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Items: 1 to 50 of 82

1.

Increased OGA Expression and Activity in Leukocytes from Patients with Diabetes: Correlation with Inflammation Markers.

Pagesy P, Tachet C, Mostefa-Kara A, Larger E, Issad T.

Exp Clin Endocrinol Diabetes. 2018 Jun 11. doi: 10.1055/a-0596-7337. [Epub ahead of print]

PMID:
29890544
2.

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice.

Fougerat A, Pan X, Smutova V, Heveker N, Cairo CW, Issad T, Larrivée B, Medin JA, Pshezhetsky AV.

Mol Metab. 2018 Jun;12:76-88. doi: 10.1016/j.molmet.2018.03.017. Epub 2018 Apr 21.

3.

[Sweet hijacking by the Tax oncoprotein of the Human T-cell lymphotropic virus type 1].

Pique C, Issad T.

Med Sci (Paris). 2018 Feb;34(2):120-122. doi: 10.1051/medsci/20183402006. Epub 2018 Feb 16. French. No abstract available.

PMID:
29451479
4.

Identification of insulin-sensitizing molecules acting by disrupting the interaction between the Insulin Receptor and Grb14.

Gondoin A, Hampe C, Eudes R, Fayolle C, Pierre-Eugène C, Miteva M, Villoutreix BO, Charnay-Pouget F, Aitken DJ, Issad T, Burnol AF.

Sci Rep. 2017 Dec 4;7(1):16901. doi: 10.1038/s41598-017-17122-6.

5.

Neuroinflammation induced by amyloid β25-35 modifies mucin-type O-glycosylation in the rat's hippocampus.

Ramos-Martinez I, Martínez-Loustalot P, Lozano L, Issad T, Limón D, Díaz A, Perez-Torres A, Guevara J, Zenteno E.

Neuropeptides. 2018 Feb;67:56-62. doi: 10.1016/j.npep.2017.11.008. Epub 2017 Nov 21.

PMID:
29174415
6.

Hijacking of the O-GlcNAcZYME complex by the HTLV-1 Tax oncoprotein facilitates viral transcription.

Groussaud D, Khair M, Tollenaere AI, Waast L, Kuo MS, Mangeney M, Martella C, Fardini Y, Coste S, Souidi M, Benit L, Pique C, Issad T.

PLoS Pathog. 2017 Jul 24;13(7):e1006518. doi: 10.1371/journal.ppat.1006518. eCollection 2017 Jul.

7.

Tau deletion promotes brain insulin resistance.

Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D.

J Exp Med. 2017 Aug 7;214(8):2257-2269. doi: 10.1084/jem.20161731. Epub 2017 Jun 26.

8.

Effect of insulin analogues on phosphatidyl inositol-3 kinase/Akt signalling in INS-1 rat pancreatic derived β-cells.

Pagesy P, Fardini Y, Nguyen TT, Lohmann M, Pierre-Eugene C, Tennagels N, Issad T.

Arch Physiol Biochem. 2016;122(2):54-60. doi: 10.3109/13813455.2015.1125364. Epub 2016 Jan 13.

PMID:
26707268
9.
10.

Regulatory O-GlcNAcylation sites on FoxO1 are yet to be identified.

Fardini Y, Perez-Cervera Y, Camoin L, Pagesy P, Lefebvre T, Issad T.

Biochem Biophys Res Commun. 2015 Jun 26;462(2):151-8. doi: 10.1016/j.bbrc.2015.04.114. Epub 2015 May 2.

PMID:
25944660
11.

30 Years Old: O-GlcNAc Reaches the Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation.

Lefebvre T, Issad T.

Front Endocrinol (Lausanne). 2015 Feb 9;6:17. doi: 10.3389/fendo.2015.00017. eCollection 2015. No abstract available.

12.

O-GlcNAcylation and Inflammation: A Vast Territory to Explore.

Baudoin L, Issad T.

