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Items: 1 to 50 of 207

1.

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc.

Lee Y, Wiriyasermkul P, Jin C, Quan L, Ohgaki R, Okuda S, Kusakizako T, Nishizawa T, Oda K, Ishitani R, Yokoyama T, Nakane T, Shirouzu M, Endou H, Nagamori S, Kanai Y, Nureki O.

Nat Struct Mol Biol. 2019 Jun;26(6):510-517. doi: 10.1038/s41594-019-0237-7. Epub 2019 Jun 3.

PMID:
31160781
2.

Structural basis for oligomerization of the prokaryotic peptide transporter PepTSo2.

Nagamura R, Fukuda M, Kawamoto A, Matoba K, Dohmae N, Ishitani R, Takagi J, Nureki O.

Acta Crystallogr F Struct Biol Commun. 2019 May 1;75(Pt 5):348-358. doi: 10.1107/S2053230X19003546. Epub 2019 Apr 24.

3.

Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9.

Hirano S, Abudayyeh OO, Gootenberg JS, Horii T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O.

Nat Commun. 2019 Apr 29;10(1):1968. doi: 10.1038/s41467-019-09741-6.

4.

Crystal structure of plant vacuolar iron transporter VIT1.

Kato T, Kumazaki K, Wada M, Taniguchi R, Nakane T, Yamashita K, Hirata K, Ishitani R, Ito K, Nishizawa T, Nureki O.

Nat Plants. 2019 Mar;5(3):308-315. doi: 10.1038/s41477-019-0367-2. Epub 2019 Feb 11.

PMID:
30742036
5.

Crystal structure of the Agrobacterium tumefaciens type VI effector-immunity complex.

Fukuhara S, Nakane T, Yamashita K, Ishii R, Ishitani R, Nureki O.

Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):810-816. doi: 10.1107/S2053230X18016369. Epub 2018 Nov 30.

6.

Cap-specific terminal N 6-methylation of RNA by an RNA polymerase II-associated methyltransferase.

Akichika S, Hirano S, Shichino Y, Suzuki T, Nishimasu H, Ishitani R, Sugita A, Hirose Y, Iwasaki S, Nureki O, Suzuki T.

Science. 2019 Jan 11;363(6423). pii: eaav0080. doi: 10.1126/science.aav0080. Epub 2018 Nov 22.

PMID:
30467178
7.

Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter.

Kusakizako T, Claxton DP, Tanaka Y, Maturana AD, Kuroda T, Ishitani R, Mchaourab HS, Nureki O.

Structure. 2019 Feb 5;27(2):293-301.e3. doi: 10.1016/j.str.2018.10.004. Epub 2018 Nov 15.

PMID:
30449688
8.

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.

Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G, Ishitani R, Tokunaga F, Nureki O.

Nat Commun. 2018 Oct 24;9(1):4424. doi: 10.1038/s41467-018-06922-7.

9.

Vibrational and Molecular Properties of Mg2+ Binding and Ion Selectivity in the Magnesium Channel MgtE.

Kimura T, Lorenz-Fonfria VA, Douki S, Motoki H, Ishitani R, Nureki O, Higashi M, Furutani Y.

J Phys Chem B. 2018 Oct 25;122(42):9681-9696. doi: 10.1021/acs.jpcb.8b07967. Epub 2018 Oct 10.

PMID:
30252477
10.

An Atomistic Model of a Precursor State of Light-Induced Channel Opening of Channelrhodopsin.

Cheng C, Kamiya M, Takemoto M, Ishitani R, Nureki O, Yoshida N, Hayashi S.

Biophys J. 2018 Oct 2;115(7):1281-1291. doi: 10.1016/j.bpj.2018.08.024. Epub 2018 Aug 27.

11.

Free Energy Landscape for the Entire Transport Cycle of Triose-Phosphate/Phosphate Translocator.

Takemoto M, Lee Y, Ishitani R, Nureki O.

Structure. 2018 Sep 4;26(9):1284-1296.e4. doi: 10.1016/j.str.2018.05.012. Epub 2018 Jun 28.

12.

Engineered CRISPR-Cas9 nuclease with expanded targeting space.

Nishimasu H, Shi X, Ishiguro S, Gao L, Hirano S, Okazaki S, Noda T, Abudayyeh OO, Gootenberg JS, Mori H, Oura S, Holmes B, Tanaka M, Seki M, Hirano H, Aburatani H, Ishitani R, Ikawa M, Yachie N, Zhang F, Nureki O.

Science. 2018 Sep 21;361(6408):1259-1262. doi: 10.1126/science.aas9129. Epub 2018 Aug 30.

