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ROR1-CAVIN3 interaction required for caveolae-dependent endocytosis and pro-survival signaling in lung adenocarcinoma.

Yamaguchi T, Hayashi M, Ida L, Yamamoto M, Lu C, Kajino T, Cheng J, Nakatochi M, Isomura H, Yamazaki M, Suzuki M, Fujimoto T, Takahashi T.

Oncogene. 2019 Mar 20. doi: 10.1038/s41388-019-0785-7. [Epub ahead of print]


Corneal endothelial cells activate innate and acquired arm of anti-viral responses after cytomegalovirus infection.

Miyazaki D, Uotani R, Inoue M, Haruki T, Shimizu Y, Yakura K, Yamagami S, Suzutani T, Hosogai M, Isomura H, Inoue Y.

Exp Eye Res. 2017 Aug;161:143-152. doi: 10.1016/j.exer.2017.06.017. Epub 2017 Jun 23.


ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1.

Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, Hotta N, Shimada Y, Isomura H, Suzuki M, Fujimoto T, Takahashi T.

Nat Commun. 2016 Jan 4;7:10060. doi: 10.1038/ncomms10060.


Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds.

Abdel-Hakiem M, Yamashita A, Atiba A, Okamura Y, Katayama M, Youssef H, Isomura H, Uzuka Y.

J Vet Med Sci. 2016 Jan;78(1):97-100. doi: 10.1292/jvms.14-0233. Epub 2015 Aug 21.


Analysis of human cytomegalovirus replication in primary cultured human corneal endothelial cells.

Hosogai M, Shima N, Nakatani Y, Inoue T, Iso T, Yokoo H, Yorifuji H, Akiyama H, Kishi S, Isomura H.

Br J Ophthalmol. 2015 Nov;99(11):1583-90. doi: 10.1136/bjophthalmol-2014-306486. Epub 2015 Aug 10.


Processing bodies accumulate in human cytomegalovirus-infected cells and do not affect viral replication at high multiplicity of infection.

Seto E, Inoue T, Nakatani Y, Yamada M, Isomura H.

Virology. 2014 Jun;458-459:151-61. doi: 10.1016/j.virol.2014.04.022. Epub 2014 May 13.


Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features.

Arima C, Kajino T, Tamada Y, Imoto S, Shimada Y, Nakatochi M, Suzuki M, Isomura H, Yatabe Y, Yamaguchi T, Yanagisawa K, Miyano S, Takahashi T.

Carcinogenesis. 2014 Oct;35(10):2224-31. doi: 10.1093/carcin/bgu127. Epub 2014 Jun 5.


Lack of presence of the human cytomegalovirus in human glioblastoma.

Yamashita Y, Ito Y, Isomura H, Takemura N, Okamoto A, Motomura K, Tsujiuchi T, Natsume A, Wakabayashi T, Toyokuni S, Tsurumi T.

Mod Pathol. 2014 Jul;27(7):922-9. doi: 10.1038/modpathol.2013.219. Epub 2013 Dec 13.


A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.

Oike T, Ogiwara H, Tominaga Y, Ito K, Ando O, Tsuta K, Mizukami T, Shimada Y, Isomura H, Komachi M, Furuta K, Watanabe S, Nakano T, Yokota J, Kohno T.

Cancer Res. 2013 Sep 1;73(17):5508-18. doi: 10.1158/0008-5472.CAN-12-4593. Epub 2013 Jul 19.


Epstein-Barr virus deubiquitinase downregulates TRAF6-mediated NF-κB signaling during productive replication.

Saito S, Murata T, Kanda T, Isomura H, Narita Y, Sugimoto A, Kawashima D, Tsurumi T.

J Virol. 2013 Apr;87(7):4060-70. doi: 10.1128/JVI.02020-12. Epub 2013 Jan 30.


Coordination of late gene transcription of human cytomegalovirus with viral DNA synthesis: recombinant viruses as potential therapeutic vaccine candidates.

Isomura H, Stinski MF.

Expert Opin Ther Targets. 2013 Feb;17(2):157-66. doi: 10.1517/14728222.2013.740460. Epub 2012 Dec 12. Review.