Front Endocrinol (Lausanne). 2015 Jan 9;5:235. doi: 10.3389/fendo.2014.00235. eCollection 2014. Review.

13.

[Protein O-GlcNAcylation and regulation of cell signalling: involvement in pathophysiology].

Issad T, Pagesy P.

Biol Aujourdhui. 2014;208(2):109-17. doi: 10.1051/jbio/2014015. Epub 2014 Sep 8. Review. French.

PMID:
25190571
14.

[Cancer research: a privileged field of investigation on chance, reductionism and holism].

Zielinska A, Issad T.

Med Sci (Paris). 2014 Jun-Jul;30(6-7):675-8. doi: 10.1051/medsci/20143006019. Epub 2014 Jul 11. French.

15.

Development of a human breast-cancer derived cell line stably expressing a bioluminescence resonance energy transfer (BRET)-based phosphatidyl inositol-3 phosphate (PIP3) biosensor.

Kuo MS, Auriau J, Pierre-Eugène C, Issad T.

PLoS One. 2014 Mar 19;9(3):e92737. doi: 10.1371/journal.pone.0092737. eCollection 2014.

16.

O-GlcNAcylation of FoxO1 in pancreatic β cells promotes Akt inhibition through an IGFBP1-mediated autocrine mechanism.

Fardini Y, Masson E, Boudah O, Ben Jouira R, Cosson C, Pierre-Eugene C, Kuo MS, Issad T.

FASEB J. 2014 Feb;28(2):1010-21. doi: 10.1096/fj.13-238378. Epub 2013 Oct 30.

PMID:
24174424
17.

O-GlcNAcylation: A New Cancer Hallmark?

Fardini Y, Dehennaut V, Lefebvre T, Issad T.

Front Endocrinol (Lausanne). 2013 Aug 12;4:99. doi: 10.3389/fendo.2013.00099. eCollection 2013.

18.

O-GlcNAcylation-inducing treatments inhibit estrogen receptor α expression and confer resistance to 4-OH-tamoxifen in human breast cancer-derived MCF-7 cells.

Kanwal S, Fardini Y, Pagesy P, N'tumba-Byn T, Pierre-Eugène C, Masson E, Hampe C, Issad T.

PLoS One. 2013 Jul 11;8(7):e69150. doi: 10.1371/journal.pone.0069150. Print 2013.

19.

Positive regulation of insulin signaling by neuraminidase 1.

Dridi L, Seyrantepe V, Fougerat A, Pan X, Bonneil E, Thibault P, Moreau A, Mitchell GA, Heveker N, Cairo CW, Issad T, Hinek A, Pshezhetsky AV.

Diabetes. 2013 Jul;62(7):2338-46. doi: 10.2337/db12-1825. Epub 2013 Mar 21.

20.

Effect of insulin analogues on insulin/IGF1 hybrid receptors: increased activation by glargine but not by its metabolites M1 and M2.

Pierre-Eugene C, Pagesy P, Nguyen TT, Neuillé M, Tschank G, Tennagels N, Hampe C, Issad T.

PLoS One. 2012;7(7):e41992. doi: 10.1371/journal.pone.0041992. Epub 2012 Jul 26.

21.

PAZ6 cells constitute a representative model for human brown pre-adipocytes.

Kazantzis M, Takahashi V, Hinkle J, Kota S, Zilberfarb V, Issad T, Abdelkarim M, Chouchane L, Strosberg AD.

Front Endocrinol (Lausanne). 2012 Feb 2;3:13. doi: 10.3389/fendo.2012.00013. eCollection 2012.

22.

Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor.

Zheng H, Worrall C, Shen H, Issad T, Seregard S, Girnita A, Girnita L.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):7055-60. doi: 10.1073/pnas.1118359109. Epub 2012 Apr 16.

23.

Sam68 interacts with IRS1.

Quintana-Portillo R, Canfrán-Duque A, Issad T, Sánchez-Margalet V, González-Yanes C.

