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Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.

Science. 2014 Sep 19;345(6203):1509-12. doi: 10.1126/science.1256337.


Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling.

Louria-Hayon I, Frelin C, Ruston J, Gish G, Jin J, Kofler MM, Lambert JP, Adissu HA, Milyavsky M, Herrington R, Minden MD, Dick JE, Gingras AC, Iscove NN, Pawson T.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20599-604. doi: 10.1073/pnas.1319665110. Epub 2013 Dec 2.


Self-renewal as a therapeutic target in human colorectal cancer.

Kreso A, van Galen P, Pedley NM, Lima-Fernandes E, Frelin C, Davis T, Cao L, Baiazitov R, Du W, Sydorenko N, Moon YC, Gibson L, Wang Y, Leung C, Iscove NN, Arrowsmith CH, Szentgyorgyi E, Gallinger S, Dick JE, O'Brien CA.

Nat Med. 2014 Jan;20(1):29-36. doi: 10.1038/nm.3418. Epub 2013 Dec 1.


Retinoic acid signaling is essential for embryonic hematopoietic stem cell development.

Chanda B, Ditadi A, Iscove NN, Keller G.

Cell. 2013 Sep 26;155(1):215-27. doi: 10.1016/j.cell.2013.08.055.


GATA-3 regulates the self-renewal of long-term hematopoietic stem cells.

Frelin C, Herrington R, Janmohamed S, Barbara M, Tran G, Paige CJ, Benveniste P, Zuñiga-Pflücker JC, Souabni A, Busslinger M, Iscove NN.

Nat Immunol. 2013 Oct;14(10):1037-44. doi: 10.1038/ni.2692. Epub 2013 Aug 25.


Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency.

Berger A, Frelin C, Shah DK, Benveniste P, Herrington R, Gerard NP, Zúñiga-Pflücker JC, Iscove NN, Paige CJ.

PLoS One. 2013;8(3):e58787. doi: 10.1371/journal.pone.0058787. Epub 2013 Mar 14.


Hoxa9 transduction induces hematopoietic stem and progenitor cell activity through direct down-regulation of geminin protein.

Ohno Y, Yasunaga S, Janmohamed S, Ohtsubo M, Saeki K, Kurogi T, Mihara K, Iscove NN, Takihara Y.

PLoS One. 2013;8(1):e53161. doi: 10.1371/journal.pone.0053161. Epub 2013 Jan 11.


Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.

Ting SB, Deneault E, Hope K, Cellot S, Chagraoui J, Mayotte N, Dorn JF, Laverdure JP, Harvey M, Hawkins ED, Russell SM, Maddox PS, Iscove NN, Sauvageau G.

Blood. 2012 Mar 15;119(11):2510-22. doi: 10.1182/blood-2011-11-393272. Epub 2011 Dec 14.


Identification of a role for the nuclear receptor EAR-2 in the maintenance of clonogenic status within the leukemia cell hierarchy.

Ichim CV, Atkins HL, Iscove NN, Wells RA.

Leukemia. 2011 Nov;25(11):1687-96. doi: 10.1038/leu.2011.137. Epub 2011 Jun 3.


Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.

Chan G, Cheung LS, Yang W, Milyavsky M, Sanders AD, Gu S, Hong WX, Liu AX, Wang X, Barbara M, Sharma T, Gavin J, Kutok JL, Iscove NN, Shannon KM, Dick JE, Neel BG, Braun BS.

Blood. 2011 Apr 21;117(16):4253-61. doi: 10.1182/blood-2010-11-319517. Epub 2011 Feb 25.


Differential expression of the BCR gene in sequential stages of murine hematopoietic hierarchy.

Khoury H, Barbara M, Iscove NN, Minden MD.

Leukemia. 2011 Apr;25(4):711-3. doi: 10.1038/leu.2010.303. Epub 2011 Jan 14. No abstract available.


Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development.

Berger A, Benveniste P, Corfe SA, Tran AH, Barbara M, Wakeham A, Mak TW, Iscove NN, Paige CJ.

Blood. 2010 Nov 11;116(19):3792-801. doi: 10.1182/blood-2010-06-291062. Epub 2010 Jul 26.


An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity.

Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN, Sauvageau G.

Cell Stem Cell. 2010 Jul 2;7(1):101-13. doi: 10.1016/j.stem.2010.06.007.


Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential.

Benveniste P, Frelin C, Janmohamed S, Barbara M, Herrington R, Hyam D, Iscove NN.

Cell Stem Cell. 2010 Jan 8;6(1):48-58. doi: 10.1016/j.stem.2009.11.014.


Scl regulates the quiescence and the long-term competence of hematopoietic stem cells.

Lacombe J, Herblot S, Rojas-Sutterlin S, Haman A, Barakat S, Iscove NN, Sauvageau G, Hoang T.

Blood. 2010 Jan 28;115(4):792-803. doi: 10.1182/blood-2009-01-201384. Epub 2009 Oct 22.


Identification of gene 3' ends by automated EST cluster analysis.

Muro EM, Herrington R, Janmohamed S, Frelin C, Andrade-Navarro MA, Iscove NN.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20286-90. doi: 10.1073/pnas.0807813105. Epub 2008 Dec 18.


Complementary and independent function for Hoxb4 and Bmi1 in HSC activity.

Faubert A, Chagraoui J, Mayotte N, Fréchette M, Iscove NN, Humphries RK, Sauvageau G.

Cold Spring Harb Symp Quant Biol. 2008;73:555-64. doi: 10.1101/sqb.2008.73.030. Epub 2008 Nov 6.


Microcytosis in ank/ank mice and the role of ANKH in promoting erythroid differentiation.

Wang J, Wang C, Tsui HW, Las Heras F, Cheng EY, Iscove NN, Chiu B, Inman RD, Pritzker KP, Tsui FW.

