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Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis.

Urmi JF, Itoh H, Muramatsu-Kato K, Kohmura-Kobayashi Y, Hariya N, Jain D, Tamura N, Uchida T, Suzuki K, Ogawa Y, Shiraki N, Mochizuki K, Kubota T, Kanayama N.

Sci Rep. 2019 Nov 19;9(1):17100. doi: 10.1038/s41598-019-52943-7.


Effect of Body Weight Change on Blood Pressure in a Japanese General Population with a Body Mass Index ≥ 22 kg/m2.

Itoh H, Kaneko H, Kiriyama H, Nakanishi K, Mizuno Y, Daimon M, Morita H, Yamamichi N, Komuro I.

Int Heart J. 2019 Nov 15. doi: 10.1536/ihj.19-314. [Epub ahead of print]


Prevalence and species richness of trematode parasites only partially recovers after the 2011 Tohoku, Japan, earthquake tsunami.

Miura O, Kanaya G, Nakai S, Itoh H, Chiba S.

Int J Parasitol. 2019 Nov 11. pii: S0020-7519(19)30257-7. doi: 10.1016/j.ijpara.2019.07.006. [Epub ahead of print]


Xanthine oxidase inhibitor ameliorates postischemic renal injury in mice by promoting resynthesis of adenine nucleotides.

Fujii K, Kubo A, Miyashita K, Sato M, Hagiwara A, Inoue H, Ryuzaki M, Tamaki M, Hishiki T, Hayakawa N, Kabe Y, Itoh H, Suematsu M.

JCI Insight. 2019 Nov 14;4(22). pii: 124816. doi: 10.1172/jci.insight.124816.


Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.

Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, Yamashita K, Shigaki S, Ono T, Yukioka H, Okano H, Nabeshima YI, Imai SI, Yasui M, Tsubota K, Itoh H.

Endocr J. 2019 Nov 2. doi: 10.1507/endocrj.EJ19-0313. [Epub ahead of print]


Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions.

Miyamoto J, Ohue-Kitano R, Mukouyama H, Nishida A, Watanabe K, Igarashi M, Irie J, Tsujimoto G, Satoh-Asahara N, Itoh H, Kimura I.

Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23813-23821. doi: 10.1073/pnas.1912573116. Epub 2019 Nov 4.


Association between olfactory sulcus morphology and olfactory functioning in schizophrenia and psychosis high-risk status.

Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Takayanagi Y, Furuichi A, Kido M, Mizukami Y, Nishiyama S, Higuchi Y, Tateno T, Itoh H, Noguchi K, Masaoka Y, Suzuki M.

Heliyon. 2019 Oct 10;5(10):e02642. doi: 10.1016/j.heliyon.2019.e02642. eCollection 2019 Oct.


Predictors of Clinical Success After Surgery for Primary Aldosteronism in the Japanese Nationwide Cohort.

Morisaki M, Kurihara I, Itoh H, Naruse M, Takeda Y, Katabami T, Ichijo T, Wada N, Yoshimoto T, Ogawa Y, Sone M, Tsuiki M, Shibata H, Kawashima J, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Suzuki T; JPAS Study Group.

J Endocr Soc. 2019 Aug 22;3(11):2012-2022. doi: 10.1210/js.2019-00295. eCollection 2019 Nov 1.


Host-symbiont specificity determined by microbe-microbe competition in an insect gut.

Itoh H, Jang S, Takeshita K, Ohbayashi T, Ohnishi N, Meng XY, Mitani Y, Kikuchi Y.

Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22673-22682. doi: 10.1073/pnas.1912397116. Epub 2019 Oct 21.


Pharmacokinetic and toxicodynamic evaluation of 5-fluorouracil administration after major hepatectomy in a rat model.

Tada K, Iwashita Y, Shiraiwa K, Uchida H, Oshima Y, Sato Y, Nakanuma H, Hirashita T, Masuda T, Endo Y, Takeuchi Y, Ohta M, Itoh H, Inomata M.