Biochem Pharmacol. 2012 Jan 1;83(1):78-87. doi: 10.1016/j.bcp.2011.09.030. Epub 2011 Oct 10.

PMID:
22005517
24.

A new highly efficient substrate-trapping mutant of protein tyrosine phosphatase 1B (PTP1B) reveals full autoactivation of the insulin receptor precursor.

Boubekeur S, Boute N, Pagesy P, Zilberfarb V, Christeff N, Issad T.

J Biol Chem. 2011 Jun 3;286(22):19373-80. doi: 10.1074/jbc.M111.222984. Epub 2011 Apr 12.

25.

O-GlcNAc modification, insulin signaling and diabetic complications.

Issad T, Masson E, Pagesy P.

Diabetes Metab. 2010 Dec;36(6 Pt 1):423-35. doi: 10.1016/j.diabet.2010.09.001. Epub 2010 Nov 11. Review.

PMID:
21074472
26.

Grb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activation.

Browaeys-Poly E, Blanquart C, Perdereau D, Antoine AF, Goenaga D, Luzy JP, Chen H, Garbay C, Issad T, Cailliau K, Burnol AF.

FEBS Lett. 2010 Nov 5;584(21):4383-8. doi: 10.1016/j.febslet.2010.09.048. Epub 2010 Oct 8.

27.

[O-GlcNAc glycosylation and regulation of cell signaling].

Issad T.

Med Sci (Paris). 2010 Aug-Sep;26(8-9):753-9. doi: 10.1051/medsci/2010268-9753. Review. French.

28.

Protein tyrosine phosphatase-1B and T-cell protein tyrosine phosphatase regulate IGF-2-induced MCF-7 cell migration.

Blanquart C, Karouri SE, Issad T.

Biochem Biophys Res Commun. 2010 Jan 29;392(1):83-8. doi: 10.1016/j.bbrc.2009.12.176. Epub 2010 Jan 7.

PMID:
20059965
29.

Insulin receptor substrates-5 and -6 are poor substrates for the insulin receptor.

Versteyhe S, Blanquart C, Hampe C, Mahmood S, Christeff N, De Meyts P, Gray SG, Issad T.

Mol Med Rep. 2010 Jan-Feb;3(1):189-93. doi: 10.3892/mmr_00000239.

PMID:
21472221
30.

Implication of protein tyrosine phosphatase 1B in MCF-7 cell proliferation and resistance to 4-OH tamoxifen.

Blanquart C, Karouri SE, Issad T.

Biochem Biophys Res Commun. 2009 Oct 2;387(4):748-53. doi: 10.1016/j.bbrc.2009.07.105. Epub 2009 Jul 25.

PMID:
19635455
31.

Molecular determinants of Grb14-mediated inhibition of insulin signaling.

Goenaga D, Hampe C, Carré N, Cailliau K, Browaeys-Poly E, Perdereau D, Holt LJ, Daly RJ, Girard J, Broutin I, Issad T, Burnol AF.

Mol Endocrinol. 2009 Jul;23(7):1043-51. doi: 10.1210/me.2008-0360. Epub 2009 Apr 9.

32.

O-GlcNAc modification of transcription factors, glucose sensing and glucotoxicity.

Issad T, Kuo M.

Trends Endocrinol Metab. 2008 Dec;19(10):380-9. doi: 10.1016/j.tem.2008.09.001. Epub 2008 Oct 17. Review.

PMID:
18929495
33.

Characterization of IRA/IRB hybrid insulin receptors using bioluminescence resonance energy transfer.

Blanquart C, Achi J, Issad T.

Biochem Pharmacol. 2008 Oct 1;76(7):873-83. doi: 10.1016/j.bcp.2008.07.027. Epub 2008 Jul 31.

PMID:
18718450
34.

[A new mode of reglulation of FoxO1 by O-GlcNAc glycosylation: involvement in the glucotoxicity phenomenon].

