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Items: 1 to 50 of 61

1.

Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures.

Hammelmann V, Stieglitz MS, Hülle H, Le Meur K, Kass J, Brümmer M, Gruner C, Rötzer RD, Fenske S, Hartmann J, Zott B, Lüthi A, Spahn S, Moser M, Isbrandt D, Ludwig A, Konnerth A, Wahl-Schott C, Biel M.

JCI Insight. 2019 May 2;4(9). pii: 126418. doi: 10.1172/jci.insight.126418. eCollection 2019 May 2.

2.

The Na+/H+ Exchanger Nhe1 Modulates Network Excitability via GABA Release.

Bocker HT, Heinrich T, Liebmann L, Hennings JC, Seemann E, Gerth M, Jakovcevski I, Preobraschenski J, Kessels MM, Westermann M, Isbrandt D, Jahn R, Qualmann B, Hübner CA.

Cereb Cortex. 2018 Dec 12. doi: 10.1093/cercor/bhy308. [Epub ahead of print]

PMID:
30541023
3.

Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks.

Gao X, Castro-Gomez S, Grendel J, Graf S, Süsens U, Binkle L, Mensching D, Isbrandt D, Kuhl D, Ohana O.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12531-12536. doi: 10.1073/pnas.1810125115. Epub 2018 Nov 15.

4.

A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism.

Stockebrand M, Sasani A, Das D, Hornig S, Hermans-Borgmeyer I, Lake HA, Isbrandt D, Lygate CA, Heerschap A, Neu A, Choe CU.

Front Physiol. 2018 Jun 22;9:773. doi: 10.3389/fphys.2018.00773. eCollection 2018.

5.

Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure.

Reichold M, Klootwijk ED, Reinders J, Otto EA, Milani M, Broeker C, Laing C, Wiesner J, Devi S, Zhou W, Schmitt R, Tegtmeier I, Sterner C, Doellerer H, Renner K, Oefner PJ, Dettmer K, Simbuerger JM, Witzgall R, Stanescu HC, Dumitriu S, Iancu D, Patel V, Mozere M, Tekman M, Jaureguiberry G, Issler N, Kesselheim A, Walsh SB, Gale DP, Howie AJ, Martins JR, Hall AM, Kasgharian M, O'Brien K, Ferreira CR, Atwal PS, Jain M, Hammers A, Charles-Edwards G, Choe CU, Isbrandt D, Cebrian-Serrano A, Davies B, Sandford RN, Pugh C, Konecki DS, Povey S, Bockenhauer D, Lichter-Konecki U, Gahl WA, Unwin RJ, Warth R, Kleta R.

J Am Soc Nephrol. 2018 Jul;29(7):1849-1858. doi: 10.1681/ASN.2017111179. Epub 2018 Apr 13.

6.

Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine.

Faller KME, Atzler D, McAndrew DJ, Zervou S, Whittington HJ, Simon JN, Aksentijevic D, Ten Hove M, Choe CU, Isbrandt D, Casadei B, Schneider JE, Neubauer S, Lygate CA.

Cardiovasc Res. 2018 Mar 1;114(3):417-430. doi: 10.1093/cvr/cvx242.

7.

Disturbances of novel object exploration and recognition in a chronic ketamine mouse model of schizophrenia.

Hauser MJ, Isbrandt D, Roeper J.

Behav Brain Res. 2017 Aug 14;332:316-326. doi: 10.1016/j.bbr.2017.06.013. Epub 2017 Jun 17.

PMID:
28634108
8.

Early-life exposure to caffeine affects the construction and activity of cortical networks in mice.

Fazeli W, Zappettini S, Marguet SL, Grendel J, Esclapez M, Bernard C, Isbrandt D.

Exp Neurol. 2017 Sep;295:88-103. doi: 10.1016/j.expneurol.2017.05.013. Epub 2017 May 30.

PMID:
28576568
9.

GABAergic Transmission during Brain Development: Multiple Effects at Multiple Stages.

Kirmse K, Hübner CA, Isbrandt D, Witte OW, Holthoff K.

Neuroscientist. 2018 Feb;24(1):36-53. doi: 10.1177/1073858417701382. Epub 2017 Apr 5. Review.

PMID:
28378628
10.

A mechanistic link between glia and neuronal excitability in acute neuroinflammation.

Isbrandt D.

J Physiol. 2017 Feb 1;595(3):603-604. doi: 10.1113/JP273252. No abstract available.

11.

