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Items: 34


PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.

Jang I, Pottekat A, Poothong J, Yong J, Lagunas-Acosta J, Charbono A, Chen Z, Scheuner DL, Liu M, Itkin-Ansari P, Arvan P, Kaufman RJ.

Elife. 2019 Jun 11;8. pii: e44528. doi: 10.7554/eLife.44528.


Proinsulin misfolding is an early event in the progression to type 2 diabetes.

Arunagiri A, Haataja L, Pottekat A, Pamenan F, Kim S, Zeltser LM, Paton AW, Paton JC, Tsai B, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P.

Elife. 2019 Jun 11;8. pii: e44532. doi: 10.7554/eLife.44532.


E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4A and Wild-Type p53.

Scully KM, Lahmy R, Signaevskaia L, Sasik R, Medal R, Kim H, French R, James B, Wu Y, Lowy AM, Itkin-Ansari P.

Cell Mol Gastroenterol Hepatol. 2018 May 16;6(2):181-198. doi: 10.1016/j.jcmgh.2018.05.002. eCollection 2018.


Induced PTF1a expression in pancreatic ductal adenocarcinoma cells activates acinar gene networks, reduces tumorigenic properties, and sensitizes cells to gemcitabine treatment.

Jakubison BL, Schweickert PG, Moser SE, Yang Y, Gao H, Scully K, Itkin-Ansari P, Liu Y, Konieczny SF.

Mol Oncol. 2018 Jun;12(7):1104-1124. doi: 10.1002/1878-0261.12314. Epub 2018 May 21.


A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer.

Villarino N, Signaevskaia L, van Niekerk J, Medal R, Kim H, Lahmy R, Scully K, Pinkerton A, Kim S, Lowy A, Itkin-Ansari P.

Oncotarget. 2017 Jun 21;8(32):53154-53167. doi: 10.18632/oncotarget.18587. eCollection 2017 Aug 8.


When Less Is Better: ER Stress and Beta Cell Proliferation.

Yong J, Itkin-Ansari P, Kaufman RJ.

Dev Cell. 2016 Jan 11;36(1):4-6. doi: 10.1016/j.devcel.2015.12.030.


The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.

Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates JR III, Itkin-Ansari P, Volkmann N, Kaufman RJ.

PLoS Biol. 2015 Oct 15;13(10):e1002277. doi: 10.1371/journal.pbio.1002277. eCollection 2015 Oct.


The basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential.

Kim S, Lahmy R, Riha C, Yang C, Jakubison BL, van Niekerk J, Staub C, Wu Y, Gates K, Dong DS, Konieczny SF, Itkin-Ansari P.

Pancreas. 2015 Jul;44(5):718-27. doi: 10.1097/MPA.0000000000000328.


Tolerance of human embryonic stem cell derived islet progenitor cells to vitrification-relevant solutions.

Lahmy R, Bolyukh VF, Castilla SM, Laurent LC, Katkov II, Itkin-Ansari P.

Cryobiology. 2015 Jun;70(3):283-6. doi: 10.1016/j.cryobiol.2015.03.005. Epub 2015 Mar 24.


Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape.

Kirk K, Hao E, Lahmy R, Itkin-Ansari P.

Stem Cell Res. 2014 May;12(3):807-14. doi: 10.1016/j.scr.2014.03.003. Epub 2014 Mar 24.


Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release.

Pottekat A, Becker S, Spencer KR, Yates JR 3rd, Manning G, Itkin-Ansari P, Balch WE.

Cell Rep. 2013 Sep 12;4(5):921-30. doi: 10.1016/j.celrep.2013.07.050. Epub 2013 Sep 5.


Cryopreservation of human insulin expressing cells macro-encapsulated in a durable therapeutic immunoisolating device theracyte.

Yakhnenko I, Wong WK, Katkov II, Itkin-Ansari P.

Cryo Letters. 2012 Nov-Dec;33(6):518-31.


HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.

Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson AD, Hostetler HA, Rodriguez-Lee M, Huang L, Spangler B, Smith L, Higginbotham J, Cashman J, Freeze H, Itkin-Ansari P, Dawson MI, Schroeder F, Cang Y, Mercola M, Levine F.

Chem Biol. 2012 Jul 27;19(7):806-18. doi: 10.1016/j.chembiol.2012.05.014.


Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells.

Lee SH, Hao E, Levine F, Itkin-Ansari P.

Islets. 2011 Nov-Dec;3(6):358-66. doi: 10.4161/isl.3.6.17923. Epub 2011 Nov 1.


The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma.

Lee SH, Hao E, Kiselyuk A, Shapiro J, Shields DJ, Lowy A, Levine F, Itkin-Ansari P.