Cancer Chemother Pharmacol. 2019 Oct 11. doi: 10.1007/s00280-019-03969-1. [Epub ahead of print]


Feature visualization of Raman spectrum analysis with deep convolutional neural network.

Fukuhara M, Fujiwara K, Maruyama Y, Itoh H.

Anal Chim Acta. 2019 Dec 9;1087:11-19. doi: 10.1016/j.aca.2019.08.064. Epub 2019 Aug 29.


Long-term phase 3 study of esaxerenone as mono or combination therapy with other antihypertensive drugs in patients with essential hypertension.

Rakugi H, Ito S, Itoh H, Okuda Y, Yamakawa S.

Hypertens Res. 2019 Dec;42(12):1932-1941. doi: 10.1038/s41440-019-0314-7. Epub 2019 Sep 25.


Biological Effects of a Simplified Synthetic Analogue of Ion-Channel-Forming Polytheonamide B on Plasma Membrane and Lysosomes.

Xue YW, Hayata A, Itoh H, Inoue M.

Chemistry. 2019 Sep 24. doi: 10.1002/chem.201903974. [Epub ahead of print]


Artificial Intelligence-assisted System Improves Endoscopic Identification of Colorectal Neoplasms.

Kudo SE, Misawa M, Mori Y, Hotta K, Ohtsuka K, Ikematsu H, Saito Y, Takeda K, Nakamura H, Ichimasa K, Ishigaki T, Toyoshima N, Kudo T, Hayashi T, Wakamura K, Baba T, Fumio I, Inoue H, Itoh H, Oda M, Mori K.

Clin Gastroenterol Hepatol. 2019 Sep 13. pii: S1542-3565(19)30997-8. doi: 10.1016/j.cgh.2019.09.009. [Epub ahead of print]


Difference in Z scores of placental weight and fetal/placental weight ratio by mode of delivery.

Matsuda Y, Itoh T, Okada E, Sasaki K, Itoh H, Kanayama N.

J Obstet Gynaecol Res. 2019 Sep 15. doi: 10.1111/jog.14117. [Epub ahead of print]


Efficacy and safety of once-weekly exenatide after switching from twice-daily exenatide in patients with type 2 diabetes.

Watanabe Y, Saisho Y, Inaishi J, Kou K, Yamauchi A, Kanazawa Y, Okubo Y, Tokui M, Imai T, Murakami R, Tsuchiya T, Sasaki H, Masaoka T, Irie J, Meguro S, Itoh H; Twin-exenatide Study Group.

J Diabetes Investig. 2019 Sep 13. doi: 10.1111/jdi.13146. [Epub ahead of print]


Effects of a Physical Therapist Led Workplace Personal-Fitness Management Program for Manufacturing Industry Workers: A Randomized Controlled Trial.

Matsugaki R, Sakata M, Itoh H, Matsushima Y, Saeki S.

J Occup Environ Med. 2019 Nov;61(11):e445-e451. doi: 10.1097/JOM.0000000000001712.


Low birth weight is associated with decline in renal function in Japanese male and female adolescents.

Murai-Takeda A, Kanda T, Azegami T, Hirose H, Inokuchi M, Tokuyama H, Wakino S, Tokumura M, Kawabe H, Mori M, Itoh H.

Clin Exp Nephrol. 2019 Dec;23(12):1364-1372. doi: 10.1007/s10157-019-01784-9. Epub 2019 Sep 7.


Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.

Miyamoto J, Igarashi M, Watanabe K, Karaki SI, Mukouyama H, Kishino S, Li X, Ichimura A, Irie J, Sugimoto Y, Mizutani T, Sugawara T, Miki T, Ogawa J, Drucker DJ, Arita M, Itoh H, Kimura I.

Nat Commun. 2019 Sep 5;10(1):4007. doi: 10.1038/s41467-019-11978-0.


Relationships between endogenous CYP3A markers and plasma amlodipine exposure and metabolism in early postpartum and non-peripartum women with hypertension.

