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Items: 1 to 50 of 119

1.

Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.

Zhao Y, Keshiya S, Atashrazm F, Gao J, Ittner LM, Alessi DR, Halliday GM, Fu Y, Dzamko N.

Neurobiol Dis. 2018 Sep 5;120:76-87. doi: 10.1016/j.nbd.2018.09.003. [Epub ahead of print]

2.

Dendritic Tau in Alzheimer's Disease.

Ittner A, Ittner LM.

Neuron. 2018 Jul 11;99(1):13-27. doi: 10.1016/j.neuron.2018.06.003. Review.

PMID:
30001506
3.

Peptide Nanofiber Substrates for Long-Term Culturing of Primary Neurons.

Martin AD, Chua SW, Au CG, Stefen H, Przybyla M, Lin Y, Bertz J, Thordarson P, Fath T, Ke YD, Ittner LM.

ACS Appl Mater Interfaces. 2018 Aug 1;10(30):25127-25134. doi: 10.1021/acsami.8b07560. Epub 2018 Jul 20.

PMID:
29979564
4.

Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice.

van Hummel A, Chan G, van der Hoven J, Morsch M, Ippati S, Suh L, Bi M, Asih PR, Lee WS, Butler TA, Przybyla M, Halliday GM, Piguet O, Kiernan MC, Chung RS, Ittner LM, Ke YD.

Am J Pathol. 2018 Jun;188(6):1447-1456. doi: 10.1016/j.ajpath.2018.03.002. Epub 2018 Mar 22.

PMID:
29577934
5.

Physiological changes in neurodegeneration - mechanistic insights and clinical utility.

Ahmed RM, Ke YD, Vucic S, Ittner LM, Seeley W, Hodges JR, Piguet O, Halliday G, Kiernan MC.

Nat Rev Neurol. 2018 May;14(5):259-271. doi: 10.1038/nrneurol.2018.23. Epub 2018 Mar 23. Review.

PMID:
29569624
6.

Generation of a New Tau Knockout (tauΔex1) Line Using CRISPR/Cas9 Genome Editing in Mice.

Tan DCS, Yao S, Ittner A, Bertz J, Ke YD, Ittner LM, Delerue F.

J Alzheimers Dis. 2018;62(2):571-578. doi: 10.3233/JAD-171058.

PMID:
29480201
7.

Epothilone D - correct drug, wrong disease.

Ke YD, Ittner LM.

Neuropathol Appl Neurobiol. 2018 Feb 13. doi: 10.1111/nan.12478. [Epub ahead of print] No abstract available.

PMID:
29437244
8.

An N-terminal motif unique to primate tau enables differential protein-protein interactions.

Stefanoska K, Volkerling A, Bertz J, Poljak A, Ke YD, Ittner LM, Ittner A.

J Biol Chem. 2018 Mar 9;293(10):3710-3719. doi: 10.1074/jbc.RA118.001784. Epub 2018 Jan 30.

9.

Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies.

Forrest SL, Kril JJ, Stevens CH, Kwok JB, Hallupp M, Kim WS, Huang Y, McGinley CV, Werka H, Kiernan MC, Götz J, Spillantini MG, Hodges JR, Ittner LM, Halliday GM.

Brain. 2018 Feb 1;141(2):521-534. doi: 10.1093/brain/awx328.

10.

Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy.

von Jonquieres G, Spencer ZHT, Rowlands BD, Klugmann CB, Bongers A, Harasta AE, Parley KE, Cederholm J, Teahan O, Pickford R, Delerue F, Ittner LM, Fröhlich D, McLean CA, Don AS, Schneider M, Housley GD, Rae CD, Klugmann M.

Acta Neuropathol. 2018 Jan;135(1):95-113. doi: 10.1007/s00401-017-1784-9. Epub 2017 Nov 7.

11.

Absence of IL-6 prevents corneal wound healing after deep excimer laser ablation in vivo.

Hafezi F, Gatzioufas Z, Angunawela R, Ittner LM.

Eye (Lond). 2018 Jan;32(1):156-157. doi: 10.1038/eye.2017.238. Epub 2017 Nov 3. No abstract available.

PMID:
29099496
12.

Tau exacerbates excitotoxic brain damage in an animal model of stroke.

Bi M, Gladbach A, van Eersel J, Ittner A, Przybyla M, van Hummel A, Chua SW, van der Hoven J, Lee WS, Müller J, Parmar J, Jonquieres GV, Stefen H, Guccione E, Fath T, Housley GD, Klugmann M, Ke YD, Ittner LM.

