Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 114


Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases.

Isoherranen N, Zhong G.

Pharmacol Ther. 2019 Aug 13:107400. doi: 10.1016/j.pharmthera.2019.107400. [Epub ahead of print] Review.


Renal Secretion of Hydrochlorothiazide Involves Organic Anion Transporter 1/3, Organic Cation Transporter 2, and Multidrug and Toxin Extrusion Protein 2-K.

Yin J, Wagner DJ, Prasad B, Isoherranen N, Thummel KE, Wang J.

Am J Physiol Renal Physiol. 2019 Jul 19. doi: 10.1152/ajprenal.00141.2019. [Epub ahead of print]


The retinoic acid hydroxylase Cyp26a1 has minor effects on postnatal vitamin A homeostasis, but is required for exogenous atRA clearance.

Zhong G, Hogarth C, Snyder JM, Palau L, Topping T, Huang W, Czuba LC, LaFrance J, Ghiaur G, Isoherranen N.

J Biol Chem. 2019 Jul 19;294(29):11166-11179. doi: 10.1074/jbc.RA119.009023. Epub 2019 Jun 5.


Discovery of a Potential Human Serum Biomarker for Chronic Seafood Toxin Exposure Using an SPR Biosensor.

Lefebvre KA, Yakes BJ, Frame E, Kendrick P, Shum S, Isoherranen N, Ferriss BE, Robertson A, Hendrix A, Marcinek DJ, Grattan L.

Toxins (Basel). 2019 May 23;11(5). pii: E293. doi: 10.3390/toxins11050293.


Characterization of Vitamin A Metabolome in Human Livers With and Without Nonalcoholic Fatty Liver Disease.

Zhong G, Kirkwood J, Won KJ, Tjota N, Jeong H, Isoherranen N.

J Pharmacol Exp Ther. 2019 Jul;370(1):92-103. doi: 10.1124/jpet.119.258517. Epub 2019 May 1.


Scaling in vitro activity of CYP3A7 suggests human fetal livers do not clear retinoic acid entering from maternal circulation.

Topletz AR, Zhong G, Isoherranen N.

Sci Rep. 2019 Mar 15;9(1):4620. doi: 10.1038/s41598-019-40995-8.


Chronic, low-level oral exposure to marine toxin, domoic acid, alters whole brain morphometry in nonhuman primates.

Petroff R, Richards T, Crouthamel B, McKain N, Stanley C, Grant KS, Shum S, Jing J, Isoherranen N, Burbacher TM.

Neurotoxicology. 2019 May;72:114-124. doi: 10.1016/j.neuro.2019.02.016. Epub 2019 Feb 28.


Determinants of Cytochrome P450 2D6 mRNA Levels in Healthy Human Liver Tissue.

Ning M, Duarte JD, Stevison F, Isoherranen N, Rubin LH, Jeong H.

Clin Transl Sci. 2019 Jul;12(4):416-423. doi: 10.1111/cts.12632. Epub 2019 Apr 3.


Emerging Role of Organ-on-a-Chip Technologies in Quantitative Clinical Pharmacology Evaluation.

Isoherranen N, Madabushi R, Huang SM.

Clin Transl Sci. 2019 Mar;12(2):113-121. doi: 10.1111/cts.12627. Review.


Preclinical modeling of exposure to a global marine bio-contaminant: Effects of in utero Domoic acid exposure on neonatal behavior and infant memory.

Grant KS, Crouthamel B, Kenney C, McKain N, Petroff R, Shum S, Jing J, Isoherranen N, Burbacher TM.

Neurotoxicol Teratol. 2019 May - Jun;73:1-8. doi: 10.1016/ Epub 2019 Jan 25.


Does In Vitro Cytochrome P450 Downregulation Translate to In Vivo Drug-Drug Interactions? Preclinical and Clinical Studies With 13-cis-Retinoic Acid.

Stevison F, Kosaka M, Kenny JR, Wong S, Hogarth C, Amory JK, Isoherranen N.

Clin Transl Sci. 2019 Jul;12(4):350-360. doi: 10.1111/cts.12616. Epub 2019 Mar 20.


Effects of oral domoic acid exposure on maternal reproduction and infant birth characteristics in a preclinical nonhuman primate model.

Burbacher TM, Grant KS, Petroff R, Shum S, Crouthamel B, Stanley C, McKain N, Jing J, Isoherranen N.

Neurotoxicol Teratol. 2019 Mar - Apr;72:10-21. doi: 10.1016/ Epub 2019 Jan 5.


Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis.

