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Items: 34


SCFFBXO22 targets HDM2 for degradation and modulates breast cancer cell invasion and metastasis.

Bai J, Wu K, Cao MH, Yang Y, Pan Y, Liu H, He Y, Itahana Y, Huang L, Zheng JN, Pan ZQ.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11754-11763. doi: 10.1073/pnas.1820990116. Epub 2019 May 28.


Tumor Suppressor p14ARF Enhances IFN-γ-Activated Immune Response by Inhibiting PIAS1 via SUMOylation.

Alagu J, Itahana Y, Sim F, Chao SH, Bi X, Itahana K.

J Immunol. 2018 Jul 15;201(2):451-464. doi: 10.4049/jimmunol.1800327. Epub 2018 May 30.


Emerging Roles of p53 Family Members in Glucose Metabolism.

Itahana Y, Itahana K.

Int J Mol Sci. 2018 Mar 8;19(3). pii: E776. doi: 10.3390/ijms19030776. Review.


Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis.

Lee HY, Itahana Y, Schuechner S, Fukuda M, Je HS, Ogris E, Virshup DM, Itahana K.

Sci Signal. 2018 Jan 9;11(512). pii: eaam7893. doi: 10.1126/scisignal.aam7893.


p53 upregulates PLCε-IP3-Ca2+ pathway and inhibits autophagy through its target gene Rap2B.

Di J, Tang J, Qian H, Franklin DA, Deisenroth C, Itahana Y, Zheng J, Zhang Y.

Oncotarget. 2017 May 23;8(39):64657-64669. doi: 10.18632/oncotarget.18112. eCollection 2017 Sep 12.


Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells.

Itahana Y, Zhang J, Göke J, Vardy LA, Han R, Iwamoto K, Cukuroglu E, Robson P, Pouladi MA, Colman A, Itahana K.

Sci Rep. 2016 Jun 27;6:28112. doi: 10.1038/srep28112.


Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.

Yeo SY, Itahana Y, Guo AK, Han R, Iwamoto K, Nguyen HT, Bao Y, Kleiber K, Wu YJ, Bay BH, Voorhoeve M, Itahana K.

Elife. 2016 Mar 9;5:e07101. doi: 10.7554/eLife.07101.


TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification.

Neo SH, Itahana Y, Alagu J, Kitagawa M, Guo AK, Lee SH, Tang K, Itahana K.

Mol Cell Biol. 2015 Aug;35(16):2851-63. doi: 10.1128/MCB.01064-14. Epub 2015 Jun 8.


The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense.

Itahana Y, Han R, Barbier S, Lei Z, Rozen S, Itahana K.

Oncogene. 2015 Apr 2;34(14):1799-810. doi: 10.1038/onc.2014.119. Epub 2014 May 26.


The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2.

He Y, Tollini L, Kim TH, Itahana Y, Zhang Y.

Cell Cycle. 2014;13(13):2101-9. doi: 10.4161/cc.29106. Epub 2014 May 7.


miR-141, a new player, joins the senescence orchestra.

Itahana Y, Neo SH, Itahana K.

Cell Cycle. 2013 Dec 1;12(23):3586-7. doi: 10.4161/cc.26960. Epub 2013 Oct 28. No abstract available.


Colorimetric detection of senescence-associated β galactosidase.

Itahana K, Itahana Y, Dimri GP.

Methods Mol Biol. 2013;965:143-56. doi: 10.1007/978-1-62703-239-1_8.


Emerging roles of mitochondrial p53 and ARF.

Itahana Y, Itahana K.

Curr Drug Targets. 2012 Dec;13(13):1633-40. Review.


TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep).

Cheng LL, Itahana Y, Lei ZD, Chia NY, Wu Y, Yu Y, Zhang SL, Thike AA, Pandey A, Rozen S, Voorhoeve PM, Yu Q, Tan PH, Bay BH, Itahana K, Tan P.

Clin Cancer Res. 2012 Aug 1;18(15):4201-12. doi: 10.1158/1078-0432.CCR-12-0036. Epub 2012 Jun 6.


Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction.

Clegg HV, Itahana Y, Itahana K, Ramalingam S, Zhang Y.

