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Items: 1 to 50 of 52

1.

Phosphorylation of Ser111 in Rab8a Modulates Rabin8-Dependent Activation by Perturbation of Side Chain Interaction Networks.

Pourjafar-Dehkordi D, Vieweg S, Itzen A, Zacharias M.

Biochemistry. 2019 Aug 20;58(33):3546-3554. doi: 10.1021/acs.biochem.9b00516. Epub 2019 Aug 8.

PMID:
31361120
2.

Exploring the Substrate Scope of the Bacterial Phosphocholine Transferase AnkX for Versatile Protein Functionalization.

Ochtrop P, Ernst S, Itzen A, Hedberg C.

Chembiochem. 2019 Sep 16;20(18):2336-2340. doi: 10.1002/cbic.201900200. Epub 2019 Aug 21.

PMID:
31054261
3.

Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a.

Sanzà P, Evans RD, Briggs DA, Cantero M, Montoliu L, Patel S, Sviderskaya EV, Itzen A, Figueiredo AC, Seabra MC, Hume AN.

J Cell Sci. 2019 Apr 30;132(9). pii: jcs212035. doi: 10.1242/jcs.212035.

4.

The protease GtgE from Salmonella exclusively targets inactive Rab GTPases.

Wachtel R, Bräuning B, Mader SL, Ecker F, Kaila VRI, Groll M, Itzen A.

Nat Commun. 2018 Jan 3;9(1):44. doi: 10.1038/s41467-017-02110-1.

5.

Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo.

Cigler M, Müller TG, Horn-Ghetko D, von Wrisberg MK, Fottner M, Goody RS, Itzen A, Müller MP, Lang K.

Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15737-15741. doi: 10.1002/anie.201706927. Epub 2017 Nov 9.

PMID:
28960788
6.

bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.

Rai A, Oprisko A, Campos J, Fu Y, Friese T, Itzen A, Goody RS, Gazdag EM, Müller MP.

Elife. 2016 Aug 23;5. pii: e18675. doi: 10.7554/eLife.18675.

7.

A pull-down procedure for the identification of unknown GEFs for small GTPases.

Koch D, Rai A, Ali I, Bleimling N, Friese T, Brockmeyer A, Janning P, Goud B, Itzen A, Müller MP, Goody RS.

Small GTPases. 2016 Apr 2;7(2):93-106. doi: 10.1080/21541248.2016.1156803. Epub 2016 Feb 26.

8.

Adenylylation of Tyr77 stabilizes Rab1b GTPase in an active state: A molecular dynamics simulation analysis.

Luitz MP, Bomblies R, Ramcke E, Itzen A, Zacharias M.

Sci Rep. 2016 Jan 28;6:19896. doi: 10.1038/srep19896.

9.

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.

Lai YC, Kondapalli C, Lehneck R, Procter JB, Dill BD, Woodroof HI, Gourlay R, Peggie M, Macartney TJ, Corti O, Corvol JC, Campbell DG, Itzen A, Trost M, Muqit MM.

EMBO J. 2015 Nov 12;34(22):2840-61. doi: 10.15252/embj.201591593. Epub 2015 Oct 15.

10.

Locking GTPases covalently in their functional states.

Wiegandt D, Vieweg S, Hofmann F, Koch D, Li F, Wu YW, Itzen A, Müller MP, Goody RS.

Nat Commun. 2015 Jul 16;6:7773. doi: 10.1038/ncomms8773.

11.

Covalent Protein Labeling by Enzymatic Phosphocholination.

Heller K, Ochtrop P, Albers MF, Zauner FB, Itzen A, Hedberg C.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10327-30. doi: 10.1002/anie.201502618. Epub 2015 Jul 3.

PMID:
26147231
12.

Molecular perspectives on protein adenylylation.

Hedberg C, Itzen A.

ACS Chem Biol. 2015 Jan 16;10(1):12-21. doi: 10.1021/cb500854e. Epub 2014 Dec 17. Review.

PMID:
25486069
13.

The Legionella longbeachae Icm/Dot substrate SidC selectively binds phosphatidylinositol 4-phosphate with nanomolar affinity and promotes pathogen vacuole-endoplasmic reticulum interactions.

Dolinsky S, Haneburger I, Cichy A, Hannemann M, Itzen A, Hilbi H.

Infect Immun. 2014 Oct;82(10):4021-33. doi: 10.1128/IAI.01685-14. Epub 2014 Jul 14.

14.

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.

Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szegő ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M.

Neurobiol Dis. 2014 Oct;70:149-61. doi: 10.1016/j.nbd.2014.06.018. Epub 2014 Jun 28.

PMID:
24983211
15.

Reaction mechanism of adenylyltransferase DrrA from Legionella pneumophila elucidated by time-resolved fourier transform infrared spectroscopy.

Gavriljuk K, Schartner J, Itzen A, Goody RS, Gerwert K, Kötting C.

J Am Chem Soc. 2014 Jul 2;136(26):9338-45. doi: 10.1021/ja501496d. Epub 2014 Jun 20.