Grizotte-Lake M, Zhong G, Duncan K, Kirkwood J, Iyer N, Smolenski I, Isoherranen N, Vaishnava S.

Immunity. 2018 Dec 18;49(6):1103-1115.e6. doi: 10.1016/j.immuni.2018.11.018.


Domoic acid in California sea lion fetal fluids indicates continuous exposure to a neuroteratogen poses risks to mammals.

Lefebvre KA, Hendrix A, Halaska B, Duignan P, Shum S, Isoherranen N, Marcinek DJ, Gulland FMD.

Harmful Algae. 2018 Nov;79:53-57. doi: 10.1016/j.hal.2018.06.003. Epub 2018 Jul 7.


Validated HPLC-MS/MS Method To Quantify Low Levels of Domoic Acid in Plasma and Urine after Subacute Exposure.

Shum S, Kirkwood JS, Jing J, Petroff R, Crouthamel B, Grant KS, Burbacher TM, Nelson WL, Isoherranen N.

ACS Omega. 2018 Sep 30;3(9):12079-12088. doi: 10.1021/acsomega.8b02115. Epub 2018 Sep 27.


Sources of all-trans retinal oxidation independent of the aldehyde dehydrogenase 1A isozymes exist in the postnatal testis†.

Beedle MT, Stevison F, Zhong G, Topping T, Hogarth C, Isoherranen N, Griswold MD.

Biol Reprod. 2019 Feb 1;100(2):547-560. doi: 10.1093/biolre/ioy200.


Development of a Dynamic Physiologically Based Mechanistic Kidney Model to Predict Renal Clearance.

Huang W, Isoherranen N.

CPT Pharmacometrics Syst Pharmacol. 2018 Sep;7(9):593-602. doi: 10.1002/psp4.12321. Epub 2018 Aug 11.


CYP26C1 Is a Hydroxylase of Multiple Active Retinoids and Interacts with Cellular Retinoic Acid Binding Proteins.

Zhong G, Ortiz D, Zelter A, Nath A, Isoherranen N.

Mol Pharmacol. 2018 May;93(5):489-503. doi: 10.1124/mol.117.111039. Epub 2018 Feb 23.


Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Individuals.

Manuzak JA, Gott TM, Kirkwood JS, Coronado E, Hensley-McBain T, Miller C, Cheu RK, Collier AC, Funderburg NT, Martin JN, Wu MC, Isoherranen N, Hunt PW, Klatt NR.

Clin Infect Dis. 2018 Jun 1;66(12):1872-1882. doi: 10.1093/cid/cix1116.


Toxicokinetics and Physiologically Based Pharmacokinetic Modeling of the Shellfish Toxin Domoic Acid in Nonhuman Primates.

Jing J, Petroff R, Shum S, Crouthamel B, Topletz AR, Grant KS, Burbacher TM, Isoherranen N.

Drug Metab Dispos. 2018 Feb;46(2):155-165. doi: 10.1124/dmd.117.078485. Epub 2017 Nov 17.


Isotretinoin administration improves sperm production in men with infertility from oligoasthenozoospermia: a pilot study.

Amory JK, Ostrowski KA, Gannon JR, Berkseth K, Stevison F, Isoherranen N, Muller CH, Walsh T.

Andrology. 2017 Nov;5(6):1115-1123. doi: 10.1111/andr.12420. Epub 2017 Oct 5.


Physiologically Based Pharmacokinetic Model of the CYP2D6 Probe Atomoxetine: Extrapolation to Special Populations and Drug-Drug Interactions.

Huang W, Nakano M, Sager J, Ragueneau-Majlessi I, Isoherranen N.

Drug Metab Dispos. 2017 Nov;45(11):1156-1165. doi: 10.1124/dmd.117.076455. Epub 2017 Aug 31.


Cannabis use during pregnancy: Pharmacokinetics and effects on child development.

Grant KS, Petroff R, Isoherranen N, Stella N, Burbacher TM.

Pharmacol Ther. 2018 Feb;182:133-151. doi: 10.1016/j.pharmthera.2017.08.014. Epub 2017 Aug 25. Review.


Inhibition of the all-trans Retinoic Acid (atRA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous atRA Signaling.

Stevison F, Hogarth C, Tripathy S, Kent T, Isoherranen N.

Drug Metab Dispos. 2017 Jul;45(7):846-854. doi: 10.1124/dmd.117.075341. Epub 2017 Apr 26.


Interaction and Transport of Methamphetamine and its Primary Metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters.

Wagner DJ, Sager JE, Duan H, Isoherranen N, Wang J.

