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Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder.

Kato TM, Kubota-Sakashita M, Fujimori-Tonou N, Saitow F, Fuke S, Masuda A, Itohara S, Suzuki H, Kato T.

Mol Psychiatry. 2018 Jun 11. doi: 10.1038/s41380-018-0074-9. [Epub ahead of print]


Excitatory Neuronal Hubs Configure Multisensory Integration of Slow Waves in Association Cortex.

Kuroki S, Yoshida T, Tsutsui H, Iwama M, Ando R, Michikawa T, Miyawaki A, Ohshima T, Itohara S.

Cell Rep. 2018 Mar 13;22(11):2873-2885. doi: 10.1016/j.celrep.2018.02.056.


Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbp1 haploinsufficiency.

Miyamoto H, Shimohata A, Abe M, Abe T, Mazaki E, Amano K, Suzuki T, Tatsukawa T, Itohara S, Sakimura K, Yamakawa K.

Hum Mol Genet. 2017 Dec 15;26(24):4961-4974. doi: 10.1093/hmg/ddx379.


Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma.

Shiihashi G, Ito D, Arai I, Kobayashi Y, Hayashi K, Otsuka S, Nakajima K, Yuzaki M, Itohara S, Suzuki N.

EBioMedicine. 2017 Oct;24:102-115. doi: 10.1016/j.ebiom.2017.09.005. Epub 2017 Sep 9.


The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways.

Sawai M, Uchida Y, Ohno Y, Miyamoto M, Nishioka C, Itohara S, Sassa T, Kihara A.

J Biol Chem. 2017 Sep 15;292(37):15538-15551. doi: 10.1074/jbc.M117.803171. Epub 2017 Aug 7.


Spinal RacGAP α-Chimaerin Is Required to Establish the Midline Barrier for Proper Corticospinal Axon Guidance.

Katori S, Noguchi-Katori Y, Itohara S, Iwasato T.

J Neurosci. 2017 Aug 9;37(32):7682-7699. doi: 10.1523/JNEUROSCI.3123-16.2017. Epub 2017 Jul 26.


Cutting-edge approaches to unwrapping the mysteries of sleep.

Hayashi Y, Itohara S.

Neurosci Res. 2017 May;118:1-2. doi: 10.1016/j.neures.2017.04.014. No abstract available.


Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults.

Yasuda K, Hayashi Y, Yoshida T, Kashiwagi M, Nakagawa N, Michikawa T, Tanaka M, Ando R, Huang A, Hosoya T, McHugh TJ, Kuwahara M, Itohara S.

Transl Psychiatry. 2017 Feb 28;7(2):e1047. doi: 10.1038/tp.2017.19.


Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments.

Yoshikawa F, Sato Y, Tohyama K, Akagi T, Furuse T, Sadakata T, Tanaka M, Shinoda Y, Hashikawa T, Itohara S, Sano Y, Ghandour MS, Wakana S, Furuichi T.

PLoS One. 2016 Nov 17;11(11):e0166732. doi: 10.1371/journal.pone.0166732. eCollection 2016.


Antagonistic negative and positive neurons of the basolateral amygdala.

Kim J, Pignatelli M, Xu S, Itohara S, Tonegawa S.

Nat Neurosci. 2016 Dec;19(12):1636-1646. doi: 10.1038/nn.4414. Epub 2016 Oct 17.


Supernova: A Versatile Vector System for Single-Cell Labeling and Gene Function Studies in vivo.

Luo W, Mizuno H, Iwata R, Nakazawa S, Yasuda K, Itohara S, Iwasato T.

Sci Rep. 2016 Oct 24;6:35747. doi: 10.1038/srep35747.


Ventral CA1 neurons store social memory.

Okuyama T, Kitamura T, Roy DS, Itohara S, Tonegawa S.

Science. 2016 Sep 30;353(6307):1536-1541.



Kida S, Itohara S.

