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Items: 42

1.

Reverse signaling by semaphorin 4C elicits SMAD1/5- and ID1/3-dependent invasive reprogramming in cancer cells.

Gurrapu S, Franzolin G, Fard D, Accardo M, Medico E, Sarotto I, Sapino A, Isella C, Tamagnone L.

Sci Signal. 2019 Aug 20;12(595). pii: eaav2041. doi: 10.1126/scisignal.aav2041.

PMID:
31431542
2.

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.

Lazzari L, Corti G, Picco G, Isella C, Montone M, Arcella P, Durinikova E, Zanella ER, Novara L, Barbosa F, Cassingena A, Cancelliere C, Medico E, Sartore-Bianchi A, Siena S, Garnett MJ, Bertotti A, Trusolino L, Di Nicolantonio F, Linnebacher M, Bardelli A, Arena S.

Clin Cancer Res. 2019 Aug 2. doi: 10.1158/1078-0432.CCR-18-3440. [Epub ahead of print]

PMID:
31375513
3.

Hospitalized Patients with Medically Unexplained Physical Symptoms: Clinical Context and Economic Costs of Healthcare Management.

Poloni N, Caselli I, Ielmini M, Mattia M, De Leo A, Di Sarno M, Isella C, Bellini A, Callegari C.

Behav Sci (Basel). 2019 Jul 19;9(7). pii: E80. doi: 10.3390/bs9070080.

4.

Evolving neoantigen profiles in colorectal cancers with DNA repair defects.

Rospo G, Lorenzato A, Amirouchene-Angelozzi N, Magrì A, Cancelliere C, Corti G, Negrino C, Amodio V, Montone M, Bartolini A, Barault L, Novara L, Isella C, Medico E, Bertotti A, Trusolino L, Germano G, Di Nicolantonio F, Bardelli A.

Genome Med. 2019 Jun 28;11(1):42. doi: 10.1186/s13073-019-0654-6.

5.

Pharmacogenetic Tests in Reducing Accesses to Emergency Services and Days of Hospitalization in Bipolar Disorder: A 2-Year Mirror Analysis.

Callegari C, Isella C, Caselli I, Poloni N, Ielmini M.

J Pers Med. 2019 Apr 30;9(2). pii: E22. doi: 10.3390/jpm9020022.

6.

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology.

Corti G, Bartolini A, Crisafulli G, Novara L, Rospo G, Montone M, Negrino C, Mussolin B, Buscarino M, Isella C, Barault L, Siravegna G, Siena S, Marsoni S, Di Nicolantonio F, Medico E, Bardelli A.

Clin Colorectal Cancer. 2019 Jun;18(2):91-101.e3. doi: 10.1016/j.clcc.2019.02.008. Epub 2019 Mar 7.

PMID:
30981604
7.

Paroxetine versus Vortioxetine for Depressive Symptoms in Postmenopausal Transition: A Preliminary Study.

Callegari C, Ielmini M, Caselli I, Lucca G, Isella C, Diurni M, Pettenon F, Poloni N.

Psychopharmacol Bull. 2019 Feb 15;49(1):28-43.

PMID:
30858637
8.

Medically Unexplained Physical Symptoms in Hospitalized Patients: A 9-Year Retrospective Observational Study.

Poloni N, Ielmini M, Caselli I, Ceccon F, Bianchi L, Isella C, Callegari C.

Front Psychiatry. 2018 Nov 23;9:626. doi: 10.3389/fpsyt.2018.00626. eCollection 2018.

9.

Integration of transcriptomic data and metabolic networks in cancer samples reveals highly significant prognostic power.

Graudenzi A, Maspero D, Di Filippo M, Gnugnoli M, Isella C, Mauri G, Medico E, Antoniotti M, Damiani C.

J Biomed Inform. 2018 Nov;87:37-49. doi: 10.1016/j.jbi.2018.09.010. Epub 2018 Sep 20.

PMID:
30244122
10.

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.

Apicella M, Giannoni E, Fiore S, Ferrari KJ, Fernández-Pérez D, Isella C, Granchi C, Minutolo F, Sottile A, Comoglio PM, Medico E, Pietrantonio F, Volante M, Pasini D, Chiarugi P, Giordano S, Corso S.

Cell Metab. 2018 Dec 4;28(6):848-865.e6. doi: 10.1016/j.cmet.2018.08.006. Epub 2018 Aug 30.

PMID:
30174307
11.

