. Epub 2013 Sep 20.

PMID:
24053231
20.

Tandem-repeat proteins: regularity plus modularity equals design-ability.

Javadi Y, Itzhaki LS.

Curr Opin Struct Biol. 2013 Aug;23(4):622-31. doi: 10.1016/j.sbi.2013.06.011. Epub 2013 Jul 4. Review.

PMID:
23831287
21.

Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.

Xu LQ, Wu S, Buell AK, Cohen SI, Chen LJ, Hu WH, Cusack SA, Itzhaki LS, Zhang H, Knowles TP, Dobson CM, Welland ME, Jones GW, Perrett S.

Philos Trans R Soc Lond B Biol Sci. 2013 Mar 25;368(1617):20110410. doi: 10.1098/rstb.2011.0410. Print 2013 May 5.

22.

Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin.

Settanni G, Serquera D, Marszalek PE, Paci E, Itzhaki LS.

PLoS Comput Biol. 2013;9(1):e1002864. doi: 10.1371/journal.pcbi.1002864. Epub 2013 Jan 17.

23.

Complex regulation controls Neurogenin3 proteolysis.

Roark R, Itzhaki L, Philpott A.

Biol Open. 2012 Dec 15;1(12):1264-72. doi: 10.1242/bio.20121750. Epub 2012 Oct 16.

24.

The how's and why's of protein folding intermediates.

Tsytlonok M, Itzhaki LS.

Arch Biochem Biophys. 2013 Mar;531(1-2):14-23. doi: 10.1016/j.abb.2012.10.006. Epub 2012 Oct 23. Review.

PMID:
23098780
25.

From artificial antibodies to nanosprings: the biophysical properties of repeat proteins.

Itzhaki LS, Lowe AR.

Adv Exp Med Biol. 2012;747:153-66. doi: 10.1007/978-1-4614-3229-6_10. Review.

PMID:
22949117
26.

Implications of 3D domain swapping for protein folding, misfolding and function.

Rousseau F, Schymkowitz J, Itzhaki LS.

Adv Exp Med Biol. 2012;747:137-52. doi: 10.1007/978-1-4614-3229-6_9. Review.

PMID:
22949116
27.

Using FlAsH to probe conformational changes in a large HEAT repeat protein.

Tsytlonok M, Itzhaki LS.

Chembiochem. 2012 May 29;13(8):1199-205. doi: 10.1002/cbic.201200012. Epub 2012 Apr 26.

PMID:
22539214
28.

Folding and binding: lingering questions, emerging answers.

Itzhaki LS, Rose GD.

Curr Opin Struct Biol. 2012 Feb;22(1):1-3. doi: 10.1016/j.sbi.2012.01.001. Epub 2012 Jan 20. No abstract available.

PMID:
22265341
29.

Toward classification of BRCA1 missense variants using a biophysical approach.

Rowling PJ, Cook R, Itzhaki LS.

J Biol Chem. 2010 Jun 25;285(26):20080-7. doi: 10.1074/jbc.M109.088922. Epub 2010 Apr 8.

30.

Mechanical unfolding of an ankyrin repeat protein.

Serquera D, Lee W, Settanni G, Marszalek PE, Paci E, Itzhaki LS.

Biophys J. 2010 Apr 7;98(7):1294-301. doi: 10.1016/j.bpj.2009.12.4287.

31.

Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase.

Murton BL, Chin WL, Ponting CP, Itzhaki LS.

J Mol Biol. 2010 May 14;398(4):481-8. doi: 10.1016/j.jmb.2010.03.036. Epub 2010 Mar 27.

PMID:
20347846
32.

Nature and nurture in protein folding and binding.

Itzhaki L, Wolynes P.

Curr Opin Struct Biol. 2010 Feb;20(1):1-2. doi: 10.1016/j.sbi.2010.01.007. Epub 2010 Feb 8. No abstract available. Erratum in: Curr Opin Struct Biol. 2010 Jun;20(3):397.

PMID:
20144542
33.

Alcohol oxidase (AOX1) from Pichia pastoris is a novel inhibitor of prion propagation and a potential ATPase.

Zhang H, Loovers HM, Xu LQ, Wang M, Rowling PJ, Itzhaki LS, Gong W, Zhou JM, Jones GW, Perrett S.

Mol Microbiol. 2009 Feb;71(3):702-16. doi: 10.1111/j.1365-2958.2008.06557.x. Epub 2008 Dec 11.