Neurobiol Learn Mem. 2016 Nov;135:1-2. doi: 10.1016/j.nlm.2016.09.001. Epub 2016 Sep 2. No abstract available.


Reassessment of long-term depression in cerebellar Purkinje cells in mice carrying mutated GluA2 C terminus.

Yamaguchi K, Itohara S, Ito M.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10192-7. doi: 10.1073/pnas.1609957113. Epub 2016 Aug 22.


CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampus.

Shinoda Y, Ishii C, Fukazawa Y, Sadakata T, Ishii Y, Sano Y, Iwasato T, Itohara S, Furuichi T.

Sci Rep. 2016 Aug 22;6:31540. doi: 10.1038/srep31540.


Cognitive deficits in single App knock-in mouse models.

Masuda A, Kobayashi Y, Kogo N, Saito T, Saido TC, Itohara S.

Neurobiol Learn Mem. 2016 Nov;135:73-82. doi: 10.1016/j.nlm.2016.07.001. Epub 2016 Jul 1.


Netrin-G1 regulates fear-like and anxiety-like behaviors in dissociable neural circuits.

Zhang Q, Sano C, Masuda A, Ando R, Tanaka M, Itohara S.

Sci Rep. 2016 Jun 27;6:28750. doi: 10.1038/srep28750.


Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain.

Monai H, Ohkura M, Tanaka M, Oe Y, Konno A, Hirai H, Mikoshiba K, Itohara S, Nakai J, Iwai Y, Hirase H.

Nat Commun. 2016 Mar 22;7:11100. doi: 10.1038/ncomms11100.


Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice.

Zhang Q, Gao X, Li C, Feliciano C, Wang D, Zhou D, Mei Y, Monteiro P, Anand M, Itohara S, Dong X, Fu Z, Feng G.

J Neurosci. 2016 Feb 17;36(7):2247-60. doi: 10.1523/JNEUROSCI.2528-15.2016.


Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins.

Zhang Q, Goto H, Akiyoshi-Nishimura S, Prosselkov P, Sano C, Matsukawa H, Yaguchi K, Nakashiba T, Itohara S.

Mol Brain. 2016 Jan 8;9:6. doi: 10.1186/s13041-016-0187-5.


Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice.

Hayashi Y, Kashiwagi M, Yasuda K, Ando R, Kanuka M, Sakai K, Itohara S.

Science. 2015 Nov 20;350(6263):957-61. doi: 10.1126/science.aad1023. Epub 2015 Oct 22.


Developmental RacGAP α2-Chimaerin Signaling Is a Determinant of the Morphological Features of Dendritic Spines in Adulthood.

Iwata R, Matsukawa H, Yasuda K, Mizuno H, Itohara S, Iwasato T.

J Neurosci. 2015 Oct 7;35(40):13728-44. doi: 10.1523/JNEUROSCI.0419-15.2015.


Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding.

Sato T, Kobayakawa R, Kobayakawa K, Emura M, Itohara S, Kizumi M, Hamana H, Tsuboi A, Hirono J.

Sci Rep. 2015 Sep 11;5:14073. doi: 10.1038/srep14073.


S100B Up-Regulates Macrophage Production of IL1β and CCL22 and Influences Severity of Retinal Inflammation.

Niven J, Hoare J, McGowan D, Devarajan G, Itohara S, Gannagé M, Teismann P, Crane I.

PLoS One. 2015 Jul 23;10(7):e0132688. doi: 10.1371/journal.pone.0132688. eCollection 2015.


Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.

Lee K, Kobayashi Y, Seo H, Kwak JH, Masuda A, Lim CS, Lee HR, Kang SJ, Park P, Sim SE, Kogo N, Kawasaki H, Kaang BK, Itohara S.

Mol Brain. 2015 Jun 24;8:38. doi: 10.1186/s13041-015-0130-1.


Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice.

Takahashi A, Lee RX, Iwasato T, Itohara S, Arima H, Bettler B, Miczek KA, Koide T.