Activity of NaV1.2 promotes neurodegeneration in an animal model of multiple sclerosis.

Schattling B, Fazeli W, Engeland B, Liu Y, Lerche H, Isbrandt D, Friese MA.

JCI Insight. 2016 Nov 17;1(19):e89810. doi: 10.1172/jci.insight.89810.

12.

Transcriptomic and metabolic analyses reveal salvage pathways in creatine-deficient AGAT(-/-) mice.

Stockebrand M, Nejad AS, Neu A, Kharbanda KK, Sauter K, Schillemeit S, Isbrandt D, Choe CU.

Amino Acids. 2016 Aug;48(8):2025-39. doi: 10.1007/s00726-016-2202-7. Epub 2016 Mar 3.

PMID:
26940723
13.

Treatment during a vulnerable developmental period rescues a genetic epilepsy.

Marguet SL, Le-Schulte VT, Merseburg A, Neu A, Eichler R, Jakovcevski I, Ivanov A, Hanganu-Opatz IL, Bernard C, Morellini F, Isbrandt D.

Nat Med. 2015 Dec;21(12):1436-44. doi: 10.1038/nm.3987. Epub 2015 Nov 23.

PMID:
26594844
14.

Homoarginine supplementation improves blood glucose in diet-induced obese mice.

Stockebrand M, Hornig S, Neu A, Atzler D, Cordts K, Böger RH, Isbrandt D, Schwedhelm E, Choe CU.

Amino Acids. 2015 Sep;47(9):1921-9. doi: 10.1007/s00726-015-2022-1. Epub 2015 Jun 16.

PMID:
26077714
15.

Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation.

Mesirca P, Alig J, Torrente AG, Müller JC, Marger L, Rollin A, Marquilly C, Vincent A, Dubel S, Bidaud I, Fernandez A, Seniuk A, Engeland B, Singh J, Miquerol L, Ehmke H, Eschenhagen T, Nargeot J, Wickman K, Isbrandt D, Mangoni ME.

Nat Commun. 2014 Aug 21;5:4664. doi: 10.1038/ncomms5664.

16.

Stable isotope dilution microquantification of creatine metabolites in plasma, whole blood and dried blood spots for pharmacological studies in mouse models of creatine deficiency.

Tran C, Yazdanpanah M, Kyriakopoulou L, Levandovskiy V, Zahid H, Naufer A, Isbrandt D, Schulze A.

Clin Chim Acta. 2014 Sep 25;436:160-8. doi: 10.1016/j.cca.2014.05.007. Epub 2014 May 28.

PMID:
24877651
17.

Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies.

Choe CU, Atzler D, Wild PS, Carter AM, Böger RH, Ojeda F, Simova O, Stockebrand M, Lackner K, Nabuurs C, Marescau B, Streichert T, Müller C, Lüneburg N, De Deyn PP, Benndorf RA, Baldus S, Gerloff C, Blankenberg S, Heerschap A, Grant PJ, Magnus T, Zeller T, Isbrandt D, Schwedhelm E.

Circulation. 2013 Sep 24;128(13):1451-61. doi: 10.1161/CIRCULATIONAHA.112.000580. Epub 2013 Sep 4.

PMID:
24004504
18.

Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.

Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P.

J Neurosci. 2013 Aug 7;33(32):12915-28, 12928a. doi: 10.1523/JNEUROSCI.5910-12.2013.

19.

Adenosine receptor antagonists including caffeine alter fetal brain development in mice.

Silva CG, Métin C, Fazeli W, Machado NJ, Darmopil S, Launay PS, Ghestem A, Nesa MP, Bassot E, Szabó E, Baqi Y, Müller CE, Tomé AR, Ivanov A, Isbrandt D, Zilberter Y, Cunha RA, Esclapez M, Bernard C.

Sci Transl Med. 2013 Aug 7;5(197):197ra104. doi: 10.1126/scitranslmed.3006258.

20.

Differential regulation of AMPK activation in leptin- and creatine-deficient mice.

Stockebrand M, Sauter K, Neu A, Isbrandt D, Choe CU.

FASEB J. 2013 Oct;27(10):4147-56. doi: 10.1096/fj.12-225136. Epub 2013 Jun 28.

PMID:
23825223
21.

Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake.

Nabuurs CI, Choe CU, Veltien A, Kan HE, van Loon LJ, Rodenburg RJ, Matschke J, Wieringa B, Kemp GJ, Isbrandt D, Heerschap A.

