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Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.

Lei M, Teo JD, Song H, McEwen HP, Yup Lee J, Couttas TA, Duncan T, Chesworth R, Bertz J, Przybyla M, Van Eersel J, Heng B, Guillemin GJ, Ittner LM, Fath T, Garner B, Ittner A, Karl T, Don AS.

J Neurosci. 2019 Nov 27;39(48):9645-9659. doi: 10.1523/JNEUROSCI.0524-19.2019. Epub 2019 Oct 22.


Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice.

Brettle M, Stefen H, Djordjevic A, Fok SYY, Chan JW, van Hummel A, van der Hoven J, Przybyla M, Volkerling A, Ke YD, Delerue F, Ittner LM, Fath T.

Front Mol Neurosci. 2019 Sep 27;12:231. doi: 10.3389/fnmol.2019.00231. eCollection 2019.


First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold.

Cheng HWA, Sokias R, Werry EL, Ittner LM, Reekie TA, Du J, Gao Q, Hibbs DE, Kassiou M.

J Med Chem. 2019 Sep 12;62(17):8235-8248. doi: 10.1021/acs.jmedchem.9b00980. Epub 2019 Aug 28.


CNS cell type-specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation.

Ke YD, Chan G, Stefanoska K, Au C, Bi M, Müller J, Przybyla M, Feiten A, Prikas E, Halliday GM, Piguet O, Kiernan MC, Kassiou M, Hodges JR, Loy CT, Mattick JS, Ittner A, Kril JJ, Sutherland GT, Ittner LM.

J Biol Chem. 2019 Sep 20;294(38):14149-14162. doi: 10.1074/jbc.RA118.005263. Epub 2019 Jul 31.


Neuroinflammation in frontotemporal dementia.

Bright F, Werry EL, Dobson-Stone C, Piguet O, Ittner LM, Halliday GM, Hodges JR, Kiernan MC, Loy CT, Kassiou M, Kril JJ.

Nat Rev Neurol. 2019 Sep;15(9):540-555. doi: 10.1038/s41582-019-0231-z. Epub 2019 Jul 19. Review.


Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders.

Werry EL, Bright FM, Piguet O, Ittner LM, Halliday GM, Hodges JR, Kiernan MC, Loy CT, Kril JJ, Kassiou M.

Int J Mol Sci. 2019 Jun 28;20(13). pii: E3161. doi: 10.3390/ijms20133161. Review.


Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues.

Ittner LM, Klugmann M, Ke YD.

Br J Pharmacol. 2019 Sep;176(18):3649-3665. doi: 10.1111/bph.14637. Epub 2019 Apr 23. Review.


Neuronal MAP kinase p38α inhibits c-Jun N-terminal kinase to modulate anxiety-related behaviour.

Stefanoska K, Bertz J, Volkerling AM, van der Hoven J, Ittner LM, Ittner A.

Sci Rep. 2018 Sep 24;8(1):14296. doi: 10.1038/s41598-018-32592-y.


Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.

Zhao Y, Keshiya S, Atashrazm F, Gao J, Ittner LM, Alessi DR, Halliday GM, Fu Y, Dzamko N.

Neurobiol Dis. 2018 Dec;120:76-87. doi: 10.1016/j.nbd.2018.09.003. Epub 2018 Sep 5.


Dendritic Tau in Alzheimer's Disease.

Ittner A, Ittner LM.

Neuron. 2018 Jul 11;99(1):13-27. doi: 10.1016/j.neuron.2018.06.003. Review.


Peptide Nanofiber Substrates for Long-Term Culturing of Primary Neurons.

Martin AD, Chua SW, Au CG, Stefen H, Przybyla M, Lin Y, Bertz J, Thordarson P, Fath T, Ke YD, Ittner LM.

ACS Appl Mater Interfaces. 2018 Aug 1;10(30):25127-25134. doi: 10.1021/acsami.8b07560. Epub 2018 Jul 20.


Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice.

van Hummel A, Chan G, van der Hoven J, Morsch M, Ippati S, Suh L, Bi M, Asih PR, Lee WS, Butler TA, Przybyla M, Halliday GM, Piguet O, Kiernan MC, Chung RS, Ittner LM, Ke YD.

Am J Pathol. 2018 Jun;188(6):1447-1456. doi: 10.1016/j.ajpath.2018.03.002. Epub 2018 Mar 22.


Physiological changes in neurodegeneration - mechanistic insights and clinical utility.

