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Items: 1 to 50 of 82

1.

DNA methylation patterns in bladder tumors of African-American patients point to distinct alterations in xenobiotic metabolism.

Vantaku V, Amara CS, Piyarathna DWB, Donepudi SR, Ambati CR, Putluri V, Tang W, Rajapakshe K, Estecio MR, Terris MK, Castro PD, Ittmann MM, Williams SB, Lerner SP, Sreekumar A, Bollag R, Coarfa C, Kornberg MD, Lotan Y, Ambs S, Putluri N.

Carcinogenesis. 2019 Jul 8. pii: bgz128. doi: 10.1093/carcin/bgz128. [Epub ahead of print]

PMID:
31284295
2.

Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer.

Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SE.

Nat Metab. 2019 Jan;1(1):70-85. doi: 10.1038/s42255-018-0002-y. Epub 2018 Nov 19.

3.

JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression.

Liu J, Wang T, Creighton CJ, Wu SP, Ray M, Janardhan KS, Willson CJ, Cho SN, Castro PD, Ittmann MM, Li JL, Davis RJ, DeMayo FJ.

Nat Commun. 2019 May 14;10(1):2148. doi: 10.1038/s41467-019-09843-1.

4.

Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms.

Wei X, Zhang L, Zhou Z, Kwon OJ, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo MM, Xu F, Creighton CJ, Ittmann MM, Xin L.

Cell Stem Cell. 2019 May 2;24(5):753-768.e6. doi: 10.1016/j.stem.2019.03.010. Epub 2019 Apr 11.

PMID:
30982770
5.

ERR1 and PGC1α associated mitochondrial alterations correlate with pan-cancer disparity in African Americans.

Piyarathna DWB, Balasubramanian A, Arnold JM, Lloyd SM, Karanam B, Castro P, Ittmann MM, Putluri N, Navone N, Jones JA, Yu W, Sandulache VC, Sikora AG, Michailidis G, Sreekumar A.

J Clin Invest. 2019 Mar 28;129(6):2351-2356. doi: 10.1172/JCI127579.

6.

Impact of diet on irinotecan toxicity in mice.

Mallick P, Shah P, Ittmann MM, Trivedi M, Hu M, Gao S, Ghose R.

Chem Biol Interact. 2018 Aug 1;291:87-94. doi: 10.1016/j.cbi.2018.06.018. Epub 2018 Jun 18.

PMID:
29913120
7.

TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis.

Singh R, Karri D, Shen H, Shao J, Dasgupta S, Huang S, Edwards DP, Ittmann MM, O'Malley BW, Yi P.

J Clin Invest. 2018 Jul 2;128(7):3129-3143. doi: 10.1172/JCI96060. Epub 2018 Jun 18.

8.

Expression of pattern recognition receptor genes and mortality in patients with colorectal adenocarcinoma.

Royse KE, Chen L, Berger DH, Ittmann MM, El-Serag HB, Balentine CJ, Graham DY, Richardson PA, Rumbaut RE, Shen X, White DL, Jiao L.

Int J Mol Epidemiol Genet. 2017 Apr 15;8(2):8-18. eCollection 2017.

9.

A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis.

Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Lu Y, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang F.

Neoplasia. 2017 May;19(5):421-428. doi: 10.1016/j.neo.2017.03.003. Epub 2017 Apr 20.

10.

CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT.

Chaudhury A, Cheema S, Fachini JM, Kongchan N, Lu G, Simon LM, Wang T, Mao S, Rosen DG, Ittmann MM, Hilsenbeck SG, Shaw CA, Neilson JR.

Nat Commun. 2016 Nov 21;7:13362. doi: 10.1038/ncomms13362.

11.

The tumor suppressive miR-200b subfamily is an ERG target gene in human prostate tumors.

Zhang Z, Lanz RB, Xiao L, Wang L, Hartig SM, Ittmann MM, Feng Q, He B.