J Physiol. 2013 Jan 15;591(2):571-92. doi: 10.1113/jphysiol.2012.241760. Epub 2012 Nov 5.

22.

L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome.

Choe CU, Nabuurs C, Stockebrand MC, Neu A, Nunes P, Morellini F, Sauter K, Schillemeit S, Hermans-Borgmeyer I, Marescau B, Heerschap A, Isbrandt D.

Hum Mol Genet. 2013 Jan 1;22(1):110-23. doi: 10.1093/hmg/dds407. Epub 2012 Oct 1. Erratum in: Hum Mol Genet. 2013 Oct 1;22(19):4030.

PMID:
23026748
23.

Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.

Marger L, Mesirca P, Alig J, Torrente A, Dubel S, Engeland B, Kanani S, Fontanaud P, Striessnig J, Shin HS, Isbrandt D, Ehmke H, Nargeot J, Mangoni ME.

Channels (Austin). 2011 May-Jun;5(3):251-61. Epub 2011 May 1.

24.

Pacemaker activity and ionic currents in mouse atrioventricular node cells.

Marger L, Mesirca P, Alig J, Torrente A, Dubel S, Engeland B, Kanani S, Fontanaud P, Striessnig J, Shin HS, Isbrandt D, Ehmke H, Nargeot J, Mangoni ME.

Channels (Austin). 2011 May-Jun;5(3):241-50. Epub 2011 May 1.

25.

A homozygous SCN5A mutation in a severe, recessive type of cardiac conduction disease.

Neu A, Eiselt M, Paul M, Sauter K, Stallmeyer B, Isbrandt D, Schulze-Bahr E.

Hum Mutat. 2010 Aug;31(8):E1609-21. doi: 10.1002/humu.21302.

PMID:
20564468
26.

Control of heart rate by cAMP sensitivity of HCN channels.

Alig J, Marger L, Mesirca P, Ehmke H, Mangoni ME, Isbrandt D.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12189-94. doi: 10.1073/pnas.0810332106. Epub 2009 Jul 1.

27.

In vivo magnetic resonance spectroscopy of transgenic mice with altered expression of guanidinoacetate methyltransferase and creatine kinase isoenzymes.

Heerschap A, Kan HE, Nabuurs CI, Renema WK, Isbrandt D, Wieringa B.

Subcell Biochem. 2007;46:119-48. Review.

PMID:
18652075
28.

Creatine uptake in mouse hearts with genetically altered creatine levels.

ten Hove M, Makinen K, Sebag-Montefiore L, Hunyor I, Fischer A, Wallis J, Isbrandt D, Lygate C, Neubauer S.

J Mol Cell Cardiol. 2008 Sep;45(3):453-9. doi: 10.1016/j.yjmcc.2008.05.023. Epub 2008 Jun 10.

29.

Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study.

Schneider JE, Stork LA, Bell JT, ten Hove M, Isbrandt D, Clarke K, Watkins H, Lygate CA, Neubauer S.

J Cardiovasc Magn Reson. 2008 Feb 6;10:9. doi: 10.1186/1532-429X-10-9.

30.

Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy.

Kan HE, Meeuwissen E, van Asten JJ, Veltien A, Isbrandt D, Heerschap A.

J Appl Physiol (1985). 2007 Jun;102(6):2121-7. Epub 2007 Mar 8.

31.

C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.

Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D.

Hum Mol Genet. 2006 Oct 1;15(19):2888-902. Epub 2006 Aug 21.

PMID:
16923798
32.

Contribution of N- and C-terminal Kv4.2 channel domains to KChIP interaction [corrected].

Callsen B, Isbrandt D, Sauter K, Hartmann LS, Pongs O, Bähring R.

J Physiol. 2005 Oct 15;568(Pt 2):397-412. Epub 2005 Aug 11. Erratum in: J Physiol. 2005 Nov 1;568(Pt 3):1067.

33.

Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice.

ten Hove M, Lygate CA, Fischer A, Schneider JE, Sang AE, Hulbert K, Sebag-Montefiore L, Watkins H, Clarke K, Isbrandt D, Wallis J, Neubauer S.

Circulation. 2005 May 17;111(19):2477-85. Epub 2005 May 9.

PMID:
15883212
34.

Biochemical and behavioural phenotyping of a mouse model for GAMT deficiency.

Torremans A, Marescau B, Possemiers I, Van Dam D, D'Hooge R, Isbrandt D, De Deyn PP.

