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Items: 1 to 50 of 236

1.

Targeting the TMPRSS2/ERG fusion mRNA using liposomal nanovectors enhances docetaxel treatment in prostate cancer.

Shao L, Kahraman N, Yan G, Wang J, Ozpolat B, Ittmann M.

Prostate. 2019 Oct 15. doi: 10.1002/pros.23918. [Epub ahead of print]

PMID:
31614005
2.

ING5 inhibits cancer aggressiveness by inhibiting Akt and activating p53 in prostate cancer.

Barlak N, Capik O, Sanli F, Kilic A, Aytatli A, Yazici A, Ortucu S, Ittmann M, Karatas OF.

Cell Biol Int. 2019 Sep 2. doi: 10.1002/cbin.11227. [Epub ahead of print]

PMID:
31475765
3.

Methionine-Homocysteine Pathway in African-American Prostate Cancer.

Gohlke JH, Lloyd SM, Basu S, Putluri V, Vareed SK, Rasaily U, Piyarathna DWB, Fuentes H, Rajendiran TM, Dorsey TH, Ambati CR, Sonavane R, Karanam B, Bhowmik SK, Kittles R, Ambs S, Mims MP, Ittmann M, Jones JA, Palapattu G, Putluri N, Michailidis G, Sreekumar A.

JNCI Cancer Spectr. 2019 Apr 25;3(2):pkz019. doi: 10.1093/jncics/pkz019. eCollection 2019 Jun.

4.

DNA methylation patterns in bladder tumors of African-American patients point to distinct alterations in xenobiotic metabolism.

Vantaku V, Amara CS, Piyarathna DWB, Donepudi SR, Ambati CR, Putluri V, Tang W, Rajapakshe K, Estecio MR, Terris MK, Castro PD, Ittmann MM, Williams SB, Lerner SP, Sreekumar A, Bollag R, Coarfa C, Kornberg MD, Lotan Y, Ambs S, Putluri N.

Carcinogenesis. 2019 Jul 8. pii: bgz128. doi: 10.1093/carcin/bgz128. [Epub ahead of print]

PMID:
31284295
5.

Short-term RANKL exposure initiates a neoplastic transcriptional program in the basal epithelium of the murine salivary gland.

Hai L, Szwarc MM, Lonard DM, Rajapakshe K, Perera D, Coarfa C, Ittmann M, Fernandez-Valdivia R, Lydon JP.

Cytokine. 2019 Nov;123:154745. doi: 10.1016/j.cyto.2019.154745. Epub 2019 Jun 18.

PMID:
31226438
6.

Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer.

Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SE.

Nat Metab. 2019 Jan;1(1):70-85. doi: 10.1038/s42255-018-0002-y. Epub 2018 Nov 19.

7.

Comparative analysis of p16 expression among African American and European American prostate cancer patients.

Wong M, Bierman Y, Pettaway C, Kittles R, Mims M, Jones J, Ittmann M.

Prostate. 2019 Aug;79(11):1274-1283. doi: 10.1002/pros.23833. Epub 2019 May 21.

8.

JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression.

Liu J, Wang T, Creighton CJ, Wu SP, Ray M, Janardhan KS, Willson CJ, Cho SN, Castro PD, Ittmann MM, Li JL, Davis RJ, DeMayo FJ.

Nat Commun. 2019 May 14;10(1):2148. doi: 10.1038/s41467-019-09843-1.

9.

Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms.

Wei X, Zhang L, Zhou Z, Kwon OJ, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo MM, Xu F, Creighton CJ, Ittmann MM, Xin L.

Cell Stem Cell. 2019 May 2;24(5):753-768.e6. doi: 10.1016/j.stem.2019.03.010. Epub 2019 Apr 11.

PMID:
30982770
10.

ERR1 and PGC1α associated mitochondrial alterations correlate with pan-cancer disparity in African Americans.

Piyarathna DWB, Balasubramanian A, Arnold JM, Lloyd SM, Karanam B, Castro P, Ittmann MM, Putluri N, Navone N, Jones JA, Yu W, Sandulache VC, Sikora AG, Michailidis G, Sreekumar A.

J Clin Invest. 2019 Mar 28;129(6):2351-2356. doi: 10.1172/JCI127579.

11.

Moving Beyond Gleason Scoring.

Miles B, Ittmann M, Wheeler T, Sayeeduddin M, Cubilla A, Rowley D, Bu P, Ding Y, Gao Y, Lee M, Ayala GE.

Arch Pathol Lab Med. 2019 May;143(5):565-570. doi: 10.5858/arpa.2018-0242-RA. Epub 2019 Mar 13.

PMID:
30865488
12.

MicroRNAs as prognostic markers in prostate cancer.

Suer I, Guzel E, Karatas OF, Creighton CJ, Ittmann M, Ozen M.