Inhibitory effect of chondroitin sulfate type E on the binding step of human T-cell leukemia virus type 1.

Jinno-Oue A, Tanaka A, Shimizu N, Mori T, Sugiura N, Kimata K, Isomura H, Hoshino H.

AIDS Res Hum Retroviruses. 2013 Mar;29(3):621-9. doi: 10.1089/AID.2012.0156. Epub 2012 Dec 16.


Epigenetic histone modification of Epstein-Barr virus BZLF1 promoter during latency and reactivation in Raji cells.

Murata T, Kondo Y, Sugimoto A, Kawashima D, Saito S, Isomura H, Kanda T, Tsurumi T.

J Virol. 2012 May;86(9):4752-61. doi: 10.1128/JVI.06768-11. Epub 2012 Feb 22.


Unexpected instability of family of repeats (FR), the critical cis-acting sequence required for EBV latent infection, in EBV-BAC systems.

Kanda T, Shibata S, Saito S, Murata T, Isomura H, Yoshiyama H, Takada K, Tsurumi T.

PLoS One. 2011;6(11):e27758. doi: 10.1371/journal.pone.0027758. Epub 2011 Nov 16.


Identification and characterization of CCAAT enhancer-binding protein (C/EBP) as a transcriptional activator for Epstein-Barr virus oncogene latent membrane protein 1.

Noda C, Murata T, Kanda T, Yoshiyama H, Sugimoto A, Kawashima D, Saito S, Isomura H, Tsurumi T.

J Biol Chem. 2011 Dec 9;286(49):42524-33. doi: 10.1074/jbc.M111.271734. Epub 2011 Oct 19.


Involvement of Jun dimerization protein 2 (JDP2) in the maintenance of Epstein-Barr virus latency.

Murata T, Noda C, Saito S, Kawashima D, Sugimoto A, Isomura H, Kanda T, Yokoyama KK, Tsurumi T.

J Biol Chem. 2011 Jun 24;286(25):22007-16. doi: 10.1074/jbc.M110.199836. Epub 2011 Apr 27.


The human cytomegalovirus gene products essential for late viral gene expression assemble into prereplication complexes before viral DNA replication.

Isomura H, Stinski MF, Murata T, Yamashita Y, Kanda T, Toyokuni S, Tsurumi T.

J Virol. 2011 Jul;85(13):6629-44. doi: 10.1128/JVI.00384-11. Epub 2011 Apr 20.


Spatiotemporally different DNA repair systems participate in Epstein-Barr virus genome maturation.

Sugimoto A, Kanda T, Yamashita Y, Murata T, Saito S, Kawashima D, Isomura H, Nishiyama Y, Tsurumi T.

J Virol. 2011 Jul;85(13):6127-35. doi: 10.1128/JVI.00258-11. Epub 2011 Apr 13.


Type of milk feeding affects hematological parameters and serum lipid profile in Japanese infants.

Isomura H, Takimoto H, Miura F, Kitazawa S, Takeuchi T, Itabashi K, Kato N.

Pediatr Int. 2011 Dec;53(6):807-13. doi: 10.1111/j.1442-200X.2011.03360.x.


Tetrameric ring formation of Epstein-Barr virus polymerase processivity factor is crucial for viral replication.

Nakayama S, Murata T, Yasui Y, Murayama K, Isomura H, Kanda T, Tsurumi T.

J Virol. 2010 Dec;84(24):12589-98. doi: 10.1128/JVI.01394-10. Epub 2010 Oct 6.


The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene.

Isomura H, Stinski MF, Murata T, Nakayama S, Chiba S, Akatsuka Y, Kanda T, Tsurumi T.

PLoS One. 2010 Jul 30;5(7):e11901. doi: 10.1371/journal.pone.0011901.


Transcriptional repression by sumoylation of Epstein-Barr virus BZLF1 protein correlates with association of histone deacetylase.

Murata T, Hotta N, Toyama S, Nakayama S, Chiba S, Isomura H, Ohshima T, Kanda T, Tsurumi T.