J Neurol Sci. 2005 Apr 15;231(1-2):49-55.

PMID:
15792821
35.

Lower force and impaired performance during high-intensity electrical stimulation in skeletal muscle of GAMT-deficient knockout mice.

Kan HE, Buse-Pot TE, Peco R, Isbrandt D, Heerschap A, de Haan A.

Am J Physiol Cell Physiol. 2005 Jul;289(1):C113-9. Epub 2005 Mar 2.

36.

Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior.

Peters HC, Hu H, Pongs O, Storm JF, Isbrandt D.

Nat Neurosci. 2005 Jan;8(1):51-60. Epub 2004 Dec 19.

PMID:
15608631
37.

In vivo cardiac 1H-MRS in the mouse.

Schneider JE, Tyler DJ, ten Hove M, Sang AE, Cassidy PJ, Fischer A, Wallis J, Sebag-Montefiore LM, Watkins H, Isbrandt D, Clarke K, Neubauer S.

Magn Reson Med. 2004 Nov;52(5):1029-35.

38.

Mutations in classical late infantile neuronal ceroid lipofuscinosis disrupt transport of tripeptidyl-peptidase I to lysosomes.

Steinfeld R, Steinke HB, Isbrandt D, Kohlschütter A, Gärtner J.

Hum Mol Genet. 2004 Oct 15;13(20):2483-91. Epub 2004 Aug 18.

PMID:
15317752
39.
40.

Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency.

Schmidt A, Marescau B, Boehm EA, Renema WK, Peco R, Das A, Steinfeld R, Chan S, Wallis J, Davidoff M, Ullrich K, Waldschütz R, Heerschap A, De Deyn PP, Neubauer S, Isbrandt D.

Hum Mol Genet. 2004 May 1;13(9):905-21. Epub 2004 Mar 17.

PMID:
15028668
41.

Effective long-term control of cardiac events with beta-blockers in a family with a common LQT1 mutation.

Wedekind H, Schwarz M, Hauenschild S, Djonlagic H, Haverkamp W, Breithardt G, Wülfing T, Pongs O, Isbrandt D, Schulze-Bahr E.

Clin Genet. 2004 Mar;65(3):233-41.

PMID:
14756674
42.

Biophysical properties of Kv3.1 channels in SH-SY5Y human neuroblastoma cells.

Friederich P, Dilger JP, Isbrandt D, Sauter K, Pongs O, Urban BW.

Receptors Channels. 2003;9(6):387-96.

PMID:
14698966
43.

N-type inactivation features of Kv4.2 channel gating.

Gebauer M, Isbrandt D, Sauter K, Callsen B, Nolting A, Pongs O, Bähring R.

Biophys J. 2004 Jan;86(1 Pt 1):210-23.

44.

Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A.

Friederich P, Solth A, Schillemeit S, Isbrandt D.

Br J Anaesth. 2004 Jan;92(1):93-101.

45.

MR spectroscopy of muscle and brain in guanidinoacetate methyltransferase (GAMT)-deficient mice: validation of an animal model to study creatine deficiency.

Renema WK, Schmidt A, van Asten JJ, Oerlemans F, Ullrich K, Wieringa B, Isbrandt D, Heerschap A.

Magn Reson Med. 2003 Nov;50(5):936-43.

46.

Pacemaker channel dysfunction in a patient with sinus node disease.

Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D.

J Clin Invest. 2003 May;111(10):1537-45.

47.
48.

Activation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism.

Neu A, Neuhoff H, Trube G, Fehr S, Ullrich K, Roeper J, Isbrandt D.

Neurobiol Dis. 2002 Nov;11(2):298-307.

PMID:
12505422
49.

Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics.

Isbrandt D, Friederich P, Solth A, Haverkamp W, Ebneth A, Borggrefe M, Funke H, Sauter K, Breithardt G, Pongs O, Schulze-Bahr E.

J Mol Med (Berl). 2002 Aug;80(8):524-32. Epub 2002 Jun 28.

PMID:
12185453
50.

A novel long-QT 5 gene mutation in the C-terminus (V109I) is associated with a mild phenotype.

Schulze-Bahr E, Schwarz M, Hauenschild S, Wedekind H, Funke H, Haverkamp W, Breithardt G, Pongs O, Isbrandt D.

J Mol Med (Berl). 2001 Sep;79(9):504-9. Erratum in: J Mol Med 2001 Sep;79(9):547. Hoffman S [corrected to Hauenschild S].

PMID:
11692163

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