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Items: 1 to 50 of 91

1.

A novel IkB kinase inhibitor attenuates ligature-induced periodontal disease in mice.

Kure K, Sato H, Suzuki JI, Itai A, Aoyama N, Izumi Y.

J Periodontal Res. 2019 Apr;54(2):164-173. doi: 10.1111/jre.12615. Epub 2018 Oct 8.

PMID:
30295325
2.

Evaluation of tolerability and efficacy of incorporating carboplatin in neoadjuvant anthracycline and taxane based therapy in a BRCA1 enriched triple-negative breast cancer cohort.

Sella T, Gal Yam EN, Levanon K, Rotenberg TS, Gadot M, Kuchuk I, Molho RB, Itai A, Modiano TM, Gold R, Kaufman B, Shimon SP.

Breast. 2018 Aug;40:141-146. doi: 10.1016/j.breast.2018.05.007. Epub 2018 May 22.

PMID:
29800932
3.

Plasminogen activator inhibitor-1 is an independent prognostic factor of ovarian cancer and IMD-4482, a novel plasminogen activator inhibitor-1 inhibitor, inhibits ovarian cancer peritoneal dissemination.

Nakatsuka E, Sawada K, Nakamura K, Yoshimura A, Kinose Y, Kodama M, Hashimoto K, Mabuchi S, Makino H, Morii E, Yamaguchi Y, Yanase T, Itai A, Morishige KI, Kimura T.

Oncotarget. 2017 Sep 12;8(52):89887-89902. doi: 10.18632/oncotarget.20834. eCollection 2017 Oct 27.

4.

The Novel IκB Kinase β Inhibitor, IMD-0560, Has Potent Therapeutic Efficacy in Ovarian Cancer Xenograft Model Mice.

Sawada I, Hashimoto K, Sawada K, Kinose Y, Nakamura K, Toda A, Nakatsuka E, Yoshimura A, Mabuchi S, Fujikawa T, Itai A, Kimura T.

Int J Gynecol Cancer. 2016 May;26(4):610-8. doi: 10.1097/IGC.0000000000000668.

PMID:
26905334
5.

Targeting Inhibitor of κB Kinase β Prevents Inflammation-Induced Preterm Delivery by Inhibiting IL-6 Production from Amniotic Cells.

Toda A, Sawada K, Fujikawa T, Wakabayashi A, Nakamura K, Sawada I, Yoshimura A, Nakatsuka E, Kinose Y, Hashimoto K, Mabuchi S, Tokuhira A, Nakayama M, Itai A, Kurachi H, Kimura T.

Am J Pathol. 2016 Mar;186(3):616-29. doi: 10.1016/j.ajpath.2015.11.004. Epub 2016 Jan 12.

PMID:
26796146
6.

Identification of QTLs controlling harvest time and fruit skin color in Japanese pear (Pyrus pyrifolia Nakai).

Yamamoto T, Terakami S, Takada N, Nishio S, Onoue N, Nishitani C, Kunihisa M, Inoue E, Iwata H, Hayashi T, Itai A, Saito T.

Breed Sci. 2014 Dec;64(4):351-61. doi: 10.1270/jsbbs.64.351. Epub 2014 Dec 1.

7.

IMD-4690, a novel specific inhibitor for plasminogen activator inhibitor-1, reduces allergic airway remodeling in a mouse model of chronic asthma via regulating angiogenesis and remodeling-related mediators.

Tezuka T, Ogawa H, Azuma M, Goto H, Uehara H, Aono Y, Hanibuchi M, Yamaguchi Y, Fujikawa T, Itai A, Nishioka Y.

PLoS One. 2015 Mar 18;10(3):e0121615. doi: 10.1371/journal.pone.0121615. eCollection 2015.

8.

Silicon-mediated changes in polyamines participate in silicon-induced salt tolerance in Sorghum bicolor L.

Yin L, Wang S, Tanaka K, Fujihara S, Itai A, Den X, Zhang S.

Plant Cell Environ. 2016 Feb;39(2):245-58. doi: 10.1111/pce.12521. Epub 2015 Apr 17.

9.

IKKβ Regulates VEGF Expression and Is a Potential Therapeutic Target for Ovarian Cancer as an Antiangiogenic Treatment.