Taguchi R, Naito T, Kubono N, Ogawa N, Itoh H, Kawakami J.

Pregnancy Hypertens. 2019 Jul;17:209-215. doi: 10.1016/j.preghy.2019.07.002. Epub 2019 Jul 4.


Vaccine Development against the Renin-Angiotensin System for the Treatment of Hypertension.

Azegami T, Itoh H.

Int J Hypertens. 2019 Aug 14;2019:9218531. doi: 10.1155/2019/9218531. eCollection 2019. Review.


Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan.

Fujii Y, Takeda Y, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Yamamto K, Ogo A, Yanase T, Okamura S, Miyauchi S, Fujita M, Suzuki T, Umakoshi H, Ogasawara T, Tsuiki M, Naruse M; JPAS Study Group.

J Hum Hypertens. 2019 Aug 28. doi: 10.1038/s41371-019-0229-4. [Epub ahead of print]


Withdrawal of the 1999 JSOG recommendation of weight gain restriction during pregnancy (Commentary of the JSOG Perinatal Committee).

Itoh H, Itakura A, Kanayama N, Ikeda T.

J Obstet Gynaecol Res. 2019 Nov;45(11):2302. doi: 10.1111/jog.14080. Epub 2019 Aug 27. No abstract available.


Correction to: Role of anemia and proteinuria in the development of subsequent renal function deterioration in a general population with preserved glomerular filtration rate: a community-based cohort study.

Kiriyama H, Kaneko H, Itoh H, Yoshida Y, Nakanishi K, Mizuno Y, Daimon M, Morita H, Yatomi Y, Komuro I.

J Nephrol. 2019 Oct;32(5):843-846. doi: 10.1007/s40620-019-00635-w.


Effects of work schedule and period of exposure on changes in urinary chromium and nickel excretion among rotating shift workers in a stainless-steel plant.

Itoh H, Wang RS, Maki S, Niu Q, Shang H, Su Y, Weng Z, Saito H, Miura N, Takahashi M.

Chronobiol Int. 2019 Oct;36(10):1439-1446. doi: 10.1080/07420528.2019.1645159. Epub 2019 Aug 1.


Treatment preference for weekly versus daily DPP-4 inhibitors in patients with type 2 diabetes mellitus: outcomes from the TRINITY trial.

Meguro S, Matsui S, Itoh H.

Curr Med Res Opin. 2019 Aug 22:1-8. doi: 10.1080/03007995.2019.1651130. [Epub ahead of print]


Successful determination of nilotinib dosage by therapeutic drug monitoring in a patient with chronic myeloid leukemia developing hepatic dysfunction: A case report.

Nakahara R, Sumimoto T, Ogata M, Sato Y, Itoh H.

Clin Case Rep. 2019 Jun 14;7(7):1419-1421. doi: 10.1002/ccr3.2191. eCollection 2019 Jul.


Association Between Acute Fall in Estimated Glomerular Filtration Rate After Treatment for Primary Aldosteronism and Long-Term Decline in Renal Function.

Kobayashi H, Abe M, Nakamura Y, Takahashi K, Fujita M, Takeda Y, Yoneda T, Kurihara I, Itoh H, Tsuiki M, Wada N, Ichijo T, Katabami T, Ogawa Y, Kawashima J, Yoshimoto T, Sone M, Inagaki N, Watanabe M, Kamemura K, Matsuda Y, Izawa S, Tanabe M, Tanabe A, Suzuki T, Naruse M; JPAS/JRAS Study Group.

Hypertension. 2019 Sep;74(3):630-638. doi: 10.1161/HYPERTENSIONAHA.119.13131. Epub 2019 Jul 22.


Renal impairment is closely associated with plasma aldosterone concentration in patients with primary aldosteronism.