J Biol Chem. 2010 Jul 30;285(31):23925-35. doi: 10.1074/jbc.M109.095356. Epub 2010 Jun 1.


Transient increases in p53-responsible gene expression at early stages of Epstein-Barr virus productive replication.

Sato Y, Shirata N, Murata T, Nakasu S, Kudoh A, Iwahori S, Nakayama S, Chiba S, Isomura H, Kanda T, Tsurumi T.

Cell Cycle. 2010 Feb 15;9(4):807-14. Epub 2010 Feb 17.


Nutritional status of lactating mothers and their breast milk concentration of iron, zinc and copper in rural Vietnam.

Nakamori M, Ninh NX, Isomura H, Yoshiike N, Hien VT, Nhug BT, Nhien NV, Nakano T, Khan NC, Yamamoto S.

J Nutr Sci Vitaminol (Tokyo). 2009 Aug;55(4):338-45.


Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.

Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T.

PLoS Pathog. 2009 Jul;5(7):e1000530. doi: 10.1371/journal.ppat.1000530. Epub 2009 Jul 31.


Epstein-Barr virus polymerase processivity factor enhances BALF2 promoter transcription as a coactivator for the BZLF1 immediate-early protein.

Nakayama S, Murata T, Murayama K, Yasui Y, Sato Y, Kudoh A, Iwahori S, Isomura H, Kanda T, Tsurumi T.

J Biol Chem. 2009 Aug 7;284(32):21557-68. doi: 10.1074/jbc.M109.015685. Epub 2009 Jun 2.


Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication.

Iwahori S, Murata T, Kudoh A, Sato Y, Nakayama S, Isomura H, Kanda T, Tsurumi T.

J Biol Chem. 2009 Jul 10;284(28):18923-31. doi: 10.1074/jbc.M109.015123. Epub 2009 May 18.


Efficient production of infectious viruses requires enzymatic activity of Epstein-Barr virus protein kinase.

Murata T, Isomura H, Yamashita Y, Toyama S, Sato Y, Nakayama S, Kudoh A, Iwahori S, Kanda T, Tsurumi T.

Virology. 2009 Jun 20;389(1-2):75-81. doi: 10.1016/j.virol.2009.04.007. Epub 2009 May 8.


Homologous recombinational repair factors are recruited and loaded onto the viral DNA genome in Epstein-Barr virus replication compartments.

Kudoh A, Iwahori S, Sato Y, Nakayama S, Isomura H, Murata T, Tsurumi T.

J Virol. 2009 Jul;83(13):6641-51. doi: 10.1128/JVI.00049-09. Epub 2009 Apr 22.


Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription.

Sato Y, Shirata N, Kudoh A, Iwahori S, Nakayama S, Murata T, Isomura H, Nishiyama Y, Tsurumi T.

Virology. 2009 May 25;388(1):204-11. doi: 10.1016/j.virol.2009.03.017. Epub 2009 Apr 16.


TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein.

Murata T, Sato Y, Nakayama S, Kudoh A, Iwahori S, Isomura H, Tajima M, Hishiki T, Ohshima T, Hijikata M, Shimotohno K, Tsurumi T.

J Biol Chem. 2009 Mar 20;284(12):8033-41. doi: 10.1074/jbc.M808466200. Epub 2009 Jan 21.


Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites.

Iwahori S, Yasui Y, Kudoh A, Sato Y, Nakayama S, Murata T, Isomura H, Tsurumi T.

Cell Signal. 2008 Oct;20(10):1795-803. doi: 10.1016/j.cellsig.2008.06.007. Epub 2008 Jun 19.


Role of the cytomegalovirus major immediate early enhancer in acute infection and reactivation from latency.

Stinski MF, Isomura H.

Med Microbiol Immunol. 2008 Jun;197(2):223-31. Epub 2007 Dec 19. Review.


Noncanonical TATA sequence in the UL44 late promoter of human cytomegalovirus is required for the accumulation of late viral transcripts.

Isomura H, Stinski MF, Kudoh A, Murata T, Nakayama S, Sato Y, Iwahori S, Tsurumi T.

J Virol. 2008 Feb;82(4):1638-46. Epub 2007 Dec 5.


