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Radiative-transfer modeling of spectra of planetary regoliths using cluster-based dense packing modifications.

Ito G, Mishchenko MI, Glotch TD.

J Geophys Res Planets. 2018 May;123(5):1203-1220. doi: 10.1029/2018JE005532. Epub 2018 Apr 19.


Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice.

Aden K, Bartsch K, Dahl J, Reijns MAM, Esser D, Sheibani-Tezerji R, Sinha A, Wottawa F, Ito G, Mishra N, Knittler K, Burkholder A, Welz L, van Es J, Tran F, Lipinski S, Kakavand N, Boeger C, Lucius R, von Schoenfels W, Schafmayer C, Lenk L, Chalaris A, Clevers H, Röcken C, Kaleta C, Rose-John S, Schreiber S, Kunkel T, Rabe B, Rosenstiel P.

Gastroenterology. 2018 Sep 28. pii: S0016-5085(18)35077-7. doi: 10.1053/j.gastro.2018.09.047. [Epub ahead of print]


ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.

Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, Tschurtschenthaler M, Saveljeva S, Bhattacharyya J, Häsler R, Bartsch K, Luzius A, Jentzsch M, Falk-Paulsen M, Stengel ST, Welz L, Schwarzer R, Rabe B, Barchet W, Krautwald S, Hartmann G, Pasparakis M, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P.

J Exp Med. 2018 Nov 5;215(11):2868-2886. doi: 10.1084/jem.20171029. Epub 2018 Sep 25.


LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.

Eguchi T, Kuwahara T, Sakurai M, Komori T, Fujimoto T, Ito G, Yoshimura SI, Harada A, Fukuda M, Koike M, Iwatsubo T.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9115-E9124. doi: 10.1073/pnas.1812196115. Epub 2018 Sep 12.


Ribbon-wise customized lingual appliance and orthodontic anchor screw for the treatment of skeletal high-angle maxillary protrusion without bowing effect.

Inami T, Ito G, Miyazawa K, Tabuchi M, Goto S.

Angle Orthod. 2018 Nov;88(6):830-840. doi: 10.2319/072717-498.1. Epub 2018 May 2.


Human Health Risk from Consumption of Marine Fish Contaminated with DDT and Its Metabolites in Maputo Bay, Mozambique.

Thompson LA, Ikenaka Y, Yohannes YB, Ichise T, Ito G, Bortey-Sam N, van Vuren JJ, Wepener V, Smit NJ, Darwish WS, Nakayama SMM, Mizukawa H, Ishizuka M.

Bull Environ Contam Toxicol. 2018 May;100(5):672-676. doi: 10.1007/s00128-018-2323-7. Epub 2018 Mar 15.


Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties.

Suzuki K, Murano T, Shimizu H, Ito G, Nakata T, Fujii S, Ishibashi F, Kawamoto A, Anzai S, Kuno R, Kuwabara K, Takahashi J, Hama M, Nagata S, Hiraguri Y, Takenaka K, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Watanabe M, Okamoto R.

J Gastroenterol. 2018 Sep;53(9):1035-1047. doi: 10.1007/s00535-018-1437-3. Epub 2018 Jan 27.


Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag.

Ito G, Tomita T.

J Vis Exp. 2017 Dec 14;(130). doi: 10.3791/56688.


Pulmonary tumor thrombotic microangiopathy successfully treated with corticosteroids: a case report.

Miyazaki S, Ikeda T, Ito G, Inoue M, Nara K, Nishinaga Y, Hasegawa Y.

J Med Case Rep. 2017 Dec 23;11(1):356. doi: 10.1186/s13256-017-1524-8.


Contribution of ATOH1+ Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium.

Ishibashi F, Shimizu H, Nakata T, Fujii S, Suzuki K, Kawamoto A, Anzai S, Kuno R, Nagata S, Ito G, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R.

Stem Cell Reports. 2018 Jan 9;10(1):27-42. doi: 10.1016/j.stemcr.2017.11.006. Epub 2017 Dec 7.


Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.