Kawashima A, Sone M, Inagaki N, Takeda Y, Itoh H, Kurihara I, Umakoshi H, Ichijo T, Katabami T, Wada N, Ogawa Y, Kawashima J, Fujita M, Miyauchi S, Okamura S, Fukuoka T, Yanase T, Izawa S, Yoshikawa Y, Hashimoto S, Yamada M, Kai T, Suzuki T, Naruse M.

Eur J Endocrinol. 2019 Jul 1. pii: EJE-19-0047.R2. doi: 10.1530/EJE-19-0047. [Epub ahead of print]


Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E.

Itoh H, Tokumoto K, Kaji T, Paudel A, Panthee S, Hamamoto H, Sekimizu K, Inoue M.

Nat Commun. 2019 Jul 5;10(1):2992. doi: 10.1038/s41467-019-10754-4.


Cost-Effectiveness of Cardiac Rehabilitation in Patients with Coronary Artery Disease: A Meta-Analysis.

Takura T, Ebata-Kogure N, Goto Y, Kohzuki M, Nagayama M, Oikawa K, Koyama T, Itoh H.

Cardiol Res Pract. 2019 Jun 4;2019:1840894. doi: 10.1155/2019/1840894. eCollection 2019. Review.


Greeting Messages from President of Japanese Society of Hypertension (JSH) The challenge of JSH: moonshot for "Conquest of hypertension in Japan".

Itoh H.

Hypertens Res. 2019 Jul;42(7):925-927. doi: 10.1038/s41440-019-0279-6. Epub 2019 Jul 5. No abstract available.


National burden of the pharmaceutical cost of wet compresses and its cost predictors: nationwide cross-sectional study in Japan.

Itoh H, Saito T, Nojiri S, Hiratsuka Y, Yokoyama K.

Health Econ Rev. 2019 Jun 29;9(1):20. doi: 10.1186/s13561-019-0238-6.


Comparative genome-wide analysis of gastric adenocarcinomas with hyperplastic polyp components.

Takayama Y, Ono Y, Mizukami Y, Itoh H, Nakajima N, Arai H, Tanaka S, Nobusawa S, Yokoo H, Onozato Y.

Virchows Arch. 2019 Sep;475(3):383-389. doi: 10.1007/s00428-019-02592-y. Epub 2019 Jun 28.


DNA Damage Repair and DNA Methylation in the Kidney.

Hayashi K, Hishikawa A, Itoh H.

Am J Nephrol. 2019;50(2):81-91. doi: 10.1159/000501356. Epub 2019 Jun 26. Review.


Efficacy and safety of dosage-escalation of low-dosage esaxerenone added to a RAS inhibitor in hypertensive patients with type 2 diabetes and albuminuria: a single-arm, open-label study.

Itoh H, Ito S, Rakugi H, Okuda Y, Nishioka S.

Hypertens Res. 2019 Oct;42(10):1572-1581. doi: 10.1038/s41440-019-0270-2. Epub 2019 Jun 25.


Population Pharmacokinetics and Pharmacodynamics of Apixaban Linking Its Plasma Concentration to Intrinsic Activated Coagulation Factor X Activity in Japanese Patients with Atrial Fibrillation.

Ueshima S, Hira D, Tomitsuka C, Nomura M, Kimura Y, Yamane T, Tabuchi Y, Ozawa T, Itoh H, Horie M, Terada T, Katsura T.

AAPS J. 2019 Jun 24;21(5):80. doi: 10.1208/s12248-019-0353-7.


Hypertension as a Metabolic Disorder and the Novel Role of the Gut.

Tanaka M, Itoh H.

Curr Hypertens Rep. 2019 Jun 24;21(8):63. doi: 10.1007/s11906-019-0964-5. Review.


Full solid-phase total synthesis of macrocyclic natural peptides using four-dimensionally orthogonal protective groups.

Itoh H, Inoue M.

Org Biomol Chem. 2019 Jul 21;17(27):6519-6527. doi: 10.1039/c9ob01130g. Epub 2019 Jun 24.


Effect of Metabolically Healthy Obesity on the Development of Carotid Plaque in the General Population: A Community-Based Cohort Study.