FOXA1 and AR in invasive breast cancer: new findings on their co-expression and impact on prognosis in ER-positive patients.

Rangel N, Fortunati N, Osella-Abate S, Annaratone L, Isella C, Catalano MG, Rinella L, Metovic J, Boldorini R, Balmativola D, Ferrando P, Marano F, Cassoni P, Sapino A, Castellano I.

BMC Cancer. 2018 Jul 3;18(1):703. doi: 10.1186/s12885-018-4624-y.

12.

Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies.

Rizzolio S, Cagnoni G, Battistini C, Bonelli S, Isella C, Van Ginderachter JA, Bernards R, Di Nicolantonio F, Giordano S, Tamagnone L.

J Clin Invest. 2018 Aug 31;128(9):3976-3990. doi: 10.1172/JCI99257. Epub 2018 Aug 13.

13.

High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis.

Avanzato D, Pupo E, Ducano N, Isella C, Bertalot G, Luise C, Pece S, Bruna A, Rueda OM, Caldas C, Di Fiore PP, Sapino A, Lanzetti L.

Cancer Res. 2018 Jul 1;78(13):3432-3444. doi: 10.1158/0008-5472.CAN-17-3018. Epub 2018 Apr 24.

14.

Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts.

Corso S, Cargnelutti M, Durando S, Menegon S, Apicella M, Migliore C, Capeloa T, Ughetto S, Isella C, Medico E, Bertotti A, Sassi F, Sarotto I, Casorzo L, Pisacane A, Mangioni M, Sottile A, Degiuli M, Fumagalli U, Sgroi G, Molfino S, De Manzoni G, Rosati R, De Simone M, Marrelli D, Saragoni L, Rausei S, Pallabazzer G, Roviello F, Cassoni P, Sapino A, Bass A, Giordano S.

Neoplasia. 2018 May;20(5):443-455. doi: 10.1016/j.neo.2018.02.003. Epub 2018 Mar 23.

15.

The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer.

Forsythe N, Refaat A, Javadi A, Khawaja H, Weir JA, Emam H, Allen WL, Burkamp F, Popovici V, Jithesh PV, Isella C, Labonte MJ, Mills IG, Johnston PG, Van Schaeybroeck S.

Mol Cancer Ther. 2018 Jun;17(6):1280-1290. doi: 10.1158/1535-7163.MCT-17-0603. Epub 2018 Feb 26.

16.

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies.

Alderdice M, Richman SD, Gollins S, Stewart JP, Hurt C, Adams R, McCorry AM, Roddy AC, Vimalachandran D, Isella C, Medico E, Maughan T, McArt DG, Lawler M, Dunne PD.

J Pathol. 2018 May;245(1):19-28. doi: 10.1002/path.5051. Epub 2018 Mar 25.

17.

A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.

Luraghi P, Bigatto V, Cipriano E, Reato G, Orzan F, Sassi F, De Bacco F, Isella C, Bellomo SE, Medico E, Comoglio PM, Bertotti A, Trusolino L, Boccaccio C.

Clin Cancer Res. 2018 Feb 15;24(4):807-820. doi: 10.1158/1078-0432.CCR-17-2151. Epub 2017 Oct 3.

18.

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.

Isella C, Brundu F, Bellomo SE, Galimi F, Zanella E, Porporato R, Petti C, Fiori A, Orzan F, Senetta R, Boccaccio C, Ficarra E, Marchionni L, Trusolino L, Medico E, Bertotti A.

Nat Commun. 2017 May 31;8:15107. doi: 10.1038/ncomms15107.

19.

Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer.

Picco G, Petti C, Sassi F, Grillone K, Migliardi G, Rossi T, Isella C, Di Nicolantonio F, Sarotto I, Sapino A, Bardelli A, Trusolino L, Bertotti A, Medico E.

J Natl Cancer Inst. 2016 Oct 22;109(2). pii: djw209. Print 2017 Feb.

20.

Corrigendum: Stromal contribution to the colorectal cancer transcriptome.

Isella C, Terrasi A, Bellomo SE, Petti C, Galatola G, Muratore A, Mellano A, Senetta R, Cassenti A, Sonetto C, Inghirami G, Trusolino L, Fekete Z, De Ridder M, Cassoni P, Storme G, Bertotti A, Medico E.

Nat Genet. 2016 Sep 28;48(10):1296. doi: 10.1038/ng1016-1296d. No abstract available.

PMID:
27681291
21.