Nat Commun. 2017 Sep 7;8(1):473. doi: 10.1038/s41467-017-00618-0.

13.

Alzheimer's Disease: Insights from Genetic Mouse Models and Current Advances in Human IPSC-Derived Neurons.

Harasta AE, Ittner LM.

Adv Neurobiol. 2017;15:3-29. doi: 10.1007/978-3-319-57193-5_1.

PMID:
28674976
14.

Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer's Disease: Testosterone as a Modifier.

Asih PR, Tegg ML, Sohrabi H, Carruthers M, Gandy SE, Saad F, Verdile G, Ittner LM, Martins RN.

J Alzheimers Dis. 2017;59(2):445-466. doi: 10.3233/JAD-161259. Review.

PMID:
28655134
15.

Generation of Genetically Modified Mice through the Microinjection of Oocytes.

Delerue F, Ittner LM.

J Vis Exp. 2017 Jun 15;(124). doi: 10.3791/55765.

PMID:
28654070
16.

Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes.

Tan RH, Kril JJ, Yang Y, Tom N, Hodges JR, Villemagne VL, Rowe CC, Leyton CE, Kwok JBJ, Ittner LM, Halliday GM.

Alzheimers Dement (Amst). 2017 May 29;9:10-20. doi: 10.1016/j.dadm.2017.05.005. eCollection 2017.

17.

Ring-opened aminothienopyridazines as novel tau aggregation inhibitors.

Moir M, Chua SW, Reekie T, Martin AD, Ittner A, Ittner LM, Kassiou M.

Medchemcomm. 2017 May 5;8(6):1275-1282. doi: 10.1039/c6md00306k. eCollection 2017 Jun 1.

18.

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

Moujalled D, Grubman A, Acevedo K, Yang S, Ke YD, Moujalled DM, Duncan C, Caragounis A, Perera ND, Turner BJ, Prudencio M, Petrucelli L, Blair I, Ittner LM, Crouch PJ, Liddell JR, White AR.

Hum Mol Genet. 2017 May 1;26(9):1732-1746. doi: 10.1093/hmg/ddx093.

PMID:
28334913
19.

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins.

Bharadwaj P, Wijesekara N, Liyanapathirana M, Newsholme P, Ittner L, Fraser P, Verdile G.

J Alzheimers Dis. 2017;59(2):421-432. doi: 10.3233/JAD-161192. Review.

PMID:
28269785
20.

Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model.

Bodea LG, Evans HT, Van der Jeugd A, Ittner LM, Delerue F, Kril J, Halliday G, Hodges J, Kiernan MC, Götz J.

Aging Cell. 2017 Apr;16(2):377-386. doi: 10.1111/acel.12565. Epub 2017 Feb 4. Erratum in: Aging Cell. 2018 Feb;17 (1):.

21.

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.

Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT.

J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30.

22.

Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology.

Ahmed RM, Irish M, van Eersel J, Ittner A, Ke YD, Volkerling A, van der Hoven J, Tanaka K, Karl T, Kassiou M, Kril JJ, Piguet O, Götz J, Kiernan MC, Halliday GM, Hodges JR, Ittner LM.

Neurosci Biobehav Rev. 2017 Mar;74(Pt A):126-138. doi: 10.1016/j.neubiorev.2017.01.004. Epub 2017 Jan 11. Review.

PMID:
28088537
23.

The Polyphenol Altenusin Inhibits in Vitro Fibrillization of Tau and Reduces Induced Tau Pathology in Primary Neurons.

Chua SW, Cornejo A, van Eersel J, Stevens CH, Vaca I, Cueto M, Kassiou M, Gladbach A, Macmillan A, Lewis L, Whan R, Ittner LM.

ACS Chem Neurosci. 2017 Apr 19;8(4):743-751. doi: 10.1021/acschemneuro.6b00433. Epub 2017 Jan 12.

PMID:
28067492
24.

ALS/FTLD: experimental models and reality.

Tan RH, Ke YD, Ittner LM, Halliday GM.

Acta Neuropathol. 2017 Feb;133(2):177-196. doi: 10.1007/s00401-016-1666-6. Epub 2017 Jan 5. Review.

PMID:
28058507
25.

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice.

Ittner A, Chua SW, Bertz J, Volkerling A, van der Hoven J, Gladbach A, Przybyla M, Bi M, van Hummel A, Stevens CH, Ippati S, Suh LS, Macmillan A, Sutherland G, Kril JJ, Silva AP, Mackay JP, Poljak A, Delerue F, Ke YD, Ittner LM.

Science. 2016 Nov 18;354(6314):904-908.