Itoh H, Kaneko H, Kiriyama H, Yoshida Y, Nakanishi K, Mizuno Y, Daimon M, Morita H, Yatomi Y, Yamamichi N, Komuro I.

J Atheroscler Thromb. 2019 Jun 22. doi: 10.5551/jat.48728. [Epub ahead of print]


Acute Interstitial Nephritis With Karyomegalic Epithelial Cells After Nivolumab Treatment-Two Case Reports.

Ryuzaki M, Tokuyama H, Uchiyama K, Nakaya H, Hasegawa K, Miyashita K, Konishi K, Hashiguchi A, Wakino S, Itoh H.

Clin Med Insights Case Rep. 2019 Jun 13;12:1179547619853647. doi: 10.1177/1179547619853647. eCollection 2019.


Effect of cigarette smoking on carotid artery atherosclerosis: a community-based cohort study.

Kiriyama H, Kaneko H, Itoh H, Yoshida Y, Nakanishi K, Mizuno Y, Daimon M, Morita H, Yamamichi N, Komuro I.

Heart Vessels. 2019 Jun 20. doi: 10.1007/s00380-019-01455-5. [Epub ahead of print]


Left Main Coronary Artery Obstruction by Huge Noncoronary Cusp Calcification After Transcatheter Aortic Valve Replacement.

Kiriyama H, Kaneko H, Itoh H, Uehara M, Kodera S, Kiyosue A, Yamauchi H, Daimon M, Ando J, Morita H, Ono M, Komuro I.

JACC Cardiovasc Interv. 2019 Jul 8;12(13):1285-1287. doi: 10.1016/j.jcin.2019.01.243. Epub 2019 Jun 12. No abstract available.


Elevated bradykinin receptor type 1 expression in postpartum acute myometritis: Possible involvement in augmented interstitial edema of the atonic gravid uterus.

Shen Y, Oda T, Tamura N, Kohmura-Kobayashi Y, Furuta-Isomura N, Yaguchi C, Uchida T, Suzuki K, Itoh H, Kanayama N.

J Obstet Gynaecol Res. 2019 Aug;45(8):1553-1561. doi: 10.1111/jog.14012. Epub 2019 Jun 10.


Interstitial Lung Disease with Anti-melanoma Differentiation-associated Protein 5 Antibody: Rapidly Progressive Perilobular Opacity.

Chino H, Sekine A, Baba T, Kitamura H, Iwasawa T, Okudela K, Takemura T, Itoh H, Sato S, Suzuki Y, Ogura T.

Intern Med. 2019 Sep 15;58(18):2605-2613. doi: 10.2169/internalmedicine.2328-18. Epub 2019 Jun 7.


Intrauterine Fetal and Neonatal Death between Small for Date and Non-Small for Date in Small for Gestational Age Infants.

Itoh T, Matsuda Y, Itoh H, Ogawa M, Sasaki K, Kanayama N.

Int J Med Sci. 2019 Mar 9;16(4):501-506. doi: 10.7150/ijms.31153. eCollection 2019.


Relation between the Updated Blood Pressure Classification according to the American College of Cardiology/American Heart Association Guidelines and Carotid Intima-Media Thickness.

Itoh H, Kaneko H, Kiriyama H, Yoshida Y, Nakanishi K, Mizuno Y, Daimon M, Morita H, Yatomi Y, Komuro I.

Am J Cardiol. 2019 Aug 1;124(3):396-401. doi: 10.1016/j.amjcard.2019.04.054. Epub 2019 May 9.


Burkholderia Gut Symbionts Associated with European and Japanese Populations of the Dock Bug Coreus marginatus (Coreoidea: Coreidae).

Ohbayashi T, Itoh H, Lachat J, Kikuchi Y, Mergaert P.

Microbes Environ. 2019 Jun 27;34(2):219-222. doi: 10.1264/jsme2.ME19011. Epub 2019 Jun 6.

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