Oncotarget. 2016 Jun 21;7(25):37993-38003. doi: 10.18632/oncotarget.9366.

12.

Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor.

Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj GV, Mauck R, Roehrborn C, Creighton CJ, Strand DW, Ittmann MM, Xin L.

Mol Cell. 2016 Sep 15;63(6):976-89. doi: 10.1016/j.molcel.2016.07.025. Epub 2016 Sep 1.

13.

A Versatile Gene Delivery System for Efficient and Tumor Specific Gene Manipulation in vivo.

Wang W, Dong B, Ittmann MM, Yang F.

Discoveries (Craiova). 2016 Apr-Jun;4(2). pii: e58. Epub 2016 Jun 22.

14.

The essential role of GATA transcription factors in adult murine prostate.

Xiao L, Feng Q, Zhang Z, Wang F, Lydon JP, Ittmann MM, Xin L, Mitsiades N, He B.

Oncotarget. 2016 Jul 26;7(30):47891-47903. doi: 10.18632/oncotarget.10294.

15.

Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model.

Kwon OJ, Zhang L, Wang J, Su Q, Feng Q, Zhang XH, Mani SA, Paulter R, Creighton CJ, Ittmann MM, Xin L.

J Clin Invest. 2016 Jul 1;126(7):2626-41. doi: 10.1172/JCI84637. Epub 2016 Jun 13.

16.

The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker.

Xiao L, Lanz RB, Frolov A, Castro PD, Zhang Z, Dong B, Xue W, Jung SY, Lydon JP, Edwards DP, Mancini MA, Feng Q, Ittmann MM, He B.

Prostate. 2016 Oct;76(14):1271-84. doi: 10.1002/pros.23213. Epub 2016 Jun 8.

PMID:
27272765
17.

Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer.

Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, Zaslavsky A, Putluri V, Vasu VT, Zhang Y, Khan AS, Lloyd S, Szafran AT, Dasgupta S, Bader DA, Stossi F, Li H, Samanta S, Cao X, Tsouko E, Huang S, Frigo DE, Chan L, Edwards DP, Kaipparettu BA, Mitsiades N, Weigel NL, Mancini M, McGuire SE, Mehra R, Ittmann MM, Chinnaiyan AM, Putluri N, Palapattu GS, Michailidis G, Sreekumar A.

Nat Commun. 2016 May 19;7:11612. doi: 10.1038/ncomms11612.

18.

Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer.

Lin SC, Kao CY, Lee HJ, Creighton CJ, Ittmann MM, Tsai SJ, Tsai SY, Tsai MJ.

Nat Commun. 2016 Apr 25;7:11418. doi: 10.1038/ncomms11418.

19.

Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression.

Lopez SM, Agoulnik AI, Zhang M, Peterson LE, Suarez E, Gandarillas GA, Frolov A, Li R, Rajapakshe K, Coarfa C, Ittmann MM, Weigel NL, Agoulnik IU.

Clin Cancer Res. 2016 Aug 1;22(15):3937-49. doi: 10.1158/1078-0432.CCR-15-1983. Epub 2016 Mar 11.

20.

Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation.

Gingras MC, Covington KR, Chang DK, Donehower LA, Gill AJ, Ittmann MM, Creighton CJ, Johns AL, Shinbrot E, Dewal N, Fisher WE; Australian Pancreatic Cancer Genome Initiative, Pilarsky C, Grützmann R, Overman MJ, Jamieson NB, Van Buren G 2nd, Drummond J, Walker K, Hampton OA, Xi L, Muzny DM, Doddapaneni H, Lee SL, Bellair M, Hu J, Han Y, Dinh HH, Dahdouli M, Samra JS, Bailey P, Waddell N, Pearson JV, Harliwong I, Wang H, Aust D, Oien KA, Hruban RH, Hodges SE, McElhany A, Saengboonmee C, Duthie FR, Grimmond SM, Biankin AV, Wheeler DA, Gibbs RA.