PMID:
27856911
26.

Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination.

Sokias R, Werry EL, Chua SW, Reekie TA, Munoz L, Wong ECN, Ittner LM, Kassiou M.

Medchemcomm. 2016 Nov 15;8(1):202-210. doi: 10.1039/c6md00523c. eCollection 2017 Jan 1.

27.

In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL.

Fröhlich D, Suchowerska AK, Spencer ZH, von Jonquieres G, Klugmann CB, Bongers A, Delerue F, Stefen H, Ittner LM, Fath T, Housley GD, Klugmann M.

Neurobiol Dis. 2017 Jan;97(Pt A):24-35. doi: 10.1016/j.nbd.2016.10.008. Epub 2016 Nov 2.

28.

No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice.

van Hummel A, Bi M, Ippati S, van der Hoven J, Volkerling A, Lee WS, Tan DC, Bongers A, Ittner A, Ke YD, Ittner LM.

PLoS One. 2016 Oct 13;11(10):e0163236. doi: 10.1371/journal.pone.0163236. eCollection 2016.

29.

Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease.

Rosa E, Mahendram S, Ke YD, Ittner LM, Ginsberg SD, Fahnestock M.

Neurobiol Aging. 2016 Dec;48:135-142. doi: 10.1016/j.neurobiolaging.2016.08.020. Epub 2016 Aug 31.

30.

Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia.

Przybyla M, Stevens CH, van der Hoven J, Harasta A, Bi M, Ittner A, van Hummel A, Hodges JR, Piguet O, Karl T, Kassiou M, Housley GD, Ke YD, Ittner LM, Eersel Jv.

Neurosci Lett. 2016 Sep 19;631:24-9. doi: 10.1016/j.neulet.2016.08.007. Epub 2016 Aug 10.

PMID:
27521751
31.

Motor cortical function determines prognosis in sporadic ALS.

Shibuya K, Park SB, Geevasinga N, Menon P, Howells J, Simon NG, Huynh W, Noto Y, Götz J, Kril JJ, Ittner LM, Hodges J, Halliday G, Vucic S, Kiernan MC.

Neurology. 2016 Aug 2;87(5):513-20. doi: 10.1212/WNL.0000000000002912. Epub 2016 Jul 8.

PMID:
27402895
32.

Tau physiology and pathomechanisms in frontotemporal lobar degeneration.

Bodea LG, Eckert A, Ittner LM, Piguet O, Götz J.

J Neurochem. 2016 Aug;138 Suppl 1:71-94. doi: 10.1111/jnc.13600. Epub 2016 Jun 15. Review.

33.

Neuronal network disintegration: common pathways linking neurodegenerative diseases.

Ahmed RM, Devenney EM, Irish M, Ittner A, Naismith S, Ittner LM, Rohrer JD, Halliday GM, Eisen A, Hodges JR, Kiernan MC.

J Neurol Neurosurg Psychiatry. 2016 Nov;87(11):1234-1241. doi: 10.1136/jnnp-2014-308350. Epub 2016 May 12. Review.

34.

PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.

Chandrakanthan V, Yeola A, Kwan JC, Oliver RA, Qiao Q, Kang YC, Zarzour P, Beck D, Boelen L, Unnikrishnan A, Villanueva JE, Nunez AC, Knezevic K, Palu C, Nasrallah R, Carnell M, Macmillan A, Whan R, Yu Y, Hardy P, Grey ST, Gladbach A, Delerue F, Ittner L, Mobbs R, Walkley CR, Purton LE, Ward RL, Wong JW, Hesson LB, Walsh W, Pimanda JE.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2306-15. doi: 10.1073/pnas.1518244113. Epub 2016 Apr 4.

35.

The frontotemporal dementia-motor neuron disease continuum.

Burrell JR, Halliday GM, Kril JJ, Ittner LM, Götz J, Kiernan MC, Hodges JR.

Lancet. 2016 Aug 27;388(10047):919-31. doi: 10.1016/S0140-6736(16)00737-6. Epub 2016 Mar 14. Review.

PMID:
26987909
36.

A Comparative Study of Variables Influencing Ischemic Injury in the Longa and Koizumi Methods of Intraluminal Filament Middle Cerebral Artery Occlusion in Mice.

Morris GP, Wright AL, Tan RP, Gladbach A, Ittner LM, Vissel B.

PLoS One. 2016 Feb 12;11(2):e0148503. doi: 10.1371/journal.pone.0148503. eCollection 2016.

37.

Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism.