PLoS One. 2012;7(5):e38212. doi: 10.1371/journal.pone.0038212. Epub 2012 May 29.


p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation.

Deisenroth C, Itahana Y, Tollini L, Jin A, Zhang Y.

J Biol Chem. 2011 Aug 12;286(32):28343-56. doi: 10.1074/jbc.M111.254227. Epub 2011 Jun 9.


p53 Oligomerization is essential for its C-terminal lysine acetylation.

Itahana Y, Ke H, Zhang Y.

J Biol Chem. 2009 Feb 20;284(8):5158-64. doi: 10.1074/jbc.M805696200. Epub 2008 Dec 23.


Expression of Id and ITF-2 genes in the mammary gland during pregnancy.

Itahana Y, Piens M, Fong S, Singh J, Sumida T, Desprez PY.

Biochem Biophys Res Commun. 2008 Aug 8;372(4):826-30. doi: 10.1016/j.bbrc.2008.05.139. Epub 2008 Jun 2.


Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation.

Itahana K, Mao H, Jin A, Itahana Y, Clegg HV, Lindström MS, Bhat KP, Godfrey VL, Evan GI, Zhang Y.

Cancer Cell. 2007 Oct;12(4):355-66.


Regulation of clusterin expression in mammary epithelial cells.

Itahana Y, Piens M, Sumida T, Fong S, Muschler J, Desprez PY.

Exp Cell Res. 2007 Mar 10;313(5):943-51. Epub 2006 Dec 24.


Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required for maintenance of the differentiated state.

Zhao Y, Johansson C, Tran T, Bettencourt R, Itahana Y, Desprez PY, Konieczny SF.

Mol Endocrinol. 2006 Sep;20(9):2187-98. Epub 2006 Apr 27.


Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells.

Singh J, Itahana Y, Knight-Krajewski S, Kanagawa M, Campbell KP, Bissell MJ, Muschler J.

Cancer Res. 2004 Sep 1;64(17):6152-9.


Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression.

Coppe JP, Itahana Y, Moore DH, Bennington JL, Desprez PY.

Clin Cancer Res. 2004 Mar 15;10(6):2044-51.


Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R, Zhang Y.

Mol Cell. 2003 Nov;12(5):1151-64.


Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells.

Itahana Y, Singh J, Sumida T, Coppe JP, Parrinello S, Bennington JL, Desprez PY.

Cancer Res. 2003 Nov 1;63(21):7098-105.


Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis.

Fong S, Itahana Y, Sumida T, Singh J, Coppe JP, Liu Y, Richards PC, Bennington JL, Lee NM, Debs RJ, Desprez PY.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13543-8. Epub 2003 Oct 24.


Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.

Itahana K, Zou Y, Itahana Y, Martinez JL, Beausejour C, Jacobs JJ, Van Lohuizen M, Band V, Campisi J, Dimri GP.

Mol Cell Biol. 2003 Jan;23(1):389-401.


A role for p53 in maintaining and establishing the quiescence growth arrest in human cells.

Itahana K, Dimri GP, Hara E, Itahana Y, Zou Y, Desprez PY, Campisi J.

J Biol Chem. 2002 May 17;277(20):18206-14. Epub 2002 Mar 5.


Id-1, ITF-2, and Id-2 comprise a network of helix-loop-helix proteins that regulate mammary epithelial cell proliferation, differentiation, and apoptosis.

Parrinello S, Lin CQ, Murata K, Itahana Y, Singh J, Krtolica A, Campisi J, Desprez PY.

J Biol Chem. 2001 Oct 19;276(42):39213-9. Epub 2001 Aug 9.


Molecular cloning and characterization of a zinc finger protein involved in Id-1-stimulated mammary epithelial cell growth.

Singh J, Itahana Y, Parrinello S, Murata K, Desprez PY.

J Biol Chem. 2001 Apr 13;276(15):11852-8. Epub 2001 Jan 16.


A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells.

Lin CQ, Singh J, Murata K, Itahana Y, Parrinello S, Liang SH, Gillett CE, Campisi J, Desprez PY.

Cancer Res. 2000 Mar 1;60(5):1332-40.

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