Drug Metab Dispos. 2017 Jul;45(7):770-778. doi: 10.1124/dmd.116.074708. Epub 2017 Apr 20.


Physiologically Based Pharmacokinetic Model of All-trans-Retinoic Acid with Application to Cancer Populations and Drug Interactions.

Jing J, Nelson C, Paik J, Shirasaka Y, Amory JK, Isoherranen N.

J Pharmacol Exp Ther. 2017 May;361(2):246-258. doi: 10.1124/jpet.117.240523. Epub 2017 Mar 8.


In vitro to in vivo extrapolation of the complex drug-drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation.

Sager JE, Tripathy S, Price LS, Nath A, Chang J, Stephenson-Famy A, Isoherranen N.

Biochem Pharmacol. 2017 Jan 1;123:85-96. doi: 10.1016/j.bcp.2016.11.007. Epub 2016 Nov 9.


Identification and Structural Characterization of Three New Metabolites of Bupropion in Humans.

Sager JE, Choiniere JR, Chang J, Stephenson-Famy A, Nelson WL, Isoherranen N.

ACS Med Chem Lett. 2016 Jun 17;7(8):791-6. doi: 10.1021/acsmedchemlett.6b00189. eCollection 2016 Aug 11.


Accelerated Skeletal Maturation in Disorders of Retinoic Acid Metabolism: A Case Report and Focused Review of the Literature.

Nilsson O, Isoherranen N, Guo MH, Lui JC, Jee YH, Guttmann-Bauman I, Acerini C, Lee W, Allikmets R, Yanovski JA, Dauber A, Baron J.

Horm Metab Res. 2016 Nov;48(11):737-744. Epub 2016 Sep 2. Review.


Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4'-OH-bupropion in vitro.

Sager JE, Price LS, Isoherranen N.

Drug Metab Dispos. 2016 Oct;44(10):1709-19. doi: 10.1124/dmd.116.072363. Epub 2016 Aug 5.


Direct protein-protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1.

Nelson CH, Peng CC, Lutz JD, Yeung CK, Zelter A, Isoherranen N.

FEBS Lett. 2016 Aug;590(16):2527-35. doi: 10.1002/1873-3468.12303. Epub 2016 Jul 28.


Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.

Vidadala RS, Rivas KL, Ojo KK, Hulverson MA, Zambriski JA, Bruzual I, Schultz TL, Huang W, Zhang Z, Scheele S, DeRocher AE, Choi R, Barrett LK, Siddaramaiah LK, Hol WG, Fan E, Merritt EA, Parsons M, Freiberg G, Marsh K, Kempf DJ, Carruthers VB, Isoherranen N, Doggett JS, Van Voorhis WC, Maly DJ.

J Med Chem. 2016 Jul 14;59(13):6531-46. doi: 10.1021/acs.jmedchem.6b00760. Epub 2016 Jul 1.


Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes.

Jing J, Isoherranen N, Robinson-Cohen C, Petrie I, Kestenbaum BR, Yeung CK.

Clin Transl Sci. 2016 Aug;9(4):207-15. doi: 10.1111/cts.12402. Epub 2016 Jun 9.


Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1.

Foti RS, Isoherranen N, Zelter A, Dickmann LJ, Buttrick BR, Diaz P, Douguet D.

J Pharmacol Exp Ther. 2016 May;357(2):281-92. doi: 10.1124/jpet.116.232637. Epub 2016 Mar 2.


All-Trans-Retinoic Acid Enhances Mitochondrial Function in Models of Human Liver.

Tripathy S, Chapman JD, Han CY, Hogarth CA, Arnold SL, Onken J, Kent T, Goodlett DR, Isoherranen N.

Mol Pharmacol. 2016 May;89(5):560-74. doi: 10.1124/mol.116.103697. Epub 2016 Feb 26.


Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, the Human Liver Retinoic Acid Hydroxylase.

Diaz P, Huang W, Keyari CM, Buttrick B, Price L, Guilloteau N, Tripathy S, Sperandio VG, Fronczek FR, Astruc-Diaz F, Isoherranen N.

J Med Chem. 2016 Mar 24;59(6):2579-95. doi: 10.1021/acs.jmedchem.5b01780. Epub 2016 Mar 15.


SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.

Huang W, Ojo KK, Zhang Z, Rivas K, Vidadala RS, Scheele S, DeRocher AE, Choi R, Hulverson MA, Barrett LK, Bruzual I, Siddaramaiah LK, Kerchner KM, Kurnick MD, Freiberg GM, Kempf D, Hol WG, Merritt EA, Neckermann G, de Hostos EL, Isoherranen N, Maly DJ, Parsons M, Doggett JS, Van Voorhis WC, Fan E.