13.

Cryo-EM structures of the human volume-regulated anion channel LRRC8.

Kasuya G, Nakane T, Yokoyama T, Jia Y, Inoue M, Watanabe K, Nakamura R, Nishizawa T, Kusakizako T, Tsutsumi A, Yanagisawa H, Dohmae N, Hattori M, Ichijo H, Yan Z, Kikkawa M, Shirouzu M, Ishitani R, Nureki O.

Nat Struct Mol Biol. 2018 Sep;25(9):797-804. doi: 10.1038/s41594-018-0109-6. Epub 2018 Aug 20.

PMID:
30127360
14.

Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR.

Maruyama T, Imai S, Kusakizako T, Hattori M, Ishitani R, Nureki O, Ito K, Maturana AD, Shimada I, Osawa M.

Elife. 2018 Apr 3;7. pii: e31596. doi: 10.7554/eLife.31596.

15.

Structural basis for xenobiotic extrusion by eukaryotic MATE transporter.

Miyauchi H, Moriyama S, Kusakizako T, Kumazaki K, Nakane T, Yamashita K, Hirata K, Dohmae N, Nishizawa T, Ito K, Miyaji T, Moriyama Y, Ishitani R, Nureki O.

Nat Commun. 2017 Nov 21;8(1):1633. doi: 10.1038/s41467-017-01541-0.

16.

Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel.

Kasuya G, Yamaura T, Ma XB, Nakamura R, Takemoto M, Nagumo H, Tanaka E, Dohmae N, Nakane T, Yu Y, Ishitani R, Matsuzaki O, Hattori M, Nureki O.

Nat Commun. 2017 Oct 12;8(1):876. doi: 10.1038/s41467-017-00887-9.

17.

Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity.

Lee Y, Nishizawa T, Takemoto M, Kumazaki K, Yamashita K, Hirata K, Minoda A, Nagatoishi S, Tsumoto K, Ishitani R, Nureki O.

Nat Plants. 2017 Oct;3(10):825-832. doi: 10.1038/s41477-017-0022-8. Epub 2017 Oct 2.

PMID:
28970497
18.

Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6.

Taniguchi R, Inoue A, Sayama M, Uwamizu A, Yamashita K, Hirata K, Yoshida M, Tanaka Y, Kato HE, Nakada-Nakura Y, Otani Y, Nishizawa T, Doi T, Ohwada T, Ishitani R, Aoki J, Nureki O.

Nature. 2017 Aug 17;548(7667):356-360. doi: 10.1038/nature23448. Epub 2017 Aug 9.

PMID:
28792932
19.

Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1.

Yamano T, Zetsche B, Ishitani R, Zhang F, Nishimasu H, Nureki O.

Mol Cell. 2017 Aug 17;67(4):633-645.e3. doi: 10.1016/j.molcel.2017.06.035. Epub 2017 Aug 3.

20.

ATP-dependent modulation of MgtE in Mg2+ homeostasis.

Tomita A, Zhang M, Jin F, Zhuang W, Takeda H, Maruyama T, Osawa M, Hashimoto KI, Kawasaki H, Ito K, Dohmae N, Ishitani R, Shimada I, Yan Z, Hattori M, Nureki O.

Nat Commun. 2017 Jul 27;8(1):148. doi: 10.1038/s41467-017-00082-w.

21.

Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1.

Nishimasu H, Yamano T, Gao L, Zhang F, Ishitani R, Nureki O.

Mol Cell. 2017 Jul 6;67(1):139-147.e2. doi: 10.1016/j.molcel.2017.04.019. Epub 2017 Jun 6.

22.

Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.

Kato K, Omura H, Ishitani R, Nureki O.

Annu Rev Biochem. 2017 Jun 20;86:541-566. doi: 10.1146/annurev-biochem-061516-044813. Epub 2017 Apr 7. Review.

PMID:
28399655
23.

Structural insights into the nucleotide base specificity of P2X receptors.

Kasuya G, Fujiwara Y, Tsukamoto H, Morinaga S, Ryu S, Touhara K, Ishitani R, Furutani Y, Hattori M, Nureki O.

Sci Rep. 2017 Mar 23;7:45208. doi: 10.1038/srep45208.

24.

Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems.

Yamada M, Watanabe Y, Gootenberg JS, Hirano H, Ran FA, Nakane T, Ishitani R, Zhang F, Nishimasu H, Nureki O.

Mol Cell. 2017 Mar 16;65(6):1109-1121.e3. doi: 10.1016/j.molcel.2017.02.007.