Kinose Y, Sawada K, Makino H, Ogura T, Mizuno T, Suzuki N, Fujikawa T, Morii E, Nakamura K, Sawada I, Toda A, Hashimoto K, Isobe A, Mabuchi S, Ohta T, Itai A, Morishige K, Kurachi H, Kimura T.

Mol Cancer Ther. 2015 Apr;14(4):909-19. doi: 10.1158/1535-7163.MCT-14-0696. Epub 2015 Jan 30.

10.

The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma.

Tada Y, Kokabu S, Sugiyama G, Nakatomi C, Aoki K, Fukushima H, Osawa K, Sugamori Y, Ohya K, Okamoto M, Fujikawa T, Itai A, Matsuo K, Watanabe S, Jimi E.

Oncotarget. 2014 Dec 15;5(23):12317-30.

11.

IκB kinase-β inhibitor IMD-0354 beneficially suppresses retinal vascular permeability in streptozotocin-induced diabetic mice.

Lennikov A, Hiraoka M, Abe A, Ohno S, Fujikawa T, Itai A, Ohguro H.

Invest Ophthalmol Vis Sci. 2014 Sep 9;55(10):6365-73. doi: 10.1167/iovs.14-14671.

PMID:
25205865
12.

Inhibition of NF-κB activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation.

Watanabe R, Azuma RW, Suzuki J, Ogawa M, Itai A, Hirata Y, Komuro I, Isobe M.

Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1761-71. doi: 10.1152/ajpheart.00159.2013. Epub 2013 Oct 4.

13.

Pathophysiological roles of nuclear factor kappaB (NF-kB) in pulmonary arterial hypertension: effects of synthetic selective NF-kB inhibitor IMD-0354.

Hosokawa S, Haraguchi G, Sasaki A, Arai H, Muto S, Itai A, Doi S, Mizutani S, Isobe M.

Cardiovasc Res. 2013 Jul 1;99(1):35-43. doi: 10.1093/cvr/cvt105. Epub 2013 Apr 30.

PMID:
23631839
14.

Spectrum based feature extraction using spectrum intensity ratio for SSVEP detection.

Itai A, Funase A.

Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5947-50. doi: 10.1109/EMBC.2012.6347348.

PMID:
23367283
15.

Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats.

Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S.

Mol Vis. 2012;18:2586-97. Epub 2012 Oct 20.

16.

Inhibition of IκB phosphorylation prevents load-induced cardiac dysfunction in mice.

Tanaka T, Ogawa M, Suzuki J, Sekinishi A, Itai A, Hirata Y, Nagai R, Isobe M.

Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1435-45. doi: 10.1152/ajpheart.00290.2012. Epub 2012 Oct 5.

17.

A novel IKK inhibitor prevents progression of restenosis after arterial injury in mice.

Hamaya R, Ogawa M, Kobayashi N, Suzuki J, Itai A, Hirata Y, Nagai R, Isobe M.

Int Heart J. 2012;53(2):133-8.

18.
19.

Effects of pharmacological suppression of plasminogen activator inhibitor-1 in myocardial remodeling after ischemia reperfusion injury.

Watanabe R, Nakajima T, Ogawa M, Suzuki J, Muto S, Itai A, Hirata Y, Nagai R, Isobe M.

Int Heart J. 2011;52(6):388-92.

20.

An IκB kinase 2 inhibitor IMD-0354 suppresses the survival of adult T-cell leukemia cells.

Uota S, Zahidunnabi Dewan M, Saitoh Y, Muto S, Itai A, Utsunomiya A, Watanabe T, Yamamoto N, Yamaoka S.

Cancer Sci. 2012 Jan;103(1):100-6. doi: 10.1111/j.1349-7006.2011.02110.x. Epub 2011 Nov 27.

21.

The effects of pharmacologic plasminogen activator inhibitor-1 inhibition in acute and chronic rejection in murine cardiac allografts.

Ogawa M, Suzuki J, Yamaguchi Y, Muto S, Itai A, Hirata Y, Isobe M, Nagai R.

Transplantation. 2011 Jan 15;91(1):21-6.

PMID:
21452408
22.

Novel IkB kinase inhibitors for treatment of nuclear factor-kB-related diseases.

Suzuki J, Ogawa M, Muto S, Itai A, Isobe M, Hirata Y, Nagai R.