Ahmed RM, Ke YD, Vucic S, Ittner LM, Seeley W, Hodges JR, Piguet O, Halliday G, Kiernan MC.

Nat Rev Neurol. 2018 May;14(5):259-271. doi: 10.1038/nrneurol.2018.23. Epub 2018 Mar 23. Review.


Generation of a New Tau Knockout (tauΔex1) Line Using CRISPR/Cas9 Genome Editing in Mice.

Tan DCS, Yao S, Ittner A, Bertz J, Ke YD, Ittner LM, Delerue F.

J Alzheimers Dis. 2018;62(2):571-578. doi: 10.3233/JAD-171058.


Epothilone D - correct drug, wrong disease.

Ke YD, Ittner LM.

Neuropathol Appl Neurobiol. 2018 Oct;44(6):548-549. doi: 10.1111/nan.12478. Epub 2018 Mar 27. No abstract available.


An N-terminal motif unique to primate tau enables differential protein-protein interactions.

Stefanoska K, Volkerling A, Bertz J, Poljak A, Ke YD, Ittner LM, Ittner A.

J Biol Chem. 2018 Mar 9;293(10):3710-3719. doi: 10.1074/jbc.RA118.001784. Epub 2018 Jan 30.


Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies.

Forrest SL, Kril JJ, Stevens CH, Kwok JB, Hallupp M, Kim WS, Huang Y, McGinley CV, Werka H, Kiernan MC, Götz J, Spillantini MG, Hodges JR, Ittner LM, Halliday GM.

Brain. 2018 Feb 1;141(2):521-534. doi: 10.1093/brain/awx328. Erratum in: Brain. 2018 Apr 1;141(4):e30.


Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy.

von Jonquieres G, Spencer ZHT, Rowlands BD, Klugmann CB, Bongers A, Harasta AE, Parley KE, Cederholm J, Teahan O, Pickford R, Delerue F, Ittner LM, Fröhlich D, McLean CA, Don AS, Schneider M, Housley GD, Rae CD, Klugmann M.

Acta Neuropathol. 2018 Jan;135(1):95-113. doi: 10.1007/s00401-017-1784-9. Epub 2017 Nov 7.


Absence of IL-6 prevents corneal wound healing after deep excimer laser ablation in vivo.

Hafezi F, Gatzioufas Z, Angunawela R, Ittner LM.

Eye (Lond). 2018 Jan;32(1):156-157. doi: 10.1038/eye.2017.238. Epub 2017 Nov 3. No abstract available.


Tau exacerbates excitotoxic brain damage in an animal model of stroke.

Bi M, Gladbach A, van Eersel J, Ittner A, Przybyla M, van Hummel A, Chua SW, van der Hoven J, Lee WS, Müller J, Parmar J, Jonquieres GV, Stefen H, Guccione E, Fath T, Housley GD, Klugmann M, Ke YD, Ittner LM.

Nat Commun. 2017 Sep 7;8(1):473. doi: 10.1038/s41467-017-00618-0.


Alzheimer's Disease: Insights from Genetic Mouse Models and Current Advances in Human IPSC-Derived Neurons.

Harasta AE, Ittner LM.

Adv Neurobiol. 2017;15:3-29. doi: 10.1007/978-3-319-57193-5_1. Review.


Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer's Disease: Testosterone as a Modifier.

Asih PR, Tegg ML, Sohrabi H, Carruthers M, Gandy SE, Saad F, Verdile G, Ittner LM, Martins RN.

J Alzheimers Dis. 2017;59(2):445-466. doi: 10.3233/JAD-161259. Review.


Generation of Genetically Modified Mice through the Microinjection of Oocytes.

Delerue F, Ittner LM.

J Vis Exp. 2017 Jun 15;(124). doi: 10.3791/55765.


Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes.

Tan RH, Kril JJ, Yang Y, Tom N, Hodges JR, Villemagne VL, Rowe CC, Leyton CE, Kwok JBJ, Ittner LM, Halliday GM.

Alzheimers Dement (Amst). 2017 May 29;9:10-20. doi: 10.1016/j.dadm.2017.05.005. eCollection 2017.


Ring-opened aminothienopyridazines as novel tau aggregation inhibitors.

Moir M, Chua SW, Reekie T, Martin AD, Ittner A, Ittner LM, Kassiou M.

Medchemcomm. 2017 May 5;8(6):1275-1282. doi: 10.1039/c6md00306k. eCollection 2017 Jun 1.


TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

Moujalled D, Grubman A, Acevedo K, Yang S, Ke YD, Moujalled DM, Duncan C, Caragounis A, Perera ND, Turner BJ, Prudencio M, Petrucelli L, Blair I, Ittner LM, Crouch PJ, Liddell JR, White AR.

Hum Mol Genet. 2017 May 1;26(9):1732-1746. doi: 10.1093/hmg/ddx093.


Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model.

Bodea LG, Evans HT, Van der Jeugd A, Ittner LM, Delerue F, Kril J, Halliday G, Hodges J, Kiernan MC, Götz J.

Aging Cell. 2017 Apr;16(2):377-386. doi: 10.1111/acel.12565. Epub 2017 Feb 4. Erratum in: Aging Cell. 2018 Feb;17 (1):.


Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.

Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT.

J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30.


Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology.

Ahmed RM, Irish M, van Eersel J, Ittner A, Ke YD, Volkerling A, van der Hoven J, Tanaka K, Karl T, Kassiou M, Kril JJ, Piguet O, Götz J, Kiernan MC, Halliday GM, Hodges JR, Ittner LM.

Neurosci Biobehav Rev. 2017 Mar;74(Pt A):126-138. doi: 10.1016/j.neubiorev.2017.01.004. Epub 2017 Jan 11. Review.


The Polyphenol Altenusin Inhibits in Vitro Fibrillization of Tau and Reduces Induced Tau Pathology in Primary Neurons.

Chua SW, Cornejo A, van Eersel J, Stevens CH, Vaca I, Cueto M, Kassiou M, Gladbach A, Macmillan A, Lewis L, Whan R, Ittner LM.

ACS Chem Neurosci. 2017 Apr 19;8(4):743-751. doi: 10.1021/acschemneuro.6b00433. Epub 2017 Jan 12.


ALS/FTLD: experimental models and reality.

Tan RH, Ke YD, Ittner LM, Halliday GM.

Acta Neuropathol. 2017 Feb;133(2):177-196. doi: 10.1007/s00401-016-1666-6. Epub 2017 Jan 5. Review.


Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice.

Ittner A, Chua SW, Bertz J, Volkerling A, van der Hoven J, Gladbach A, Przybyla M, Bi M, van Hummel A, Stevens CH, Ippati S, Suh LS, Macmillan A, Sutherland G, Kril JJ, Silva AP, Mackay JP, Poljak A, Delerue F, Ke YD, Ittner LM.

Science. 2016 Nov 18;354(6314):904-908.


Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination.

Sokias R, Werry EL, Chua SW, Reekie TA, Munoz L, Wong ECN, Ittner LM, Kassiou M.

Medchemcomm. 2016 Nov 15;8(1):202-210. doi: 10.1039/c6md00523c. eCollection 2017 Jan 1.


In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL.

Fröhlich D, Suchowerska AK, Spencer ZH, von Jonquieres G, Klugmann CB, Bongers A, Delerue F, Stefen H, Ittner LM, Fath T, Housley GD, Klugmann M.

Neurobiol Dis. 2017 Jan;97(Pt A):24-35. doi: 10.1016/j.nbd.2016.10.008. Epub 2016 Nov 2.


No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice.

van Hummel A, Bi M, Ippati S, van der Hoven J, Volkerling A, Lee WS, Tan DC, Bongers A, Ittner A, Ke YD, Ittner LM.

PLoS One. 2016 Oct 13;11(10):e0163236. doi: 10.1371/journal.pone.0163236. eCollection 2016.


Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease.

Rosa E, Mahendram S, Ke YD, Ittner LM, Ginsberg SD, Fahnestock M.

Neurobiol Aging. 2016 Dec;48:135-142. doi: 10.1016/j.neurobiolaging.2016.08.020. Epub 2016 Aug 31.


Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia.

Przybyla M, Stevens CH, van der Hoven J, Harasta A, Bi M, Ittner A, van Hummel A, Hodges JR, Piguet O, Karl T, Kassiou M, Housley GD, Ke YD, Ittner LM, Eersel Jv.

Neurosci Lett. 2016 Sep 19;631:24-9. doi: 10.1016/j.neulet.2016.08.007. Epub 2016 Aug 10.


Motor cortical function determines prognosis in sporadic ALS.

Shibuya K, Park SB, Geevasinga N, Menon P, Howells J, Simon NG, Huynh W, Noto Y, Götz J, Kril JJ, Ittner LM, Hodges J, Halliday G, Vucic S, Kiernan MC.