Ahmed RM, Irish M, Piguet O, Halliday GM, Ittner LM, Farooqi S, Hodges JR, Kiernan MC.

Lancet Neurol. 2016 Mar;15(3):332-42. doi: 10.1016/S1474-4422(15)00380-4. Epub 2016 Jan 26. Review. Erratum in: Lancet Neurol. 2016 Apr;15(4):352.

PMID:
26822748
38.

Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.

Leshchyns'ka I, Liew HT, Shepherd C, Halliday GM, Stevens CH, Ke YD, Ittner LM, Sytnyk V.

Nat Commun. 2015 Nov 27;6:8836. doi: 10.1038/ncomms9836.

39.

Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons.

Brettle M, Suchowerska AK, Chua SW, Ittner LM, Fath T.

Neurosci Lett. 2015 Nov 16;609:223-8. doi: 10.1016/j.neulet.2015.09.034. Epub 2015 Oct 21.

PMID:
26499959
40.

First Demonstration of Positive Allosteric-like Modulation at the Human Wild Type Translocator Protein (TSPO).

Narlawar R, Werry EL, Scarf AM, Hanani R, Chua SW, King VA, Barron ML, Martins RN, Ittner LM, Rendina LM, Kassiou M.

J Med Chem. 2015 Nov 12;58(21):8743-9. doi: 10.1021/acs.jmedchem.5b01288. Epub 2015 Oct 23.

PMID:
26461041
41.

Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.

Ke YD, van Hummel A, Stevens CH, Gladbach A, Ippati S, Bi M, Lee WS, Krüger S, van der Hoven J, Volkerling A, Bongers A, Halliday G, Haass NK, Kiernan M, Delerue F, Ittner LM.

Acta Neuropathol. 2015 Nov;130(5):661-78. doi: 10.1007/s00401-015-1486-0. Epub 2015 Oct 5.

PMID:
26437864
42.

The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies.

Verdile G, Asih PR, Barron AM, Wahjoepramono EJ, Ittner LM, Martins RN.

Horm Behav. 2015 Nov;76:81-90. doi: 10.1016/j.yhbeh.2015.05.020. Epub 2015 Jun 27. Review.

PMID:
26122291
43.

FTD and ALS--translating mouse studies into clinical trials.

Ittner LM, Halliday GM, Kril JJ, Götz J, Hodges JR, Kiernan MC.

Nat Rev Neurol. 2015 Jun;11(6):360-6. doi: 10.1038/nrneurol.2015.65. Epub 2015 May 5. Review.

PMID:
25939274
44.

Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration.

van Eersel J, Stevens CH, Przybyla M, Gladbach A, Stefanoska K, Chan CK, Ong WY, Hodges JR, Sutherland GT, Kril JJ, Abramowski D, Staufenbiel M, Halliday GM, Ittner LM.

Neuropathol Appl Neurobiol. 2015 Dec;41(7):906-25. doi: 10.1111/nan.12233. Epub 2015 May 30.

PMID:
25763777
45.

Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia.

Purushothuman S, Johnstone DM, Nandasena C, Eersel Jv, Ittner LM, Mitrofanis J, Stone J.

Neurosci Lett. 2015 Mar 30;591:155-9. doi: 10.1016/j.neulet.2015.02.037. Epub 2015 Feb 19.

PMID:
25703226
46.

Tau aggregation and its interplay with amyloid-β.

Nisbet RM, Polanco JC, Ittner LM, Götz J.

Acta Neuropathol. 2015 Feb;129(2):207-20. doi: 10.1007/s00401-014-1371-2. Epub 2014 Dec 10. Review.

47.

p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer's disease.

Ittner AA, Gladbach A, Bertz J, Suh LS, Ittner LM.

Acta Neuropathol Commun. 2014 Oct 21;2:149. doi: 10.1186/s40478-014-0149-z.

48.

Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.

Ittner A, Bertz J, Suh LS, Stevens CH, Götz J, Ittner LM.

J Neurochem. 2015 Jan;132(1):135-45. doi: 10.1111/jnc.12821. Epub 2014 Aug 1.

49.

The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo.

Ittner AA, Bertz J, Chan TY, van Eersel J, Polly P, Ittner LM.

Diabetologia. 2014 Jul;57(7):1410-9. doi: 10.1007/s00125-014-3230-z. Epub 2014 Apr 15.

PMID:
24733160
50.

The translocator protein as a drug target in Alzheimer's disease.

Chua SW, Kassiou M, Ittner LM.

Expert Rev Neurother. 2014 Apr;14(4):439-48. doi: 10.1586/14737175.2014.896201. Review.

PMID:
24625007

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