Expert Opin Investig Drugs. 2011 Mar;20(3):395-405. doi: 10.1517/13543784.2011.559162. Review.

PMID:
21314234
23.

Effects of specific chemical suppressors of plasminogen activator inhibitor-1 in cardiovascular diseases.

Suzuki J, Ogawa M, Muto S, Itai A, Hirata Y, Isobe M, Nagai R.

Expert Opin Investig Drugs. 2011 Feb;20(2):255-64. doi: 10.1517/13543784.2011.546784. Epub 2011 Jan 3. Review.

PMID:
21194395
24.

Aldosterone-induced kidney injury is mediated by NFκB activation.

Fukuda S, Horimai C, Harada K, Wakamatsu T, Fukasawa H, Muto S, Itai A, Hayashi M.

Clin Exp Nephrol. 2011 Feb;15(1):41-9. doi: 10.1007/s10157-010-0373-1. Epub 2010 Nov 12.

PMID:
21072674
25.

IκB kinase β inhibitor IMD-0354 suppresses airway remodelling in a Dermatophagoides pteronyssinus-sensitized mouse model of chronic asthma.

Ogawa H, Azuma M, Muto S, Nishioka Y, Honjo A, Tezuka T, Uehara H, Izumi K, Itai A, Sone S.

Clin Exp Allergy. 2011 Jan;41(1):104-15. doi: 10.1111/j.1365-2222.2010.03564.x.

PMID:
20573155
26.

A novel NF-κB inhibitor improves glucocorticoid sensitivity of canine neoplastic lymphoid cells by up-regulating expression of glucocorticoid receptors.

Matsuda A, Tanaka A, Muto S, Ohmori K, Furusaka T, Jung K, Karasawa K, Okamoto N, Oida K, Itai A, Matsuda H.

Res Vet Sci. 2010 Dec;89(3):378-82. doi: 10.1016/j.rvsc.2010.03.017. Epub 2010 Apr 1.

PMID:
20362310
27.

Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis.

Hayakawa Y, Maeda S, Nakagawa H, Hikiba Y, Shibata W, Sakamoto K, Yanai A, Hirata Y, Ogura K, Muto S, Itai A, Omata M.

J Gastroenterol. 2009;44(9):935-43. doi: 10.1007/s00535-009-0098-7. Epub 2009 Jun 26.

PMID:
19557302
28.

A novel IKK inhibitor suppresses heart failure and chronic remodeling after myocardial ischemia via MMP alteration.

Wakatsuki S, Suzuki J, Ogawa M, Masumura M, Muto S, Shimizu T, Takayama K, Itai A, Isobe M.

Expert Opin Ther Targets. 2008 Dec;12(12):1469-76. doi: 10.1517/14728220802551140 .

PMID:
19007316
29.

A specific inhibitor of plasminogen activator inhibitor-1 suppresses rat autoimmune myocarditis.

Suzuki J, Ogawa M, Muto S, Itai A, Isobe M.

Expert Opin Ther Targets. 2008 Nov;12(11):1313-20. doi: 10.1517/14728222.12.11.1313 .

PMID:
18851689
30.

Antiallergic and anti-inflammatory effects of a novel I kappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation.

Sugita A, Ogawa H, Azuma M, Muto S, Honjo A, Yanagawa H, Nishioka Y, Tani K, Itai A, Sone S.

Int Arch Allergy Immunol. 2009;148(3):186-98. doi: 10.1159/000161579. Epub 2008 Oct 10.

PMID:
18849610
31.

The effects of pharmacological PAI-1 inhibition on thrombus formation and neointima formation after arterial injury.

Suzuki J, Ogawa M, Muto S, Yamaguchi Y, Itai A, Isobe M.

Expert Opin Ther Targets. 2008 Jul;12(7):783-94. doi: 10.1517/14728222.12.7.783 .

PMID:
18554148
32.

Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells.

Ochiai T, Saito Y, Saitoh T, Dewan MZ, Shioya A, Kobayashi M, Kawachi H, Muto S, Itai A, Uota S, Eishi Y, Yamamoto N, Tanaka S, Arii S, Yamaoka S.

J Med Dent Sci. 2008 Mar;55(1):49-59.

PMID:
19845150
33.

Expressed sequence tags from persimmon at different developmental stages.

