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Items: 24


Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.

Lei M, Teo JD, Song H, McEwen HP, Yup Lee J, Couttas TA, Duncan T, Chesworth R, Bertz J, Przybyla M, Van Eersel J, Heng B, Guillemin GJ, Ittner LM, Fath T, Garner B, Ittner A, Karl T, Don AS.

J Neurosci. 2019 Nov 27;39(48):9645-9659. doi: 10.1523/JNEUROSCI.0524-19.2019. Epub 2019 Oct 22.


CNS cell type-specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation.

Ke YD, Chan G, Stefanoska K, Au C, Bi M, Müller J, Przybyla M, Feiten A, Prikas E, Halliday GM, Piguet O, Kiernan MC, Kassiou M, Hodges JR, Loy CT, Mattick JS, Ittner A, Kril JJ, Sutherland GT, Ittner LM.

J Biol Chem. 2019 Sep 20;294(38):14149-14162. doi: 10.1074/jbc.RA118.005263. Epub 2019 Jul 31.


Neuronal MAP kinase p38α inhibits c-Jun N-terminal kinase to modulate anxiety-related behaviour.

Stefanoska K, Bertz J, Volkerling AM, van der Hoven J, Ittner LM, Ittner A.

Sci Rep. 2018 Sep 24;8(1):14296. doi: 10.1038/s41598-018-32592-y.


Dendritic Tau in Alzheimer's Disease.

Ittner A, Ittner LM.

Neuron. 2018 Jul 11;99(1):13-27. doi: 10.1016/j.neuron.2018.06.003. Review.


Generation of a New Tau Knockout (tauΔex1) Line Using CRISPR/Cas9 Genome Editing in Mice.

Tan DCS, Yao S, Ittner A, Bertz J, Ke YD, Ittner LM, Delerue F.

J Alzheimers Dis. 2018;62(2):571-578. doi: 10.3233/JAD-171058.


An N-terminal motif unique to primate tau enables differential protein-protein interactions.

Stefanoska K, Volkerling A, Bertz J, Poljak A, Ke YD, Ittner LM, Ittner A.

J Biol Chem. 2018 Mar 9;293(10):3710-3719. doi: 10.1074/jbc.RA118.001784. Epub 2018 Jan 30.


Tau exacerbates excitotoxic brain damage in an animal model of stroke.

Bi M, Gladbach A, van Eersel J, Ittner A, Przybyla M, van Hummel A, Chua SW, van der Hoven J, Lee WS, Müller J, Parmar J, Jonquieres GV, Stefen H, Guccione E, Fath T, Housley GD, Klugmann M, Ke YD, Ittner LM.

Nat Commun. 2017 Sep 7;8(1):473. doi: 10.1038/s41467-017-00618-0.


Ring-opened aminothienopyridazines as novel tau aggregation inhibitors.

Moir M, Chua SW, Reekie T, Martin AD, Ittner A, Ittner LM, Kassiou M.

Medchemcomm. 2017 May 5;8(6):1275-1282. doi: 10.1039/c6md00306k. eCollection 2017 Jun 1.


Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology.

Ahmed RM, Irish M, van Eersel J, Ittner A, Ke YD, Volkerling A, van der Hoven J, Tanaka K, Karl T, Kassiou M, Kril JJ, Piguet O, Götz J, Kiernan MC, Halliday GM, Hodges JR, Ittner LM.

Neurosci Biobehav Rev. 2017 Mar;74(Pt A):126-138. doi: 10.1016/j.neubiorev.2017.01.004. Epub 2017 Jan 11. Review.


Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice.

Ittner A, Chua SW, Bertz J, Volkerling A, van der Hoven J, Gladbach A, Przybyla M, Bi M, van Hummel A, Stevens CH, Ippati S, Suh LS, Macmillan A, Sutherland G, Kril JJ, Silva AP, Mackay JP, Poljak A, Delerue F, Ke YD, Ittner LM.

Science. 2016 Nov 18;354(6314):904-908.


No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice.

van Hummel A, Bi M, Ippati S, van der Hoven J, Volkerling A, Lee WS, Tan DC, Bongers A, Ittner A, Ke YD, Ittner LM.

