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Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis.

Touil H, Kobert A, Lebeurrier N, Rieger A, Saikali P, Lambert C, Fawaz L, Moore CS, Prat A, Gommerman J, Antel JP, Itoyama Y, Nakashima I, Bar-Or A; Canadian B Cell Team in MS.

J Neuroinflammation. 2018 Apr 19;15(1):114. doi: 10.1186/s12974-018-1136-2.


Long-term efficacy and safety of fingolimod in Japanese patients with relapsing multiple sclerosis: 3-year results of the phase 2 extension study.

Saida T, Itoyama Y, Kikuchi S, Hao Q, Kurosawa T, Ueda K, Auberson LZ, Tsumiyama I, Nagato K, Kira JI.

BMC Neurol. 2017 Jan 28;17(1):17. doi: 10.1186/s12883-017-0794-5.


Perceptions regarding a range of work-related issues and corresponding support needs of individuals with an intractable disease.

Imahashi K, Fukatsu R, Nakajima Y, Nakamura M, Ito T, Horigome M, Haruna Y, Noda T, Itoyama Y.

Intractable Rare Dis Res. 2016 Aug;5(3):202-6. doi: 10.5582/irdr.2016.01041.


Impact of the Great East Japan Earthquake in 2011 on MS and NMOSD: a study in Sendai, Japan.

Kanamori Y, Nakashima I, Takai Y, Misu T, Kuroda H, Nishiyama S, Takahashi T, Sato S, Fujimori J, Higuchi J, Itoyama Y, Aoki M, Fujihara K.

J Neurol Neurosurg Psychiatry. 2017 Apr;88(4):362-364. doi: 10.1136/jnnp-2016-313890. Epub 2016 Aug 17. No abstract available.


Complement-dependent and -independent aquaporin 4-antibody-mediated cytotoxicity in human astrocytes: Pathogenetic implications in neuromyelitis optica.

Nishiyama S, Misu T, Nuriya M, Takano R, Takahashi T, Nakashima I, Yasui M, Itoyama Y, Aoki M, Fujihara K.

Biochem Biophys Rep. 2016 May 18;7:45-51. doi: 10.1016/j.bbrep.2016.05.012. eCollection 2016 Sep.


FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion.

Suzuki N, Aoki M, Warita H, Kato M, Mizuno H, Shimakura N, Akiyama T, Furuya H, Hokonohara T, Iwaki A, Togashi S, Konno H, Itoyama Y.

J Hum Genet. 2015 Oct;60(10):653-4. doi: 10.1038/jhg.2015.93. No abstract available.


Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients.

Abe K, Itoyama Y, Sobue G, Tsuji S, Aoki M, Doyu M, Hamada C, Kondo K, Yoneoka T, Akimoto M, Yoshino H; Edaravone ALS Study Group.

Amyotroph Lateral Scler Frontotemporal Degener. 2014 Dec;15(7-8):610-7. doi: 10.3109/21678421.2014.959024. Epub 2014 Oct 6.


Fingolimod (FTY720) therapy in Japanese patients with relapsing multiple sclerosis over 12 months: results of a phase 2 observational extension.

Kira J, Itoyama Y, Kikuchi S, Hao Q, Kurosawa T, Nagato K, Tsumiyama I, von Rosenstiel P, Zhang-Auberson L, Saida T.

BMC Neurol. 2014 Jan 29;14:21. doi: 10.1186/1471-2377-14-21.


The pathology of an autoimmune astrocytopathy: lessons learned from neuromyelitis optica.

Lucchinetti CF, Guo Y, Popescu BF, Fujihara K, Itoyama Y, Misu T.

Brain Pathol. 2014 Jan;24(1):83-97. doi: 10.1111/bpa.12099. Review.


Aquaporin-4 antibody-positive cases beyond current diagnostic criteria for NMO spectrum disorders.

Sato DK, Nakashima I, Takahashi T, Misu T, Waters P, Kuroda H, Nishiyama S, Suzuki C, Takai Y, Fujihara K, Itoyama Y, Aoki M.

Neurology. 2013 Jun 11;80(24):2210-6. doi: 10.1212/WNL.0b013e318296ea08. Epub 2013 May 15.


Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica.

Misu T, Höftberger R, Fujihara K, Wimmer I, Takai Y, Nishiyama S, Nakashima I, Konno H, Bradl M, Garzuly F, Itoyama Y, Aoki M, Lassmann H.

Acta Neuropathol. 2013 Jun;125(6):815-27. doi: 10.1007/s00401-013-1116-7. Epub 2013 Apr 12.


Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study.

