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Items: 1 to 50 of 90

1.

Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets.

Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Wactor A, Nelson-Maney N, Morris A, Guo L, Weyrich A, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA.

Elife. 2019 May 1;8. pii: e44031. doi: 10.7554/eLife.44031.

2.

Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood.

Bhatlekar S, Basak I, Edelstein LC, Campbell RA, Lindsey CR, Italiano JE Jr, Weyrich AS, Rowley JW, Rondina MT, Sola-Visner M, Bray PF.

Haematologica. 2019 Oct;104(10):2075-2083. doi: 10.3324/haematol.2018.204685. Epub 2019 Feb 7.

3.

Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis.

Johnson KE, Ceglowski JR, Roweth HG, Forward JA, Tippy MD, El-Husayni S, Kulenthirarajan R, Malloy MW, Machlus KR, Chen WY, Italiano JE Jr, Battinelli EM.

Blood Adv. 2019 Jan 22;3(2):198-211. doi: 10.1182/bloodadvances.2018026161.

4.

Unlocking the Molecular Secrete(s) of α-Granule Biogenesis.

Noetzli LJ, Italiano JE Jr.

Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2539-2541. doi: 10.1161/ATVBAHA.118.311614. No abstract available.

PMID:
30354241
5.

Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1550-E1559. doi: 10.1073/pnas.1720553115. Epub 2018 Jan 31.

6.

Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets.

Zufferey A, Speck ER, Machlus KR, Aslam R, Guo L, McVey MJ, Kim M, Kapur R, Boilard E, Italiano JE Jr, Semple JW.

Blood Adv. 2017 Sep 8;1(20):1773-1785. doi: 10.1182/bloodadvances.2017007021. eCollection 2017 Sep 12.

7.

Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice.

Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE Jr, Weyrich AS, Bear JE, Bergmeier W.

Blood Adv. 2017 Aug 8;1(18):1398-1408. doi: 10.1182/bloodadvances.2017006973.

8.

Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis.

Machlus KR, Wu SK, Vijey P, Soussou TS, Liu ZJ, Shacham E, Unger TJ, Kashyap T, Klebanov B, Sola-Visner M, Crochiere M, Italiano JE Jr, Landesman Y.

Blood. 2017 Aug 31;130(9):1132-1143. doi: 10.1182/blood-2016-11-752840. Epub 2017 Jun 19.

9.

Megakaryocytes compensate for Kit insufficiency in murine arthritis.

Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura Y, Ware J, Gurish MF, Italiano JE, Boilard E, Nigrovic PA.

J Clin Invest. 2017 May 1;127(5):1714-1724. doi: 10.1172/JCI84598. Epub 2017 Apr 4.

10.

Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis.

Johnson KE, Forward JA, Tippy MD, Ceglowski JR, El-Husayni S, Kulenthirarajan R, Machlus KR, Mayer EL, Italiano JE Jr, Battinelli EM.

Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):664-674. doi: 10.1161/ATVBAHA.116.308791. Epub 2017 Feb 2.

11.

DREAM plays an important role in platelet activation and thrombogenesis.

Kim K, Tseng A, Barazia A, Italiano JE, Cho J.

Blood. 2017 Jan 12;129(2):209-225. doi: 10.1182/blood-2016-07-724419. Epub 2016 Nov 30.

12.

Human thrombopoiesis depends on Protein kinase Cδ/protein kinase Cε functional couple.

Carubbi C, Masselli E, Martini S, Galli D, Aversa F, Mirandola P, Italiano JE Jr, Gobbi G, Vitale M.

Haematologica. 2016 Jul;101(7):812-20. doi: 10.3324/haematol.2015.137984. Epub 2016 Apr 14.

13.

Lysyl oxidase is associated with increased thrombosis and platelet reactivity.

Matsuura S, Mi R, Koupenova M, Eliades A, Patterson S, Toselli P, Thon J, Italiano JE Jr, Trackman PC, Papadantonakis N, Ravid K.

Blood. 2016 Mar 17;127(11):1493-501. doi: 10.1182/blood-2015-02-629667. Epub 2016 Jan 11.