Kuo M, Zilberfarb V, Gangneux N, Christeff N, Issad T.

Med Sci (Paris). 2008 Apr;24(4):369-71. doi: 10.1051/medsci/2008244369. French. No abstract available.

35.

O-GlcNAc modification of FoxO1 increases its transcriptional activity: a role in the glucotoxicity phenomenon?

Kuo M, Zilberfarb V, Gangneux N, Christeff N, Issad T.

Biochimie. 2008 May;90(5):679-85. doi: 10.1016/j.biochi.2008.03.005. Epub 2008 Mar 21. Review.

PMID:
18359296
36.

O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene.

Kuo M, Zilberfarb V, Gangneux N, Christeff N, Issad T.

FEBS Lett. 2008 Mar 5;582(5):829-34. doi: 10.1016/j.febslet.2008.02.010. Epub 2008 Feb 14.

37.

Effects of intranasal administration of a leptin-secreting Lactococcus lactis recombinant on food intake, body weight, and immune response of mice.

Bermúdez-Humarán LG, Nouaille S, Zilberfarb V, Corthier G, Gruss A, Langella P, Issad T.

Appl Environ Microbiol. 2007 Aug;73(16):5300-7. Epub 2007 Jun 29.

38.

The use of bioluminescence resonance energy transfer for the study of therapeutic targets: application to tyrosine kinase receptors.

Issad T, Blanquart C, Gonzalez-Yanes C.

Expert Opin Ther Targets. 2007 Apr;11(4):541-56. Review.

PMID:
17373883
39.

Interaction between the insulin receptor and Grb14: a dynamic study in living cells using BRET.

Nouaille S, Blanquart C, Zilberfarb V, Boute N, Perdereau D, Burnol AF, Issad T.

Biochem Pharmacol. 2006 Nov 30;72(11):1355-66. Epub 2006 Aug 28.

PMID:
16934761
40.

Monitoring the activation state of insulin/insulin-like growth factor-1 hybrid receptors using bioluminescence resonance energy transfer.

Blanquart C, Gonzalez-Yanes C, Issad T.

Mol Pharmacol. 2006 Nov;70(5):1802-11. Epub 2006 Aug 22.

41.

Bioluminescence resonance energy transfer to monitor protein-protein interactions.

Issad T, Jockers R.

Methods Mol Biol. 2006;332:195-209.

PMID:
16878694
42.

Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor.

Nouaille S, Blanquart C, Zilberfarb V, Boute N, Perdereau D, Roix J, Burnol AF, Issad T.

EMBO Rep. 2006 May;7(5):512-8. Epub 2006 Mar 31.

44.

Interaction of PTPB with the insulin receptor precursor during its biosynthesis in the endoplasmic reticulum.

Issad T, Boute N, Boubekeur S, Lacasa D.

Biochimie. 2005 Jan;87(1):111-6. Review.

PMID:
15733745
45.
46.

The formation of an intrachain disulfide bond in the leptin protein is necessary for efficient leptin secretion.

Boute N, Zilberfarb V, Camoin L, Bonnafous S, Le Marchand-Brustel Y, Issad T.

Biochimie. 2004 Jun;86(6):351-6.

PMID:
15358050
47.

Looking for an insulin pill? Use the BRET methodology!

Issad T, Boute N, Boubekeur S, Lacasa D, Pernet K.

Diabetes Metab. 2003 Apr;29(2 Pt 1):111-7. Review.

PMID:
12746630
48.
49.

The activity of the insulin receptor assessed by bioluminescence resonance energy transfer.

Issad T, Boute N, Pernet K.

Ann N Y Acad Sci. 2002 Nov;973:120-3.

PMID:
12485847
50.

The use of resonance energy transfer in high-throughput screening: BRET versus FRET.

Boute N, Jockers R, Issad T.

Trends Pharmacol Sci. 2002 Aug;23(8):351-4. Review.

PMID:
12377570

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