Kikuchi A, Baba T, Hasegawa T, Kobayashi M, Sugeno N, Konno M, Miura E, Hosokai Y, Ishioka T, Nishio Y, Hirayama K, Suzuki K, Aoki M, Takahashi S, Fukuda H, Itoyama Y, Mori E, Takeda A.

BMJ Open. 2013 Mar 1;3(3). pii: e002249. doi: 10.1136/bmjopen-2012-002249.


Clinical features and a mutation with late onset of limb girdle muscular dystrophy 2B.

Takahashi T, Aoki M, Suzuki N, Tateyama M, Yaginuma C, Sato H, Hayasaka M, Sugawara H, Ito M, Abe-Kondo E, Shimakura N, Ibi T, Kuru S, Wakayama T, Sobue G, Fujii N, Saito T, Matsumura T, Funakawa I, Mukai E, Kawanami T, Morita M, Yamazaki M, Hasegawa T, Shimizu J, Tsuji S, Kuzuhara S, Tanaka H, Yoshioka M, Konno H, Onodera H, Itoyama Y.

J Neurol Neurosurg Psychiatry. 2013 Apr;84(4):433-40. doi: 10.1136/jnnp-2011-301339. Epub 2012 Dec 15.


[Clinical translation of hepatocyte growth factor for amyotrophic lateral sclerosis].

Warita H, Kato M, Suzuki N, Itoyama Y, Aoki M.

Rinsho Shinkeigaku. 2012;52(11):1214-7. Japanese.


Two cases of elderly-onset hereditary neuropathy with liability to pressure palsy manifesting bilateral peroneal nerve palsies.

Kawaguchi N, Suzuki N, Tateyama M, Takai Y, Misu T, Nakashima I, Itoyama Y, Aoki M.

Case Rep Neurol. 2012 Sep;4(3):149-55. doi: 10.1159/000342132. Epub 2012 Oct 25.


Two cases of lumbosacral myeloradiculitis with anti-aquaporin-4 antibody.

Takai Y, Misu T, Nakashima I, Takahashi T, Itoyama Y, Fujihara K, Aoki M.

Neurology. 2012 Oct 23;79(17):1826-8. doi: 10.1212/WNL.0b013e3182703ff7. Epub 2012 Oct 10. No abstract available.


Increase of complement fragment C5a in cerebrospinal fluid during exacerbation of neuromyelitis optica.

Kuroda H, Fujihara K, Takano R, Takai Y, Takahashi T, Misu T, Nakashima I, Sato S, Itoyama Y, Aoki M.

J Neuroimmunol. 2013 Jan 15;254(1-2):178-82. doi: 10.1016/j.jneuroim.2012.09.002. Epub 2012 Sep 25.


Neutralizing antibodies are associated with a reduction of interferon-β efficacy during the treatment of Japanese multiple sclerosis patients.

Sato DK, Nakashima I, Fukazawa T, Shimizu Y, Tomizawa Y, Yokoyama K, Misu T, Creeke PI, Farrell R, Giovannoni G, Itoyama Y, Fujihara K, Aoki M.

Tohoku J Exp Med. 2012 Oct;228(2):85-92.


Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.

Konno M, Hasegawa T, Baba T, Miura E, Sugeno N, Kikuchi A, Fiesel FC, Sasaki T, Aoki M, Itoyama Y, Takeda A.

Mol Neurodegener. 2012 Aug 14;7:38. doi: 10.1186/1750-1326-7-38.


Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.

Sawada Y, Nishio Y, Suzuki K, Hirayama K, Takeda A, Hosokai Y, Ishioka T, Itoyama Y, Takahashi S, Fukuda H, Mori E.

PLoS One. 2012;7(6):e38498. doi: 10.1371/journal.pone.0038498. Epub 2012 Jun 7.


Intramuscular interferon beta-1a is effective in Japanese patients with relapsing-remitting multiple sclerosis: a pre-treatment versus treatment comparison study of gadolinium-enhanced MRI brain lesions.

Saida T, Itoyama Y, Tashiro K, Kira J, Hao Q; Interferon Beta-1a Multiple Sclerosis Study Group of Japan.

Mult Scler. 2012 Dec;18(12):1782-90. doi: 10.1177/1352458512442261. Epub 2012 Apr 4.


A randomized, controlled trial of fingolimod (FTY720) in Japanese patients with multiple sclerosis.

Saida T, Kikuchi S, Itoyama Y, Hao Q, Kurosawa T, Nagato K, Tang D, Zhang-Auberson L, Kira J.

Mult Scler. 2012 Sep;18(9):1269-77. doi: 10.1177/1352458511435984. Epub 2012 Feb 21.