34.

Conjugation in polyyne rods: to what extent is charge delocalization coupled to geometrical changes?

Itzhaki L, Rozental E, Altus E, Basch H, Hoz S.

J Phys Chem A. 2008 Dec 18;112(50):12812-5. doi: 10.1021/jp800467g.

PMID:
18800780
35.

Shifting transition states in the unfolding of a large ankyrin repeat protein.

Werbeck ND, Rowling PJ, Chellamuthu VR, Itzhaki LS.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9982-7. doi: 10.1073/pnas.0705300105. Epub 2008 Jul 16. Erratum in: Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13696.

36.

The quest to understand protein folding.

Itzhaki L, Wolynes P.

Curr Opin Struct Biol. 2008 Feb;18(1):1-3. doi: 10.1016/j.sbi.2008.01.001. Epub 2008 Feb 11. No abstract available.

PMID:
18262783
37.

ATPase site architecture and helicase mechanism of an archaeal MCM.

Moreau MJ, McGeoch AT, Lowe AR, Itzhaki LS, Bell SD.

Mol Cell. 2007 Oct 26;28(2):304-14.

38.

Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein.

Werbeck ND, Itzhaki LS.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7863-8. Epub 2007 May 2.

39.

Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils.

Lian HY, Zhang H, Zhang ZR, Loovers HM, Jones GW, Rowling PJ, Itzhaki LS, Zhou JM, Perrett S.

J Biol Chem. 2007 Apr 20;282(16):11931-40. Epub 2007 Feb 26.

40.

Rational redesign of the folding pathway of a modular protein.

Lowe AR, Itzhaki LS.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2679-84. Epub 2007 Feb 13.

41.

Biophysical characterisation of the small ankyrin repeat protein myotrophin.

Lowe AR, Itzhaki LS.

J Mol Biol. 2007 Jan 26;365(4):1245-55. Epub 2006 Oct 21.

PMID:
17113103
42.

Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry.

Yao ZP, Zhou M, Kelly SE, Seeliger MA, Robinson CV, Itzhaki LS.

J Mol Biol. 2006 Oct 27;363(3):673-86. Epub 2006 Aug 16.

PMID:
16979657
43.

Domain swapping in p13suc1 results in formation of native-like, cytotoxic aggregates.

Rousseau F, Wilkinson H, Villanueva J, Serrano L, Schymkowitz JW, Itzhaki LS.

J Mol Biol. 2006 Oct 20;363(2):496-505. Epub 2006 Jul 29.

PMID:
16963085
44.

Auxetics at the molecular level: a negative poisson's ratio in molecular rods.

Pour N, Itzhaki L, Hoz B, Altus E, Basch H, Hoz S.

Angew Chem Int Ed Engl. 2006 Sep 11;45(36):5981-3. No abstract available.

PMID:
16906614
45.

Folding and fibril formation of the cell cycle protein Cks1.

Bader R, Seeliger MA, Kelly SE, Ilag LL, Meersman F, Limones A, Luisi BF, Dobson CM, Itzhaki LS.

J Biol Chem. 2006 Jul 7;281(27):18816-24. Epub 2006 May 4.

46.

Harder than diamond: determining the cross-sectional area and Young's modulus of molecular rods.

Itzhaki L, Altus E, Basch H, Hoz S.

Angew Chem Int Ed Engl. 2005 Dec 1;44(45):7432-5. No abstract available.

PMID:
16240306
47.

Crystal structure of the ENT domain of human EMSY.

Chavali GB, Ekblad CM, Basu BP, Brissett NC, Veprintsev D, Hughes-Davies L, Kouzarides T, Itzhaki LS, Doherty AJ.

J Mol Biol. 2005 Jul 29;350(5):964-73.

PMID:
15978617
48.

Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.

Ekblad CM, Chavali GB, Basu BP, Freund SM, Veprintsev D, Hughes-Davies L, Kouzarides T, Doherty AJ, Itzhaki LS.

EMBO Rep. 2005 Jul;6(7):675-80.

49.

Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins.

Seeliger MA, Spichty M, Kelly SE, Bycroft M, Freund SM, Karplus M, Itzhaki LS.

J Biol Chem. 2005 Aug 26;280(34):30448-59. Epub 2005 Mar 16.

50.

Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis.

Ekblad CM, Friedler A, Veprintsev D, Weinberg RL, Itzhaki LS.

Protein Sci. 2004 Mar;13(3):617-25.

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