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Year Number of Results
2005 1
2006 2
2008 6
2009 5
2010 3
2011 3
2012 5
2013 10
2014 11
2015 8
2016 8
2017 9
2018 8
2019 15
2020 24
2021 28
2022 13
2023 22
2024 9

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166 results

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Page 1
Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex.
Gu L, Jin X, Liang H, Yang C, Zhang Y. Gu L, et al. Pharmacol Res. 2023 Jun;192:106789. doi: 10.1016/j.phrs.2023.106789. Epub 2023 May 4. Pharmacol Res. 2023. PMID: 37149115 Free article.
In addition, mass spectrometry analysis showed that CSNK1A1 binds to ITGB5 in HCC cells. Further study indicated that ITGB5 increased the protein level of CSNK1A1 through the EGFR-AKT-mTOR pathway in HCC. Upregulated CSNK1A1 phosphorylates ITGB5 to enhance th …
In addition, mass spectrometry analysis showed that CSNK1A1 binds to ITGB5 in HCC cells. Further study indicated that ITGB5 in …
ITGB5 Plays a Key Role in Escherichia coli F4ac-Induced Diarrhea in Piglets.
Wang W, Liu Y, Tang H, Yu Y, Zhang Q. Wang W, et al. Front Immunol. 2019 Dec 11;10:2834. doi: 10.3389/fimmu.2019.02834. eCollection 2019. Front Immunol. 2019. PMID: 31921118 Free PMC article.
Disruption of ITGB5 significantly reduced ETEC F4ac adhesion to porcine intestinal epithelial cells. In contrast, overexpression of ITGB5 significantly enhanced the adhesion. A GST pull-down assay with purified FaeG and ITGB5 also showed that FaeG binds direc …
Disruption of ITGB5 significantly reduced ETEC F4ac adhesion to porcine intestinal epithelial cells. In contrast, overexpression of …
ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.
Wen X, Chen S, Chen X, Qiu H, Wang W, Zhang N, Liu W, Wang T, Ding X, Zhang L. Wen X, et al. Front Oncol. 2022 Sep 30;12:887068. doi: 10.3389/fonc.2022.887068. eCollection 2022. Front Oncol. 2022. PMID: 36249018 Free PMC article.
However, it is unknown whether ITGB5 participates in the occurrence and development of PAAD. In this study, we confirmed a high expression of ITGB5 in PAAD and its role in promoting invasiveness and transitivity in PAAD. ...Collectively, these results show that I …
However, it is unknown whether ITGB5 participates in the occurrence and development of PAAD. In this study, we confirmed a high expre …
ITGB5 mutation discovered in a Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome.
Cheng T, Yuan X, Yuan S, Zhu J, Tang S, Zhang Y. Cheng T, et al. Open Life Sci. 2021 Dec 10;16(1):1268-1277. doi: 10.1515/biol-2021-0129. eCollection 2021. Open Life Sci. 2021. PMID: 34966851 Free PMC article.
Using whole-exome sequence analysis, we discovered another possible mutational cause of BPES in integrin subunit beta 5 (ITGB5). The ITGB5 mutation (c.608T>C, p.Ile203Thr) appears in the base sequence of all BPES(+) patients in this family, and it appears to be a …
Using whole-exome sequence analysis, we discovered another possible mutational cause of BPES in integrin subunit beta 5 (ITGB5). The …
[The effects of down-regulated ITGB5 expression on the proliferation of keloid fibroblasts].
Yang T, Chen M, Ma K, Fu X. Yang T, et al. Zhonghua Zheng Xing Wai Ke Za Zhi. 2017 Jan;33(1):49-52. Zhonghua Zheng Xing Wai Ke Za Zhi. 2017. PMID: 30070797 Chinese.
OBJECTIVE: To explore the effects of down-regulated ITGB5 expression on the proliferation of keloid fibroblasts and clarify the possible role of beta5-integrin (ITGB5) in keloid. METHODS: Construct lentiviral sh-RNA-expression vector targeting ITGB5 and infec …
OBJECTIVE: To explore the effects of down-regulated ITGB5 expression on the proliferation of keloid fibroblasts and clarify the possi …
Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG.
Gu Y, Liu Y, Fu L, Zhai L, Zhu J, Han Y, Jiang Y, Zhang Y, Zhang P, Jiang Z, Zhang X, Cao X. Gu Y, et al. Nat Med. 2019 Feb;25(2):312-322. doi: 10.1038/s41591-018-0309-y. Epub 2019 Jan 14. Nat Med. 2019. PMID: 30643287
These B cells selectively promoted lymph node metastasis by producing pathogenic IgG that targeted glycosylated membrane protein HSPA4, and activated the HSPA4-binding protein ITGB5 and the downstream Src/NF-kappaB pathway in tumor cells for CXCR4/SDF1alpha-axis-mediated m …
These B cells selectively promoted lymph node metastasis by producing pathogenic IgG that targeted glycosylated membrane protein HSPA4, and …
Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis.
Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. Zhu Z, et al. Cell Stem Cell. 2020 Feb 6;26(2):187-204.e10. doi: 10.1016/j.stem.2019.11.016. Epub 2020 Jan 16. Cell Stem Cell. 2020. PMID: 31956038 Free PMC article.
ZIKV infection was disrupted by genetic targeting of ITGAV or its binding partner ITGB5 and by an antibody specific for integrin alpha(v)beta(5). ZIKV selectively eliminated GSCs from species-matched human mature cerebral organoids and GBM surgical specimens, which was rev …
ZIKV infection was disrupted by genetic targeting of ITGAV or its binding partner ITGB5 and by an antibody specific for integrin alph …
Combination of single-cell and bulk RNA seq reveals the immune infiltration landscape and targeted therapeutic drugs in spinal cord injury.
Zhang Q, Yu B, Zhang Y, Tian Y, Yang S, Chen Y, Wu H. Zhang Q, et al. Front Immunol. 2023 Jan 19;14:1068359. doi: 10.3389/fimmu.2023.1068359. eCollection 2023. Front Immunol. 2023. PMID: 36742334 Free PMC article.
After using the Autodock software to dock immune hub genes and drugs that may be combined, the effectiveness of the drug was verified using an in vivo experiment with the T9 SCI mouse model. RESULTS: In the bulk-RNA seq, B2m, Itgb5, and Vav1 were identified as immune hub g …
After using the Autodock software to dock immune hub genes and drugs that may be combined, the effectiveness of the drug was verified using …
166 results