Cell Rep. 2016 Feb 2;14(4):907-919. doi: 10.1016/j.celrep.2015.12.005. Epub 2016 Jan 21.

21.

Aberrant Activation of the RANK Signaling Receptor Induces Murine Salivary Gland Tumors.

Szwarc MM, Kommagani R, Jacob AP, Dougall WC, Ittmann MM, Lydon JP.

PLoS One. 2015 Jun 10;10(6):e0128467. doi: 10.1371/journal.pone.0128467. eCollection 2015.

22.

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes.

Caruana I, Savoldo B, Hoyos V, Weber G, Liu H, Kim ES, Ittmann MM, Marchetti D, Dotti G.

Nat Med. 2015 May;21(5):524-9. doi: 10.1038/nm.3833. Epub 2015 Apr 13.

23.

Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis.

Dasgupta S, Putluri N, Long W, Zhang B, Wang J, Kaushik AK, Arnold JM, Bhowmik SK, Stashi E, Brennan CA, Rajapakshe K, Coarfa C, Mitsiades N, Ittmann MM, Chinnaiyan AM, Sreekumar A, O'Malley BW.

J Clin Invest. 2015 Mar 2;125(3):1174-88. doi: 10.1172/JCI76029. Epub 2015 Feb 9.

24.

Interaction of the Androgen Receptor, ETV1, and PTEN Pathways in Mouse Prostate Varies with Pathological Stage and Predicts Cancer Progression.

Higgins J, Brogley M, Palanisamy N, Mehra R, Ittmann MM, Li JZ, Tomlins SA, Robins DM.

Horm Cancer. 2015 Jun;6(2-3):67-86. doi: 10.1007/s12672-014-0215-9. Epub 2015 Jan 29.

25.

GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex.

He B, Lanz RB, Fiskus W, Geng C, Yi P, Hartig SM, Rajapakshe K, Shou J, Wei L, Shah SS, Foley C, Chew SA, Eedunuri VK, Bedoya DJ, Feng Q, Minami T, Mitsiades CS, Frolov A, Weigel NL, Hilsenbeck SG, Rosen DG, Palzkill T, Ittmann MM, Song Y, Coarfa C, O'Malley BW, Mitsiades N.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18261-6. doi: 10.1073/pnas.1421415111. Epub 2014 Dec 8.

26.

Stromal TGF-β signaling induces AR activation in prostate cancer.

Yang F, Chen Y, Shen T, Guo D, Dakhova O, Ittmann MM, Creighton CJ, Zhang Y, Dang TD, Rowley DR.

Oncotarget. 2014 Nov 15;5(21):10854-69.

27.

Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells.

Candelaria NR, Addanki S, Zheng J, Nguyen-Vu T, Karaboga H, Dey P, Gabbi C, Vedin LL, Liu K, Wu W, Jonsson PK, Lin JZ, Su F, Bollu LR, Hodges SE, McElhany AL, Issazadeh MA, Fisher WE, Ittmann MM, Steffensen KR, Gustafsson JÅ, Lin CY.

PLoS One. 2014 Sep 3;9(9):e106289. doi: 10.1371/journal.pone.0106289. eCollection 2014.

28.

Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells.

Kwon OJ, Valdez JM, Zhang L, Zhang B, Wei X, Su Q, Ittmann MM, Creighton CJ, Xin L.

Nat Commun. 2014 Jul 22;5:4416. doi: 10.1038/ncomms5416.

29.

The prostate cancer TMPRSS2:ERG fusion synergizes with the vitamin D receptor (VDR) to induce CYP24A1 expression-limiting VDR signaling.

Kim JS, Roberts JM, Bingman WE 3rd, Shao L, Wang J, Ittmann MM, Weigel NL.

Endocrinology. 2014 Sep;155(9):3262-73. doi: 10.1210/en.2013-2019. Epub 2014 Jun 13.

30.

Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin.

Kwon OJ, Zhang L, Ittmann MM, Xin L.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):E592-600. doi: 10.1073/pnas.1318157111. Epub 2013 Dec 23.