14.

Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation.

Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE Jr.

Blood. 2016 Mar 17;127(11):1468-80. doi: 10.1182/blood-2015-08-663146. Epub 2016 Jan 7.

15.

CCL5 derived from platelets increases megakaryocyte proplatelet formation.

Machlus KR, Johnson KE, Kulenthirarajan R, Forward JA, Tippy MD, Soussou TS, El-Husayni SH, Wu SK, Wang S, Watnick RS, Italiano JE Jr, Battinelli EM.

Blood. 2016 Feb 18;127(7):921-6. doi: 10.1182/blood-2015-05-644583. Epub 2015 Dec 8.

16.

Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia.

Bury L, Falcinelli E, Chiasserini D, Springer TA, Italiano JE Jr, Gresele P.

Haematologica. 2016 Jan;101(1):46-56. doi: 10.3324/haematol.2015.130849. Epub 2015 Oct 9.

17.

Abnormal megakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice.

Barbieri SS, Petrucci G, Tarantino E, Amadio P, Rocca B, Pesce M, Machlus KR, Ranelletti FO, Gianellini S, Weksler B, Italiano JE Jr, Tremoli E.

Thromb Haemost. 2015 Nov 25;114(6):1218-29. doi: 10.1160/TH14-10-0872. Epub 2015 Aug 13.

PMID:
26272103
18.

Road blocks in making platelets for transfusion.

Thon JN, Medvetz DA, Karlsson SM, Italiano JE Jr.

J Thromb Haemost. 2015 Jun;13 Suppl 1:S55-62. doi: 10.1111/jth.12942. Review.

19.

IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.

Nishimura S, Nagasaki M, Kunishima S, Sawaguchi A, Sakata A, Sakaguchi H, Ohmori T, Manabe I, Italiano JE Jr, Ryu T, Takayama N, Komuro I, Kadowaki T, Eto K, Nagai R.

J Cell Biol. 2015 May 11;209(3):453-66. doi: 10.1083/jcb.201410052.

20.

Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.

Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE Jr, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, Poncz M, Weiss MJ.

J Clin Invest. 2015 Jun;125(6):2369-74. doi: 10.1172/JCI77670. Epub 2015 May 11.

21.

Platelet bioreactor-on-a-chip.

Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE Jr.

Blood. 2014 Sep 18;124(12):1857-67.

22.

Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein.

Bender M, Thon JN, Ehrlicher AJ, Wu S, Mazutis L, Deschmann E, Sola-Visner M, Italiano JE, Hartwig JH.

Blood. 2015 Jan 29;125(5):860-8. doi: 10.1182/blood-2014-09-600858. Epub 2014 Nov 19.

23.

A secreted tyrosine kinase acts in the extracellular environment.

Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE Jr, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M.

Cell. 2014 Aug 28;158(5):1033-1044. doi: 10.1016/j.cell.2014.06.048. Erratum in: Cell. 2014 Nov 6;159(4):955.

24.

Proteasome function is required for platelet production.

Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE Jr, Christensen H, Kahr WH, Li DY, Weyrich AS.

J Clin Invest. 2014 Sep;124(9):3757-66. doi: 10.1172/JCI75247. Epub 2014 Jul 25.

25.

Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation.

Machlus KR, Thon JN, Italiano JE Jr.

Br J Haematol. 2014 Apr;165(2):227-36. doi: 10.1111/bjh.12758. Epub 2014 Feb 6. Review.

PMID:
24499183
26.

Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4.

Hildick-Smith GJ, Cooney JD, Garone C, Kremer LS, Haack TB, Thon JN, Miyata N, Lieber DS, Calvo SE, Akman HO, Yien YY, Huston NC, Branco DS, Shah DI, Freedman ML, Koehler CM, Italiano JE Jr, Merkenschlager A, Beblo S, Strom TM, Meitinger T, Freisinger P, Donati MA, Prokisch H, Mootha VK, DiMauro S, Paw BH.