Prostate. 2019 Feb;79(3):265-271. doi: 10.1002/pros.23731. Epub 2018 Oct 21.

PMID:
30345533
13.

Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers.

Zhang Y, Zheng D, Zhou T, Song H, Hulsurkar M, Su N, Liu Y, Wang Z, Shao L, Ittmann M, Gleave M, Han H, Xu F, Liao W, Wang H, Li W.

Nat Commun. 2018 Oct 4;9(1):4080. doi: 10.1038/s41467-018-06177-2.

14.

Impact of diet on irinotecan toxicity in mice.

Mallick P, Shah P, Ittmann MM, Trivedi M, Hu M, Gao S, Ghose R.

Chem Biol Interact. 2018 Aug 1;291:87-94. doi: 10.1016/j.cbi.2018.06.018. Epub 2018 Jun 18.

PMID:
29913120
15.

TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis.

Singh R, Karri D, Shen H, Shao J, Dasgupta S, Huang S, Edwards DP, Ittmann MM, O'Malley BW, Yi P.

J Clin Invest. 2018 Jul 2;128(7):3129-3143. doi: 10.1172/JCI96060. Epub 2018 Jun 18.

16.

Fibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2/ERG fusion gene and decreased PTEN.

Shao L, Wang J, Karatas OF, Feng S, Zhang Y, Creighton CJ, Ittmann M.

Oncotarget. 2018 Feb 12;9(18):14456-14471. doi: 10.18632/oncotarget.24470. eCollection 2018 Mar 6.

17.

Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases.

Chen F, Zhang Y, Gibbons DL, Deneen B, Kwiatkowski DJ, Ittmann M, Creighton CJ.

Clin Cancer Res. 2018 May 1;24(9):2182-2193. doi: 10.1158/1078-0432.CCR-17-3378. Epub 2018 Feb 9.

18.

Influence of the neural microenvironment on prostate cancer.

Coarfa C, Florentin D, Putluri N, Ding Y, Au J, He D, Ragheb A, Frolov A, Michailidis G, Lee M, Kadmon D, Miles B, Smith C, Ittmann M, Rowley D, Sreekumar A, Creighton CJ, Ayala G.

Prostate. 2018 Feb;78(2):128-139. doi: 10.1002/pros.23454. Epub 2017 Nov 13.

19.

Anatomy and Histology of the Human and Murine Prostate.

Ittmann M.

Cold Spring Harb Perspect Med. 2018 May 1;8(5). pii: a030346. doi: 10.1101/cshperspect.a030346. Review.

PMID:
29038334
20.

Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.

Bluemn EG, Coleman IM, Lucas JM, Coleman RT, Hernandez-Lopez S, Tharakan R, Bianchi-Frias D, Dumpit RF, Kaipainen A, Corella AN, Yang YC, Nyquist MD, Mostaghel E, Hsieh AC, Zhang X, Corey E, Brown LG, Nguyen HM, Pienta K, Ittmann M, Schweizer M, True LD, Wise D, Rennie PS, Vessella RL, Morrissey C, Nelson PS.

Cancer Cell. 2017 Oct 9;32(4):474-489.e6. doi: 10.1016/j.ccell.2017.09.003.

21.

miR-33a is a tumor suppressor microRNA that is decreased in prostate cancer.

Karatas OF, Wang J, Shao L, Ozen M, Zhang Y, Creighton CJ, Ittmann M.

Oncotarget. 2017 Jul 24;8(36):60243-60256. doi: 10.18632/oncotarget.19521. eCollection 2017 Sep 1.

22.

Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Chen F, Zhang Y, Bossé D, Lalani AA, Hakimi AA, Hsieh JJ, Choueiri TK, Gibbons DL, Ittmann M, Creighton CJ.

Nat Commun. 2017 Aug 4;8(1):199. doi: 10.1038/s41467-017-00289-x.

23.

RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression.

Wang Y, Wang J, Zhang L, Karatas OF, Shao L, Zhang Y, Castro P, Creighton CJ, Ittmann M.

Cancer Res. 2017 Aug 15;77(16):4247-4257. doi: 10.1158/0008-5472.CAN-17-0669. Epub 2017 Jun 13.

24.

Comprehensive Genomic Characterization of Upper Tract Urothelial Carcinoma.

Moss TJ, Qi Y, Xi L, Peng B, Kim TB, Ezzedine NE, Mosqueda ME, Guo CC, Czerniak BA, Ittmann M, Wheeler DA, Lerner SP, Matin SF.

Eur Urol. 2017 Oct;72(4):641-649. doi: 10.1016/j.eururo.2017.05.048. Epub 2017 Jun 7.

PMID:
28601352
25.

Expression of pattern recognition receptor genes and mortality in patients with colorectal adenocarcinoma.