Fan Y, Howden AJM, Sarhan AR, Lis P, Ito G, Martinez TN, Brockmann K, Gasser T, Alessi DR, Sammler EM.

Biochem J. 2018 Jan 2;475(1):23-44. doi: 10.1042/BCJ20170803.


Assessment of DDT contamination in house rat as a possible bioindicator in DDT-sprayed areas from Ethiopia and South Africa.

Yohannes YB, Ikenaka Y, Ito G, Nakayama SMM, Mizukawa H, Wepener V, Smit NJ, Van Vuren JHJ, Ishizuka M.

Environ Sci Pollut Res Int. 2017 Oct;24(30):23763-23770. doi: 10.1007/s11356-017-9911-7. Epub 2017 Sep 1.


Efficacy of a third or later antiepileptic drug regimen according to epilepsy syndrome among adult patients.

Ito G, Okumura A, Kanemoto K.

Epilepsy Res. 2017 Oct;136:103-108. doi: 10.1016/j.eplepsyres.2017.07.018. Epub 2017 Aug 3.


Analysis of DNA methylation of potential age-related methylation sites in canine peripheral blood leukocytes.

Ito G, Yoshimura K, Momoi Y.

J Vet Med Sci. 2017 Apr 8;79(4):745-750. doi: 10.1292/jvms.16-0341. Epub 2017 Mar 4.


Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine.

Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R.

Data Brief. 2016 Dec 29;10:551-556. doi: 10.1016/j.dib.2016.12.045. eCollection 2017 Feb.


Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.

Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1296-1303. doi: 10.1016/j.bbrc.2016.12.031. Epub 2016 Dec 8.


PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.

Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Murano T, Ito G, Shimizu H, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Araki A, Ohtsuka K, Okamoto R, Watanabe M.

Sci Rep. 2016 Nov 9;6:36795. doi: 10.1038/srep36795.


Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.

Ito G, Katsemonova K, Tonelli F, Lis P, Baptista MA, Shpiro N, Duddy G, Wilson S, Ho PW, Ho SL, Reith AD, Alessi DR.

Biochem J. 2016 Sep 1;473(17):2671-85. doi: 10.1042/BCJ20160557. Epub 2016 Jul 29.


Response to Comment on "Sensitivity of seafloor bathymetry to climate-driven fluctuations in mid-ocean ridge magma supply".

Olive JA, Behn MD, Ito G, Buck WR, Escartín J, Howell S.

Science. 2016 Jul 15;353(6296):229. doi: 10.1126/science.aaf2022.


Response to Comment on "Sensitivity of seafloor bathymetry to climate-driven fluctuations in mid-ocean ridge magma supply".

Olive JA, Behn MD, Ito G, Buck WR, Escartín J, Howell S.

Science. 2016 Jun 17;352(6292):1405. doi: 10.1126/science.aaf2021.


[Did a 16th century Christian missionary observe that the Japanese were collectivists?].

Takano Y, Ito G.

Shinrigaku Kenkyu. 2016 Feb;86(6):584-8. Japanese.


Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, Wachter S, Lorentzen E, Duddy G, Wilson S, Baptista MA, Fiske BK, Fell MJ, Morrow JA, Reith AD, Alessi DR, Mann M.

Elife. 2016 Jan 29;5. pii: e12813. doi: 10.7554/eLife.12813.


Sensitivity of seafloor bathymetry to climate-driven fluctuations in mid-ocean ridge magma supply.

Olive JA, Behn MD, Ito G, Buck WR, Escartín J, Howell S.

Science. 2015 Oct 16;350(6258):310-3. doi: 10.1126/science.aad0715.


A Fulminant Case of Granulomatosis with Polyangiitis with Meningeal and Parenchymal Involvement.

Yajima R, Toyoshima Y, Wada Y, Takahashi T, Arakawa H, Ito G, Kobayashi D, Yamada M, Kawachi I, Narita I, Takahashi H, Nishizawa M.

Case Rep Neurol. 2015 Apr 30;7(1):101-4. doi: 10.1159/000381942. eCollection 2015 Jan-Apr.


Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor.

