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The iron-regulated vacuolar Legionella pneumophila MavN protein is a transition-metal transporter.

Christenson ET, Isaac DT, Yoshida K, Lipo E, Kim JS, Ghirlando R, Isberg RR, Banerjee A.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17775-17785. doi: 10.1073/pnas.1902806116. Epub 2019 Aug 20.


Iron-Sulfur Cluster Repair Contributes to Yersinia pseudotuberculosis Survival within Deep Tissues.

Davis KM, Krupp J, Clark S, Isberg RR.

Infect Immun. 2019 Sep 19;87(10). pii: e00533-19. doi: 10.1128/IAI.00533-19. Print 2019 Oct.


Acinetobacter baumannii: Envelope Determinants That Control Drug Resistance, Virulence, and Surface Variability.

Geisinger E, Huo W, Hernandez-Bird J, Isberg RR.

Annu Rev Microbiol. 2019 Sep 8;73:481-506. doi: 10.1146/annurev-micro-020518-115714. Epub 2019 Jun 14.


The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication.

Geisinger E, Vargas-Cuebas G, Mortman NJ, Syal S, Dai Y, Wainwright EL, Lazinski D, Wood S, Zhu Z, Anthony J, van Opijnen T, Isberg RR.

MBio. 2019 Jun 11;10(3). pii: e01127-19. doi: 10.1128/mBio.01127-19.


New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems.

Fasciano AC, Mecsas J, Isberg RR.

Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.BAI-0013-2019. Review.


Legionella pneumophila translocated translation inhibitors are required for bacterial-induced host cell cycle arrest.

Sol A, Lipo E, de Jesús-Díaz DA, Murphy C, Devereux M, Isberg RR.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3221-3228. doi: 10.1073/pnas.1820093116. Epub 2019 Feb 4.


An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia.

Morgan JM, Lam HN, Delgado J, Luu J, Mohammadi S, Isberg RR, Wang H, Auerbuch V.

Front Cell Infect Microbiol. 2018 Nov 22;8:404. doi: 10.3389/fcimb.2018.00404. eCollection 2018.


One for All, but Not All for One: Social Behavior during Bacterial Diseases.

Davis KM, Isberg RR.

Trends Microbiol. 2019 Jan;27(1):64-74. doi: 10.1016/j.tim.2018.09.001. Epub 2018 Sep 19. Review.


Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses.

Liu BC, Sarhan J, Panda A, Muendlein HI, Ilyukha V, Coers J, Yamamoto M, Isberg RR, Poltorak A.

Cell Rep. 2018 Jul 3;24(1):155-168.e5. doi: 10.1016/j.celrep.2018.06.012.


A global regulatory system links virulence and antibiotic resistance to envelope homeostasis in Acinetobacter baumannii.

Geisinger E, Mortman NJ, Vargas-Cuebas G, Tai AK, Isberg RR.

PLoS Pathog. 2018 May 24;14(5):e1007030. doi: 10.1371/journal.ppat.1007030. eCollection 2018 May.


Host Cell S Phase Restricts Legionella pneumophila Intracellular Replication by Destabilizing the Membrane-Bound Replication Compartment.

de Jesús-Díaz DA, Murphy C, Sol A, Dorer M, Isberg RR.

MBio. 2017 Aug 22;8(4). pii: e02345-16. doi: 10.1128/mBio.02345-16.


Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation.

Mitchell G, Isberg RR.

Cell Host Microbe. 2017 Aug 9;22(2):166-175. doi: 10.1016/j.chom.2017.07.005. Review.


Interplay Between Antibiotic Resistance and Virulence During Disease Promoted by Multidrug-Resistant Bacteria.

Geisinger E, Isberg RR.

J Infect Dis. 2017 Feb 15;215(suppl_1):S9-S17. doi: 10.1093/infdis/jiw402. Review.


A Single Legionella Effector Catalyzes a Multistep Ubiquitination Pathway to Rearrange Tubular Endoplasmic Reticulum for Replication.

Kotewicz KM, Ramabhadran V, Sjoblom N, Vogel JP, Haenssler E, Zhang M, Behringer J, Scheck RA, Isberg RR.

Cell Host Microbe. 2017 Feb 8;21(2):169-181. doi: 10.1016/j.chom.2016.12.007. Epub 2016 Dec 29.


Identification and Characterization of a Candidate Wolbachia pipientis Type IV Effector That Interacts with the Actin Cytoskeleton.

Sheehan KB, Martin M, Lesser CF, Isberg RR, Newton IL.

MBio. 2016 Jul 5;7(4). pii: e00622-16. doi: 10.1128/mBio.00622-16.


Defining heterogeneity within bacterial populations via single cell approaches.