31.

FGFR1-WNT-TGF-β signaling in prostate cancer mouse models recapitulates human reactive stroma.

Carstens JL, Shahi P, Van Tsang S, Smith B, Creighton CJ, Zhang Y, Seamans A, Seethammagari M, Vedula I, Levitt JM, Ittmann MM, Rowley DR, Spencer DM.

Cancer Res. 2014 Jan 15;74(2):609-20. doi: 10.1158/0008-5472.CAN-13-1093. Epub 2013 Dec 4.

32.

Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.

Tennakoon JB, Shi Y, Han JJ, Tsouko E, White MA, Burns AR, Zhang A, Xia X, Ilkayeva OR, Xin L, Ittmann MM, Rick FG, Schally AV, Frigo DE.

Oncogene. 2014 Nov 6;33(45):5251-61. doi: 10.1038/onc.2013.463. Epub 2013 Nov 4.

33.

ERManI is a target of miR-125b and promotes transformation phenotypes in hepatocellular carcinoma (HCC).

Pan S, Cheng X, Chen H, Castro PD, Ittmann MM, Hutson AW, Zapata SK, Sifers RN.

PLoS One. 2013 Aug 5;8(8):e72829. doi: 10.1371/journal.pone.0072829. Print 2013.

34.

A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.

Zhang B, Chen H, Zhang L, Dakhova O, Zhang Y, Lewis MT, Creighton CJ, Ittmann MM, Xin L.

Oncogene. 2014 Jun 12;33(24):3099-108. doi: 10.1038/onc.2013.281. Epub 2013 Jul 15.

35.

HLA-restricted NY-ESO-1 peptide immunotherapy for metastatic castration resistant prostate cancer.

Sonpavde G, Wang M, Peterson LE, Wang HY, Joe T, Mims MP, Kadmon D, Ittmann MM, Wheeler TM, Gee AP, Wang RF, Hayes TG.

Invest New Drugs. 2014 Apr;32(2):235-242. doi: 10.1007/s10637-013-9960-9. Epub 2013 Apr 23.

36.

SULT2B1b sulfotransferase: induction by vitamin D receptor and reduced expression in prostate cancer.

Seo YK, Mirkheshti N, Song CS, Kim S, Dodds S, Ahn SC, Christy B, Mendez-Meza R, Ittmann MM, Abboud-Werner S, Chatterjee B.

Mol Endocrinol. 2013 Jun;27(6):925-39. doi: 10.1210/me.2012-1369. Epub 2013 Apr 11.

37.

FGFR1 is essential for prostate cancer progression and metastasis.

Yang F, Zhang Y, Ressler SJ, Ittmann MM, Ayala GE, Dang TD, Wang F, Rowley DR.

Cancer Res. 2013 Jun 15;73(12):3716-24. doi: 10.1158/0008-5472.CAN-12-3274. Epub 2013 Apr 10.

38.

ERK and AKT signaling drive MED1 overexpression in prostate cancer in association with elevated proliferation and tumorigenicity.

Jin F, Irshad S, Yu W, Belakavadi M, Chekmareva M, Ittmann MM, Abate-Shen C, Fondell JD.

Mol Cancer Res. 2013 Jul;11(7):736-47. doi: 10.1158/1541-7786.MCR-12-0618. Epub 2013 Mar 28.

39.

Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2.

Li L, Yang G, Ren C, Tanimoto R, Hirayama T, Wang J, Hawke D, Kim SM, Lee JS, Goltsov AA, Park S, Ittmann MM, Troncoso P, Thompson TC.

Mol Oncol. 2013 Jun;7(3):484-96. doi: 10.1016/j.molonc.2012.12.005. Epub 2012 Dec 31.

40.

Development and clinical validation of a real-time PCR assay for PITX2 DNA methylation to predict prostate-specific antigen recurrence in prostate cancer patients following radical prostatectomy.