25.

Correction: Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II.

Meng J, Jiang JJ, Atsumi T, Bando H, Okuyama Y, Sabharwal L, Nakagawa I, Higuchi H, Ota M, Okawara M, Ishitani R, Nureki O, Higo D, Arima Y, Ogura H, Kamimura D, Murakami M.

J Immunol. 2017 Jan 15;198(2):971. doi: 10.4049/jimmunol.1601918. No abstract available.

26.

Crystal structures of the TRIC trimeric intracellular cation channel orthologues.

Kasuya G, Hiraizumi M, Maturana AD, Kumazaki K, Fujiwara Y, Liu K, Nakada-Nakura Y, Iwata S, Tsukada K, Komori T, Uemura S, Goto Y, Nakane T, Takemoto M, Kato HE, Yamashita K, Wada M, Ito K, Ishitani R, Hattori M, Nureki O.

Cell Res. 2016 Dec;26(12):1288-1301. doi: 10.1038/cr.2016.140.

27.

Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide.

Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, Nureki O.

Sci Rep. 2016 Oct 10;6:34756. doi: 10.1038/srep34756.

28.

Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA.

Matsumoto N, Nishimasu H, Sakakibara K, Nishida KM, Hirano T, Ishitani R, Siomi H, Siomi MC, Nureki O.

Cell. 2016 Oct 6;167(2):484-497.e9. doi: 10.1016/j.cell.2016.09.002. Epub 2016 Sep 29.

29.

Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II.

Meng J, Jiang JJ, Atsumi T, Bando H, Okuyama Y, Sabharwal L, Nakagawa I, Higuchi H, Ota M, Okawara M, Ishitani R, Nureki O, Higo D, Arima Y, Ogura H, Kamimura D, Murakami M.

J Immunol. 2016 Oct 15;197(8):3111-3119. Epub 2016 Sep 14. Erratum in: J Immunol. 2017 Jan 15;198(2):971.

30.

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.

Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F.

Nat Commun. 2016 Aug 24;7:12547. doi: 10.1038/ncomms12547.

31.

Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide.

Morita J, Kato K, Nakane T, Kondo Y, Fukuda H, Nishimasu H, Ishitani R, Nureki O.

Nat Commun. 2016 Aug 8;7:12383. doi: 10.1038/ncomms12383.

32.

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization.

Kato K, Satouh Y, Nishimasu H, Kurabayashi A, Morita J, Fujihara Y, Oji A, Ishitani R, Ikawa M, Nureki O.

Nat Commun. 2016 Jul 15;7:12198. doi: 10.1038/ncomms12198.

33.

LCP crystallization and X-ray diffraction analysis of VcmN, a MATE transporter from Vibrio cholerae.

Kusakizako T, Tanaka Y, Hipolito CJ, Kuroda T, Ishitani R, Suga H, Nureki O.

Acta Crystallogr F Struct Biol Commun. 2016 Jul;72(Pt 7):552-7. doi: 10.1107/S2053230X16008931. Epub 2016 Jun 22.

34.

Structural basis for amino acid export by DMT superfamily transporter YddG.

Tsuchiya H, Doki S, Takemoto M, Ikuta T, Higuchi T, Fukui K, Usuda Y, Tabuchi E, Nagatoishi S, Tsumoto K, Nishizawa T, Ito K, Dohmae N, Ishitani R, Nureki O.

Nature. 2016 Jun 16;534(7607):417-20. doi: 10.1038/nature17991. Epub 2016 May 30.

PMID:
27281193
35.

Data processing pipeline for serial femtosecond crystallography at SACLA.

Nakane T, Joti Y, Tono K, Yabashi M, Nango E, Iwata S, Ishitani R, Nureki O.

J Appl Crystallogr. 2016 Apr 18;49(Pt 3):1035-1041. eCollection 2016 Jun 1.

36.

Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.

Yamano T, Nishimasu H, Zetsche B, Hirano H, Slaymaker IM, Li Y, Fedorova I, Nakane T, Makarova KS, Koonin EV, Ishitani R, Zhang F, Nureki O.

Cell. 2016 May 5;165(4):949-62. doi: 10.1016/j.cell.2016.04.003. Epub 2016 Apr 21.

37.

Structural basis for specific inhibition of Autotaxin by a DNA aptamer.

Kato K, Ikeda H, Miyakawa S, Futakawa S, Nonaka Y, Fujiwara M, Okudaira S, Kano K, Aoki J, Morita J, Ishitani R, Nishimasu H, Nakamura Y, Nureki O.

