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Items: 49


Robust Microfabrication of Highly Parallelized Three-Dimensional Microfluidics on Silicon.

Yadavali S, Lee D, Issadore D.

Sci Rep. 2019 Aug 21;9(1):12213. doi: 10.1038/s41598-019-48515-4.


Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting.

Liu JF, Jang B, Issadore D, Tsourkas A.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Jun 26:e1571. doi: 10.1002/wnan.1571. [Epub ahead of print] Review.


Multi-Dimensional Mapping of Brain-Derived Extracellular Vesicle MicroRNA Biomarker for Traumatic Brain Injury Diagnostics.

Ko J, Hemphill M, Yang Z, Beard K, Sewell E, Shallcross J, Schweizer M, Sandsmark DK, Diaz-Arrastia R, Kim J, Meaney D, Issadore D.

J Neurotrauma. 2019 May 6. doi: 10.1089/neu.2018.6220. [Epub ahead of print]


Large-scale production of compound bubbles using parallelized microfluidics for efficient extraction of metal ions.

Jeong HH, Chen Z, Yadavali S, Xu J, Issadore D, Lee D.

Lab Chip. 2019 Mar 13;19(6):1101-1102. doi: 10.1039/c9lc90021g.


Mobile platform for rapid sub-picogram-per-milliliter, multiplexed, digital droplet detection of proteins.

Yelleswarapu V, Buser JR, Haber M, Baron J, Inapuri E, Issadore D.

Proc Natl Acad Sci U S A. 2019 Feb 14. pii: 201814110. doi: 10.1073/pnas.1814110116. [Epub ahead of print]


Large-scale production of compound bubbles using parallelized microfluidics for efficient extraction of metal ions.

Jeong HH, Chen Z, Yadavali S, Xu J, Issadore D, Lee D.

Lab Chip. 2019 Feb 12;19(4):665-673. doi: 10.1039/c8lc01267a. Erratum in: Lab Chip. 2019 Mar 13;19(6):1101-1102.


Diagnosis of traumatic brain injury using miRNA signatures in nanomagnetically isolated brain-derived extracellular vesicles.

Ko J, Hemphill M, Yang Z, Sewell E, Na YJ, Sandsmark DK, Haber M, Fisher SA, Torre EA, Svane KC, Omelchenko A, Firestein BL, Diaz-Arrastia R, Kim J, Meaney DF, Issadore D.

Lab Chip. 2018 Dec 7;18(23):3617-3630. doi: 10.1039/c8lc00672e. Epub 2018 Oct 25.


Radiofrequency-Triggered Drug Release from Nanoliposomes with Millimeter-Scale Resolution Using a Superimposed Static Gating Field.

Liu JF, Neel N, Dang P, Lamb M, McKenna J, Rodgers L, Litt B, Cheng Z, Tsourkas A, Issadore D.

Small. 2018 Nov;14(44):e1802563. doi: 10.1002/smll.201802563. Epub 2018 Oct 4.


miRNA Profiling of Magnetic Nanopore-Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer.

Ko J, Bhagwat N, Black T, Yee SS, Na YJ, Fisher S, Kim J, Carpenter EL, Stanger BZ, Issadore D.

Cancer Res. 2018 Jul 1;78(13):3688-3697. doi: 10.1158/0008-5472.CAN-17-3703. Epub 2018 May 7.


Injectable Granular Hydrogels with Multifunctional Properties for Biomedical Applications.

Mealy JE, Chung JJ, Jeong HH, Issadore D, Lee D, Atluri P, Burdick JA.

Adv Mater. 2018 May;30(20):e1705912. doi: 10.1002/adma.201705912. Epub 2018 Mar 30.


Silicon and glass very large scale microfluidic droplet integration for terascale generation of polymer microparticles.

Yadavali S, Jeong HH, Lee D, Issadore D.

Nat Commun. 2018 Mar 26;9(1):1222. doi: 10.1038/s41467-018-03515-2.


Machine learning to detect signatures of disease in liquid biopsies - a user's guide.

Ko J, Baldassano SN, Loh PL, Kording K, Litt B, Issadore D.

Lab Chip. 2018 Jan 30;18(3):395-405. doi: 10.1039/c7lc00955k. Review.


Microfluidic diafiltration-on-chip using an integrated magnetic peristaltic micropump.

Liu JF, Yadavali S, Tsourkas A, Issadore D.

Lab Chip. 2017 Nov 7;17(22):3796-3803. doi: 10.1039/c7lc00954b.


Combining Machine Learning and Nanofluidic Technology To Diagnose Pancreatic Cancer Using Exosomes.

Ko J, Bhagwat N, Yee SS, Ortiz N, Sahmoud A, Black T, Aiello NM, McKenzie L, O'Hara M, Redlinger C, Romeo J, Carpenter EL, Stanger BZ, Issadore D.

ACS Nano. 2017 Nov 28;11(11):11182-11193. doi: 10.1021/acsnano.7b05503. Epub 2017 Oct 17.


A magnetic micropore chip for rapid (<1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis.