A cis element between the TATA Box and the transcription start site of the major immediate-early promoter of human cytomegalovirus determines efficiency of viral replication.

Isomura H, Stinski MF, Kudoh A, Nakayama S, Murata T, Sato Y, Iwahori S, Tsurumi T.

J Virol. 2008 Jan;82(2):849-58. Epub 2007 Nov 7.


Cutaneous toxoplasmosis in a female Japanese cat.

Park CH, Ikadai H, Yoshida E, Isomura H, Inukai H, Oyamada T.

Vet Pathol. 2007 Sep;44(5):683-7.


Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein.

Iwahori S, Shirata N, Kawaguchi Y, Weller SK, Sato Y, Kudoh A, Nakayama S, Isomura H, Tsurumi T.

J Virol. 2007 Sep;81(18):9653-64. Epub 2007 Jul 3.


Phosphorylation of MCM4 at sites inactivating DNA helicase activity of the MCM4-MCM6-MCM7 complex during Epstein-Barr virus productive replication.

Kudoh A, Daikoku T, Ishimi Y, Kawaguchi Y, Shirata N, Iwahori S, Isomura H, Tsurumi T.

J Virol. 2006 Oct;80(20):10064-72.


Establishment of a novel foreign gene delivery system combining an HSV amplicon with an attenuated replication-competent virus, HSV-1 HF10.

Zhang L, Daikoku T, Ohtake K, Ohtsuka J, Nawa A, Kudoh A, Iwahori S, Isomura H, Nishiyama Y, Tsurumi T.

J Virol Methods. 2006 Nov;137(2):177-83. Epub 2006 Jul 18.


[Tissue tropism of herpesviruses].

Isomura H, Tsurumi T.

Nihon Rinsho. 2006 Mar;64 Suppl 3:24-8. Review. Japanese. No abstract available.


Postreplicative mismatch repair factors are recruited to Epstein-Barr virus replication compartments.

Daikoku T, Kudoh A, Sugaya Y, Iwahori S, Shirata N, Isomura H, Tsurumi T.

J Biol Chem. 2006 Apr 21;281(16):11422-30. Epub 2006 Feb 28.


Activation of ataxia telangiectasia-mutated DNA damage checkpoint signal transduction elicited by herpes simplex virus infection.

Shirata N, Kudoh A, Daikoku T, Tatsumi Y, Fujita M, Kiyono T, Sugaya Y, Isomura H, Ishizaki K, Tsurumi T.

J Biol Chem. 2005 Aug 26;280(34):30336-41. Epub 2005 Jun 17.


Relationship of coffee consumption with risk factors of atherosclerosis in rats.

Sakamoto W, Isomura H, Fujie K, Takahashi K, Nakao K, Izumi H.

Ann Nutr Metab. 2005 May-Jun;49(3):149-54. Epub 2005 Jun 1.


Homocysteine attenuates the expression of osteocalcin but enhances osteopontin in MC3T3-E1 preosteoblastic cells.

Sakamoto W, Isomura H, Fujie K, Deyama Y, Kato A, Nishihira J, Izumi H.

Biochim Biophys Acta. 2005 Apr 15;1740(1):12-6. Epub 2005 Apr 1.


The effect of vitamin K2 on bone metabolism in aged female rats.

Sakamoto W, Isomura H, Fujie K, Iizuka T, Nishihira J, Tatebe G, Takahashi K, Osaki Y, Komai M, Tamai H.

Osteoporos Int. 2005 Dec;16(12):1604-10. Epub 2005 Apr 22.


Characterization of localized seminal vesicle amyloidosis causing hemospermia: an analysis using immunohistochemistry and magnetic resonance imaging.

Furuya S, Masumori N, Furuya R, Tsukamoto T, Isomura H, Tamakawa M.

J Urol. 2005 Apr;173(4):1273-7.


Architecture of replication compartments formed during Epstein-Barr virus lytic replication.

Daikoku T, Kudoh A, Fujita M, Sugaya Y, Isomura H, Shirata N, Tsurumi T.

J Virol. 2005 Mar;79(6):3409-18.

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