Nat Struct Mol Biol. 2016 May;23(5):395-401. doi: 10.1038/nsmb.3200. Epub 2016 Apr 4.

PMID:
27043297
38.

Mechanisms for Two-Step Proton Transfer Reactions in the Outward-Facing Form of MATE Transporter.

Nishima W, Mizukami W, Tanaka Y, Ishitani R, Nureki O, Sugita Y.

Biophys J. 2016 Mar 29;110(6):1346-54. doi: 10.1016/j.bpj.2016.01.027.

39.

Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9.

Hirano S, Nishimasu H, Ishitani R, Nureki O.

Mol Cell. 2016 Mar 17;61(6):886-94. doi: 10.1016/j.molcel.2016.02.018.

40.

Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase.

Morita J, Kano K, Kato K, Takita H, Sakagami H, Yamamoto Y, Mihara E, Ueda H, Sato T, Tokuyama H, Arai H, Asou H, Takagi J, Ishitani R, Nishimasu H, Nureki O, Aoki J.

Sci Rep. 2016 Feb 18;6:20995. doi: 10.1038/srep20995.

41.

Structure and Engineering of Francisella novicida Cas9.

Hirano H, Gootenberg JS, Horii T, Abudayyeh OO, Kimura M, Hsu PD, Nakane T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O.

Cell. 2016 Feb 25;164(5):950-61. doi: 10.1016/j.cell.2016.01.039. Epub 2016 Feb 11.

42.

Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels.

Kasuya G, Fujiwara Y, Takemoto M, Dohmae N, Nakada-Nakura Y, Ishitani R, Hattori M, Nureki O.

Cell Rep. 2016 Feb 2;14(4):932-944. doi: 10.1016/j.celrep.2015.12.087. Epub 2016 Jan 21.

43.

Crystal Structures of SecYEG in Lipidic Cubic Phase Elucidate a Precise Resting and a Peptide-Bound State.

Tanaka Y, Sugano Y, Takemoto M, Mori T, Furukawa A, Kusakizako T, Kumazaki K, Kashima A, Ishitani R, Sugita Y, Nureki O, Tsukazaki T.

Cell Rep. 2015 Nov 24;13(8):1561-8. doi: 10.1016/j.celrep.2015.10.025. Epub 2015 Nov 12.

44.

Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin.

Taniguchi R, Kato HE, Font J, Deshpande CN, Wada M, Ito K, Ishitani R, Jormakka M, Nureki O.

Nat Commun. 2015 Oct 13;6:8545. doi: 10.1038/ncomms9545.

45.

Crystal Structure of Staphylococcus aureus Cas9.

Nishimasu H, Cong L, Yan WX, Ran FA, Zetsche B, Li Y, Kurabayashi A, Ishitani R, Zhang F, Nureki O.

Cell. 2015 Aug 27;162(5):1113-26. doi: 10.1016/j.cell.2015.08.007.

46.

Molecular Dynamics of Channelrhodopsin at the Early Stages of Channel Opening.

Takemoto M, Kato HE, Koyama M, Ito J, Kamiya M, Hayashi S, Maturana AD, Deisseroth K, Ishitani R, Nureki O.

PLoS One. 2015 Jun 26;10(6):e0131094. doi: 10.1371/journal.pone.0131094. eCollection 2015.

47.

Atomistic design of microbial opsin-based blue-shifted optogenetics tools.

Kato HE, Kamiya M, Sugo S, Ito J, Taniguchi R, Orito A, Hirata K, Inutsuka A, Yamanaka A, Maturana AD, Ishitani R, Sudo Y, Hayashi S, Nureki O.

Nat Commun. 2015 May 15;6:7177. doi: 10.1038/ncomms8177.

48.

Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK.

Fukuda M, Takeda H, Kato HE, Doki S, Ito K, Maturana AD, Ishitani R, Nureki O.

Nat Commun. 2015 May 11;6:7097. doi: 10.1038/ncomms8097.

49.

Crystal Structure and Activity of the Endoribonuclease Domain of the piRNA Pathway Factor Maelstrom.

Matsumoto N, Sato K, Nishimasu H, Namba Y, Miyakubi K, Dohmae N, Ishitani R, Siomi H, Siomi MC, Nureki O.

Cell Rep. 2015 Apr 21;11(3):366-75. doi: 10.1016/j.celrep.2015.03.030. Epub 2015 Apr 9.

50.

Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase.

Kato K, Ishii R, Hirano S, Ishitani R, Nureki O.

Structure. 2015 May 5;23(5):843-850. doi: 10.1016/j.str.2015.01.023. Epub 2015 Apr 9.

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