Am J Hum Genet. 2013 Nov 7;93(5):906-14. doi: 10.1016/j.ajhg.2013.09.011. Epub 2013 Oct 10.

27.

Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response.

Battinelli EM, Markens BA, Kulenthirarajan RA, Machlus KR, Flaumenhaft R, Italiano JE Jr.

Blood. 2014 Jan 2;123(1):101-12. doi: 10.1182/blood-2013-02-485011. Epub 2013 Sep 24.

28.

Animating platelet production adds physiological context.

Thon JN, Kitterman AC, Italiano JE Jr.

Trends Mol Med. 2013 Oct;19(10):583-5. doi: 10.1016/j.molmed.2013.07.010. Epub 2013 Aug 14.

29.

Proplatelet generation in the mouse requires PKCε-dependent RhoA inhibition.

Gobbi G, Mirandola P, Carubbi C, Masselli E, Sykes SM, Ferraro F, Nouvenne A, Thon JN, Italiano JE Jr, Vitale M.

Blood. 2013 Aug 15;122(7):1305-11. doi: 10.1182/blood-2013-04-490599. Epub 2013 Jul 9.

30.

The incredible journey: From megakaryocyte development to platelet formation.

Machlus KR, Italiano JE Jr.

J Cell Biol. 2013 Jun 10;201(6):785-96. doi: 10.1083/jcb.201304054. Review.

31.

Dynamin-related protein-1 controls fusion pore dynamics during platelet granule exocytosis.

Koseoglu S, Dilks JR, Peters CG, Fitch-Tewfik JL, Fadel NA, Jasuja R, Italiano JE Jr, Haynes CL, Flaumenhaft R.

Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):481-8. doi: 10.1161/ATVBAHA.112.255737. Epub 2013 Jan 3.

32.

Unraveling mechanisms that control platelet production.

Italiano JE Jr.

Semin Thromb Hemost. 2013 Feb;39(1):15-24. doi: 10.1055/s-0032-1331157. Epub 2012 Dec 24. Review.

PMID:
23266965
33.

Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.

Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, Coma S, Italiano JE Jr, Mammoto A, Bielenberg DR, Klagsbrun M.

J Biol Chem. 2013 Jan 25;288(4):2210-22. doi: 10.1074/jbc.M112.397398. Epub 2012 Nov 29.

34.

Canonical Wnt signaling in megakaryocytes regulates proplatelet formation.

Macaulay IC, Thon JN, Tijssen MR, Steele BM, MacDonald BT, Meade G, Burns P, Rendon A, Salunkhe V, Murphy RP, Bennett C, Watkins NA, He X, Fitzgerald DJ, Italiano JE Jr, Maguire PB.

Blood. 2013 Jan 3;121(1):188-96. doi: 10.1182/blood-2012-03-416875. Epub 2012 Nov 16.

35.

The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance.

Drabek K, Gutiérrez L, Vermeij M, Clapes T, Patel SR, Boisset JC, van Haren J, Pereira AL, Liu Z, Akinci U, Nikolic T, van Ijcken W, van den Hout M, Meinders M, Melo C, Sambade C, Drabek D, Hendriks RW, Philipsen S, Mommaas M, Grosveld F, Maiato H, Italiano JE Jr, Robin C, Galjart N.

Cell Rep. 2012 Oct 25;2(4):781-8. doi: 10.1016/j.celrep.2012.08.040. Epub 2012 Oct 19.

36.

Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis.

Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano JE Jr, Hartwig JH, Walter U.

Exp Hematol. 2013 Jan;41(1):91-101.e4. doi: 10.1016/j.exphem.2012.09.001. Epub 2012 Sep 11.

37.

A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site.

Nürnberg ST, Rendon A, Smethurst PA, Paul DS, Voss K, Thon JN, Lloyd-Jones H, Sambrook JG, Tijssen MR; HaemGen Consortium, Italiano JE Jr, Deloukas P, Gottgens B, Soranzo N, Ouwehand WH.

Blood. 2012 Dec 6;120(24):4859-68. doi: 10.1182/blood-2012-01-401893. Epub 2012 Sep 12.