J Neurosci. 2015 Apr 22;35(16):6452-63. doi: 10.1523/JNEUROSCI.2450-14.2015.


Thalamic adenylyl cyclase 1 is required for barrel formation in the somatosensory cortex.

Suzuki A, Lee LJ, Hayashi Y, Muglia L, Itohara S, Erzurumlu RS, Iwasato T.

Neuroscience. 2015 Apr 2;290:518-29. doi: 10.1016/j.neuroscience.2015.01.043. Epub 2015 Jan 30.


Netrin-G/NGL complexes encode functional synaptic diversification.

Matsukawa H, Akiyoshi-Nishimura S, Zhang Q, Luján R, Yamaguchi K, Goto H, Yaguchi K, Hashikawa T, Sano C, Shigemoto R, Nakashiba T, Itohara S.

J Neurosci. 2014 Nov 19;34(47):15779-92. doi: 10.1523/JNEUROSCI.1141-14.2014.


Cdk5/p35 functions as a crucial regulator of spatial learning and memory.

Mishiba T, Tanaka M, Mita N, He X, Sasamoto K, Itohara S, Ohshima T.

Mol Brain. 2014 Nov 18;7:82. doi: 10.1186/s13041-014-0082-x.


Thalamic NMDA receptor function is necessary for patterning of the thalamocortical somatosensory map and for sensorimotor behaviors.

Arakawa H, Suzuki A, Zhao S, Tsytsarev V, Lo FS, Hayashi Y, Itohara S, Iwasato T, Erzurumlu RS.

J Neurosci. 2014 Sep 3;34(36):12001-14. doi: 10.1523/JNEUROSCI.1663-14.2014.


RacGAP α2-chimaerin function in development adjusts cognitive ability in adulthood.

Iwata R, Ohi K, Kobayashi Y, Masuda A, Iwama M, Yasuda Y, Yamamori H, Tanaka M, Hashimoto R, Itohara S, Iwasato T.

Cell Rep. 2014 Sep 11;8(5):1257-64. doi: 10.1016/j.celrep.2014.07.047. Epub 2014 Aug 21.


Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.

Srimontri P, Endo S, Sakamoto T, Nakayama Y, Kurosaka A, Itohara S, Hirabayashi Y, Kato K.

J Neurochem. 2014 Dec;131(5):675-87. doi: 10.1111/jnc.12838. Epub 2014 Aug 21.


Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells.

Kawase S, Kuwako K, Imai T, Renault-Mihara F, Yaguchi K, Itohara S, Okano H.

Stem Cells Dev. 2014 Sep 15;23(18):2250-61. doi: 10.1089/scd.2014.0219.


Review of studies that have used knockout mice to assess normal function of prion protein under immunological or pathophysiological stress.

Onodera T, Sakudo A, Tsubone H, Itohara S.

Microbiol Immunol. 2014 Jul;58(7):361-74. doi: 10.1111/1348-0421.12162. Review.


Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2.

Ono K, Clavairoly A, Nomura T, Gotoh H, Uno A, Armant O, Takebayashi H, Zhang Q, Shimamura K, Itohara S, Parras CM, Ikenaka K.

Development. 2014 May;141(10):2075-84. doi: 10.1242/dev.097790.


Single App knock-in mouse models of Alzheimer's disease.

Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, Iwata N, Saido TC.

Nat Neurosci. 2014 May;17(5):661-3. doi: 10.1038/nn.3697. Epub 2014 Apr 13.


NMDAR-regulated dynamics of layer 4 neuronal dendrites during thalamocortical reorganization in neonates.

Mizuno H, Luo W, Tarusawa E, Saito YM, Sato T, Yoshimura Y, Itohara S, Iwasato T.

Neuron. 2014 Apr 16;82(2):365-79. doi: 10.1016/j.neuron.2014.02.026. Epub 2014 Mar 27.


Identification of transcriptional regulatory elements for Ntng1 and Ntng2 genes in mice.