PMID:
24950229
16.

The structure of the N-terminal domain of the Legionella protein SidC.

Gazdag EM, Schöbel S, Shkumatov AV, Goody RS, Itzen A.

J Struct Biol. 2014 Apr;186(1):188-94. doi: 10.1016/j.jsb.2014.02.003. Epub 2014 Feb 17.

PMID:
24556577
17.

The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting.

Li F, Yi L, Zhao L, Itzen A, Goody RS, Wu YW.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2572-7. doi: 10.1073/pnas.1313655111. Epub 2014 Feb 3.

18.

Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation.

Langemeyer L, Nunes Bastos R, Cai Y, Itzen A, Reinisch KM, Barr FA.

Elife. 2014 Feb 11;3:e01623. doi: 10.7554/eLife.01623.

19.

Direct targeting of Rab-GTPase-effector interactions.

Spiegel J, Cromm PM, Itzen A, Goody RS, Grossmann TN, Waldmann H.

Angew Chem Int Ed Engl. 2014 Feb 24;53(9):2498-503. doi: 10.1002/anie.201308568. Epub 2014 Jan 31.

PMID:
24481744
20.

Exploring adenylylation and phosphocholination as post-translational modifications.

Müller MP, Albers MF, Itzen A, Hedberg C.

Chembiochem. 2014 Jan 3;15(1):19-26. doi: 10.1002/cbic.201300508. Epub 2013 Oct 31. Review.

PMID:
24174209
21.

Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB.

Guo Z, Hou X, Goody RS, Itzen A.

J Biol Chem. 2013 Nov 8;288(45):32466-74. doi: 10.1074/jbc.M113.498329. Epub 2013 Sep 26.

22.

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.

Rothmeier E, Pfaffinger G, Hoffmann C, Harrison CF, Grabmayr H, Repnik U, Hannemann M, Wölke S, Bausch A, Griffiths G, Müller-Taubenberger A, Itzen A, Hilbi H.

PLoS Pathog. 2013 Sep;9(9):e1003598. doi: 10.1371/journal.ppat.1003598. Epub 2013 Sep 19.

23.

Modulation of small GTPases by Legionella.

Goody RS, Itzen A.

Curr Top Microbiol Immunol. 2013;376:117-33. doi: 10.1007/82_2013_340. Review.

PMID:
23918171
24.

Membrane extraction of Rab proteins by GDP dissociation inhibitor characterized using attenuated total reflection infrared spectroscopy.

Gavriljuk K, Itzen A, Goody RS, Gerwert K, Kötting C.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13380-5. doi: 10.1073/pnas.1307655110. Epub 2013 Jul 29.

25.

RabGEFs are a major determinant for specific Rab membrane targeting.

Blümer J, Rey J, Dehmelt L, Mazel T, Wu YW, Bastiaens P, Goody RS, Itzen A.

J Cell Biol. 2013 Feb 4;200(3):287-300. doi: 10.1083/jcb.201209113.

26.

Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB.

Mihai Gazdag E, Streller A, Haneburger I, Hilbi H, Vetter IR, Goody RS, Itzen A.

EMBO Rep. 2013 Feb;14(2):199-205. doi: 10.1038/embor.2012.211. Epub 2013 Jan 4.

27.

Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail.

Gavriljuk K, Gazdag EM, Itzen A, Kötting C, Goody RS, Gerwert K.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21348-53. doi: 10.1073/pnas.1214431110. Epub 2012 Dec 12.

28.

Protein-DNA arrays as tools for detection of protein-protein interactions by mass spectrometry.

Gogolin L, Schroeder H, Itzen A, Goody RS, Niemeyer CM, Becker CF.

Chembiochem. 2013 Jan 2;14(1):92-9. doi: 10.1002/cbic.201200597. Epub 2012 Dec 3.

PMID:
23208955
29.

Specific localization of Rabs at intracellular membranes.

Blümer J, Wu YW, Goody RS, Itzen A.

Biochem Soc Trans. 2012 Dec 1;40(6):1421-5. doi: 10.1042/BST20120225.

PMID:
23176492
30.

Characterization of enzymes from Legionella pneumophila involved in reversible adenylylation of Rab1 protein.

Müller MP, Shkumatov AV, Oesterlin LK, Schoebel S, Goody PR, Goody RS, Itzen A.

J Biol Chem. 2012 Oct 12;287(42):35036-46. doi: 10.1074/jbc.M112.396861. Epub 2012 Aug 7.

31.

Crystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndrome.

Hagemann N, Hou X, Goody RS, Itzen A, Erdmann KS.

Small GTPases. 2012 Apr-Jun;3(2):107-10. doi: 10.4161/sgtp.19380. Review.

PMID:
22790198
32.

Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor.

Oesterlin LK, Goody RS, Itzen A.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5621-6. doi: 10.1073/pnas.1121161109. Epub 2012 Mar 12.

33.

Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins.

Goody PR, Heller K, Oesterlin LK, Müller MP, Itzen A, Goody RS.