Neurology. 2016 Aug 2;87(5):513-20. doi: 10.1212/WNL.0000000000002912. Epub 2016 Jul 8.


Tau physiology and pathomechanisms in frontotemporal lobar degeneration.

Bodea LG, Eckert A, Ittner LM, Piguet O, Götz J.

J Neurochem. 2016 Aug;138 Suppl 1:71-94. doi: 10.1111/jnc.13600. Epub 2016 Jun 15. Review.


Neuronal network disintegration: common pathways linking neurodegenerative diseases.

Ahmed RM, Devenney EM, Irish M, Ittner A, Naismith S, Ittner LM, Rohrer JD, Halliday GM, Eisen A, Hodges JR, Kiernan MC.

J Neurol Neurosurg Psychiatry. 2016 Nov;87(11):1234-1241. doi: 10.1136/jnnp-2014-308350. Epub 2016 May 12. Review.


The frontotemporal dementia-motor neuron disease continuum.

Burrell JR, Halliday GM, Kril JJ, Ittner LM, Götz J, Kiernan MC, Hodges JR.

Lancet. 2016 Aug 27;388(10047):919-31. doi: 10.1016/S0140-6736(16)00737-6. Epub 2016 Mar 14. Review.


A Comparative Study of Variables Influencing Ischemic Injury in the Longa and Koizumi Methods of Intraluminal Filament Middle Cerebral Artery Occlusion in Mice.

Morris GP, Wright AL, Tan RP, Gladbach A, Ittner LM, Vissel B.

PLoS One. 2016 Feb 12;11(2):e0148503. doi: 10.1371/journal.pone.0148503. eCollection 2016.


Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism.

Ahmed RM, Irish M, Piguet O, Halliday GM, Ittner LM, Farooqi S, Hodges JR, Kiernan MC.

Lancet Neurol. 2016 Mar;15(3):332-42. doi: 10.1016/S1474-4422(15)00380-4. Epub 2016 Jan 26. Review. Erratum in: Lancet Neurol. 2016 Apr;15(4):352.


Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.

Leshchyns'ka I, Liew HT, Shepherd C, Halliday GM, Stevens CH, Ke YD, Ittner LM, Sytnyk V.

Nat Commun. 2015 Nov 27;6:8836. doi: 10.1038/ncomms9836.


Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons.

Brettle M, Suchowerska AK, Chua SW, Ittner LM, Fath T.

Neurosci Lett. 2015 Nov 16;609:223-8. doi: 10.1016/j.neulet.2015.09.034. Epub 2015 Oct 21.


First Demonstration of Positive Allosteric-like Modulation at the Human Wild Type Translocator Protein (TSPO).

Narlawar R, Werry EL, Scarf AM, Hanani R, Chua SW, King VA, Barron ML, Martins RN, Ittner LM, Rendina LM, Kassiou M.

J Med Chem. 2015 Nov 12;58(21):8743-9. doi: 10.1021/acs.jmedchem.5b01288. Epub 2015 Oct 23.


Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.

Ke YD, van Hummel A, Stevens CH, Gladbach A, Ippati S, Bi M, Lee WS, Krüger S, van der Hoven J, Volkerling A, Bongers A, Halliday G, Haass NK, Kiernan M, Delerue F, Ittner LM.

Acta Neuropathol. 2015 Nov;130(5):661-78. doi: 10.1007/s00401-015-1486-0. Epub 2015 Oct 5.


The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies.

Verdile G, Asih PR, Barron AM, Wahjoepramono EJ, Ittner LM, Martins RN.

Horm Behav. 2015 Nov;76:81-90. doi: 10.1016/j.yhbeh.2015.05.020. Epub 2015 Jun 27. Review.


FTD and ALS--translating mouse studies into clinical trials.

Ittner LM, Halliday GM, Kril JJ, Götz J, Hodges JR, Kiernan MC.

Nat Rev Neurol. 2015 Jun;11(6):360-6. doi: 10.1038/nrneurol.2015.65. Epub 2015 May 5. Review.


Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration.

van Eersel J, Stevens CH, Przybyla M, Gladbach A, Stefanoska K, Chan CK, Ong WY, Hodges JR, Sutherland GT, Kril JJ, Abramowski D, Staufenbiel M, Halliday GM, Ittner LM.

Neuropathol Appl Neurobiol. 2015 Dec;41(7):906-25. doi: 10.1111/nan.12233. Epub 2015 May 30.


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