Exp Cell Res. 2007 Dec 10;313(20):4120-9. Epub 2007 Sep 20.


OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1.

Lin YW, Deveney R, Barbara M, Iscove NN, Nimer SD, Slape C, Aplan PD.

Cancer Res. 2005 Aug 15;65(16):7151-8.


In vitro and in vivo expansion of hematopoietic stem cells.

Sauvageau G, Iscove NN, Humphries RK.

Oncogene. 2004 Sep 20;23(43):7223-32. Review.


A novel role for STAT1 in regulating murine erythropoiesis: deletion of STAT1 results in overall reduction of erythroid progenitors and alters their distribution.

Halupa A, Bailey ML, Huang K, Iscove NN, Levy DE, Barber DL.

Blood. 2005 Jan 15;105(2):552-61. Epub 2004 Jun 22.


Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.

Levantini E, Giorgetti A, Cerisoli F, Traggiai E, Guidi A, Martin R, Acampora D, Aplan PD, Keller G, Simeone A, Iscove NN, Hoang T, Magli MC.

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10299-303. Epub 2003 Aug 21.


Hematopoietic stem cells engraft in mice with absolute efficiency.

Benveniste P, Cantin C, Hyam D, Iscove NN.

Nat Immunol. 2003 Jul;4(7):708-13. Epub 2003 May 25.


Representation is faithfully preserved in global cDNA amplified exponentially from sub-picogram quantities of mRNA.

Iscove NN, Barbara M, Gu M, Gibson M, Modi C, Winegarden N.

Nat Biotechnol. 2002 Sep;20(9):940-3. Epub 2002 Aug 12.


Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations.

Morshead CM, Benveniste P, Iscove NN, van der Kooy D.

Nat Med. 2002 Mar;8(3):268-73.


Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells.

Boehmelt G, Wakeham A, Elia A, Sasaki T, Plyte S, Potter J, Yang Y, Tsang E, Ruland J, Iscove NN, Dennis JW, Mak TW.

EMBO J. 2000 Oct 2;19(19):5092-104.


Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis.

Singh N, Phillips RA, Iscove NN, Egan SE.

Exp Hematol. 2000 May;28(5):527-34.


Cloning and characterization of the murine glucosamine-6-phosphate acetyltransferase EMeg32. Differential expression and intracellular membrane association.

Boehmelt G, Fialka I, Brothers G, McGinley MD, Patterson SD, Mo R, Hui CC, Chung S, Huber LA, Mak TW, Iscove NN.

J Biol Chem. 2000 Apr 28;275(17):12821-32.


Gene expression in individual cells: analysis using global single cell reverse transcription polymerase chain reaction (GSC RT-PCR).

Brail LH, Jang A, Billia F, Iscove NN, Klamut HJ, Hill RP.

Mutat Res. 1999 Aug;406(2-4):45-54.


Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells.

Fernandes MJ, Finnegan AA, Siracusa LD, Brenner C, Iscove NN, Calabretta B.

Cancer Res. 1999 Jun 1;59(11):2709-17.


Impaired granulocytic differentiation in vitro in hematopoietic cells lacking retinoic acid receptors alpha1 and gamma.

Labrecque J, Allan D, Chambon P, Iscove NN, Lohnes D, Hoang T.

Blood. 1998 Jul 15;92(2):607-15.


Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy.

Claudio JO, Liew CC, Dempsey AA, Cukerman E, Stewart AK, Na E, Atkins HL, Iscove NN, Hawley RG.

Genomics. 1998 May 15;50(1):44-52.


SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.

Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T.

J Biol Chem. 1997 Oct 31;272(44):27804-11.


Expression mapping of adhesion receptor genes during differentiation of individual hematopoietic precursors.

Voura EB, Billia F, Iscove NN, Hawley RG.

Exp Hematol. 1997 Oct;25(11):1172-9.


Cell-specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo.

Govoni G, Gauthier S, Billia F, Iscove NN, Gros P.

J Leukoc Biol. 1997 Aug;62(2):277-86.


Expression of the Id family helix-loop-helix regulators during growth and development in the hematopoietic system.

Cooper CL, Brady G, Bilia F, Iscove NN, Quesenberry PJ.

Blood. 1997 May 1;89(9):3155-65.


HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.

Kiefer F, Tibbles LA, Anafi M, Janssen A, Zanke BW, Lassam N, Pawson T, Woodgett JR, Iscove NN.

EMBO J. 1996 Dec 16;15(24):7013-25.


Expression of basic helix-loop-helix transcription factors in explant hematopoietic progenitors.

Quesenberry PJ, Iscove NN, Cooper C, Brady G, Newburger PE, Stein GS, Stein JS, Reddy GP, Pearson-White S.

J Cell Biochem. 1996 Jun 1;61(3):478-88.


Expression of rhombotin 2 in normal and leukaemic haemopoietic cells.

Dong WF, Billia F, Atkins HL, Iscove NN, Minden MD.

Br J Haematol. 1996 May;93(2):280-6.


Opposing effects of the basic helix-loop-helix transcription factor SCL on erythroid and monocytic differentiation.

Hoang T, Paradis E, Brady G, Billia F, Nakahara K, Iscove NN, Kirsch IR.

Blood. 1996 Jan 1;87(1):102-11.


The LSP1 gene is expressed in cultured normal and transformed mouse macrophages.

Jongstra J, Ittel ME, Iscove NN, Brady G.

Mol Immunol. 1994 Oct;31(15):1125-31.


Stromal cell independent growth of bipotent B cell--macrophage precursors from murine fetal liver.

Kee BL, Cumano A, Iscove NN, Paige CJ.

Int Immunol. 1994 Mar;6(3):401-7.


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