EMBO J. 2012 Apr 4;31(7):1774-84. doi: 10.1038/emboj.2012.16. Epub 2012 Feb 3.

34.

Protein LidA from Legionella is a Rab GTPase supereffector.

Schoebel S, Cichy AL, Goody RS, Itzen A.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17945-50. doi: 10.1073/pnas.1113133108. Epub 2011 Oct 19.

35.

Efficient synthesis and applications of peptides containing adenylylated tyrosine residues.

Smit C, Blümer J, Eerland MF, Albers MF, Müller MP, Goody RS, Itzen A, Hedberg C.

Angew Chem Int Ed Engl. 2011 Sep 19;50(39):9200-4. doi: 10.1002/anie.201103203. Epub 2011 Aug 25. No abstract available.

PMID:
21919157
36.

Atomic resolution structure of EhpR: phenazine resistance in Enterobacter agglomerans Eh1087 follows principles of bleomycin/mitomycin C resistance in other bacteria.

Yu S, Vit A, Devenish S, Mahanty HK, Itzen A, Goody RS, Blankenfeldt W.

BMC Struct Biol. 2011 Aug 17;11:33. doi: 10.1186/1472-6807-11-33.

37.

Covalent coercion by Legionella pneumophila.

Itzen A, Goody RS.

Cell Host Microbe. 2011 Aug 18;10(2):89-91. doi: 10.1016/j.chom.2011.08.002.

38.

One-pot dual-labeling of a protein by two chemoselective reactions.

Yi L, Sun H, Itzen A, Triola G, Waldmann H, Goody RS, Wu YW.

Angew Chem Int Ed Engl. 2011 Aug 29;50(36):8287-90. doi: 10.1002/anie.201100840. Epub 2011 Jul 14. No abstract available.

PMID:
21761514
39.

The versatile Legionella effector protein DrrA.

Goody RS, Müller MP, Schoebel S, Oesterlin LK, Blümer J, Peters H, Blankenfeldt W, Itzen A.

Commun Integr Biol. 2011 Jan;4(1):72-4. doi: 10.4161/cib.4.1.13857.

40.

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.

Hou X, Hagemann N, Schoebel S, Blankenfeldt W, Goody RS, Erdmann KS, Itzen A.

EMBO J. 2011 Apr 20;30(8):1659-70. doi: 10.1038/emboj.2011.60. Epub 2011 Mar 4.

41.

Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization.

Roland JT, Bryant DM, Datta A, Itzen A, Mostov KE, Goldenring JR.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2789-94. doi: 10.1073/pnas.1010754108. Epub 2011 Jan 31.

42.

Adenylylation: renaissance of a forgotten post-translational modification.

Itzen A, Blankenfeldt W, Goody RS.

Trends Biochem Sci. 2011 Apr;36(4):221-8. doi: 10.1016/j.tibs.2010.12.004. Epub 2011 Jan 20. Review.

PMID:
21256032
43.

Identification and characterisation of novel Mss4-binding Rab GTPases.

Wixler V, Wixler L, Altenfeld A, Ludwig S, Goody RS, Itzen A.

Biol Chem. 2011 Mar;392(3):239-48. doi: 10.1515/BC.2011.022.

PMID:
21194374
44.

GTPases involved in vesicular trafficking: structures and mechanisms.

Itzen A, Goody RS.

Semin Cell Dev Biol. 2011 Feb;22(1):48-56. doi: 10.1016/j.semcdb.2010.10.003. Epub 2010 Oct 15. Review.

PMID:
20951823
45.

The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b.

Müller MP, Peters H, Blümer J, Blankenfeldt W, Goody RS, Itzen A.

Science. 2010 Aug 20;329(5994):946-9. doi: 10.1126/science.1192276. Epub 2010 Jul 22.

46.

High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA.

Schoebel S, Blankenfeldt W, Goody RS, Itzen A.

EMBO Rep. 2010 Aug;11(8):598-604. doi: 10.1038/embor.2010.97. Epub 2010 Jul 9.

47.

RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity.

Schoebel S, Oesterlin LK, Blankenfeldt W, Goody RS, Itzen A.

Mol Cell. 2009 Dec 25;36(6):1060-72. doi: 10.1016/j.molcel.2009.11.014.

48.

Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli.

Bleimling N, Alexandrov K, Goody R, Itzen A.

Protein Expr Purif. 2009 Jun;65(2):190-5. doi: 10.1016/j.pep.2008.12.002. Epub 2008 Dec 13.

PMID:
19116169
49.

Key determinants of Rab specificity.

Itzen A, Goody RS.

Structure. 2008 Oct 8;16(10):1437-9. doi: 10.1016/j.str.2008.09.002. No abstract available.

50.

Sec2 is a highly efficient exchange factor for the Rab protein Sec4.

Itzen A, Rak A, Goody RS.

J Mol Biol. 2007 Feb 2;365(5):1359-67. Epub 2006 Nov 3.

PMID:
17134721

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