Hatcher JM, Zhang J, Choi HG, Ito G, Alessi DR, Gray NS.

ACS Med Chem Lett. 2015 Apr 7;6(5):584-9. doi: 10.1021/acsmedchemlett.5b00064. eCollection 2015 May 14.


Gene analysis of signal-joint T cell receptor excision circles and their relationship to age in dogs.

Ito G, Yoshimura K, Momoi Y.

Vet Immunol Immunopathol. 2015 Jul 15;166(1-2):1-7. doi: 10.1016/j.vetimm.2015.05.003. Epub 2015 May 16.


Structural Characterization of LRRK2 Inhibitors.

Gilsbach BK, Messias AC, Ito G, Sattler M, Alessi DR, Wittinghofer A, Kortholt A.

J Med Chem. 2015 May 14;58(9):3751-6. doi: 10.1021/jm5018779. Epub 2015 May 1.


Proteoglycan from salmon nasal cartridge [corrected] promotes in vitro wound healing of fibroblast monolayers via the CD44 receptor.

Ito G, Kobayashi T, Takeda Y, Sokabe M.

Biochem Biophys Res Commun. 2015 Jan 16;456(3):792-8. doi: 10.1016/j.bbrc.2014.12.037. Epub 2014 Dec 13. Erratum in: Biochem Biophys Res Commun. 2015 Aug 14;464(1):367.


Factors related to stability following the surgical correction of skeletal open bite.

Ito G, Koh M, Fujita T, Shirakura M, Ueda H, Tanne K.

Aust Orthod J. 2014 May;30(1):61-6.


Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine.

Shimizu H, Okamoto R, Ito G, Fujii S, Nakata T, Suzuki K, Murano T, Mizutani T, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M.

PeerJ. 2014 May 1;2:e370. doi: 10.7717/peerj.370. eCollection 2014.


Cooling dynamics of photoexcited C6(-) and C6H(-).

Ito G, Furukawa T, Tanuma H, Matsumoto J, Shiromaru H, Majima T, Goto M, Azuma T, Hansen K.

Phys Rev Lett. 2014 May 9;112(18):183001. Epub 2014 May 8.


Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955.

Ito G, Fujimoto T, Kamikawaji S, Kuwahara T, Iwatsubo T.

PLoS One. 2014 May 16;9(5):e97988. doi: 10.1371/journal.pone.0097988. eCollection 2014.


Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients.

Dinardo CL, Ito GM, Sampaio LR, Mendrone Júnior A.

Rev Bras Hematol Hemoter. 2013;35(6):414-6. doi: 10.5581/1516-8484.20130123.


Effects of aliskiren on blood pressure and humoral factors in hypertensive hemodialysis patients previously on angiotensin II receptor antagonists.

Ito T, Ishikawa E, Fujimoto N, Okubo S, Ito G, Ichikawa T, Nomura S, Ito M.

Clin Exp Hypertens. 2014;36(7):497-502. doi: 10.3109/10641963.2013.863323. Epub 2014 Jan 16.


Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells.

Murano T, Okamoto R, Ito G, Nakata T, Hibiya S, Shimizu H, Fujii S, Kano Y, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Tsuchiya K, Nakamura T, Watanabe M.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):840-6. doi: 10.1016/j.bbrc.2013.12.061. Epub 2013 Dec 14.


Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells.

Ito G, Okamoto R, Murano T, Shimizu H, Fujii S, Nakata T, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Okada E, Araki A, Ohtsuka K, Tsuchiya K, Nakamura T, Watanabe M.

PLoS One. 2013 Nov 5;8(11):e79693. doi: 10.1371/journal.pone.0079693. eCollection 2013.


Differential effects of familial parkinson mutations in LRRK2 revealed by a systematic analysis of autophosphorylation.

Kamikawaji S, Ito G, Sano T, Iwatsubo T.

Biochemistry. 2013 Sep 3;52(35):6052-62. doi: 10.1021/bi400596m. Epub 2013 Aug 23.


P2X7 receptor and cytokines contribute to extra-territorial facial pain.