38.

Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10.

Meyer I, Kunert S, Schwiebert S, Hagedorn I, Italiano JE Jr, Dütting S, Nieswandt B, Bachmann S, Schulze H.

Blood. 2012 Oct 25;120(17):3594-602. doi: 10.1182/blood-2012-01-401737. Epub 2012 Aug 30.

PMID:
22936655
39.

Platelets: production, morphology and ultrastructure.

Thon JN, Italiano JE.

Handb Exp Pharmacol. 2012;(210):3-22. doi: 10.1007/978-3-642-29423-5_1. Review.

PMID:
22918725
40.

T granules in human platelets function in TLR9 organization and signaling.

Thon JN, Peters CG, Machlus KR, Aslam R, Rowley J, Macleod H, Devine MT, Fuchs TA, Weyrich AS, Semple JW, Flaumenhaft R, Italiano JE Jr.

J Cell Biol. 2012 Aug 20;198(4):561-74. doi: 10.1083/jcb.201111136.

41.

MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation.

Smith EC, Thon JN, Devine MT, Lin S, Schulz VP, Guo Y, Massaro SA, Halene S, Gallagher P, Italiano JE Jr, Krause DS.

Blood. 2012 Sep 13;120(11):2317-29. doi: 10.1182/blood-2012-04-420828. Epub 2012 Jul 17.

42.

Does size matter in platelet production?

Thon JN, Italiano JE Jr.

Blood. 2012 Aug 23;120(8):1552-61. doi: 10.1182/blood-2012-04-408724. Epub 2012 Jun 4. Review.

43.

High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)--mediated inhibition of platelet production.

Thon JN, Devine MT, Jurak Begonja A, Tibbitts J, Italiano JE Jr.

Blood. 2012 Sep 6;120(10):1975-84. doi: 10.1182/blood-2012-04-420968. Epub 2012 Jun 4.

44.

Microtubule and cortical forces determine platelet size during vascular platelet production.

Thon JN, Macleod H, Begonja AJ, Zhu J, Lee KC, Mogilner A, Hartwig JH, Italiano JE Jr.

Nat Commun. 2012 May 22;3:852. doi: 10.1038/ncomms1838.

PMID:
22617292
45.

The origin and function of platelet glycosyltransferases.

Wandall HH, Rumjantseva V, Sørensen AL, Patel-Hett S, Josefsson EC, Bennett EP, Italiano JE Jr, Clausen H, Hartwig JH, Hoffmeister KM.

Blood. 2012 Jul 19;120(3):626-35. doi: 10.1182/blood-2012-02-409235. Epub 2012 May 21.

46.

VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients.

Peterson JE, Zurakowski D, Italiano JE Jr, Michel LV, Connors S, Oenick M, D'Amato RJ, Klement GL, Folkman J.

Angiogenesis. 2012 Jun;15(2):265-73. doi: 10.1007/s10456-012-9259-z. Epub 2012 Mar 9.

PMID:
22402885
47.

Visualization and manipulation of the platelet and megakaryocyte cytoskeleton.

Thon JN, Italiano JE.

Methods Mol Biol. 2012;788:109-25. doi: 10.1007/978-1-61779-307-3_9.

PMID:
22130704
48.

Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis.

Battinelli EM, Markens BA, Italiano JE Jr.

Blood. 2011 Aug 4;118(5):1359-69. doi: 10.1182/blood-2011-02-334524. Epub 2011 Jun 16.

49.

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.

Patel-Hett S, Wang H, Begonja AJ, Thon JN, Alden EC, Wandersee NJ, An X, Mohandas N, Hartwig JH, Italiano JE Jr.

Blood. 2011 Aug 11;118(6):1641-52. doi: 10.1182/blood-2011-01-330688. Epub 2011 May 12.

50.

Platelets and the immune continuum.

Semple JW, Italiano JE Jr, Freedman J.

Nat Rev Immunol. 2011 Apr;11(4):264-74. doi: 10.1038/nri2956. Review.

PMID:
21436837

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