Ko J, Bhagwat N, Yee SS, Black T, Redlinger C, Romeo J, O'Hara M, Raj A, Carpenter EL, Stanger BZ, Issadore D.

Lab Chip. 2017 Sep 12;17(18):3086-3096. doi: 10.1039/c7lc00703e.


Liter-scale production of uniform gas bubbles via parallelization of flow-focusing generators.

Jeong HH, Yadavali S, Issadore D, Lee D.

Lab Chip. 2017 Jul 25;17(15):2667-2673. doi: 10.1039/c7lc00295e.


Ultra-high throughput detection (1 million droplets per second) of fluorescent droplets using a cell phone camera and time domain encoded optofluidics.

Yelleswarapu VR, Jeong HH, Yadavali S, Issadore D.

Lab Chip. 2017 Mar 14;17(6):1083-1094. doi: 10.1039/c6lc01489e.


Smartphone-enabled optofluidic exosome diagnostic for concussion recovery.

Ko J, Hemphill MA, Gabrieli D, Wu L, Yelleswarapu V, Lawrence G, Pennycooke W, Singh A, Meaney DF, Issadore D.

Sci Rep. 2016 Aug 8;6:31215. doi: 10.1038/srep31215.


Magnetic Nickel iron Electroformed Trap (MagNET): a master/replica fabrication strategy for ultra-high throughput (>100 mL h(-1)) immunomagnetic sorting.

Ko J, Yelleswarapu V, Singh A, Shah N, Issadore D.

Lab Chip. 2016 Aug 2;16(16):3049-57. doi: 10.1039/c6lc00487c.


Toolbox for Exploring Modular Gene Regulation in Synthetic Biology Training.

Magaraci MS, Bermudez JG, Yogish D, Pak DH, Mollov V, Tycko J, Issadore D, Mannickarottu SG, Chow BY.

ACS Synth Biol. 2016 Jul 15;5(7):781-5. doi: 10.1021/acssynbio.6b00057. Epub 2016 May 12.


Diagnostic technologies for circulating tumour cells and exosomes.

Shao H, Chung J, Issadore D.

Biosci Rep. 2015 Nov 24;36(1):e00292. doi: 10.1042/BSR20150180. Review.


Kilo-scale droplet generation in three-dimensional monolithic elastomer device (3D MED).

Jeong HH, Yelleswarapu VR, Yadavali S, Issadore D, Lee D.

Lab Chip. 2015 Dec 7;15(23):4387-92. doi: 10.1039/c5lc01025j.


Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices.

Ko J, Carpenter E, Issadore D.

Analyst. 2016 Jan 21;141(2):450-460. doi: 10.1039/c5an01610j. Review.


Multiplexed detection of viral infections using rapid in situ RNA analysis on a chip.

Shaffer SM, Joshi RP, Chambers BS, Sterken D, Biaesch AG, Gabrieli DJ, Li Y, Feemster KA, Hensley SE, Issadore D, Raj A.

Lab Chip. 2015 Aug 7;15(15):3170-82. doi: 10.1039/c5lc00459d.


Point-of-care rare cell cancer diagnostics.

Issadore D.

Methods Mol Biol. 2015;1256:123-37. doi: 10.1007/978-1-4939-2172-0_9.


Miniaturized, multiplexed readout of droplet-based microfluidic assays using time-domain modulation.

Muluneh M, Kim B, Buchsbaum G, Issadore D.

Lab Chip. 2014 Dec 21;14(24):4638-46. doi: 10.1039/c4lc00819g. Epub 2014 Oct 14. Erratum in: Lab Chip. 2014 Dec 21;14(24):4696.


A multi-scale PDMS fabrication strategy to bridge the size mismatch between integrated circuits and microfluidics.

Muluneh M, Issadore D.

Lab Chip. 2014 Dec 7;14(23):4552-8. doi: 10.1039/c4lc00869c. Epub 2014 Oct 6.


Magnetic sensing technology for molecular analyses.

Issadore D, Park YI, Shao H, Min C, Lee K, Liong M, Weissleder R, Lee H.

Lab Chip. 2014 Jul 21;14(14):2385-97. doi: 10.1039/c4lc00314d. Review.


Track-etched magnetic micropores for immunomagnetic isolation of pathogens.

Muluneh M, Shang W, Issadore D.

Adv Healthc Mater. 2014 Jul;3(7):1078-85. doi: 10.1002/adhm.201300502. Epub 2014 Feb 17.


Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip.

Chung J, Issadore D, Ullal A, Lee K, Weissleder R, Lee H.

Biomicrofluidics. 2013 Sep 17;7(5):54107. doi: 10.1063/1.4821923. eCollection 2013.


Laser micromachined hybrid open/paper microfluidic chips.

Chumo B, Muluneh M, Issadore D.

Biomicrofluidics. 2013 Dec 4;7(6):64109. doi: 10.1063/1.4840575. eCollection 2013.


Hybrid soft-lithography/laser machined microchips for the parallel generation of droplets.

Muluneh M, Issadore D.

Lab Chip. 2013 Dec 21;13(24):4750-4. doi: 10.1039/c3lc50979f.