PLoS One. 2016 Oct 13;11(10):e0163236. doi: 10.1371/journal.pone.0163236. eCollection 2016.


Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia.

Przybyla M, Stevens CH, van der Hoven J, Harasta A, Bi M, Ittner A, van Hummel A, Hodges JR, Piguet O, Karl T, Kassiou M, Housley GD, Ke YD, Ittner LM, Eersel Jv.

Neurosci Lett. 2016 Sep 19;631:24-9. doi: 10.1016/j.neulet.2016.08.007. Epub 2016 Aug 10.


Neuronal network disintegration: common pathways linking neurodegenerative diseases.

Ahmed RM, Devenney EM, Irish M, Ittner A, Naismith S, Ittner LM, Rohrer JD, Halliday GM, Eisen A, Hodges JR, Kiernan MC.

J Neurol Neurosurg Psychiatry. 2016 Nov;87(11):1234-1241. doi: 10.1136/jnnp-2014-308350. Epub 2016 May 12. Review.


p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer's disease.

Ittner AA, Gladbach A, Bertz J, Suh LS, Ittner LM.

Acta Neuropathol Commun. 2014 Oct 21;2:149. doi: 10.1186/s40478-014-0149-z.


Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.

Ittner A, Bertz J, Suh LS, Stevens CH, Götz J, Ittner LM.

J Neurochem. 2015 Jan;132(1):135-45. doi: 10.1111/jnc.12821. Epub 2014 Aug 1.


The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo.

Ittner AA, Bertz J, Chan TY, van Eersel J, Polly P, Ittner LM.

Diabetologia. 2014 Jul;57(7):1410-9. doi: 10.1007/s00125-014-3230-z. Epub 2014 Apr 15.


Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung.

Ittner A, Block H, Reichel CA, Varjosalo M, Gehart H, Sumara G, Gstaiger M, Krombach F, Zarbock A, Ricci R.

J Exp Med. 2012 Nov 19;209(12):2229-46. doi: 10.1084/jem.20120677. Epub 2012 Nov 5.


Hairless promotes PPARγ expression and is required for white adipogenesis.

Kumpf S, Mihlan M, Goginashvili A, Grandl G, Gehart H, Godel A, Schmidt J, Müller J, Bezzi M, Ittner A, Guccione E, Wolfrum C, Ricci R.

EMBO Rep. 2012 Nov 6;13(11):1012-20. doi: 10.1038/embor.2012.133. Epub 2012 Sep 11.


Lessons from tau-deficient mice.

Ke YD, Suchowerska AK, van der Hoven J, De Silva DM, Wu CW, van Eersel J, Ittner A, Ittner LM.

Int J Alzheimers Dis. 2012;2012:873270. doi: 10.1155/2012/873270. Epub 2012 Jun 6.


Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice.

Bi M, Ittner A, Ke YD, Götz J, Ittner LM.

PLoS One. 2011;6(12):e26860. doi: 10.1371/journal.pone.0026860. Epub 2011 Dec 8.


Tau-targeted treatment strategies in Alzheimer's disease.

Götz J, Ittner A, Ittner LM.

Br J Pharmacol. 2012 Mar;165(5):1246-59. doi: 10.1111/j.1476-5381.2011.01713.x. Review.


Brief update on different roles of tau in neurodegeneration.

Ittner A, Ke YD, van Eersel J, Gladbach A, Götz J, Ittner LM.

IUBMB Life. 2011 Jul;63(7):495-502. doi: 10.1002/iub.467. Review.


Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice.

Attems J, Ittner A, Jellinger K, Nitsch RM, Maj M, Wagner L, Götz J, Heikenwalder M.

J Neural Transm (Vienna). 2011 May;118(5):737-45. doi: 10.1007/s00702-011-0626-5. Epub 2011 Mar 26.


MAPK signalling in cellular metabolism: stress or wellness?

Gehart H, Kumpf S, Ittner A, Ricci R.

EMBO Rep. 2010 Nov;11(11):834-40. doi: 10.1038/embor.2010.160. Epub 2010 Oct 8. Review.

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