Murasaki K, Watanabe M, Takahashi K, Ito G, Suekawa Y, Inubushi T, Hirose N, Uchida T, Tanne K.

J Dent Res. 2013 Mar;92(3):260-5. doi: 10.1177/0022034512474668. Epub 2013 Jan 22.


[Kampo therapy for inflammatory bowel diseases].

Oikawa T, Ito G, Hanawa T.

Nihon Rinsho. 2012 Feb;70 Suppl 1:365-9. Japanese. No abstract available.


Correlation between efficacy of PSK postoperative adjuvant immunochemotherapy for gastric cancer and expression of MHC class I.

Ito G, Tanaka H, Ohira M, Yoshii M, Muguruma K, Kubo N, Yashiro M, Yamada N, Maeda K, Sawada T, Hirakawa K.

Exp Ther Med. 2012 Jun;3(6):925-930. Epub 2012 Apr 2.


P2X7 receptor in the trigeminal sensory nuclear complex contributes to tactile allodynia/hyperalgesia following trigeminal nerve injury.

Ito G, Suekawa Y, Watanabe M, Takahashi K, Inubushi T, Murasaki K, Hirose N, Hiyama S, Uchida T, Tanne K.

Eur J Pain. 2013 Feb;17(2):185-99. doi: 10.1002/j.1532-2149.2012.00174.x. Epub 2012 Aug 3.


Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans.

Kuwahara T, Tonegawa R, Ito G, Mitani S, Iwatsubo T.

J Biol Chem. 2012 Mar 2;287(10):7098-109. doi: 10.1074/jbc.M111.237131. Epub 2012 Jan 9.


[A case of long-term survival after undergoing S-1 based multidisciplinary therapy for liver metastasis of gastric cancer].

Ito G, Kubo N, Tanaka H, Muguruma K, Sakurai K, Kimura K, Nagahara H, Noda E, Amano R, Yamada N, Yashiro M, Maeda K, Sawada T, Nakata B, Ohira M, Hirakawa K.

Gan To Kagaku Ryoho. 2011 Nov;38(12):2348-50. Review. Japanese.


Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form.

Ito G, Iwatsubo T.

Biochem J. 2012 Feb 1;441(3):987-94. doi: 10.1042/BJ20111215.


Critical tooth number without subjective dysphagia.

Fukai K, Takiguchi T, Ando Y, Aoyama H, Miyakawa Y, Ito G, Inoue M, Sasaki H.

Geriatr Gerontol Int. 2011 Oct;11(4):482-7. doi: 10.1111/j.1447-0594.2011.00722.x. Epub 2011 Jun 27.


Identification of HLA-A*0201- and A*2402-restricted epitopes of mucin 5AC expressed in advanced pancreatic cancer.

Yamazoe S, Tanaka H, Iwauchi T, Yoshii M, Ito G, Amano R, Yamada N, Sawada T, Ohira M, Hirakawa K.

Pancreas. 2011 Aug;40(6):896-904. doi: 10.1097/MPA.0b013e31821ad8d1.


Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound.

Hoshi H, Saito H, Iijima H, Uchida M, Wada T, Ito G, Tanaka H, Sawada T, Hirakawa K.

Oncol Rep. 2011 Apr;25(4):905-13. doi: 10.3892/or.2011.1155. Epub 2011 Jan 19.


Presenilin-2 mutation causes early amyloid accumulation and memory impairment in a transgenic mouse model of Alzheimer's disease.

Toda T, Noda Y, Ito G, Maeda M, Shimizu T.

J Biomed Biotechnol. 2011;2011:617974. doi: 10.1155/2011/617974. Epub 2010 Dec 29.


IL-1beta in the trigeminal subnucleus caudalis contributes to extra-territorial allodynia/hyperalgesia following a trigeminal nerve injury.

Takahashi K, Watanabe M, Suekawa Y, Ito G, Inubushi T, Hirose N, Murasaki K, Hiyama S, Uchida T, Tanne K.

Eur J Pain. 2011 May;15(5):467.e1-14. doi: 10.1016/j.ejpain.2010.10.006. Epub 2010 Nov 18.


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