Davis KM, Isberg RR.

Bioessays. 2016 Aug;38(8):782-90. doi: 10.1002/bies.201500121. Epub 2016 Jun 6. Review.


CD8(+) T cells specific to a single Yersinia pseudotuberculosis epitope restrict bacterial replication in the liver but fail to provide sterilizing immunity.

Shen H, Gonzalez-Juarbe N, Blanchette K, Crimmins G, Bergman MA, Isberg RR, Orihuela CJ, Dube PH.

Infect Genet Evol. 2016 Sep;43:289-96. doi: 10.1016/j.meegid.2016.06.008. Epub 2016 Jun 4.


Iron Limitation Triggers Early Egress by the Intracellular Bacterial Pathogen Legionella pneumophila.

O'Connor TJ, Zheng H, VanRheenen SM, Ghosh S, Cianciotto NP, Isberg RR.

Infect Immun. 2016 Jul 21;84(8):2185-2197. doi: 10.1128/IAI.01306-15. Print 2016 Aug.


Inhibition of host cell translation elongation by Legionella pneumophila blocks the host cell unfolded protein response.

Hempstead AD, Isberg RR.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6790-7. doi: 10.1073/pnas.1508716112. Epub 2015 Nov 23.


Robust bioengineered 3D functional human intestinal epithelium.

Chen Y, Lin Y, Davis KM, Wang Q, Rnjak-Kovacina J, Li C, Isberg RR, Kumamoto CA, Mecsas J, Kaplan DL.

Sci Rep. 2015 Sep 16;5:13708. doi: 10.1038/srep13708.


MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth.

Isaac DT, Laguna RK, Valtz N, Isberg RR.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5208-17. doi: 10.1073/pnas.1511389112. Epub 2015 Sep 1.


Endoplasmic Reticulum Tubule Protein Reticulon 4 Associates with the Legionella pneumophila Vacuole and with Translocated Substrate Ceg9.

Haenssler E, Ramabhadran V, Murphy CS, Heidtman MI, Isberg RR.

Infect Immun. 2015 Sep;83(9):3479-89. doi: 10.1128/IAI.00507-15. Epub 2015 Jun 22.


Modulation of the host innate immune and inflammatory response by translocated bacterial proteins.

Asrat S, Davis KM, Isberg RR.

Cell Microbiol. 2015 Jun;17(6):785-795. doi: 10.1111/cmi.12445. Epub 2015 May 4. Review.


Antibiotic modulation of capsular exopolysaccharide and virulence in Acinetobacter baumannii.

Geisinger E, Isberg RR.

PLoS Pathog. 2015 Feb 13;11(2):e1004691. doi: 10.1371/journal.ppat.1004691. eCollection 2015 Feb.


Community behavior and spatial regulation within a bacterial microcolony in deep tissue sites serves to protect against host attack.

Davis KM, Mohammadi S, Isberg RR.

Cell Host Microbe. 2015 Jan 14;17(1):21-31. doi: 10.1016/j.chom.2014.11.008. Epub 2014 Dec 11.


Plague's partners in crime.

Davis KM, Isberg RR.

Immunity. 2014 Sep 18;41(3):347-349. doi: 10.1016/j.immuni.2014.09.003.


Bacterial pathogen manipulation of host membrane trafficking.

Asrat S, de Jesús DA, Hempstead AD, Ramabhadran V, Isberg RR.

Annu Rev Cell Dev Biol. 2014;30:79-109. doi: 10.1146/annurev-cellbio-100913-013439. Epub 2014 Aug 6. Review.


The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines.

Asrat S, Dugan AS, Isberg RR.

PLoS Pathog. 2014 Jul 24;10(7):e1004229. doi: 10.1371/journal.ppat.1004229. eCollection 2014 Jul.


iMAD, a genetic screening strategy for dissecting complex interactions between a pathogen and its host.

O'Connor TJ, Isberg RR.

Nat Protoc. 2014 Aug;9(8):1916-30. doi: 10.1038/nprot.2014.133. Epub 2014 Jul 17.


Maintenance of vacuole integrity by bacterial pathogens.

Creasey EA, Isberg RR.

Curr Opin Microbiol. 2014 Feb;17:46-52. doi: 10.1016/j.mib.2013.11.005. Epub 2013 Dec 12. Review.


Host signal transduction and protein kinases implicated in Legionella infection.

Hempstead AD, Isberg RR.

Curr Top Microbiol Immunol. 2013;376:249-69. doi: 10.1007/82_2013_342. Review.


IcmQ in the Type 4b secretion system contains an NAD+ binding domain.

Farelli JD, Gumbart JC, Akey IV, Hempstead A, Amyot W, Head JF, McKnight CJ, Isberg RR, Akey CW.