Royse KE, Chen L, Berger DH, Ittmann MM, El-Serag HB, Balentine CJ, Graham DY, Richardson PA, Rumbaut RE, Shen X, White DL, Jiao L.

Int J Mol Epidemiol Genet. 2017 Apr 15;8(2):8-18. eCollection 2017.

26.

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.

Zhang Y, Kwok-Shing Ng P, Kucherlapati M, Chen F, Liu Y, Tsang YH, de Velasco G, Jeong KJ, Akbani R, Hadjipanayis A, Pantazi A, Bristow CA, Lee E, Mahadeshwar HS, Tang J, Zhang J, Yang L, Seth S, Lee S, Ren X, Song X, Sun H, Seidman J, Luquette LJ, Xi R, Chin L, Protopopov A, Westbrook TF, Shelley CS, Choueiri TK, Ittmann M, Van Waes C, Weinstein JN, Liang H, Henske EP, Godwin AK, Park PJ, Kucherlapati R, Scott KL, Mills GB, Kwiatkowski DJ, Creighton CJ.

Cancer Cell. 2017 Jun 12;31(6):820-832.e3. doi: 10.1016/j.ccell.2017.04.013. Epub 2017 May 18.

27.

RET Signaling in Prostate Cancer.

Ban K, Feng S, Shao L, Ittmann M.

Clin Cancer Res. 2017 Aug 15;23(16):4885-4896. doi: 10.1158/1078-0432.CCR-17-0528. Epub 2017 May 10.

28.

A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis.

Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Lu Y, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang F.

Neoplasia. 2017 May;19(5):421-428. doi: 10.1016/j.neo.2017.03.003. Epub 2017 Apr 20.

29.

SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein.

Geng C, Kaochar S, Li M, Rajapakshe K, Fiskus W, Dong J, Foley C, Dong B, Zhang L, Kwon OJ, Shah SS, Bolaki M, Xin L, Ittmann M, O'Malley BW, Coarfa C, Mitsiades N.

Oncogene. 2017 Aug 17;36(33):4767-4777. doi: 10.1038/onc.2017.80. Epub 2017 Apr 17.

30.

Cellular interactions of the phosphorylated form of AKT in prostate cancer.

Hammerich KH, Frolov A, Li R, Ittmann M, Ayala GE.

Hum Pathol. 2017 May;63:98-109. doi: 10.1016/j.humpath.2017.02.014. Epub 2017 Mar 11.

PMID:
28300578
31.

SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling.

Blattner M, Liu D, Robinson BD, Huang D, Poliakov A, Gao D, Nataraj S, Deonarine LD, Augello MA, Sailer V, Ponnala L, Ittmann M, Chinnaiyan AM, Sboner A, Chen Y, Rubin MA, Barbieri CE.

Cancer Cell. 2017 Mar 13;31(3):436-451. doi: 10.1016/j.ccell.2017.02.004.

32.

Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors.

Feng S, Shao L, Castro P, Coleman I, Nelson PS, Smith PD, Davies BR, Ittmann M.

Oncotarget. 2017 Jan 24;8(4):6179-6192. doi: 10.18632/oncotarget.14049.

33.

CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT.

Chaudhury A, Cheema S, Fachini JM, Kongchan N, Lu G, Simon LM, Wang T, Mao S, Rosen DG, Ittmann MM, Hilsenbeck SG, Shaw CA, Neilson JR.

Nat Commun. 2016 Nov 21;7:13362. doi: 10.1038/ncomms13362.

34.

Identification of microRNA profile specific to cancer stem-like cells directly isolated from human larynx cancer specimens.

Karatas OF, Suer I, Yuceturk B, Yilmaz M, Oz B, Guven G, Cansiz H, Creighton CJ, Ittmann M, Ozen M.

BMC Cancer. 2016 Nov 5;16(1):853.

35.

MNX1 Is Oncogenically Upregulated in African-American Prostate Cancer.

Zhang L, Wang J, Wang Y, Zhang Y, Castro P, Shao L, Sreekumar A, Putluri N, Guha N, Deepak S, Padmanaban A, Creighton CJ, Ittmann M.

Cancer Res. 2016 Nov 1;76(21):6290-6298. Epub 2016 Aug 30.

36.

The tumor suppressive miR-200b subfamily is an ERG target gene in human prostate tumors.

Zhang Z, Lanz RB, Xiao L, Wang L, Hartig SM, Ittmann MM, Feng Q, He B.

Oncotarget. 2016 Jun 21;7(25):37993-38003. doi: 10.18632/oncotarget.9366.

37.

Positive association of collagen type I with non-muscle invasive bladder cancer progression.

Brooks M, Mo Q, Krasnow R, Ho PL, Lee YC, Xiao J, Kurtova A, Lerner S, Godoy G, Jian W, Castro P, Chen F, Rowley D, Ittmann M, Chan KS.