Microchip-based detection of magnetically labeled cancer biomarkers.

Muluneh M, Issadore D.

Adv Drug Deliv Rev. 2014 Feb;66:101-9. doi: 10.1016/j.addr.2013.09.013. Epub 2013 Oct 5. Review.


Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells.

Castro CM, Ghazani AA, Chung J, Shao H, Issadore D, Yoon TJ, Weissleder R, Lee H.

Lab Chip. 2014 Jan 7;14(1):14-23. doi: 10.1039/c3lc50621e. Epub 2013 Jul 8. Review.


Microwave dielectric heating of non-aqueous droplets in a microfluidic device for nanoparticle synthesis.

Koziej D, Floryan C, Sperling RA, Ehrlicher AJ, Issadore D, Westervelt R, Weitz DA.

Nanoscale. 2013 Jun 21;5(12):5468-75. doi: 10.1039/c3nr00500c.


μHall chip for sensitive detection of bacteria.

Issadore D, Chung HJ, Chung J, Budin G, Weissleder R, Lee H.

Adv Healthc Mater. 2013 Sep;2(9):1224-8. doi: 10.1002/adhm.201200380. Epub 2013 Mar 12.


Microfluidic cell sorter (μFCS) for on-chip capture and analysis of single cells.

Chung J, Shao H, Reiner T, Issadore D, Weissleder R, Lee H.

Adv Healthc Mater. 2012 Jul;1(4):432-6. doi: 10.1002/adhm.201200046. Epub 2012 May 2.


Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector.

Issadore D, Chung J, Shao H, Liong M, Ghazani AA, Castro CM, Weissleder R, Lee H.

Sci Transl Med. 2012 Jul 4;4(141):141ra92. doi: 10.1126/scitranslmed.3003747.


Magnetic Nanoparticles and microNMR for Diagnostic Applications.

Shao H, Min C, Issadore D, Liong M, Yoon TJ, Weissleder R, Lee H.

Theranostics. 2012;2(1):55-65. doi: 10.7150/thno.3465. Epub 2012 Jan 1.


Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance.

Liong M, Fernandez-Suarez M, Issadore D, Min C, Tassa C, Reiner T, Fortune SM, Toner M, Lee H, Weissleder R.

Bioconjug Chem. 2011 Dec 21;22(12):2390-4. doi: 10.1021/bc200490r. Epub 2011 Nov 7.


Ubiquitous detection of gram-positive bacteria with bioorthogonal magnetofluorescent nanoparticles.

Chung HJ, Reiner T, Budin G, Min C, Liong M, Issadore D, Lee H, Weissleder R.

ACS Nano. 2011 Nov 22;5(11):8834-41. doi: 10.1021/nn2029692. Epub 2011 Oct 10.


Nanoparticle-mediated measurement of target-drug binding in cancer cells.

Ullal AV, Reiner T, Yang KS, Gorbatov R, Min C, Issadore D, Lee H, Weissleder R.

ACS Nano. 2011 Nov 22;5(11):9216-24. doi: 10.1021/nn203450p. Epub 2011 Oct 13.


Miniature magnetic resonance system for point-of-care diagnostics.

Issadore D, Min C, Liong M, Chung J, Weissleder R, Lee H.

Lab Chip. 2011 Jul 7;11(13):2282-7. doi: 10.1039/c1lc20177h. Epub 2011 May 5.


Self-assembled magnetic filter for highly efficient immunomagnetic separation.

Issadore D, Shao H, Chung J, Newton A, Pittet M, Weissleder R, Lee H.

Lab Chip. 2011 Jan 7;11(1):147-51. doi: 10.1039/c0lc00149j. Epub 2010 Oct 14.


A microfluidic microprocessor: controlling biomimetic containers and cells using hybrid integrated circuit/microfluidic chips.

Issadore D, Franke T, Brown KA, Westervelt RM.

Lab Chip. 2010 Nov 7;10(21):2937-43. doi: 10.1039/c0lc00092b. Epub 2010 Sep 8.


Scaling of transverse nuclear magnetic relaxation due to magnetic nanoparticle aggregation.

Brown KA, Vassiliou CC, Issadore D, Berezovsky J, Cima MJ, Westervelt RM.

J Magn Magn Mater. 2010 Oct 1;322(20):3122-3126.


High Voltage Dielectrophoretic and Magnetophoretic Hybrid Integrated Circuit / Microfluidic Chip.

Issadore D, Franke T, Brown KA, Hunt TP, Westervelt RM.

J Microelectromech Syst. 2009 Dec;18(6):1220-1225.


Microwave dielectric heating of drops in microfluidic devices.

Issadore D, Humphry KJ, Brown KA, Sandberg L, Weitz DA, Westervelt RM.

Lab Chip. 2009 Jun 21;9(12):1701-6. doi: 10.1039/b822357b. Epub 2009 Mar 19.


Integrated circuit/microfluidic chip to programmably trap and move cells and droplets with dielectrophoresis.

Hunt TP, Issadore D, Westervelt RM.

Lab Chip. 2008 Jan;8(1):81-7. Epub 2007 Nov 2.


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