Mol Cancer Res. 2011 Jun;9(6):782-90. doi: 10.1158/1541-7786.MCR-10-0535. Epub 2011 Apr 15.


Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen.

Kiselyuk A, Farber-Katz S, Cohen T, Lee SH, Geron I, Azimi B, Heynen-Genel S, Singer O, Price J, Mercola M, Itkin-Ansari P, Levine F.

J Biomol Screen. 2010 Jul;15(6):663-70. doi: 10.1177/1087057110372257. Epub 2010 Jun 14.


Adult human beta-cell neogenesis?

Demeterco C, Hao E, Lee SH, Itkin-Ansari P, Levine F.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:46-53. doi: 10.1111/j.1463-1326.2009.01105.x. Review.


Real-time bioluminescence imaging of macroencapsulated fibroblasts reveals allograft protection in rhesus monkeys (Macaca mulatta).

Tarantal AF, Lee CC, Itkin-Ansari P.

Transplantation. 2009 Jul 15;88(1):38-41. doi: 10.1097/TP.0b013e3181a9ee6c.


Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene.

Dawson MI, Ye M, Cao X, Farhana L, Hu QY, Zhao Y, Xu LP, Kiselyuk A, Correa RG, Yang L, Hou T, Reed JC, Itkin-Ansari P, Levine F, Sanner MF, Fontana JA, Zhang XK.

ChemMedChem. 2009 Jul;4(7):1106-19. doi: 10.1002/cmdc.200800447.


Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies.

Lee SH, Hao E, Savinov AY, Geron I, Strongin AY, Itkin-Ansari P.

Transplantation. 2009 Apr 15;87(7):983-91. doi: 10.1097/TP.0b013e31819c86ea.


Islet specific Wnt activation in human type II diabetes.

Lee SH, Demeterco C, Geron I, Abrahamsson A, Levine F, Itkin-Ansari P.

Exp Diabetes Res. 2008;2008:728763. doi: 10.1155/2008/728763. Epub 2009 Jan 20.


beta-cell Regeneration: neogenesis, replication or both?

Levine F, Itkin-Ansari P.

J Mol Med (Berl). 2008 Mar;86(3):247-58. Epub 2007 Oct 6. Review.


HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion.

Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F.

Biochem Biophys Res Commun. 2007 Apr 6;355(2):331-7. Epub 2007 Feb 5.


Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas.

Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F.

Nat Med. 2006 Mar;12(3):310-6. Epub 2006 Feb 19.


NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor.

Itkin-Ansari P, Marcora E, Geron I, Tyrberg B, Demeterco C, Hao E, Padilla C, Ratineau C, Leiter A, Lee JE, Levine F.

Dev Dyn. 2005 Jul;233(3):946-53.


Sources of beta-cells for human cell-based therapies for diabetes.

Itkin-Ansari P, Levine F.

Cell Biochem Biophys. 2004;40(3 Suppl):103-12. Review.


Cell-based therapies for diabetes: progress towards a transplantable human beta cell line.

Itkin-Ansari P, Geron I, Hao E, Demeterco C, Tyrberg B, Levine F.

Ann N Y Acad Sci. 2003 Nov;1005:138-47.


c-Myc controls proliferation versus differentiation in human pancreatic endocrine cells.

Demeterco C, Itkin-Ansari P, Tyrberg B, Ford LP, Jarvis RA, Levine F.

J Clin Endocrinol Metab. 2002 Jul;87(7):3475-85.


Beta-cell differentiation from a human pancreatic cell line in vitro and in vivo.

de la Tour D, Halvorsen T, Demeterco C, Tyrberg B, Itkin-Ansari P, Loy M, Yoo SJ, Hao E, Bossie S, Levine F.

Mol Endocrinol. 2001 Mar;15(3):476-83.


PDX-1 and cell-cell contact act in synergy to promote delta-cell development in a human pancreatic endocrine precursor cell line.

Itkin-Ansari P, Demeterco C, Bossie S, de la Tour DD, Beattie GM, Movassat J, Mally MI, Hayek A, Levine F.

Mol Endocrinol. 2000 Jun;14(6):814-22.


Sustained proliferation of PDX-1+ cells derived from human islets.

Beattie GM, Itkin-Ansari P, Cirulli V, Leibowitz G, Lopez AD, Bossie S, Mally MI, Levine F, Hayek A.

Diabetes. 1999 May;48(5):1013-9.


Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas.

Wang S, Beattie GM, Mally MI, Cirulli V, Itkin-Ansari P, Lopez AD, Hayek A, Levine F.

Cell Transplant. 1997 Jan-Feb;6(1):59-67.


E2A gene products are not required for insulin gene expression.

Itkin-Ansari P, Bain G, Beattie GM, Murre C, Hayek A, Levine F.

Endocrinology. 1996 Aug;137(8):3540-3.


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