Oncotarget. 2016 Dec 13;7(50):82609-82619. doi: 10.18632/oncotarget.12089.

38.

Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor.

Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj GV, Mauck R, Roehrborn C, Creighton CJ, Strand DW, Ittmann MM, Xin L.

Mol Cell. 2016 Sep 15;63(6):976-89. doi: 10.1016/j.molcel.2016.07.025. Epub 2016 Sep 1.

39.

Neuronal Trans-Differentiation in Prostate Cancer Cells.

Farach A, Ding Y, Lee M, Creighton C, Delk NA, Ittmann M, Miles B, Rowley D, Farach-Carson MC, Ayala GE.

Prostate. 2016 Oct;76(14):1312-25. doi: 10.1002/pros.23221. Epub 2016 Jul 12.

40.

A Versatile Gene Delivery System for Efficient and Tumor Specific Gene Manipulation in vivo.

Wang W, Dong B, Ittmann MM, Yang F.

Discoveries (Craiova). 2016 Apr-Jun;4(2). pii: e58. Epub 2016 Jun 22.

41.

The essential role of GATA transcription factors in adult murine prostate.

Xiao L, Feng Q, Zhang Z, Wang F, Lydon JP, Ittmann MM, Xin L, Mitsiades N, He B.

Oncotarget. 2016 Jul 26;7(30):47891-47903. doi: 10.18632/oncotarget.10294.

42.

Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer.

Su Q, Zhang B, Zhang L, Dang T, Rowley D, Ittmann M, Xin L.

Oncogene. 2017 Feb 2;36(5):618-627. doi: 10.1038/onc.2016.232. Epub 2016 Jun 27.

43.

Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model.

Kwon OJ, Zhang L, Wang J, Su Q, Feng Q, Zhang XH, Mani SA, Paulter R, Creighton CJ, Ittmann MM, Xin L.

J Clin Invest. 2016 Jul 1;126(7):2626-41. doi: 10.1172/JCI84637. Epub 2016 Jun 13.

44.

The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker.

Xiao L, Lanz RB, Frolov A, Castro PD, Zhang Z, Dong B, Xue W, Jung SY, Lydon JP, Edwards DP, Mancini MA, Feng Q, Ittmann MM, He B.

Prostate. 2016 Oct;76(14):1271-84. doi: 10.1002/pros.23213. Epub 2016 Jun 8.

PMID:
27272765
45.

Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer.

Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, Zaslavsky A, Putluri V, Vasu VT, Zhang Y, Khan AS, Lloyd S, Szafran AT, Dasgupta S, Bader DA, Stossi F, Li H, Samanta S, Cao X, Tsouko E, Huang S, Frigo DE, Chan L, Edwards DP, Kaipparettu BA, Mitsiades N, Weigel NL, Mancini M, McGuire SE, Mehra R, Ittmann MM, Chinnaiyan AM, Putluri N, Palapattu GS, Michailidis G, Sreekumar A.

Nat Commun. 2016 May 19;7:11612. doi: 10.1038/ncomms11612.

46.

GRK3 is a direct target of CREB activation and regulates neuroendocrine differentiation of prostate cancer cells.

Sang M, Hulsurkar M, Zhang X, Song H, Zheng D, Zhang Y, Li M, Xu J, Zhang S, Ittmann M, Li W.

Oncotarget. 2016 Jul 19;7(29):45171-45185. doi: 10.18632/oncotarget.9359.

47.

Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer.

Lin SC, Kao CY, Lee HJ, Creighton CJ, Ittmann MM, Tsai SJ, Tsai SY, Tsai MJ.

Nat Commun. 2016 Apr 25;7:11418. doi: 10.1038/ncomms11418.

48.

Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B.

Woodfield SE, Guo RJ, Liu Y, Major AM, Hollingsworth EF, Indiviglio S, Whittle SB, Mo Q, Bean AJ, Ittmann M, Lopez-Terrada D, Zage PE.

Genes Cancer. 2016 Jan;7(1-2):13-26.

49.

Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression.

Lopez SM, Agoulnik AI, Zhang M, Peterson LE, Suarez E, Gandarillas GA, Frolov A, Li R, Rajapakshe K, Coarfa C, Ittmann MM, Weigel NL, Agoulnik IU.

Clin Cancer Res. 2016 Aug 1;22(15):3937-49. doi: 10.1158/1078-0432.CCR-15-1983. Epub 2016 Mar 11.

50.

A Polymorphism in the FGFR4 Gene Is Associated With Risk of Neuroblastoma and Altered Receptor Degradation.

Whittle SB, Reyes S, Du M, Gireud M, Zhang L, Woodfield SE, Ittmann M, Scheurer ME, Bean AJ, Zage PE.

J Pediatr Hematol Oncol. 2016 Mar;38(2):131-8. doi: 10.1097/MPH.0000000000000506.

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