Involvement of activated microglia in increased vulnerability of motoneurons after facial nerve avulsion in presymptomatic amyotrophic lateral sclerosis model rats.

Sanagi T, Nakamura Y, Suzuki E, Uchino S, Aoki M, Warita H, Itoyama Y, Kohsaka S, Ohsawa K.

Glia. 2012 May;60(5):782-93. doi: 10.1002/glia.22308. Epub 2012 Feb 16.


Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3 year longitudinal study.

Baba T, Kikuchi A, Hirayama K, Nishio Y, Hosokai Y, Kanno S, Hasegawa T, Sugeno N, Konno M, Suzuki K, Takahashi S, Fukuda H, Aoki M, Itoyama Y, Mori E, Takeda A.

Brain. 2012 Jan;135(Pt 1):161-9. doi: 10.1093/brain/awr321.


Recurrent hypogeusia in a patient with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).

Kawaguchi N, Sugeno N, Endo K, Miura E, Misu T, Nakashima I, Itoyama Y.

J Clin Neurosci. 2012 Apr;19(4):604-5. doi: 10.1016/j.jocn.2011.06.027. Epub 2012 Jan 27.


[Regenerative therapies for amyotrophic lateral sclerosis using hepatocyte growth factor].

Aoki M, Warita H, Suzuki N, Kato M, Itoyama Y.

Rinsho Shinkeigaku. 2011 Nov;51(11):1195-8. Japanese.


The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.

Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Kobayashi M, Miura E, Tanaka N, Tamai K, Furukawa K, Arai H, Mori F, Wakabayashi K, Aoki M, Itoyama Y, Takeda A.

PLoS One. 2011;6(12):e29460. doi: 10.1371/journal.pone.0029460. Epub 2011 Dec 22.


Epitope analysis of cerebrospinal fluid IgG in Japanese multiple sclerosis patients using phage display method.

Fujimori J, Nakashima I, Fujihara K, Misu T, Sato S, Itoyama Y.

Mult Scler Int. 2011;2011:353417. doi: 10.1155/2011/353417. Epub 2011 Nov 10.


Continuous administration of poloxamer 188 reduces overload-induced muscular atrophy in dysferlin-deficient SJL mice.

Suzuki N, Akiyama T, Takahashi T, Komuro H, Warita H, Tateyama M, Itoyama Y, Aoki M.

Neurosci Res. 2012 Feb;72(2):181-6. doi: 10.1016/j.neures.2011.10.005. Epub 2011 Oct 21.


[Pathogenesis of Neuromyelitis Optica: aquaporin 4 autoimmunity and astrocytopathy].

Misu T, Fujihara K, Takahashi T, Takano R, Nishiyama S, Takai Y, Nakashima I, Sato S, Lassmann H, Itoyama Y.

Rinsho Shinkeigaku. 2010 Nov;50(11):872. Japanese. No abstract available.


A case of delayed encephalopathy after carbon monoxide poisoning longitudinally monitored by diffusion tensor imaging.

Kuroda H, Fujihara K, Takahashi S, Shinozawa Y, Itoyama Y.

AJNR Am J Neuroradiol. 2012 Apr;33(4):E52-4. doi: 10.3174/ajnr.A2600. Epub 2011 Aug 18.


Pain in neuromyelitis optica and its effect on quality of life: a cross-sectional study.

Kanamori Y, Nakashima I, Takai Y, Nishiyama S, Kuroda H, Takahashi T, Kanaoka-Suzuki C, Misu T, Fujihara K, Itoyama Y.

Neurology. 2011 Aug 16;77(7):652-8. doi: 10.1212/WNL.0b013e318229e694. Epub 2011 Aug 3.


[Case of multiple sclerosis with "yes-yes" type head tremor].

Omata K, Suzuki N, Izumi R, Nagata M, Nishiyama S, Nakashima I, Itoyama Y.

Rinsho Shinkeigaku. 2011 Apr;51(4):282-5. Japanese.


Transient increases in anti-aquaporin-4 antibody titers following rituximab treatment in neuromyelitis optica, in association with elevated serum BAFF levels.

Nakashima I, Takahashi T, Cree BA, Kim HJ, Suzuki C, Genain CP, Vincent T, Fujihara K, Itoyama Y, Bar-Or A.

J Clin Neurosci. 2011 Jul;18(7):997-8. doi: 10.1016/j.jocn.2010.12.011. Epub 2011 May 11.


White matter involvement in idiopathic normal pressure hydrocephalus: a voxel-based diffusion tensor imaging study.