[A MULTIDISCIPLINARY BIOPSYCHOSOCIAL INTEGRATED APPROACH IN ORGANIZATION OF REHABILITATIVE ACTIVITY IN NURSING HOMES (RSA)].

Panella L, Piccioni D, Borcescu L, Isella C, Callegari C.

G Ital Med Lav Ergon. 2015 Oct-Dec;37(4):255-9. Italian.

PMID:
26934811
22.

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Medico E, Russo M, Picco G, Cancelliere C, Valtorta E, Corti G, Buscarino M, Isella C, Lamba S, Martinoglio B, Veronese S, Siena S, Sartore-Bianchi A, Beccuti M, Mottolese M, Linnebacher M, Cordero F, Di Nicolantonio F, Bardelli A.

Nat Commun. 2015 Apr 30;6:7002. doi: 10.1038/ncomms8002.

23.

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis.

Ling H, Pickard K, Ivan C, Isella C, Ikuo M, Mitter R, Spizzo R, Bullock M, Braicu C, Pileczki V, Vincent K, Pichler M, Stiegelbauer V, Hoefler G, Almeida MI, Hsiao A, Zhang X, Primrose J, Packham G, Liu K, Bojja K, Gafà R, Xiao L, Rossi S, Song JH, Vannini I, Fanini F, Kopetz S, Zweidler-McKay P, Wang X, Ionescu C, Irimie A, Fabbri M, Lanza G, Hamilton SR, Berindan-Neagoe I, Medico E, Mirnezami A, Calin GA, Nicoloso MS.

Gut. 2016 Jun;65(6):977-989. doi: 10.1136/gutjnl-2015-309372. Epub 2015 Mar 24.

24.

Stromal contribution to the colorectal cancer transcriptome.

Isella C, Terrasi A, Bellomo SE, Petti C, Galatola G, Muratore A, Mellano A, Senetta R, Cassenti A, Sonetto C, Inghirami G, Trusolino L, Fekete Z, De Ridder M, Cassoni P, Storme G, Bertotti A, Medico E.

Nat Genet. 2015 Apr;47(4):312-9. doi: 10.1038/ng.3224. Epub 2015 Feb 23. Erratum in: Nat Genet. 2016 Sep 28;48(10):1296.

25.

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

Zanella ER, Galimi F, Sassi F, Migliardi G, Cottino F, Leto SM, Lupo B, Erriquez J, Isella C, Comoglio PM, Medico E, Tejpar S, Budinská E, Trusolino L, Bertotti A.

Sci Transl Med. 2015 Jan 28;7(272):272ra12. doi: 10.1126/scitranslmed.3010445.

26.

MicroRNA-mRNA interactions underlying colorectal cancer molecular subtypes.

Cantini L, Isella C, Petti C, Picco G, Chiola S, Ficarra E, Caselle M, Medico E.

Nat Commun. 2015 Nov 17;6:8878. doi: 10.1038/ncomms9878.

27.

Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.

Petti C, Picco G, Martelli ML, Trisolini E, Bucci E, Perera T, Isella C, Medico E.

Oncotarget. 2015 Jan 1;6(1):221-33.

28.

TNF-α promotes invasive growth through the MET signaling pathway.

Bigatto V, De Bacco F, Casanova E, Reato G, Lanzetti L, Isella C, Sarotto I, Comoglio PM, Boccaccio C.

Mol Oncol. 2015 Feb;9(2):377-88. doi: 10.1016/j.molonc.2014.09.002. Epub 2014 Sep 26.

29.

Primary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signature.

D'Amico L, Patanè S, Grange C, Bussolati B, Isella C, Fontani L, Godio L, Cilli M, D'Amelio P, Isaia G, Medico E, Ferracini R, Roato I.

Br J Cancer. 2013 Jun 25;108(12):2525-36. doi: 10.1038/bjc.2013.271.

30.

MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases.

Isella C, Mellano A, Galimi F, Petti C, Capussotti L, De Simone M, Bertotti A, Medico E, Muratore A.

Ann Surg. 2013 Jun;257(6):1089-95. doi: 10.1097/SLA.0b013e31828f96bc.

31.

The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β.

Sessa R, Seano G, di Blasio L, Gagliardi PA, Isella C, Medico E, Cotelli F, Bussolino F, Primo L.

Biochim Biophys Acta. 2012 Oct;1823(10):1925-35. doi: 10.1016/j.bbamcr.2012.07.011. Epub 2012 Jul 31.