Nakagawa T, Nakatsuka A, Yano K, Yasugahira S, Nakamura R, Sun N, Itai A, Suzuki T, Itamura H.

Plant Cell Rep. 2008 May;27(5):931-8. doi: 10.1007/s00299-008-0518-9. Epub 2008 Feb 27.

PMID:
18301901
34.

Activation of IkappaB kinase and NF-kappaB is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils.

Yanai A, Maeda S, Shibata W, Hikiba Y, Sakamoto K, Nakagawa H, Ohmae T, Hirata Y, Ogura K, Muto S, Itai A, Omata M.

Infect Immun. 2008 Feb;76(2):781-7. Epub 2007 Dec 10.

35.

Starting point to molecular design: efficient automated 3D model builder Key3D.

Mizutani MY, Nakamura K, Ichinose T, Itai A.

Chem Pharm Bull (Tokyo). 2006 Dec;54(12):1680-5.

36.

Topical application with a new NF-kappaB inhibitor improves atopic dermatitis in NC/NgaTnd mice.

Tanaka A, Muto S, Jung K, Itai A, Matsuda H.

J Invest Dermatol. 2007 Apr;127(4):855-63. Epub 2006 Oct 19.

37.

A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model.

Haraguchi G, Suzuki J, Kosuge H, Ogawa M, Koga N, Muto S, Itai A, Kagechika H, Shudo K, Isobe M.

J Mol Cell Cardiol. 2006 Nov;41(5):885-92. Epub 2006 Sep 11.

PMID:
16963076
38.

Inhibition of NF-{kappa}B improves left ventricular remodeling and cardiac dysfunction after myocardial infarction.

Onai Y, Suzuki J, Maejima Y, Haraguchi G, Muto S, Itai A, Isobe M.

Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H530-8. Epub 2006 Aug 18.

39.

Effective handling of induced-fit motion in flexible docking.

Mizutani MY, Takamatsu Y, Ichinose T, Nakamura K, Itai A.

Proteins. 2006 Jun 1;63(4):878-91.

PMID:
16532451
40.

New approaches to mechanism analysis for drug discovery using DNA microarray data combined with KeyMolnet.

Sato H, Ishida S, Toda K, Matsuda R, Hayashi Y, Shigetaka M, Fukuda M, Wakamatsu Y, Itai A.

Curr Drug Discov Technol. 2005 Jun;2(2):89-98.

PMID:
16472233
41.

A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice.

Inayama M, Nishioka Y, Azuma M, Muto S, Aono Y, Makino H, Tani K, Uehara H, Izumi K, Itai A, Sone S.

Am J Respir Crit Care Med. 2006 May 1;173(9):1016-22. Epub 2006 Feb 2.

PMID:
16456147
42.
43.

Effect of nuclear factor-kappaB inhibition on rheumatoid fibroblast-like synoviocytes and collagen induced arthritis.

Okazaki Y, Sawada T, Nagatani K, Komagata Y, Inoue T, Muto S, Itai A, Yamamoto K.

J Rheumatol. 2005 Aug;32(8):1440-7.

PMID:
16078317
44.
45.

A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors.

Tanaka A, Konno M, Muto S, Kambe N, Morii E, Nakahata T, Itai A, Matsuda H.

Blood. 2005 Mar 15;105(6):2324-31. Epub 2004 Nov 23.

47.

A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance.

Kamon J, Yamauchi T, Muto S, Takekawa S, Ito Y, Hada Y, Ogawa W, Itai A, Kasuga M, Tobe K, Kadowaki T.

Biochem Biophys Res Commun. 2004 Oct 8;323(1):242-8.

PMID:
15351728
48.

Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury.

Onai Y, Suzuki J, Kakuta T, Maejima Y, Haraguchi G, Fukasawa H, Muto S, Itai A, Isobe M.

Cardiovasc Res. 2004 Jul 1;63(1):51-9.

PMID:
15194461
50.

Rapid identification of 1-aminocyclopropane-1-carboxylate (ACC) synthase genotypes in cultivars of Japanese pear (Pyrus pyrifolia Nakai) using CAPS markers.

Itai A, Kotaki T, Tanabe K, Tamura F, Kawaguchi D, Fukuda M.

Theor Appl Genet. 2003 May;106(7):1266-72. Epub 2003 Feb 11.

PMID:
12748778

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