Kanno S, Abe N, Saito M, Takagi M, Nishio Y, Hayashi A, Uchiyama M, Hanaki R, Kikuchi H, Hiraoka K, Yamasaki H, Iizuka O, Takeda A, Itoyama Y, Takahashi S, Mori E.

J Neurol. 2011 Nov;258(11):1949-57. doi: 10.1007/s00415-011-6038-5. Epub 2011 Apr 22.


Therapeutic efficacy of interferon β-1b in Japanese patients with optic-spinal multiple sclerosis.

Shimizu Y, Fujihara K, Kubo S, Takahashi T, Misu T, Nakashima I, Yokoyama K, Itoyama Y, Uchiyama S.

Tohoku J Exp Med. 2011 Mar;223(3):211-4.


Illusory misidentifications and cortical hypometabolism in Parkinson's disease.

Ishioka T, Hirayama K, Hosokai Y, Takeda A, Suzuki K, Nishio Y, Sawada Y, Takahashi S, Fukuda H, Itoyama Y, Mori E.

Mov Disord. 2011 Apr;26(5):837-43. doi: 10.1002/mds.23576. Epub 2011 Mar 2.


Herpes labialis in multiple sclerosis with a trigeminal lesion.

Suzuki N, Mizuno H, Nakashima I, Itoyama Y.

Intern Med. 2011;50(3):259. Epub 2011 Feb 1. No abstract available.


Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease.

Baba T, Takeda A, Kikuchi A, Nishio Y, Hosokai Y, Hirayama K, Hasegawa T, Sugeno N, Suzuki K, Mori E, Takahashi S, Fukuda H, Itoyama Y.

Mov Disord. 2011 Mar;26(4):621-8. doi: 10.1002/mds.23602. Epub 2011 Jan 31.


Feasibility study for functional test battery of SOD transgenic rat (H46R) and evaluation of edaravone, a free radical scavenger.

Aoki M, Warita H, Mizuno H, Suzuki N, Yuki S, Itoyama Y.

Brain Res. 2011 Mar 25;1382:321-5. doi: 10.1016/j.brainres.2011.01.058. Epub 2011 Jan 26.


Transient cytotoxic edema in the splenium of the corpus callosum.

Kikuchi A, Takeda A, Itoyama Y.

Intern Med. 2010;49(24):2711. Epub 2010 Dec 15. No abstract available.


Dendritic cells in muscle lesions of sarcoidosis.

Tateyama M, Fujihara K, Itoyama Y.

Hum Pathol. 2011 Mar;42(3):340-6. doi: 10.1016/j.humpath.2010.07.011. Epub 2010 Dec 15.


[A recalcitrant case of encephalitis with voltage-gated potassium channel antibodies].

Fujimori J, Endo M, Irino S, Shiga Y, Shiraishi H, Motomura M, Tanno T, Hisanaga K, Itoyama Y.

Brain Nerve. 2010 Nov;62(11):1252-7. Japanese.


Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy.

Hasegawa T, Baba T, Kobayashi M, Konno M, Sugeno N, Kikuchi A, Itoyama Y, Takeda A.

Neurochem Int. 2010 Dec;57(8):857-66. doi: 10.1016/j.neuint.2010.09.002. Epub 2010 Sep 16.


[New insights into the pathogenesis of neuromyelitis optica].

Misu T, Takahashi T, Nishiyama S, Takano R, Nakashima I, Fujihara K, Itoyama Y.

Brain Nerve. 2010 Sep;62(9):921-31. Review. Japanese.


[A concept of neuromyelitis optica in Japan].

Nakashima I, Fujihara K, Itoyama Y.

Brain Nerve. 2010 Sep;62(9):913-9. Japanese.


A case of McArdle disease: efficacy of vitamin B6 on fatigability and impaired glycogenolysis.

Izumi R, Suzuki N, Kato K, Warita H, Tateyama M, Nakashima I, Itoyama Y.

Intern Med. 2010;49(15):1623-5. Epub 2010 Aug 2. Review.


Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis.

Sanagi T, Yuasa S, Nakamura Y, Suzuki E, Aoki M, Warita H, Itoyama Y, Uchino S, Kohsaka S, Ohsawa K.

J Neurosci Res. 2010 Sep;88(12):2736-46. doi: 10.1002/jnr.22424.


Astrocytic damage is far more severe than demyelination in NMO: a clinical CSF biomarker study.

Takano R, Misu T, Takahashi T, Sato S, Fujihara K, Itoyama Y.

Neurology. 2010 Jul 20;75(3):208-16. doi: 10.1212/WNL.0b013e3181e2414b.


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