Dietrich D, Hasinger O, Bañez LL, Sun L, van Leenders GJ, Wheeler TM, Bangma CH, Wernert N, Perner S, Freedland SJ, Corman JM, Ittmann MM, Lark AL, Madden JF, Hartmann A, Schatz P, Kristiansen G.

J Mol Diagn. 2013 Mar;15(2):270-9. doi: 10.1016/j.jmoldx.2012.11.002. Epub 2012 Dec 22.

41.

COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.

Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, Ittmann MM, Tsai SJ, Tsai MJ, Tsai SY.

Nature. 2013 Jan 10;493(7431):236-40. doi: 10.1038/nature11674. Epub 2012 Nov 28.

42.

Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity.

Valdez JM, Zhang L, Su Q, Dakhova O, Zhang Y, Shahi P, Spencer DM, Creighton CJ, Ittmann MM, Xin L.

Cell Stem Cell. 2012 Nov 2;11(5):676-88. doi: 10.1016/j.stem.2012.07.003.

43.

Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis.

Shahi P, Park D, Pond AC, Seethammagari M, Chiou SH, Cho K, Carstens JL, Decker WK, McCrea PD, Ittmann MM, Rosen JM, Spencer DM.

PLoS One. 2012;7(1):e30814. doi: 10.1371/journal.pone.0030814. Epub 2012 Jan 27.

44.

Common structural and epigenetic changes in the genome of castration-resistant prostate cancer.

Friedlander TW, Roy R, Tomlins SA, Ngo VT, Kobayashi Y, Azameera A, Rubin MA, Pienta KJ, Chinnaiyan A, Ittmann MM, Ryan CJ, Paris PL.

Cancer Res. 2012 Feb 1;72(3):616-25. doi: 10.1158/0008-5472.CAN-11-2079. Epub 2011 Dec 7.

45.

GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction.

Li L, Ren C, Yang G, Fattah EA, Goltsov AA, Kim SM, Lee JS, Park S, Demayo FJ, Ittmann MM, Troncoso P, Thompson TC.

Cancer Res. 2011 Dec 15;71(24):7694-704. doi: 10.1158/0008-5472.CAN-11-1714. Epub 2011 Oct 24.

46.

GLIPR1 tumor suppressor gene expressed by adenoviral vector as neoadjuvant intraprostatic injection for localized intermediate or high-risk prostate cancer preceding radical prostatectomy.

Sonpavde G, Thompson TC, Jain RK, Ayala GE, Kurosaka S, Edamura K, Tabata K, Ren C, Goltsov AA, Mims MP, Hayes TG, Ittmann MM, Wheeler TM, Gee A, Miles BJ, Kadmon D.

Clin Cancer Res. 2011 Nov 15;17(22):7174-82. doi: 10.1158/1078-0432.CCR-11-1899. Epub 2011 Sep 20.

47.

Recurrent chimeric RNAs enriched in human prostate cancer identified by deep sequencing.

Kannan K, Wang L, Wang J, Ittmann MM, Li W, Yen L.

Proc Natl Acad Sci U S A. 2011 May 31;108(22):9172-7. doi: 10.1073/pnas.1100489108. Epub 2011 May 12.

48.

Detection of recurrent rearrangement breakpoints from copy number data.

Ritz A, Paris PL, Ittmann MM, Collins C, Raphael BJ.

BMC Bioinformatics. 2011 Apr 21;12:114. doi: 10.1186/1471-2105-12-114.

49.

INPP4B: the new kid on the PI3K block.

Agoulnik IU, Hodgson MC, Bowden WA, Ittmann MM.

Oncotarget. 2011 Apr;2(4):321-8. Review.

50.

Associations between arachidonic acid metabolism gene polymorphisms and prostate cancer risk.

Amirian ES, Ittmann MM, Scheurer ME.

Prostate. 2011 Sep 15;71(13):1382-9. doi: 10.1002/pros.21354. Epub 2011 Feb 9.

PMID:
21308720

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