ACS Med Chem Lett. 2015 Oct 22;6(12):1184-1189. eCollection 2015 Dec 10.


ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes.

Kent T, Arnold SL, Fasnacht R, Rowsey R, Mitchell D, Hogarth CA, Isoherranen N, Griswold MD.

Biol Reprod. 2016 Jan;94(1):12. doi: 10.1095/biolreprod.115.131458. Epub 2015 Dec 2.


Impact of Sample Matrix on Accuracy of Peptide Quantification: Assessment of Calibrator and Internal Standard Selection and Method Validation.

Arnold SL, Stevison F, Isoherranen N.

Anal Chem. 2016 Jan 5;88(1):746-53. doi: 10.1021/acs.analchem.5b03004. Epub 2015 Dec 14.


Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content.

Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE.

Pharmacogenomics J. 2016 Aug;16(4):375-87. doi: 10.1038/tpj.2015.58. Epub 2015 Sep 1.


Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification.

Sager JE, Yu J, Ragueneau-Majlessi I, Isoherranen N.

Drug Metab Dispos. 2015 Nov;43(11):1823-37. doi: 10.1124/dmd.115.065920. Epub 2015 Aug 21. Review.


Role of Retinoic Acid-Metabolizing Cytochrome P450s, CYP26, in Inflammation and Cancer.

Stevison F, Jing J, Tripathy S, Isoherranen N.

Adv Pharmacol. 2015;74:373-412. doi: 10.1016/bs.apha.2015.04.006. Epub 2015 May 27. Review.


Pharmacological inhibition of ALDH1A in mice decreases all-trans retinoic acid concentrations in a tissue specific manner.

Arnold SL, Kent T, Hogarth CA, Griswold MD, Amory JK, Isoherranen N.

Biochem Pharmacol. 2015 Jun 1;95(3):177-92. doi: 10.1016/j.bcp.2015.03.001. Epub 2015 Mar 9.


Dealing with the complex drug-drug interactions: towards mechanistic models.

Varma MV, Pang KS, Isoherranen N, Zhao P.

Biopharm Drug Dispos. 2015 Mar;36(2):71-92. doi: 10.1002/bdd.1934. Epub 2015 Feb 10. Review.


Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics.

Tay-Sontheimer J, Shireman LM, Beyer RP, Senn T, Witten D, Pearce RE, Gaedigk A, Gana Fomban CL, Lutz JD, Isoherranen N, Thummel KE, Fiehn O, Leeder JS, Lin YS.

Pharmacogenomics. 2014 Dec;15(16):1947-62. doi: 10.2217/pgs.14.155. Erratum in: Pharmacogenomics. 2015 Jan;16(2):174. Pharmacogenomics. 2015 Jul;16(8):913.


Processive pulses of retinoic acid propel asynchronous and continuous murine sperm production.

Hogarth CA, Arnold S, Kent T, Mitchell D, Isoherranen N, Griswold MD.

Biol Reprod. 2015 Feb;92(2):37. doi: 10.1095/biolreprod.114.126326. Epub 2014 Dec 17.


Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations.

Arnold SL, Kent T, Hogarth CA, Schlatt S, Prasad B, Haenisch M, Walsh T, Muller CH, Griswold MD, Amory JK, Isoherranen N.

J Lipid Res. 2015 Feb;56(2):342-57. doi: 10.1194/jlr.M054718. Epub 2014 Dec 11.


Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids.

Topletz AR, Tripathy S, Foti RS, Shimshoni JA, Nelson WL, Isoherranen N.

Mol Pharmacol. 2015;87(3):430-41. doi: 10.1124/mol.114.096784. Epub 2014 Dec 9.


Inhibition of retinoic acid biosynthesis by the bisdichloroacetyldiamine WIN 18,446 markedly suppresses spermatogenesis and alters retinoid metabolism in mice.

Paik J, Haenisch M, Muller CH, Goldstein AS, Arnold S, Isoherranen N, Brabb T, Treuting PM, Amory JK.

J Biol Chem. 2014 May 23;289(21):15104-17. doi: 10.1074/jbc.M113.540211. Epub 2014 Apr 7.


Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4.

Sager JE, Lutz JD, Foti RS, Davis C, Kunze KL, Isoherranen N.

Clin Pharmacol Ther. 2014 Jun;95(6):653-62. doi: 10.1038/clpt.2014.50. Epub 2014 Feb 25.

Supplemental Content

Loading ...
Support Center