Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 17

1.

Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis.

Istvan ES, Das S, Bhatnagar S, Beck JR, Owen E, Llinas M, Ganesan SM, Niles JC, Winzeler E, Vaidya AB, Goldberg DE.

Elife. 2019 Mar 19;8. pii: e40529. doi: 10.7554/eLife.40529.

2.

Development of piperazine-based hydroxamic acid inhibitors against falcilysin, an essential malarial protease.

Chance JP, Fejzic H, Hernandez O, Istvan ES, Andaya A, Maslov N, Aispuro R, Crisanto T, Nguyen H, Vidal B, Serrano W, Kuwahara B, Pugne Andanado C, Goldberg DE, Mallari JP.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1846-1848. doi: 10.1016/j.bmcl.2018.04.010. Epub 2018 Apr 19.

PMID:
29691139
3.

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.

Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, Arriaga I, Bopp S, Corey VC, Gnädig NF, Coburn-Flynn O, Reimer C, Gupta P, Murithi JM, Moura PA, Fuchs O, Sasaki E, Kim SW, Teng CH, Wang LT, Akidil A, Adjalley S, Willis PA, Siegel D, Tanaseichuk O, Zhong Y, Zhou Y, Llinás M, Ottilie S, Gamo FJ, Lee MCS, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA.

Science. 2018 Jan 12;359(6372):191-199. doi: 10.1126/science.aan4472.

4.

Esterase mutation is a mechanism of resistance to antimalarial compounds.

Istvan ES, Mallari JP, Corey VC, Dharia NV, Marshall GR, Winzeler EA, Goldberg DE.

Nat Commun. 2017 Jan 20;8:14240. doi: 10.1038/ncomms14240.

5.

A broad analysis of resistance development in the malaria parasite.

Corey VC, Lukens AK, Istvan ES, Lee MCS, Franco V, Magistrado P, Coburn-Flynn O, Sakata-Kato T, Fuchs O, Gnädig NF, Goldgof G, Linares M, Gomez-Lorenzo MG, De Cózar C, Lafuente-Monasterio MJ, Prats S, Meister S, Tanaseichuk O, Wree M, Zhou Y, Willis PA, Gamo FJ, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA.

Nat Commun. 2016 Jun 15;7:11901. doi: 10.1038/ncomms11901.

6.

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state.

Babbitt SE, Altenhofen L, Cobbold SA, Istvan ES, Fennell C, Doerig C, Llinás M, Goldberg DE.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3278-87. doi: 10.1073/pnas.1209823109. Epub 2012 Oct 29.

7.

Validation of isoleucine utilization targets in Plasmodium falciparum.

Istvan ES, Dharia NV, Bopp SE, Gluzman I, Winzeler EA, Goldberg DE.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1627-32. doi: 10.1073/pnas.1011560108. Epub 2011 Jan 4.

8.

Hemoglobin-degrading plasmepsin II is active as a monomer.

Liu J, Istvan ES, Goldberg DE.

J Biol Chem. 2006 Dec 15;281(50):38682-8. Epub 2006 Oct 13.

9.

Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems.

Liu J, Istvan ES, Gluzman IY, Gross J, Goldberg DE.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8840-5. Epub 2006 May 26.

10.

Distal substrate interactions enhance plasmepsin activity.

Istvan ES, Goldberg DE.

J Biol Chem. 2005 Feb 25;280(8):6890-6. Epub 2004 Dec 1.

11.

Structural mechanism for statin inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Istvan ES.

Am Heart J. 2002 Dec;144(6 Suppl):S27-32. Review.

PMID:
12486413
12.

Bacterial and mammalian HMG-CoA reductases: related enzymes with distinct architectures.

Istvan ES.

Curr Opin Struct Biol. 2001 Dec;11(6):746-51. Review.

PMID:
11751057
13.

Structural mechanism for statin inhibition of HMG-CoA reductase.

Istvan ES, Deisenhofer J.

Science. 2001 May 11;292(5519):1160-4.

14.

The structure of the catalytic portion of human HMG-CoA reductase.

Istvan ES, Deisenhofer J.

Biochim Biophys Acta. 2000 Dec 15;1529(1-3):9-18. Review.

PMID:
11111074
15.
16.
17.

Crystallization and preliminary X-ray analysis of fructose 6-phosphate, 2-kinase:fructose 2,6-bisphosphatase.

Istvan ES, Hasemann CA, Kurumbail RG, Uyeda K, Deisenhofer J.

Protein Sci. 1995 Nov;4(11):2439-41.

Supplemental Content

Loading ...
Support Center