Structure. 2013 Aug 6;21(8):1361-73. doi: 10.1016/j.str.2013.05.017. Epub 2013 Jul 11.


Poison domains block transit of translocated substrates via the Legionella pneumophila Icm/Dot system.

Amyot WM, deJesus D, Isberg RR.

Infect Immun. 2013 Sep;81(9):3239-52. doi: 10.1128/IAI.00552-13. Epub 2013 Jun 24. Erratum in: Infect Immun. 2014 Oct;82(10):4436.


QnAs with Ralph R. Isberg.

Isberg RR.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):801. doi: 10.1073/pnas.1221885110. Epub 2013 Jan 7. No abstract available.


Cdc42 interacts with the exocyst complex to promote phagocytosis.

Mohammadi S, Isberg RR.

J Cell Biol. 2013 Jan 7;200(1):81-93. doi: 10.1083/jcb.201204090.


Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen.

O'Connor TJ, Boyd D, Dorer MS, Isberg RR.

Science. 2012 Dec 14;338(6113):1440-4. doi: 10.1126/science.1229556.


Analysis of Legionella infection using RNAi in Drosophila cells.

De Jesús DA, O'Connor TJ, Isberg RR.

Methods Mol Biol. 2013;954:251-64. doi: 10.1007/978-1-62703-161-5_15.


The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation.

Choy A, Dancourt J, Mugo B, O'Connor TJ, Isberg RR, Melia TJ, Roy CR.

Science. 2012 Nov 23;338(6110):1072-6. doi: 10.1126/science.1227026. Epub 2012 Oct 25.


The Legionella pneumophila EnhC protein interferes with immunostimulatory muramyl peptide production to evade innate immunity.

Liu M, Haenssler E, Uehara T, Losick VP, Park JT, Isberg RR.

Cell Host Microbe. 2012 Aug 16;12(2):166-76. doi: 10.1016/j.chom.2012.06.004.


Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes.

Crimmins GT, Mohammadi S, Green ER, Bergman MA, Isberg RR, Mecsas J.

PLoS Pathog. 2012;8(8):e1002828. doi: 10.1371/journal.ppat.1002828. Epub 2012 Aug 2.


Experimental evolution of Legionella pneumophila in mouse macrophages leads to strains with altered determinants of environmental survival.

Ensminger AW, Yassin Y, Miron A, Isberg RR.

PLoS Pathog. 2012;8(5):e1002731. doi: 10.1371/journal.ppat.1002731. Epub 2012 May 31.


Yersinia entry into host cells requires Rab5-dependent dephosphorylation of PI(4,5)P₂ and membrane scission.

Sarantis H, Balkin DM, De Camilli P, Isberg RR, Brumell JH, Grinstein S.

Cell Host Microbe. 2012 Feb 16;11(2):117-28. doi: 10.1016/j.chom.2012.01.010.


The protein SdhA maintains the integrity of the Legionella-containing vacuole.

Creasey EA, Isberg RR.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3481-6. doi: 10.1073/pnas.1121286109. Epub 2012 Jan 30.


Analyzing microbial disease at high resolution: following the fate of the bacterium during infection.

Crimmins GT, Isberg RR.

Curr Opin Microbiol. 2012 Feb;15(1):23-7. doi: 10.1016/j.mib.2011.11.005. Epub 2011 Dec 3. Review.


Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion.

O'Connor TJ, Adepoju Y, Boyd D, Isberg RR.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14733-40. doi: 10.1073/pnas.1111678108. Epub 2011 Aug 22. Erratum in: Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17856.


Control of host cell phosphorylation by legionella pneumophila.

Haenssler E, Isberg RR.

Front Microbiol. 2011 Apr 4;2:64. doi: 10.3389/fmicb.2011.00064. eCollection 2011.


The E Block motif is associated with Legionella pneumophila translocated substrates.

Huang L, Boyd D, Amyot WM, Hempstead AD, Luo ZQ, O'Connor TJ, Chen C, Machner M, Montminy T, Isberg RR.

Cell Microbiol. 2011 Feb;13(2):227-45. doi: 10.1111/j.1462-5822.2010.01531.x. Epub 2010 Nov 3.


E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates.

Ensminger AW, Isberg RR.

Infect Immun. 2010 Sep;78(9):3905-19. doi: 10.1128/IAI.00344-10. Epub 2010 Jun 14.


Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1).

Rajagopal S, Ji Y, Xu K, Li Y, Wicks K, Liu J, Wong KW, Herman IM, Isberg RR, Buchsbaum RJ.

J Biol Chem. 2010 Jun 4;285(23):18060-71. doi: 10.1074/jbc.M109.051490. Epub 2010 Apr 1.

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