32.

High-throughput molecular analysis from leftover of fine needle aspiration cytology of mammographically detected breast cancer.

Annaratone L, Marchiò C, Renzulli T, Castellano I, Cantarella D, Isella C, Macrì L, Mariscotti G, Balmativola D, Cantanna E, Deambrogio C, Pietribiasi F, Arisio R, Schmitt F, Medico E, Sapino A.

Transl Oncol. 2012 Jun;5(3):180-9. Epub 2012 Jun 1.

33.

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer.

Bertotti A, Migliardi G, Galimi F, Sassi F, Torti D, Isella C, Corà D, Di Nicolantonio F, Buscarino M, Petti C, Ribero D, Russolillo N, Muratore A, Massucco P, Pisacane A, Molinaro L, Valtorta E, Sartore-Bianchi A, Risio M, Capussotti L, Gambacorta M, Siena S, Medico E, Sapino A, Marsoni S, Comoglio PM, Bardelli A, Trusolino L.

Cancer Discov. 2011 Nov;1(6):508-23. doi: 10.1158/2159-8290.CD-11-0109. Epub 2011 Sep 2.

34.

Transcriptional hallmarks of Noonan syndrome and Noonan-like syndrome with loose anagen hair.

Ferrero GB, Picco G, Baldassarre G, Flex E, Isella C, Cantarella D, Corà D, Chiesa N, Crescenzio N, Timeus F, Merla G, Mazzanti L, Zampino G, Rossi C, Silengo M, Tartaglia M, Medico E.

Hum Mutat. 2012 Apr;33(4):703-9. doi: 10.1002/humu.22026. Epub 2012 Feb 14.

35.

MiR-1 downregulation cooperates with MACC1 in promoting MET overexpression in human colon cancer.

Migliore C, Martin V, Leoni VP, Restivo A, Atzori L, Petrelli A, Isella C, Zorcolo L, Sarotto I, Casula G, Comoglio PM, Columbano A, Giordano S.

Clin Cancer Res. 2012 Feb 1;18(3):737-47. doi: 10.1158/1078-0432.CCR-11-1699. Epub 2011 Dec 16.

36.

Mulcom: a multiple comparison statistical test for microarray data in Bioconductor.

Isella C, Renzulli T, Corà D, Medico E.

BMC Bioinformatics. 2011 Sep 28;12:382. doi: 10.1186/1471-2105-12-382.

37.

Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations.

Galimi F, Torti D, Sassi F, Isella C, Corà D, Gastaldi S, Ribero D, Muratore A, Massucco P, Siatis D, Paraluppi G, Gonella F, Maione F, Pisacane A, David E, Torchio B, Risio M, Salizzoni M, Capussotti L, Perera T, Medico E, Di Renzo MF, Comoglio PM, Trusolino L, Bertotti A.

Clin Cancer Res. 2011 May 15;17(10):3146-56. doi: 10.1158/1078-0432.CCR-10-3377. Epub 2011 Mar 29.

38.

The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer.

Mira A, Isella C, Renzulli T, Cantarella D, Martelli ML, Medico E.

Oncogene. 2009 Dec 17;28(50):4444-55. doi: 10.1038/onc.2009.296. Epub 2009 Oct 19.

39.

The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells.

Tardito S, Isella C, Medico E, Marchiò L, Bevilacqua E, Hatzoglou M, Bussolati O, Franchi-Gazzola R.

J Biol Chem. 2009 Sep 4;284(36):24306-19. doi: 10.1074/jbc.M109.026583. Epub 2009 Jun 26.

40.

A molecular signature for Epithelial to Mesenchymal transition in a human colon cancer cell system is revealed by large-scale microarray analysis.

Joyce T, Cantarella D, Isella C, Medico E, Pintzas A.

Clin Exp Metastasis. 2009;26(6):569-87. doi: 10.1007/s10585-009-9256-9. Epub 2009 Apr 2.

PMID:
19340593
41.

Exploiting orthologue diversity for systematic detection of gain-of-function phenotypes.

Martelli ML, Isella C, Mira A, Fu L, Cantarella D, Medico E.

BMC Genomics. 2008 May 29;9:254. doi: 10.1186/1471-2164-9-254.

42.

Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers.

Arena S, Isella C, Martini M, de Marco A, Medico E, Bardelli A.

Cancer Res. 2007 Sep 15;67(18):8468-76.

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