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Items: 11


Assessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens.

Zanetti F, Sewer A, Scotti E, Titz B, Schlage WK, Leroy P, Kondylis A, Vuillaume G, Iskandar AR, Guedj E, Trivedi K, Schneider T, Elamin A, Martin F, Frentzel S, Ivanov NV, Peitsch MC, Hoeng J.

Food Chem Toxicol. 2018 May;115:148-169. doi: 10.1016/j.fct.2018.02.062. Epub 2018 Mar 2.


Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment.

Iskandar AR, Martin F, Leroy P, Schlage WK, Mathis C, Titz B, Kondylis A, Schneider T, Vuillaume G, Sewer A, Guedj E, Trivedi K, Elamin A, Frentzel S, Ivanov NV, Peitsch MC, Hoeng J.

Food Chem Toxicol. 2018 May;115:109-126. doi: 10.1016/j.fct.2018.02.063. Epub 2018 Mar 1.


A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures.

Iskandar AR, Mathis C, Schlage WK, Frentzel S, Leroy P, Xiang Y, Sewer A, Majeed S, Ortega-Torres L, Johne S, Guedj E, Trivedi K, Kratzer G, Merg C, Elamin A, Martin F, Ivanov NV, Peitsch MC, Hoeng J.

Toxicol In Vitro. 2017 Mar;39:29-51. doi: 10.1016/j.tiv.2016.11.009. Epub 2016 Nov 16.


β-Cryptoxanthin Reduced Lung Tumor Multiplicity and Inhibited Lung Cancer Cell Motility by Downregulating Nicotinic Acetylcholine Receptor α7 Signaling.

Iskandar AR, Miao B, Li X, Hu KQ, Liu C, Wang XD.

Cancer Prev Res (Phila). 2016 Nov;9(11):875-886. Epub 2016 Sep 13.


Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures.

Zanetti F, Sewer A, Mathis C, Iskandar AR, Kostadinova R, Schlage WK, Leroy P, Majeed S, Guedj E, Trivedi K, Martin F, Elamin A, Merg C, Ivanov NV, Frentzel S, Peitsch MC, Hoeng J.

Chem Res Toxicol. 2016 Aug 15;29(8):1252-69. doi: 10.1021/acs.chemrestox.6b00174. Epub 2016 Aug 5.


3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product.

Iskandar AR, Mathis C, Martin F, Leroy P, Sewer A, Majeed S, Kuehn D, Trivedi K, Grandolfo D, Cabanski M, Guedj E, Merg C, Frentzel S, Ivanov NV, Peitsch MC, Hoeng J.

ALTEX. 2017;34(1):23-48. doi: 10.14573/altex.1605041. Epub 2016 Jul 7.


A framework for in vitro systems toxicology assessment of e-liquids.

Iskandar AR, Gonzalez-Suarez I, Majeed S, Marescotti D, Sewer A, Xiang Y, Leroy P, Guedj E, Mathis C, Schaller JP, Vanscheeuwijck P, Frentzel S, Martin F, Ivanov NV, Peitsch MC, Hoeng J.

Toxicol Mech Methods. 2016 Jul;26(6):389-413. doi: 10.3109/15376516.2016.1170251. Epub 2016 Apr 26.


Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts.

Iskandar AR, Xiang Y, Frentzel S, Talikka M, Leroy P, Kuehn D, Guedj E, Martin F, Mathis C, Ivanov NV, Peitsch MC, Hoeng J.

Toxicol Sci. 2015 Sep;147(1):207-21. doi: 10.1093/toxsci/kfv122. Epub 2015 Jun 16.


In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures.

Schlage WK, Iskandar AR, Kostadinova R, Xiang Y, Sewer A, Majeed S, Kuehn D, Frentzel S, Talikka M, Geertz M, Mathis C, Ivanov N, Hoeng J, Peitsch MC.

Toxicol Mech Methods. 2014 Oct;24(7):470-87. doi: 10.3109/15376516.2014.943441. Epub 2014 Sep 11.


Systems approaches evaluating the perturbation of xenobiotic metabolism in response to cigarette smoke exposure in nasal and bronchial tissues.

Iskandar AR, Martin F, Talikka M, Schlage WK, Kostadinova R, Mathis C, Hoeng J, Peitsch MC.

Biomed Res Int. 2013;2013:512086. doi: 10.1155/2013/512086. Epub 2013 Oct 3.


β-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice.

Iskandar AR, Liu C, Smith DE, Hu KQ, Choi SW, Ausman LM, Wang XD.

Cancer Prev Res (Phila). 2013 Apr;6(4):309-20. doi: 10.1158/1940-6207.CAPR-12-0368. Epub 2012 Dec 28.

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