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Items: 24

1.

Generation and characterization of B7-H4/B7S1/B7x-deficient mice.

Suh WK, Wang S, Duncan GS, Miyazaki Y, Cates E, Walker T, Gajewska BU, Deenick E, Dawicki W, Okada H, Wakeham A, Itie A, Watts TH, Ohashi PS, Jordana M, Yoshida H, Mak TW.

Mol Cell Biol. 2006 Sep;26(17):6403-11.

2.

The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.

Suh WK, Gajewska BU, Okada H, Gronski MA, Bertram EM, Dawicki W, Duncan GS, Bukczynski J, Plyte S, Elia A, Wakeham A, Itie A, Chung S, Da Costa J, Arya S, Horan T, Campbell P, Gaida K, Ohashi PS, Watts TH, Yoshinaga SK, Bray MR, Jordana M, Mak TW.

Nat Immunol. 2003 Sep;4(9):899-906. Epub 2003 Aug 17.

PMID:
12925852
3.

Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).

Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5431-6. Epub 2003 Apr 17.

4.

Generation and characterization of Smac/DIABLO-deficient mice.

Okada H, Suh WK, Jin J, Woo M, Du C, Elia A, Duncan GS, Wakeham A, Itie A, Lowe SW, Wang X, Mak TW.

Mol Cell Biol. 2002 May;22(10):3509-17.

5.

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.

Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, Mirtsos C, Takada H, Wakeham A, Itie A, Li S, Penninger JM, Wesche H, Ohashi PS, Mak TW, Yeh WC.

Nature. 2002 Apr 18;416(6882):750-6. Epub 2002 Mar 31.

PMID:
11923871
6.

The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.

Hara H, Takeda A, Takeuchi M, Wakeham AC, Itié A, Sasaki M, Mak TW, Yoshimura A, Nomoto K, Yoshida H.

J Immunol. 2002 Mar 1;168(5):2288-95. Erratum in: J Immunol 2002 Apr 15;168(8):4241.

7.

ICOS is essential for effective T-helper-cell responses.

Tafuri A, Shahinian A, Bladt F, Yoshinaga SK, Jordana M, Wakeham A, Boucher LM, Bouchard D, Chan VS, Duncan G, Odermatt B, Ho A, Itie A, Horan T, Whoriskey JS, Pawson T, Penninger JM, Ohashi PS, Mak TW.

Nature. 2001 Jan 4;409(6816):105-9.

PMID:
11343123
8.

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.

Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L.

Curr Biol. 2000 Nov 16;10(22):1459-62. Erratum in: Curr Biol 2001 Jun 5;11(11):907.

9.

Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo.

Liu Y, Snow BE, Hande MP, Baerlocher G, Kickhoefer VA, Yeung D, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L.

Mol Cell Biol. 2000 Nov;20(21):8178-84.

10.

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription.

Bonnard M, Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, Itié A, Wakeham A, Shahinian A, Henzel WJ, Elia AJ, Shillinglaw W, Mak TW, Cao Z, Yeh WC.

EMBO J. 2000 Sep 15;19(18):4976-85.

11.

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.

Yeh WC, Itie A, Elia AJ, Ng M, Shu HB, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel DV, Mak TW.

Immunity. 2000 Jun;12(6):633-42.

12.

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.

Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM.

Science. 2000 Feb 11;287(5455):1040-6.

13.

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.

Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, Oliveira-dos-Santos A, Mariathasan S, Bouchard D, Wakeham A, Itie A, Le J, Ohashi PS, Sarosi I, Nishina H, Lipkowitz S, Penninger JM.

Nature. 2000 Jan 13;403(6766):211-6.

PMID:
10646608
14.

Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.

Sirard C, Kim S, Mirtsos C, Tadich P, Hoodless PA, Itié A, Maxson R, Wrana JL, Mak TW.

J Biol Chem. 2000 Jan 21;275(3):2063-70.

15.

Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells.

Kapp U, Yeh WC, Patterson B, Elia AJ, Kägi D, Ho A, Hessel A, Tipsword M, Williams A, Mirtsos C, Itie A, Moyle M, Mak TW.

J Exp Med. 1999 Jun 21;189(12):1939-46.

16.

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.

Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, Morony S, Capparelli C, Van G, Kaufman S, van der Heiden A, Itie A, Wakeham A, Khoo W, Sasaki T, Cao Z, Penninger JM, Paige CJ, Lacey DL, Dunstan CR, Boyle WJ, Goeddel DV, Mak TW.

Genes Dev. 1999 Apr 15;13(8):1015-24.

17.

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival.

Liu Q, Sasaki T, Kozieradzki I, Wakeham A, Itie A, Dumont DJ, Penninger JM.

Genes Dev. 1999 Apr 1;13(7):786-91.

18.

Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma.

Elchebly M, Wagner J, Kennedy TE, Lanctôt C, Michaliszyn E, Itié A, Drouin J, Tremblay ML.

Nat Genet. 1999 Mar;21(3):330-3.

PMID:
10080191
19.

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.

Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM.

Nature. 1999 Jan 28;397(6717):315-23.

PMID:
9950424
20.

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.

Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M, Mak TW.

Curr Biol. 1998 Oct 22;8(21):1169-78.

21.

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.

Sirard C, de la Pompa JL, Elia A, Itie A, Mirtsos C, Cheung A, Hahn S, Wakeham A, Schwartz L, Kern SE, Rossant J, Mak TW.

Genes Dev. 1998 Jan 1;12(1):107-19.

22.

Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice.

You-Ten KE, Muise ES, Itié A, Michaliszyn E, Wagner J, Jothy S, Lapp WS, Tremblay ML.

J Exp Med. 1997 Aug 29;186(5):683-93.

23.

Brca2 is required for embryonic cellular proliferation in the mouse.

Suzuki A, de la Pompa JL, Hakem R, Elia A, Yoshida R, Mo R, Nishina H, Chuang T, Wakeham A, Itie A, Koo W, Billia P, Ho A, Fukumoto M, Hui CC, Mak TW.

Genes Dev. 1997 May 15;11(10):1242-52.

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