Yaguchi K, Nishimura-Akiyoshi S, Kuroki S, Onodera T, Itohara S.

Mol Brain. 2014 Mar 19;7:19. doi: 10.1186/1756-6606-7-19.


Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal locomotor circuits.

Borgius L, Nishimaru H, Caldeira V, Kunugise Y, Löw P, Reig R, Itohara S, Iwasato T, Kiehn O.

J Neurosci. 2014 Mar 12;34(11):3841-53. doi: 10.1523/JNEUROSCI.4992-13.2014.


Spatiotemporal calcium dynamics in single astrocytes and its modulation by neuronal activity.

Wu YW, Tang X, Arizono M, Bannai H, Shih PY, Dembitskaya Y, Kazantsev V, Tanaka M, Itohara S, Mikoshiba K, Semyanov A.

Cell Calcium. 2014 Feb;55(2):119-29. doi: 10.1016/j.ceca.2013.12.006. Epub 2014 Jan 8.


Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer.

Kondo T, Isono K, Kondo K, Endo TA, Itohara S, Vidal M, Koseki H.

Dev Cell. 2014 Jan 13;28(1):94-101. doi: 10.1016/j.devcel.2013.11.021. Epub 2013 Dec 26.


CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain.

Sadakata T, Kakegawa W, Shinoda Y, Hosono M, Katoh-Semba R, Sekine Y, Sato Y, Tanaka M, Iwasato T, Itohara S, Furuyama K, Kawaguchi Y, Ishizaki Y, Yuzaki M, Furuichi T.

J Neurosci. 2013 Oct 30;33(44):17326-34. doi: 10.1523/JNEUROSCI.2777-13.2013.


Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells.

Matsuyama M, Tanaka H, Inoko A, Goto H, Yonemura S, Kobori K, Hayashi Y, Kondo E, Itohara S, Izawa I, Inagaki M.

J Biol Chem. 2013 Dec 13;288(50):35626-35. doi: 10.1074/jbc.M113.514737. Epub 2013 Oct 18.


Different antigenicities of the N-terminal region of cellular and scrapie prion proteins.

Ushiki-Kaku Y, Iwamaru Y, Masujin K, Imamura M, Itohara S, Ogawa-Goto K, Hattori S, Yokoyama T.

Microbiol Immunol. 2013 Nov;57(11):792-6. doi: 10.1111/1348-0421.12105.


Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.

Song YS, Lee HJ, Prosselkov P, Itohara S, Kim E.

J Cell Sci. 2013 Nov 1;126(Pt 21):4926-38. doi: 10.1242/jcs.129718. Epub 2013 Aug 28.


Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.

Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, Yanagawa Y, Tamamaki N, Hensch TK, Itohara S, Yamakawa K.

Hum Mol Genet. 2013 Dec 1;22(23):4784-804. doi: 10.1093/hmg/ddt331. Epub 2013 Aug 6.


Synthesis and biological evaluation of symmetrical 2,4,6-trisubstituted 1,3,5-triazine derivatives.

Mibu N, Yokomizo K, Takemura S, Ueki N, Itohara S, Zhou J, Miyata T, Sumoto K.

Chem Pharm Bull (Tokyo). 2013;61(8):823-33.


Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion.

Hägglund M, Dougherty KJ, Borgius L, Itohara S, Iwasato T, Kiehn O.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11589-94. doi: 10.1073/pnas.1304365110. Epub 2013 Jun 24.


Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.

Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A.

Mol Cell Biol. 2013 Jul;33(14):2787-96. doi: 10.1128/MCB.00192-13. Epub 2013 May 20.


Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice.

Kobayashi Y, Sano Y, Vannoni E, Goto H, Suzuki H, Oba A, Kawasaki H, Kanba S, Lipp HP, Murphy NP, Wolfer DP, Itohara S.

Front Behav Neurosci. 2013 Mar 12;7:17. doi: 10.3389/fnbeh.2013.00017. eCollection 2013.

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